| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| I-Hsiao Chen, Ying-Chi Du, Mei-Chin Lu, An-Shen Lin, Pei-Wen Hsieh, Chin-Chung Wu, Shu-Li Chen, Hsin-Fu Yen, Fang-Rong Chang, Yang-Chang W. Lupane-type triterpenoids from Microtropis fokienensis and Perrottetia arisanensis and the apoptotic effect of 28-hydroxy-3-oxo-lup-20(29)-en-30-al. Journal of natural products. vol 71. issue 8. 2008-12-05. PMID:18590313. |
compound 8 (28-hydroxy-3-oxo-lup-20(29)-en-30-al) was among the most cytotoxic substances obtained and was found to induce apoptosis of human leukemia hl60 cells and mediate cleavage of parp and up-regulation of bax proteins. |
2008-12-05 |
2023-08-12 |
human |
| Neal B Blatt, Anthony E Boitano, Costas A Lyssiotis, Anthony W Opipari, Gary D Glic. Bz-423 superoxide signals apoptosis via selective activation of JNK, Bak, and Bax. Free radical biology & medicine. vol 45. issue 9. 2008-12-04. PMID:18718527. |
bz-423 superoxide signals apoptosis via selective activation of jnk, bak, and bax. |
2008-12-04 |
2023-08-12 |
mouse |
| Neal B Blatt, Anthony E Boitano, Costas A Lyssiotis, Anthony W Opipari, Gary D Glic. Bz-423 superoxide signals apoptosis via selective activation of JNK, Bak, and Bax. Free radical biology & medicine. vol 45. issue 9. 2008-12-04. PMID:18718527. |
jnk signals activation of bax and bak which then induces mitochondrial outer membrane permeabilization to cause the release of cytochrome c and a commitment to apoptosis. |
2008-12-04 |
2023-08-12 |
mouse |
| Shigeru Takahashi, Yoshitaka Yoshimura, Tsuneyuki Yamamoto, Minoru Wakit. Cellular expression of Bcl-2 and Bax in atrophic submandibular glands of rats. International journal of experimental pathology. vol 89. issue 5. 2008-12-04. PMID:18808524. |
the present study aimed to establish whether bcl-2 and bax, members of the bcl-2 gene family, regulating the signalling pathway of apoptosis were involved in duct cell survival and acinar cell death in atrophic submandibular glands. |
2008-12-04 |
2023-08-12 |
rat |
| Shigeru Takahashi, Yoshitaka Yoshimura, Tsuneyuki Yamamoto, Minoru Wakit. Cellular expression of Bcl-2 and Bax in atrophic submandibular glands of rats. International journal of experimental pathology. vol 89. issue 5. 2008-12-04. PMID:18808524. |
these observations suggest that bcl-2 inhibits duct cell apoptosis and bax promotes apoptosis of acinar cells during atrophy of submandibular glands. |
2008-12-04 |
2023-08-12 |
rat |
| Mei-Li Liu, Long-Chuan Y. Potential protection of green tea polyphenols against ultraviolet irradiation-induced injury on rat cortical neurons. Neuroscience letters. vol 444. issue 3. 2008-12-03. PMID:18722507. |
protective effects of green tea polyphenols on uv-c light irradiation-induced apoptosis in cortical neurons were demonstrated by testing the content of bax, which is involved in cell death. |
2008-12-03 |
2023-08-12 |
rat |
| Igor Sukhotnik, Dan Shteinberg, Shani Ben Lulu, Yulia Bashenko, Jorge G Mogilner, Benno M Ure, Ron Shaoul, Arnold G Cora. Effect of transforming growth factor-alpha on enterocyte apoptosis is correlated with EGF receptor expression along the villus-crypt axis during methotrexate-induced intestinal mucositis in a rat. Apoptosis : an international journal on programmed cell death. vol 13. issue 11. 2008-12-03. PMID:18803016. |
in vivo experiment, a decreased levels of apoptosis in mtx- tgf-alpha rats corresponded with the decrease in bax and with the increase in bcl-2 at both mrna and protein levels. |
2008-12-03 |
2023-08-12 |
rat |
| Cristina Natal, Teresa Modol, Juan A Osés-Prieto, Natalia López-Moratalla, María J Iraburu, María J López-Zabalz. Specific protein nitration in nitric oxide-induced apoptosis of human monocytes. Apoptosis : an international journal on programmed cell death. vol 13. issue 11. 2008-12-03. PMID:18819005. |
the peroxynitrite generator sin-1 promoted apoptosis in monocytes based on oligonucleosomal dna fragmentation, caspase-3 and -9 activation, bcl-2 depletion and accumulation of bax and p53 proteins. |
2008-12-03 |
2023-08-12 |
human |
| Charles H Rundle, Xiaoguang Wang, Matilda H-C Sheng, Jon E Wergedal, K-H William Lau, Subburaman Moha. Bax deficiency in mice increases cartilage production during fracture repair through a mechanism involving increased chondrocyte proliferation without changes in apoptosis. Bone. vol 43. issue 5. 2008-12-02. PMID:18708175. |
bax deficiency in mice increases cartilage production during fracture repair through a mechanism involving increased chondrocyte proliferation without changes in apoptosis. |
2008-12-02 |
2023-08-12 |
mouse |
| Charles H Rundle, Xiaoguang Wang, Matilda H-C Sheng, Jon E Wergedal, K-H William Lau, Subburaman Moha. Bax deficiency in mice increases cartilage production during fracture repair through a mechanism involving increased chondrocyte proliferation without changes in apoptosis. Bone. vol 43. issue 5. 2008-12-02. PMID:18708175. |
tunel analysis showed no significant differences in the number of either chondrocyte or non-chondrocyte apoptotic cells between bax ko and c57bl/6j fractures at 7 or 14 days post-fracture, indicating that the increased number of chondrocytes in bax ko fractures was not due to reduced apoptosis. |
2008-12-02 |
2023-08-12 |
mouse |
| Charles H Rundle, Xiaoguang Wang, Matilda H-C Sheng, Jon E Wergedal, K-H William Lau, Subburaman Moha. Bax deficiency in mice increases cartilage production during fracture repair through a mechanism involving increased chondrocyte proliferation without changes in apoptosis. Bone. vol 43. issue 5. 2008-12-02. PMID:18708175. |
analysis of expression of apoptotic genes revealed that although the expression levels of bcl-2 and bcl-xl were not different between the bax ko and c57bl/6j mice at 7 or 14 days post-fracture, the expression of bh3-domain only bak and "bik-like" pro-apoptotic gene increased approximately 1.5-fold and approximately 2-fold, respectively, in bax ko fractures at 7 and 14 days post-fracture, compared to c57bl/6j fractures, suggesting that up-regulation of the bak and bik-like pro-apoptotic genes in bax ko mice might compensate for the lack of bax functions in the context of apoptosis. |
2008-12-02 |
2023-08-12 |
mouse |
| Charles H Rundle, Xiaoguang Wang, Matilda H-C Sheng, Jon E Wergedal, K-H William Lau, Subburaman Moha. Bax deficiency in mice increases cartilage production during fracture repair through a mechanism involving increased chondrocyte proliferation without changes in apoptosis. Bone. vol 43. issue 5. 2008-12-02. PMID:18708175. |
in conclusion, this study demonstrates for the first time that bax has an important role in the early stage of fracture healing, and that the increased callus size and cartilage area in bax ko fractures was due to increased chondrocyte proliferation and not to reduced apoptosis or increased chondrocyte hypertrophy. |
2008-12-02 |
2023-08-12 |
mouse |
| Yan Wang, Lynne M Ausman, Robert M Russell, Andrew S Greenberg, Xiang-Dong Wan. Increased apoptosis in high-fat diet-induced nonalcoholic steatohepatitis in rats is associated with c-Jun NH2-terminal kinase activation and elevated proapoptotic Bax. The Journal of nutrition. vol 138. issue 10. 2008-12-02. PMID:18806094. |
increased apoptosis in high-fat diet-induced nonalcoholic steatohepatitis in rats is associated with c-jun nh2-terminal kinase activation and elevated proapoptotic bax. |
2008-12-02 |
2023-08-12 |
rat |
| Toshihiko Oka, Tomoko Sayano, Shoko Tamai, Sadaki Yokota, Hiroki Kato, Gen Fujii, Katsuyoshi Mihar. Identification of a novel protein MICS1 that is involved in maintenance of mitochondrial morphology and apoptotic release of cytochrome c. Molecular biology of the cell. vol 19. issue 6. 2008-12-01. PMID:18417609. |
mics1 overproduction induces mitochondrial aggregation and partially inhibits cytochrome c release during apoptosis, regardless of the occurrence of bax targeting. |
2008-12-01 |
2023-08-12 |
Not clear |
| Hsin-Ling Yang, Ssu-Ching Chen, Chih-Sheng Chen, Sheng-Yang Wang, You-Cheng Hse. Alpinia pricei rhizome extracts induce apoptosis of human carcinoma KB cells via a mitochondria-dependent apoptotic pathway. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. vol 46. issue 10. 2008-12-01. PMID:18768154. |
this increase in ap extract-induced apoptosis was also associated with a reduction in the levels of bcl-2, a potent cell-death inhibitor, and an increase in levels of the bax protein, which heterodimerizes with and thereby inhibits bcl-2. |
2008-12-01 |
2023-08-12 |
human |
| Jialong Guo, Kailun Zhang, Yanmei Ji, Xionggang Jiang, Shunqing Zu. Effects of ethyl pyruvate on myocardial apoptosis and expression of Bcl-2 and Bax proteins after ischemia-reperfusion in rats. Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban. vol 28. issue 3. 2008-11-26. PMID:18563323. |
effects of ethyl pyruvate on myocardial apoptosis and expression of bcl-2 and bax proteins after ischemia-reperfusion in rats. |
2008-11-26 |
2023-08-12 |
rat |
| Jialong Guo, Kailun Zhang, Yanmei Ji, Xionggang Jiang, Shunqing Zu. Effects of ethyl pyruvate on myocardial apoptosis and expression of Bcl-2 and Bax proteins after ischemia-reperfusion in rats. Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban. vol 28. issue 3. 2008-11-26. PMID:18563323. |
in order to study the effects of ethyl pyruvate on cardiomyocyte apoptosis following ischemia/reperfusion (i/r) in vitro and the expression of bcl-2 and bax proteins, isolated rat hearts were perfused in a langendorff model. |
2008-11-26 |
2023-08-12 |
rat |
| Jialong Guo, Kailun Zhang, Yanmei Ji, Xionggang Jiang, Shunqing Zu. Effects of ethyl pyruvate on myocardial apoptosis and expression of Bcl-2 and Bax proteins after ischemia-reperfusion in rats. Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban. vol 28. issue 3. 2008-11-26. PMID:18563323. |
these results demonstrate that ep could inhibit apoptosis of cardiac myocytes possibly via alleviating oxidative stress, up-regulating bcl-2 and down-regulating bax proteins. |
2008-11-26 |
2023-08-12 |
rat |
| Karim Iskander, Roberto J Barrios, Anil K Jaiswa. Disruption of NAD(P)H:quinone oxidoreductase 1 gene in mice leads to radiation-induced myeloproliferative disease. Cancer research. vol 68. issue 19. 2008-11-26. PMID:18829548. |
exposure of nqo1(-/-) mice to gamma-radiation resulted in reduced apoptosis in granulocytes and lack of induction of p53, p21, and bax. |
2008-11-26 |
2023-08-12 |
mouse |
| Tatiana Kniazhanski, Anna Jackman, Alina Heyfets, Pinhas Gonen, Eliezer Flescher, Levana Sherma. Methyl jasmonate induces cell death with mixed characteristics of apoptosis and necrosis in cervical cancer cells. Cancer letters. vol 271. issue 1. 2008-11-24. PMID:18599197. |
cell death induced by mj displayed features characteristic to both apoptosis and necrosis, and was associated with different changes in the levels of p53, p21, bcl-2 and bax in the various cervical cancer lines. |
2008-11-24 |
2023-08-12 |
human |