| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| C J Percy, L Brown, D A Power, D W Johnson, G C Gob. Obesity and hypertension have differing oxidant handling molecular pathways in age-related chronic kidney disease. Mechanisms of ageing and development. vol 130. issue 3. 2009-05-14. PMID:19041334. |
young adult (3 months) and old (21-24 months) spontaneously-hypertensive (shr), normotensive wistar-kyoto (wky) and wistar rats (normotensive, obese in ageing) were compared for renal functional and physiological parameters, renal fibrosis and inflammation, oxidative stress (hemeoxygenase-1/ho-1), apoptosis and cell injury (including bax:bcl-2), phosphorylated and non-phosphorylated forms of oxidant and energy sensing proteins (p66shc, ampk), signal transduction proteins (erk1/2, pkb), and transcription factors (nf-kappab, foxo1). |
2009-05-14 |
2023-08-12 |
rat |
| Marc-Antoine Sani, Erick J Dufourc, Gerhard Gröbne. How does the Bax-alpha1 targeting sequence interact with mitochondrial membranes? The role of cardiolipin. Biochimica et biophysica acta. vol 1788. issue 3. 2009-05-14. PMID:19161978. |
cd studies revealed, that the cardiolipin mediated electrostatic locking of bax-alpha1 at the cs membrane surface promotes conformational changes into an alpha-helical state; a process which seems to be necessary to induce further conformational transition events in activated bax which finally causes irreversible membrane permeabilization during the mitochondrial apoptosis. |
2009-05-14 |
2023-08-12 |
Not clear |
| Jian Zhong, Jing Chen, Tingbin Cao, Lijuan Wang, Weiguo Zhang, Daoyan Liu, Zhiming Zh. Adenovirus-mediated FKBP12.6 overexpression induces hypertrophy and apoptosis in cultured neonatal cardiomyocytes. Clinical and experimental pharmacology & physiology. vol 36. issue 2. 2009-05-12. PMID:18759859. |
at the same time, overexpression of fkbp12.6 induced apoptosis of cardiomyocytes, as determined by both bax protein expression and dna fragmentation. |
2009-05-12 |
2023-08-12 |
human |
| Yi-Ying Zhang, Tao Deng, Zhi-Fang Hu, Qiu-Ping Zhang, Jing Zhang, Hua Jian. [Mechanisms of inhibiting proliferation and inducing apoptosis of human gastric cancer cell line SGC7901 by ursolic acid]. Ai zheng = Aizheng = Chinese journal of cancer. vol 25. issue 4. 2009-05-11. PMID:16613675. |
this study was to investigate the effect of ua on cox-2, bcl-2 and bax expression in human gastric cancer cell line sgc7901, and explore its potential mechanisms of inhibiting proliferation and inducing apoptosis. |
2009-05-11 |
2023-08-12 |
human |
| Eun-Jung Park, Hye-Young Min, Hwa-Jin Chung, Ji-Young Hong, You-Jin Kang, Tran Manh Hung, Ui Joung Youn, Yeong Shik Kim, Kihwan Bae, Sam Sik Kang, Sang Kook Le. Down-regulation of c-Src/EGFR-mediated signaling activation is involved in the honokiol-induced cell cycle arrest and apoptosis in MDA-MB-231 human breast cancer cells. Cancer letters. vol 277. issue 2. 2009-05-07. PMID:19135778. |
apoptosis caused by honokiol was also concomitant with the cleavage of caspases (caspase-3, -8, and -9) and bid along with the suppressive expression of bcl-2, but it was independent on the expression of bax and p53. |
2009-05-07 |
2023-08-12 |
human |
| Michael A Joyce, Kathie-Anne Walters, Sue-Ellen Lamb, Mathew M Yeh, Lin-Fu Zhu, Norman Kneteman, Jason S Doyle, Michael G Katze, D Lorne Tyrrel. HCV induces oxidative and ER stress, and sensitizes infected cells to apoptosis in SCID/Alb-uPA mice. PLoS pathogens. vol 5. issue 2. 2009-05-05. PMID:19242562. |
we found that the er chaperone bip/grp78 was increased in hcv-infected cells as was activated bax, but the activator of er stress-mediated apoptosis chop was not. |
2009-05-05 |
2023-08-12 |
mouse |
| Michael A Joyce, Kathie-Anne Walters, Sue-Ellen Lamb, Mathew M Yeh, Lin-Fu Zhu, Norman Kneteman, Jason S Doyle, Michael G Katze, D Lorne Tyrrel. HCV induces oxidative and ER stress, and sensitizes infected cells to apoptosis in SCID/Alb-uPA mice. PLoS pathogens. vol 5. issue 2. 2009-05-05. PMID:19242562. |
we conclude that hcv contributes to hepatocyte damage and apoptosis by inducing stress and pro-apoptotic bax while preventing the induction of anti-apoptotic nf-kappab and bcl-xl, thus sensitizing hepatocytes to apoptosis. |
2009-05-05 |
2023-08-12 |
mouse |
| Silvia Rodríguez-Mulero, Eduard Montany. Islet graft response to transplantation injury includes upregulation of protective as well as apoptotic genes. Cell transplantation. vol 17. issue 9. 2009-05-04. PMID:19177839. |
we studied the expression of a set of selected genes involved in apoptosis (bcl2, bclx(l), bax, bad, bid, and chop), cytokine defense, (socs-1 and socs-3), or free radical protection (hmox1, cu/zn-sod, mn-sod, and hsp70). |
2009-05-04 |
2023-08-12 |
rat |
| Takeshi Nishikawa, Nelson H Tsuno, Takeshi Tsuchiya, Satomi Yoneyama, Jun Yamada, Yasutaka Shuno, Yurai Okaji, Junichiro Tanaka, Joji Kitayama, Koki Takahashi, Hirokazu Nagaw. Sulforaphane stimulates activation of proapoptotic protein bax leading to apoptosis of endothelial progenitor cells. Annals of surgical oncology. vol 16. issue 2. 2009-04-30. PMID:19034579. |
sulforaphane stimulates activation of proapoptotic protein bax leading to apoptosis of endothelial progenitor cells. |
2009-04-30 |
2023-08-12 |
human |
| A Ray, S Roy, S Agarwal, S Bhattachary. As2O3 toxicity in rat hepatocytes: manifestation of caspase-mediated apoptosis. Toxicology and industrial health. vol 24. issue 10. 2009-04-30. PMID:19141569. |
apoptosis was triggered by caspase activation and over expression of bax at 10 microm as(2)o(3) and at 20 and 40 microm concentrations of as(2)o(3), map kinases were found to mediate the apoptotic pathway. |
2009-04-30 |
2023-08-12 |
rat |
| Cecilia Eliana Hanzel, Sandra Viviana Verstraete. Tl(I) and Tl(III) activate both mitochondrial and extrinsic pathways of apoptosis in rat pheochromocytoma (PC12) cells. Toxicology and applied pharmacology. vol 236. issue 1. 2009-04-30. PMID:19371624. |
both cations lead to bax oligomerization and caused apoptosis inducing factor (aif), endonuclease g (endo g), and cytochrome c release from mitochondria, but they did not activate caspase dependent dnase (cad). |
2009-04-30 |
2023-08-12 |
rat |
| Desiree A Steimer, Kelli Boyd, Osamu Takeuchi, Jill K Fisher, Gerard P Zambetti, Joseph T Opferma. Selective roles for antiapoptotic MCL-1 during granulocyte development and macrophage effector function. Blood. vol 113. issue 12. 2009-04-28. PMID:19064728. |
however, blockade of intrinsic apoptosis by lineage-specific deletion of both multidomain proapoptotics bax and bak was capable of rescuing the neutropenia associated with mcl-1 deletion. |
2009-04-28 |
2023-08-12 |
Not clear |
| Bin Chang, Guangzhi Liu, Gong Yang, Imelda Mercado-Uribe, Miao Huang, Jinsong Li. REDD1 is required for RAS-mediated transformation of human ovarian epithelial cells. Cell cycle (Georgetown, Tex.). vol 8. issue 5. 2009-04-28. PMID:19221489. |
redd1 overexpression decreased apoptosis and associated with increased expression of bcl-x(l) or bcl-2 and decreased expression of fadd, caspase1, caspase8, caspase 9, caspase 10, bax, bad and bcl-x(s). |
2009-04-28 |
2023-08-12 |
mouse |
| Yong Chun Jin, Wooyeol Kim, Yu Mi Ha, Il Woo Shin, Ju Tae Sohn, Hye Jung Kim, Han Geuk Seo, Jea Heun Lee, Ki Churl Chan. Propofol limits rat myocardial ischemia and reperfusion injury with an associated reduction in apoptotic cell death in vivo. Vascular pharmacology. vol 50. issue 1-2. 2009-04-27. PMID:18996224. |
apoptosis was evaluated by western blot analysis (bcl-2, bax expression), dna strand breaks, tunel analysis and measuring myocardial caspase-3 activity. |
2009-04-27 |
2023-08-12 |
rat |
| Natalia Ermak, Bernard Lacour, Tilman B Drüeke, Stéphanie Vicc. Role of reactive oxygen species and Bax in oxidized low density lipoprotein-induced apoptosis of human monocytes. Atherosclerosis. vol 200. issue 2. 2009-04-24. PMID:18282575. |
role of reactive oxygen species and bax in oxidized low density lipoprotein-induced apoptosis of human monocytes. |
2009-04-24 |
2023-08-12 |
human |
| Natalia Ermak, Bernard Lacour, Tilman B Drüeke, Stéphanie Vicc. Role of reactive oxygen species and Bax in oxidized low density lipoprotein-induced apoptosis of human monocytes. Atherosclerosis. vol 200. issue 2. 2009-04-24. PMID:18282575. |
oxldl-induced u937 cells apoptosis involved ros generation, mitochondrial bax translocation with a disruption of mitochondrial membrane potential, cytosolic liberation of cytochrome c and subsequently activation of caspases-9 and -3. |
2009-04-24 |
2023-08-12 |
human |
| Chia-Fang Tsai, Yu-Wen Hsu, Wen-Kang Chen, Yung-Chyuan Ho, Fung-Jou L. Enhanced induction of mitochondrial damage and apoptosis in human leukemia HL-60 cells due to electrolyzed-reduced water and glutathione. Bioscience, biotechnology, and biochemistry. vol 73. issue 2. 2009-04-24. PMID:19202298. |
the results of apoptotic related protein indicated that the induction of hl-60 cell death was caused by the induction of apoptosis through upregulation of bax and downregulation of bcl-2. |
2009-04-24 |
2023-08-12 |
human |
| Xiang-Wei Yuan, Xiao-Feng Zhu, Xiu-Fang Huang, Pu-Yi Sheng, Ai-Shan He, Zi-Bo Yang, Rong Deng, Gong-Kan Feng, Wei-Ming Lia. P14ARF sensitizes human osteosarcoma cells to cisplatin-induced apoptosis in a p53-independent manner. Cancer biology & therapy. vol 6. issue 7. 2009-04-23. PMID:17611411. |
this sensitization of cisplatin-induced apoptosis was associated with upregulation of p53, bax and p21 in u2os cells. |
2009-04-23 |
2023-08-12 |
human |
| Jun Jiang, Jianan Wang, Changling Li, Shan Ping Yu, Ling We. Dual roles of tumor necrosis factor-alpha receptor-1 in a mouse model of hindlimb ischemia. Vascular medicine (London, England). vol 14. issue 1. 2009-04-23. PMID:19144778. |
western blot analysis revealed less expression of pro-apoptotic markers bax and cleaved caspase-3 in tnfr-1-/- mice 1 day after ischemia, supporting the hypothesis that the absence of tnfr-1 results in a reduction of apoptosis. |
2009-04-23 |
2023-08-12 |
mouse |
| Lihong Fan, Kunzheng Wang, Bin Chen. Effects of buyang huanwu decoction on apoptosis of nervous cells and expressions of Bcl-2 and bax in the spinal cord of ischemia-reperfusion injury in rabbits. Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan. vol 26. issue 2. 2009-04-21. PMID:16817283. |
effects of buyang huanwu decoction on apoptosis of nervous cells and expressions of bcl-2 and bax in the spinal cord of ischemia-reperfusion injury in rabbits. |
2009-04-21 |
2023-08-12 |
Not clear |