| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Toshifumi Takahashi, Hideki Igarashi, Jun Kawagoe, Mitsuyoshi Amita, Shuichiro Hara, Hirohisa Kurach. Poor embryo development in mouse oocytes aged in vitro is associated with impaired calcium homeostasis. Biology of reproduction. vol 80. issue 3. 2009-06-25. PMID:19038861. |
because embryo fragmentation is closely related to apoptosis, we examined expression of bax (a proapototic protein) and bcl2 (an antiapoptotic protein) in in vitro-aged oocytes. |
2009-06-25 |
2023-08-12 |
mouse |
| Jun Ren, Sara A Babcock, Qun Li, Anna F Huff, Shi-Yan Li, Thomas A Dose. Aldehyde dehydrogenase-2 transgene ameliorates chronic alcohol ingestion-induced apoptosis in cerebral cortex. Toxicology letters. vol 187. issue 3. 2009-06-25. PMID:19429258. |
western blot was performed to examine expression (or its activation) of aldh2, the pro- and anti-apoptotic proteins caspase-8, bax, bcl-2, omi/htra2, apoptosis repressor with caspase recruitment domain (arc), flice-like inhibitory protein (flip), x-linked inhibitor of apoptosis protein (xiap), akt, glycogen synthase kinase-3beta (gsk-3beta), p38, c-jun n-terminal kinase (jnk) and extracellular signal-regulated kinase (erk). |
2009-06-25 |
2023-08-12 |
mouse |
| Letteria Minutoli, Pietro Antonuccio, Francesca Polito, Alessandra Bitto, Francesco Squadrito, Vincenzo Di Stefano, Piero Antonio Nicotina, Carmine Fazzari, Daniele Maisano, Carmelo Romeo, Domenica Altavill. Mitogen-activated protein kinase 3/mitogen-activated protein kinase 1 activates apoptosis during testicular ischemia-reperfusion injury in a nuclear factor-kappaB-independent manner. European journal of pharmacology. vol 604. issue 1-3. 2009-06-24. PMID:19135439. |
mapk3/mapk1, bax, caspase-3 and -9 and tnf-alpha expression were assessed along with histological examination and an immunostaining for protein of apoptosis. |
2009-06-24 |
2023-08-12 |
mouse |
| Chen Chen, Guiling Li, Wanmin Liao, Jun Wu, Liu Liu, Ding Ma, Jianfeng Zhou, Reem H Elbekai, Matthew L Edin, Darryl C Zeldin, Dao Wen Wan. Selective inhibitors of CYP2J2 related to terfenadine exhibit strong activity against human cancers in vitro and in vivo. The Journal of pharmacology and experimental therapeutics. vol 329. issue 3. 2009-06-23. PMID:19289568. |
inhibition of cyp2j2 also significantly potentiated human tumor cell apoptosis and caused a corresponding increase in caspase-3 activity and change in expression of apoptosis-related proteins bax and bcl-2. |
2009-06-23 |
2023-08-12 |
human |
| Jamie S Mader, Neeloffer Mookherjee, Robert E W Hancock, R Chris Bleackle. The human host defense peptide LL-37 induces apoptosis in a calpain- and apoptosis-inducing factor-dependent manner involving Bax activity. Molecular cancer research : MCR. vol 7. issue 5. 2009-06-23. PMID:19435812. |
the human host defense peptide ll-37 induces apoptosis in a calpain- and apoptosis-inducing factor-dependent manner involving bax activity. |
2009-06-23 |
2023-08-12 |
human |
| Jamie S Mader, Neeloffer Mookherjee, Robert E W Hancock, R Chris Bleackle. The human host defense peptide LL-37 induces apoptosis in a calpain- and apoptosis-inducing factor-dependent manner involving Bax activity. Molecular cancer research : MCR. vol 7. issue 5. 2009-06-23. PMID:19435812. |
of interest, both bcl-2-overexpressing cells and cells deficient in bax and bak proteins displayed a significant reduction in ll-37-induced apoptosis. |
2009-06-23 |
2023-08-12 |
human |
| Jamie S Mader, Neeloffer Mookherjee, Robert E W Hancock, R Chris Bleackle. The human host defense peptide LL-37 induces apoptosis in a calpain- and apoptosis-inducing factor-dependent manner involving Bax activity. Molecular cancer research : MCR. vol 7. issue 5. 2009-06-23. PMID:19435812. |
together, these data show that ll-37-induced apoptosis is mediated via the mitochondria-associated pathway in a caspase-independent and calpain- and aif-dependent manner that involves bax activation and translocation to mitochondria. |
2009-06-23 |
2023-08-12 |
human |
| Sujoy Bhattacharya, Ramesh M Ray, Leonard R Johnso. Role of polyamines in p53-dependent apoptosis of intestinal epithelial cells. Cellular signalling. vol 21. issue 4. 2009-06-22. PMID:19136059. |
increased p53 levels and its phosphorylation increased bax protein, caspase-9, -3 activation and apoptosis. |
2009-06-22 |
2023-08-12 |
Not clear |
| Rong Chu, Meenakshi Upreti, Wen-Xing Ding, Xiao-Ming Yin, Timothy C Chamber. Regulation of Bax by c-Jun NH2-terminal kinase and Bcl-xL in vinblastine-induced apoptosis. Biochemical pharmacology. vol 78. issue 3. 2009-06-22. PMID:19427996. |
regulation of bax by c-jun nh2-terminal kinase and bcl-xl in vinblastine-induced apoptosis. |
2009-06-22 |
2023-08-12 |
Not clear |
| Rong Chu, Meenakshi Upreti, Wen-Xing Ding, Xiao-Ming Yin, Timothy C Chamber. Regulation of Bax by c-Jun NH2-terminal kinase and Bcl-xL in vinblastine-induced apoptosis. Biochemical pharmacology. vol 78. issue 3. 2009-06-22. PMID:19427996. |
these findings provide novel insight into the role of bax and its regulation in vinblastine-induced apoptosis. |
2009-06-22 |
2023-08-12 |
Not clear |
| Jia-Jun Liu, Yong Zhang, Dong-Jun Lin, Ruo-Zhi Xia. Tanshinone IIA inhibits leukemia THP-1 cell growth by induction of apoptosis. Oncology reports. vol 21. issue 4. 2009-06-18. PMID:19288011. |
western blotting showed cleavage of the caspase-3 zymogen protein (32-kda) with the appearance of its 20-kda subunit and a dose-dependent cleavage of parp, with the appearance of 89-kda fragment; the expression of bcl-2 and survivin was down-regulated remarkably while bax expression was up-regulated concurrently after the cells were treated with tanshinone iia for 48 h. we therefore conclude that tanshinone iia has significant growth inhibition effects on thp-1 cells by induction of apoptosis, and that tanshinone iia-induced apoptosis on thp-1 cells is mainly related to the disruption of deltapsim and activation of caspase-3 as well as down-regulation of anti-apoptotic protein bcl-2, survivin and up-regulation of pro-apoptotic protein bax. |
2009-06-18 |
2023-08-12 |
Not clear |
| Barbora Brodska, Petra Otevrelova, Ivan Kalouse. Variations in c-Myc and p21WAF1 expression protect normal peripheral blood lymphocytes against BimEL-mediated cell death. Cell biochemistry and function. vol 27. issue 3. 2009-06-18. PMID:19330811. |
the bax activator bimel increased rapidly, driving cells towards apoptosis likely controlled by c-myc and p21(waf1) activities. |
2009-06-18 |
2023-08-12 |
Not clear |
| Hea Jin Park, Srujana Rayalam, Mary Anne Della-Fera, Suresh Ambati, Jeong-Yeh Yang, Clifton A Bail. Withaferin A induces apoptosis and inhibits adipogenesis in 3T3-L1 adipocytes. BioFactors (Oxford, England). vol 33. issue 2. 2009-06-18. PMID:19346589. |
induction of apoptosis by wa in mature adipocytes was mediated by increased erk1/2 phosphorylation and altered bax and bcl2 protein expression. |
2009-06-18 |
2023-08-12 |
Not clear |
| Jilao Fan, Kyung-No Son, Sevim Yildiz Arslan, Zhiguo Liang, Howard L Lipto. Theiler's murine encephalomyelitis virus leader protein is the only nonstructural protein tested that induces apoptosis when transfected into mammalian cells. Journal of virology. vol 83. issue 13. 2009-06-18. PMID:19403676. |
infection of murine macrophages in culture induces apoptosis that is bax dependent through the intrinsic or mitochondrial pathway, restricting infectious-virus yields and raising the possibility that apoptosis represents a mechanism to attenuate tmev yet promote macrophage-to-macrophage spread during persistent infection. |
2009-06-18 |
2023-08-12 |
mouse |
| Beatriz Santamaría, Alberto Benito-Martin, Alvaro Conrado Ucero, Ana Reyero, Rafael Selgas, Marta Ruiz-Ortega, Jesús Egido, Alberto Orti. Bcl-xL prevents peritoneal dialysis solution-induced leukocyte apoptosis. Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis. vol 28 Suppl 5. 2009-06-17. PMID:19008541. |
since apoptosis induced by pds requires bax, we explored the role of an antiapoptotic protein of the same family, bcl-xl, in pds-induced apoptosis in cultured peripheral blood mononuclear cells and monocytic thp-1 cells. |
2009-06-17 |
2023-08-12 |
Not clear |
| Ruiping Zhang, Xiping Zhang, Jie Zhang, Junsheng Wu, Qian Ye, Rujun Xu, Jing Ye, Xin Fang, Lu Jin, Jiao He, Wenqin Yua. Efficacy and mechanism of Salvia miltiorrhizae injection in the treatment of rats with severe acute pancreatitis. Inflammation. vol 32. issue 2. 2009-06-17. PMID:19238530. |
at 3, 6 and 12 h after operation, the mortality rate, ascitic volumes, pathological changes in the pancreas, contents of amylase and endotoxin in plasma as well as il-6, il-18, et-1 and no in serum, the staining intensity of bax and nf-kappab p56 proteins, and the changes in apoptosis index of pancreatic cells in rats in each group were observed. |
2009-06-17 |
2023-08-12 |
rat |
| Jiahua Yu, Kang-Beom Kwon, Jin-Woo Park, Han-Jung Chae, Byung-Hyun Par. Bax inhibitor-1 overexpression reduces the suppressive effect of calcium mobilizing agent on adipogenesis. The international journal of biochemistry & cell biology. vol 41. issue 8-9. 2009-06-17. PMID:19433315. |
bax inhibitor-1 is a conserved protein which suppresses endoplasmic reticulum stress-induced apoptosis and regulates calcium release from the endoplasmic reticulum. |
2009-06-17 |
2023-08-12 |
Not clear |
| Antonello A Romani, Silvia Desenzani, Marina M Morganti, Silvia La Monica, Angelo F Borghetti, Paolo Solian. Zoledronic acid determines S-phase arrest but fails to induce apoptosis in cholangiocarcinoma cells. Biochemical pharmacology. vol 78. issue 2. 2009-06-17. PMID:19464430. |
the lack of tp53 or loss of its function, the large constitutive expressions of anti-apoptotic proteins bcl-xl and hsp27 together with the low level of the pro-apoptotic bax are the likely factors which protect cells from apoptosis. |
2009-06-17 |
2023-08-12 |
human |
| Aftab Taiyab, Amere S Sreedhar, Ch Mohan Ra. Hsp90 inhibitors, GA and 17AAG, lead to ER stress-induced apoptosis in rat histiocytoma. Biochemical pharmacology. vol 78. issue 2. 2009-06-17. PMID:19464431. |
we conclude that inhibition of hsp90 leads to er stress-induced mitochondria-mediated apoptosis and that bax and ca(2+) play an important role in mitochondrial damage. |
2009-06-17 |
2023-08-12 |
rat |
| K L Khanduja, S Kumar, N Varma, S C Varma, P K Avti, C M Patha. Enhancement in alpha-tocopherol succinate-induced apoptosis by all-trans-retinoic acid in primary leukemic cells: role of antioxidant defense, Bax and c-myc. Molecular and cellular biochemistry. vol 319. issue 1-2. 2009-06-16. PMID:18642056. |
enhancement in alpha-tocopherol succinate-induced apoptosis by all-trans-retinoic acid in primary leukemic cells: role of antioxidant defense, bax and c-myc. |
2009-06-16 |
2023-08-12 |
Not clear |