| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Li-li Zhou, Li-na Yang, Li Wan. [The expression of apoptosis related genes Bcl-2 and Bax protein in dysfunctional uterine bleeding]. Zhonghua shi yan he lin chuang bing du xue za zhi = Zhonghua shiyan he linchuang bingduxue zazhi = Chinese journal of experimental and clinical virology. vol 22. issue 6. 2009-07-29. PMID:19544644. |
to research the expression of apoptosis related genes bcl-2 and bax protein in dysfunctional uterine bleeding. |
2009-07-29 |
2023-08-12 |
Not clear |
| Divya Purushothaman, Apurva Sari. Cytokine-dependent regulation of NADPH oxidase activity and the consequences for activated T cell homeostasis. The Journal of experimental medicine. vol 206. issue 7. 2009-07-29. PMID:19546249. |
using mice deficient for the catalytic subunit gp91(phox) to characterize the molecular link to activated t cell apoptosis, we show that gp91(phox)-deficient t (t(-/-)) cells generated mitochondrial superoxide but had diminished hydrogen peroxide production in response to neglect, which, in turn, regulated jun n-terminal kinase-dependent bax activation and apoptosis. |
2009-07-29 |
2023-08-12 |
mouse |
| Mohamed F Ismail, Doaa A Ali, Augusta Fernando, Mohamed E Abdraboh, Rajiv L Gaur, Wael M Ibrahim, Madhwa H G Raj, Allal Ouhti. Chemoprevention of rat liver toxicity and carcinogenesis by Spirulina. International journal of biological sciences. vol 5. issue 4. 2009-07-28. PMID:19521547. |
in addition, sp increased bax and decreased bcl-2 expression, indicating induction of apoptosis by 48hrs. |
2009-07-28 |
2023-08-12 |
rat |
| Manjari Chaudhari, R Jayaraj, A S B Bhaskar, P V Lakshmana Ra. Oxidative stress induction by T-2 toxin causes DNA damage and triggers apoptosis via caspase pathway in human cervical cancer cells. Toxicology. vol 262. issue 2. 2009-07-28. PMID:19524637. |
western blot analysis showed increase in levels of mitochondrial apoptogenic factors bax, bcl-2, cytochrome-c followed by activation of caspases-9, -3 and -7 leading to dna fragmentation and apoptosis. |
2009-07-28 |
2023-08-12 |
human |
| Yeon-Gu Kim, Jee Yon Kim, Chaya Mohan, Gyun Min Le. Effect of Bcl-xL overexpression on apoptosis and autophagy in recombinant Chinese hamster ovary cells under nutrient-deprived condition. Biotechnology and bioengineering. vol 103. issue 4. 2009-07-27. PMID:19266576. |
immunoprecipitation analysis with a flag-tagged bcl-x(l) revealed that bcl-x(l) interacts with bax and bak, essential mediators of caspase-dependent apoptosis, as well as with beclin-1, an essential mediator of autophagy, and may inhibit their pro-cell death function. |
2009-07-27 |
2023-08-12 |
Not clear |
| Gum-Yong Kang, Eung-Ryoung Lee, Jung-Hyun Kim, Jin Woo Jung, Jun Lim, Sang Kyung Kim, Ssang-Goo Cho, Kwang Pyo Ki. Downregulation of PLK-1 expression in kaempferol-induced apoptosis of MCF-7 cells. European journal of pharmacology. vol 611. issue 1-3. 2009-07-23. PMID:19356725. |
western blot analysis showed cleavage of poly (adp-ribose) polymerase (parp), caspase-7, bax, and caspase-9 indicating that the intracellular pathway of apoptosis was involved. |
2009-07-23 |
2023-08-12 |
human |
| Logan Banadyga, Kirstin Veugelers, Stephanie Campbell, Michele Barr. The fowlpox virus BCL-2 homologue, FPV039, interacts with activated Bax and a discrete subset of BH3-only proteins to inhibit apoptosis. Journal of virology. vol 83. issue 14. 2009-07-23. PMID:19439472. |
the fowlpox virus bcl-2 homologue, fpv039, interacts with activated bax and a discrete subset of bh3-only proteins to inhibit apoptosis. |
2009-07-23 |
2023-08-12 |
Not clear |
| Logan Banadyga, Kirstin Veugelers, Stephanie Campbell, Michele Barr. The fowlpox virus BCL-2 homologue, FPV039, interacts with activated Bax and a discrete subset of BH3-only proteins to inhibit apoptosis. Journal of virology. vol 83. issue 14. 2009-07-23. PMID:19439472. |
thus, to effectively inhibit apoptosis, a number of viruses also inhibit bax. |
2009-07-23 |
2023-08-12 |
Not clear |
| Logan Banadyga, Kirstin Veugelers, Stephanie Campbell, Michele Barr. The fowlpox virus BCL-2 homologue, FPV039, interacts with activated Bax and a discrete subset of BH3-only proteins to inhibit apoptosis. Journal of virology. vol 83. issue 14. 2009-07-23. PMID:19439472. |
here we show that fpv039 inhibited apoptosis induced by bax overexpression and prevented both the conformational activation of bax and the subsequent formation of bax oligomers at the mitochondria, two critical steps in the induction of apoptosis. |
2009-07-23 |
2023-08-12 |
Not clear |
| Logan Banadyga, Kirstin Veugelers, Stephanie Campbell, Michele Barr. The fowlpox virus BCL-2 homologue, FPV039, interacts with activated Bax and a discrete subset of BH3-only proteins to inhibit apoptosis. Journal of virology. vol 83. issue 14. 2009-07-23. PMID:19439472. |
fpv039 also inhibited apoptosis induced by the bh3-only proteins, upstream activators of bak and bax, despite interacting detectably with only two: biml and bik. |
2009-07-23 |
2023-08-12 |
Not clear |
| Logan Banadyga, Kirstin Veugelers, Stephanie Campbell, Michele Barr. The fowlpox virus BCL-2 homologue, FPV039, interacts with activated Bax and a discrete subset of BH3-only proteins to inhibit apoptosis. Journal of virology. vol 83. issue 14. 2009-07-23. PMID:19439472. |
collectively, our data suggest that fpv039 inhibits apoptosis by sequestering and inactivating multiple proapoptotic bcl-2 proteins, including certain bh3-only proteins and both of the critical "gatekeepers" of apoptosis, bak and bax. |
2009-07-23 |
2023-08-12 |
Not clear |
| Huanchen Sha, Qingyong Ma, Rajiv Kumar Jha, Zheng Wan. Resveratrol ameliorates lung injury via inhibition of apoptosis in rats with severe acute pancreatitis. Experimental lung research. vol 35. issue 4. 2009-07-22. PMID:19415550. |
the authors investigated mitochondrial cytochrome c release and evaluated the bax, bcl-2, and caspase-3 expression levels in lung tissue over the time course of apoptosis. |
2009-07-22 |
2023-08-12 |
rat |
| Petra K Wäster, Karin M Ollinge. Redox-dependent translocation of p53 to mitochondria or nucleus in human melanocytes after UVA- and UVB-induced apoptosis. The Journal of investigative dermatology. vol 129. issue 7. 2009-07-20. PMID:19158844. |
although different intracellular location of p53, uva/b induced apoptosis through the intrinsic pathway detected as translocation of bax to mitochondria, release of cytochrome c, and activation of caspases. |
2009-07-20 |
2023-08-12 |
human |
| Deepa S De Silva, Richard M Wilson, Christoph Hutchinson, Peter C Ip, Anthony G Garcia, Steve Lancel, Masa Ito, David R Pimentel, Flora Sa. Fenofibrate inhibits aldosterone-induced apoptosis in adult rat ventricular myocytes via stress-activated kinase-dependent mechanisms. American journal of physiology. Heart and circulatory physiology. vol 296. issue 6. 2009-07-17. PMID:19395558. |
although aldosterone increased the expression of both stress-activated protein kinases, pretreatment with fenofibrate (10 microm) decreased aldosterone-mediated apoptosis by inhibiting only jnk phosphorylation and the aldosterone-induced increases in bax, p53, and cleaved caspase-3 and decreases in bcl-2 protein expression in arvm. |
2009-07-17 |
2023-08-12 |
rat |
| Claudio Festuccia, Giovanni Luca Gravina, Anna Maria D'Alessandro, Paola Muzi, Danilo Millimaggi, Vincenza Dolo, Enrico Ricevuto, Carlo Vicentini, Mauro Bologn. Azacitidine improves antitumor effects of docetaxel and cisplatin in aggressive prostate cancer models. Endocrine-related cancer. vol 16. issue 2. 2009-07-16. PMID:19153211. |
reduced tumor proliferation and induced apoptosis in both xenografts upmodulating the expression of p16inka, bax, bak, p21/waf1, and p27/kip1, and inhibiting the activation of akt activity and the expression of cyclin d1, bcl-2, and bcl-xl. |
2009-07-16 |
2023-08-12 |
mouse |
| Shu-Jing Wu, Shun-Pang Chang, Doung-Liang Lin, Shyh-Shyan Wang, Fwu-Feuu Hou, Lean-Teik N. Supercritical carbon dioxide extract of Physalis peruviana induced cell cycle arrest and apoptosis in human lung cancer H661 cells. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. vol 47. issue 6. 2009-07-16. PMID:19425186. |
scepp-5 not only induced cell cycle arrest at s phase, it also up-regulated the expression of pro-apoptotic protein (bax) and down-regulated the inhibitor of apoptosis protein (iap). |
2009-07-16 |
2023-08-12 |
human |
| Santosh K Katiyar, Syed M Meeran, Nandan Katiyar, Suhail Akhta. p53 Cooperates berberine-induced growth inhibition and apoptosis of non-small cell human lung cancer cells in vitro and tumor xenograft growth in vivo. Molecular carcinogenesis. vol 48. issue 1. 2009-07-15. PMID:18459128. |
the berberine-induced apoptosis of both the a549 and h1299 human lung cancer cells was associated with the disruption of mitochondrial membrane potential, reduction in the levels of bcl-2, bcl-xl while increase in bax, bak, and activation of caspase-3. |
2009-07-15 |
2023-08-12 |
mouse |
| Jinxin Wang, Li Zhao, Yang Hu, Qinglong Guo, Lei Zhang, Xiaojian Wang, Nianguang Li, Qidong Yo. Studies on chemical structure modification and biology of a natural product, gambogic acid (I): Synthesis and biological evaluation of oxidized analogues of gambogic acid. European journal of medicinal chemistry. vol 44. issue 6. 2009-07-15. PMID:18996626. |
moreover, in this paper the cellular growth inhibitor 39-hydroxy-6-methoxy-gambogic acid methyl ester (10) was identified as a hepg2 cell apoptosis inhibitor through annexin-v/pi double staining assay and the expression of the related apoptotic proteins (bax and bcl-2). |
2009-07-15 |
2023-08-12 |
Not clear |
| Juraj Kopacek, Karol Ondrias, Barbora Sedlakova, Jana Tomaskova, Lucia Zahradnikova, Jan Sedlak, Zdena Sulova, Alexandra Zahradnikova, Jaromir Pastorek, Olga Krizanov. Type 2 IP(3) receptors are involved in uranyl acetate induced apoptosis in HEK 293 cells. Toxicology. vol 262. issue 1. 2009-07-15. PMID:19460415. |
this increase was associated with elevated expression of proapoptotic factors bax and caspase 3 and also by higher extent of apoptosis. |
2009-07-15 |
2023-08-12 |
human |
| Bingshe Han, Yun Ren, Liying Guan, Wei Wei, Fangyuan Hua, Yang Yang, Tao Yang, Tingming Cao, Hua Dong, Huazhen Pan, Caimin X. Sodium selenite induces apoptosis in acute promyelocytic leukemia-derived NB4 cells through mitochondria-dependent pathway. Oncology research. vol 17. issue 8. 2009-07-15. PMID:19544974. |
here we showed that mitochondrial apoptosis signaling pathway played a vital role in apoptosis induced by sodium selenite based on the following findings: 1) cytochrome c release, activation of caspase 9, mitochondrial targeting, and oligermerization of bax; 2) caspase 9, but not caspase 8, inhibitor could attenuate apoptosis; 3) downregulation of bax and bad by sirna could delay sodium selenite-induced apoptosis. |
2009-07-15 |
2023-08-12 |
Not clear |