| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Fangming Gao, Jose F Ponte, Panagiotis Papageorgis, Mary Levy, Sait Ozturk, Arthur W Lambert, Hongjie Pan, Dharmaraj Chinnappan, Kuang-Hung Cheng, Arunthathi Thiagalingam, Hamid M Abdolmaleky, Sam Thiagalinga. hBub1 deficiency triggers a novel p53 mediated early apoptotic checkpoint pathway in mitotic spindle damaged cells. Cancer biology & therapy. vol 8. issue 7. 2009-08-27. PMID:19242126. |
this phenomenon is further supported by the upregulation of p53 downstream pro-apoptotic genes, bax and puma as well as a corresponding increase in the cleavage products of parp and caspase 3, markers of apoptosis, upon depletion of hbub1 in sac activated cells. |
2009-08-27 |
2023-08-12 |
Not clear |
| Lucia Gatta, Alessio Cardinale, Francesca Wannenes, Claudia Consoli, Andrea Armani, Francesca Molinari, Caterina Mammi, Fabrizio Stocchi, Margherita Torti, Giuseppe M C Rosano, Massimo Fin. Peripheral blood mononuclear cells from mild cognitive impairment patients show deregulation of Bax and Sod1 mRNAs. Neuroscience letters. vol 453. issue 1. 2009-08-27. PMID:19429011. |
sod1 mrna levels were studied to analyse the anti-oxidative pathway, while bax and bcl-2 mrnas levels and parp protein cleavage were monitored to study apoptosis. |
2009-08-27 |
2023-08-12 |
human |
| Delphine Mérino, Maybelline Giam, Peter D Hughes, Owen M Siggs, Klaus Heger, Lorraine A O'Reilly, Jerry M Adams, Andreas Strasser, Erinna F Lee, Walter D Fairlie, Philippe Bouille. The role of BH3-only protein Bim extends beyond inhibiting Bcl-2-like prosurvival proteins. The Journal of cell biology. vol 186. issue 3. 2009-08-26. PMID:19651893. |
proteins of the bcl-2 family are critical regulators of apoptosis, but how its bh3-only members activate the essential effectors bax and bak remains controversial. |
2009-08-26 |
2023-08-12 |
mouse |
| Hong-Qing Zhuang, Jian Sun, Zhi-Yong Yuan, Jun Wang, Lu-Jun Zhao, Ping Wang, Xiu-Bao Ren, Chang-Li Wan. Radiosensitizing effects of gefitinib at different administration times in vitro. Cancer science. vol 100. issue 8. 2009-08-25. PMID:19432883. |
cell apoptosis and cell-cycle distribution were investigated using flow cytometry; meanwhile, the expression of p21, cdc25c, bcl-2, bax, rad51 and phosphorylated dna-pkcs (phospho-dna-pk) after 6 gy irradiation and/or gefitinib were determined by western blot analysis. |
2009-08-25 |
2023-08-12 |
Not clear |
| Hong-Qing Zhuang, Jian Sun, Zhi-Yong Yuan, Jun Wang, Lu-Jun Zhao, Ping Wang, Xiu-Bao Ren, Chang-Li Wan. Radiosensitizing effects of gefitinib at different administration times in vitro. Cancer science. vol 100. issue 8. 2009-08-25. PMID:19432883. |
increased cell apoptosis and cell cycle arrest were further supported by the expression changes of bcl-2, bax, p21, cdc25c, rad51 and phospho-dna-pk at the same time. |
2009-08-25 |
2023-08-12 |
Not clear |
| Salvatore Cuzzocrea, Hans-Peter Deigner, Tiziana Genovese, Emanuela Mazzon, Emanuela Esposito, Concetta Crisafulli, Rosanna Di Paola, Placido Bramanti, George Matuschak, Daniela Salvemin. Inhibition of ceramide biosynthesis ameliorates pathological consequences of spinal cord injury. Shock (Augusta, Ga.). vol 31. issue 6. 2009-08-21. PMID:18838947. |
fumonisin b1, tyclodecan-9-xanthogenate (d609), and (3-carbazol-9-yl-propyl)-[2-(3,4-dimethoxy-phenyl)-ethyl]-methylamine (nb6) inhibitors of, respectively, ceramide synthase, acid sphingomyelinase, and the secretory form of acid sphingomyelinase significantly reduced the degree of (i) ceramide formation, (ii) tissue injury, (iii) neutrophil infiltration, (iv) nitrotyrosine formation, (v) tnf-alpha and il-1beta production and apoptosis (tunel staining and bax and bcl-2 expression). |
2009-08-21 |
2023-08-12 |
mouse |
| Hakan Gürleyen, Hans Christiansen, Khodr Tello, Joszef Dudas, Robert M Hermann, Margret Rave-Fränk, Clemens F Hess, Giuliano Ramadori, Bernhard Sail. Irradiation leads to sensitization of hepatocytes to TNF-alpha-mediated apoptosis by upregulation of IkappaB expression. Radiation and environmental biophysics. vol 48. issue 1. 2009-08-21. PMID:18956207. |
cleavage of bid, upregulation of bax, downregulation of bcl-2 and release of cytochrome c after tnf-alpha-administration depend on radiation-induced upregulation of ikappab, thus demonstrating an apoptosis permitting effect of ikappab. |
2009-08-21 |
2023-08-12 |
Not clear |
| J-S Li, W Zhang, Z-M Kang, S-J Ding, W-W Liu, J H Zhang, Y-T Guan, X-J Su. Hyperbaric oxygen preconditioning reduces ischemia-reperfusion injury by inhibition of apoptosis via mitochondrial pathway in rat brain. Neuroscience. vol 159. issue 4. 2009-08-20. PMID:19185051. |
hbo-pc reduced cytoplasm cytochrome c levels, decreased caspase enzyme activity, upregulated the ratio of bcl-2 and bax expression, and abated the apoptosis of ischemic tissue. |
2009-08-20 |
2023-08-12 |
rat |
| Mayank Singh, Neeta Sing. Molecular mechanism of curcumin induced cytotoxicity in human cervical carcinoma cells. Molecular and cellular biochemistry. vol 325. issue 1-2. 2009-08-20. PMID:19191010. |
curcumin mediated apoptosis in these cells appears to be due to upregulation of proapoptotic bax, aif, release of cytochrome c and down regulation of antiapoptotic bcl-2, bcl-xl in hela and siha. |
2009-08-20 |
2023-08-12 |
human |
| Sanjit Kumar Dhar, Daret K St Clai. Nucleophosmin blocks mitochondrial localization of p53 and apoptosis. The Journal of biological chemistry. vol 284. issue 24. 2009-08-20. PMID:19366707. |
however, the increase in bax level in the absence of p53 in mitochondria did not lead to an increase in tpa-induced apoptosis, suggesting that the presence of p53 in mitochondria is important. |
2009-08-20 |
2023-08-12 |
Not clear |
| Johna van Stelten, Filo Silva, Dominique Belin, Thomas J Silhav. Effects of antibiotics and a proto-oncogene homolog on destruction of protein translocator SecY. Science (New York, N.Y.). vol 325. issue 5941. 2009-08-20. PMID:19661432. |
intriguingly, ycca is a functional homolog of the proto-oncogene product bax inhibitor-1, which may share a similar mechanism of action in regulating apoptosis upon prolonged secretion stress. |
2009-08-20 |
2023-08-12 |
Not clear |
| T Boonmars, P Srirach, B Kaewsamut, T Srisawangwong, S Pinlaor, P Pinlaor, P Yongvanit, P Sithithawor. Apoptosis-related gene expression in hamster opisthorchiasis post praziquantel treatment. Parasitology research. vol 102. issue 3. 2009-08-19. PMID:18058134. |
the expression of apoptosis-related genes [i.e., apoptosis gene bcl-2-associated protein x (bax), caspase 9, p53, and protein kinase b (pkb)] was detected by real-time reverse transcription polymerase chain reaction. |
2009-08-19 |
2023-08-12 |
Not clear |
| Ting-Ching Chen, Kuang-Chi Lai, Jai-Sing Yang, Ching-Lung Liao, Te-Chun Hsia, Guang-Wei Chen, Jen-Jyh Lin, Hui-Ju Lin, Tsan-Hung Chiu, Yih-Jing Tang, Jing-Gung Chun. Involvement of reactive oxygen species and caspase-dependent pathway in berberine-induced cell cycle arrest and apoptosis in C6 rat glioma cells. International journal of oncology. vol 34. issue 6. 2009-08-18. PMID:19424587. |
these results demonstrate that the cytotoxicity of berberine in c6 rat glioma cells is attributable to apoptosis mainly through induced g2/m-arrested cells, in an er-dependent manner, via a mitochondria-dependent caspase pathway regulated by bax and bcl-2. |
2009-08-18 |
2023-08-12 |
rat |
| Jia-Jun Liu, Ting Hu, Xiang-Yuan Wu, Chun-Zhi Wang, Yan Xu, Yong Zhang, Ruo-Zhi Xiao, Dong-Jun Lin, Ren-Wei Huang, Qiang Li. Peroxisome proliferator-activated receptor-gamma agonist rosiglitazone--induced apoptosis in leukemia k562 cells and its mechanisms of action. International journal of toxicology. vol 28. issue 2. 2009-08-18. PMID:19482836. |
we therefore conclude that rgz induces apoptosis in k562 cells in vitro, and that rgz-induced apoptosis in k562 cells is highly correlated with activation of caspase-3, decreasing telomerase activity, down-regulation of the anti-apoptotic protein bcl-2, and up-regulation of the pro-apoptotic protein bax. |
2009-08-18 |
2023-08-12 |
Not clear |
| Hua Zhang, Baoshan Xu, Huirong Xie, Bo Zhou, Hong Ouyang, Gang Ning, Ge Li, Meijia Zhang, Guoliang Xi. Lanosterol metabolic product(s) is involved in primordial folliculogenesis and establishment of primordial follicle pool in mouse fetal ovary. Molecular reproduction and development. vol 76. issue 5. 2009-08-17. PMID:18937335. |
furthermore, ay9944-a-7 decreased the expression of apoptosis gene bax and significantly prevented oocyte apoptosis from 15.37 +/- 1.97% to 3.68 +/- 0.27% (p < 0.01) in neonatal ovary in vitro. |
2009-08-17 |
2023-08-12 |
mouse |
| Na Li, Peihui Lin, Chuanxi Cai, Zui Pan, Noah Weisleder, Jianjie M. The amino-terminal peptide of Bax perturbs intracellular Ca2+ homeostasis to enhance apoptosis in prostate cancer cells. American journal of physiology. Cell physiology. vol 296. issue 2. 2009-08-17. PMID:19091958. |
the amino-terminal peptide of bax perturbs intracellular ca2+ homeostasis to enhance apoptosis in prostate cancer cells. |
2009-08-17 |
2023-08-12 |
human |
| Na Li, Peihui Lin, Chuanxi Cai, Zui Pan, Noah Weisleder, Jianjie M. The amino-terminal peptide of Bax perturbs intracellular Ca2+ homeostasis to enhance apoptosis in prostate cancer cells. American journal of physiology. Cell physiology. vol 296. issue 2. 2009-08-17. PMID:19091958. |
during apoptosis, proteolytic cleavage of bax at the amino terminus generates a truncated bax of approximately 18 kda (p18bax) and an amino-terminal peptide of approximately 3 kda (p3bax). |
2009-08-17 |
2023-08-12 |
human |
| Na Li, Peihui Lin, Chuanxi Cai, Zui Pan, Noah Weisleder, Jianjie M. The amino-terminal peptide of Bax perturbs intracellular Ca2+ homeostasis to enhance apoptosis in prostate cancer cells. American journal of physiology. Cell physiology. vol 296. issue 2. 2009-08-17. PMID:19091958. |
whereas extensive studies have shown that p18bax behaves like a bh3 protein with enhanced pro-apoptotic function over that of the full-length bax (p21bax), little is known about the function of p3bax in apoptosis. |
2009-08-17 |
2023-08-12 |
human |
| Na Li, Peihui Lin, Chuanxi Cai, Zui Pan, Noah Weisleder, Jianjie M. The amino-terminal peptide of Bax perturbs intracellular Ca2+ homeostasis to enhance apoptosis in prostate cancer cells. American journal of physiology. Cell physiology. vol 296. issue 2. 2009-08-17. PMID:19091958. |
we have previously shown that bax and ca2+ play a synergistic role in amplifying apoptosis signaling and that store-operated ca2+ entry (soce) contributes to bax-mediated apoptosis in prostate cancer cells. |
2009-08-17 |
2023-08-12 |
human |
| Pallab Maity, Samik Bindu, Sumanta Dey, Manish Goyal, Athar Alam, Chinmay Pal, Russel Reiter, Uday Bandyopadhya. Melatonin reduces indomethacin-induced gastric mucosal cell apoptosis by preventing mitochondrial oxidative stress and the activation of mitochondrial pathway of apoptosis. Journal of pineal research. vol 46. issue 3. 2009-08-17. PMID:19220725. |
melatonin inhibits the important steps of indomethacin-induced activation of mitochondrial pathway of apoptosis such as upregulation of the expression of bax and bak, and the downregulation of bcl-2 and bclxl. |
2009-08-17 |
2023-08-12 |
Not clear |