| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Deep Raj Sharma, Aditya Sunkaria, Amanjit Bal, Yangchen D Bhutia, R Vijayaraghavan, S J S Flora, Kiran Dip Gil. Neurobehavioral impairments, generation of oxidative stress and release of pro-apoptotic factors after chronic exposure to sulphur mustard in mouse brain. Toxicology and applied pharmacology. vol 240. issue 2. 2009-10-08. PMID:19560481. |
immunoblotting of cytochrome c, bcl-2, bax and activation of caspase-3 suggest induction of apoptosis in a dose dependent manner. |
2009-10-08 |
2023-08-12 |
mouse |
| Olena Ivashyna, Ana J García-Sáez, Jonas Ries, Eric T Christenson, Petra Schwille, Paul H Schlesinge. Detergent-activated BAX protein is a monomer. The Journal of biological chemistry. vol 284. issue 36. 2009-10-05. PMID:19564333. |
at the onset of apoptosis, monomeric, cytoplasmic bax is activated and translocates to the outer mitochondrial membrane, where it forms an oligomeric pore. |
2009-10-05 |
2023-08-12 |
Not clear |
| Soumik Agarwal, Sonali Roy, Atish Ray, Shibnath Mazumder, Shelley Bhattachary. Arsenic trioxide and lead acetate induce apoptosis in adult rat hepatic stem cells. Cell biology and toxicology. vol 25. issue 4. 2009-10-02. PMID:18618274. |
arsenic and lead were found to trigger apoptosis as revealed by dna ladder formation, western blots of apoptotic factors, and reverse transcriptase polymerase chain reaction analyses of bax and bcl-2. |
2009-10-02 |
2023-08-12 |
rat |
| Alicia F Pearce, Douglas S Lyle. Vesicular stomatitis virus induces apoptosis primarily through Bak rather than Bax by inactivating Mcl-1 and Bcl-XL. Journal of virology. vol 83. issue 18. 2009-10-02. PMID:19587033. |
vesicular stomatitis virus induces apoptosis primarily through bak rather than bax by inactivating mcl-1 and bcl-xl. |
2009-10-02 |
2023-08-12 |
Not clear |
| Alicia F Pearce, Douglas S Lyle. Vesicular stomatitis virus induces apoptosis primarily through Bak rather than Bax by inactivating Mcl-1 and Bcl-XL. Journal of virology. vol 83. issue 18. 2009-10-02. PMID:19587033. |
our results showed that bak is more important than bax for the induction of apoptosis in this system. |
2009-10-02 |
2023-08-12 |
Not clear |
| Zhiyong Wang, Andrea Havasi, Jonathan M Gall, Haiping Mao, John H Schwartz, Steven C Borka. Beta-catenin promotes survival of renal epithelial cells by inhibiting Bax. Journal of the American Society of Nephrology : JASN. vol 20. issue 9. 2009-10-02. PMID:19696224. |
furthermore, active beta-catenin decreased bax activation, oligomerization, and translocation to mitochondria, and reduced both organelle membrane injury and apoptosis. |
2009-10-02 |
2023-08-12 |
Not clear |
| Tiziana Genovese, Emanuela Esposito, Emanuela Mazzon, Rosanna Di Paola, Rosaria Meli, Rocco Caminiti, Placido Bramanti, Mitchell P Fink, Salvatore Cuzzocre. Beneficial effects of ethyl pyruvate in a mouse model of spinal cord injury. Shock (Augusta, Ga.). vol 32. issue 2. 2009-10-01. PMID:18948848. |
treatment with ep (75, 25, or 8.5 mg/kg) 1 and 6 h after the sci significantly decreased (a) the degree of spinal cord inflammation and tissue injury (histological score), (b) neutrophil infiltration (myeloperoxidase activity), (c) nitrotyrosine formation and inos expression, (d) proinflammatory cytokines expression, (e) nuclear factor kappab activation, (f) extracellular signal-regulated kinase 1/2 mitogen-activated protein kinase phosphorylation, and (g) apoptosis (tunel staining, fas ligand, bax, and bcl-2 expression). |
2009-10-01 |
2023-08-12 |
mouse |
| Xin-Yuan Gao, Hong-Yu Kuang, Wei Zou, Xiao-Min Liu, Hong-Bin Lin, Yi Yan. The timing of re-institution of good blood glucose control affects apoptosis and expression of Bax and Bcl-2 in the retina of diabetic rats. Molecular biology reports. vol 36. issue 7. 2009-10-01. PMID:18991018. |
the timing of re-institution of good blood glucose control affects apoptosis and expression of bax and bcl-2 in the retina of diabetic rats. |
2009-10-01 |
2023-08-12 |
rat |
| Xin-Yuan Gao, Hong-Yu Kuang, Wei Zou, Xiao-Min Liu, Hong-Bin Lin, Yi Yan. The timing of re-institution of good blood glucose control affects apoptosis and expression of Bax and Bcl-2 in the retina of diabetic rats. Molecular biology reports. vol 36. issue 7. 2009-10-01. PMID:18991018. |
we explored the effect of re-institution of good blood glucose control on apoptosis and apoptosis related genes (bax and bcl-2) in the retina of diabetic rats. |
2009-10-01 |
2023-08-12 |
rat |
| Xin-Yuan Gao, Hong-Yu Kuang, Wei Zou, Xiao-Min Liu, Hong-Bin Lin, Yi Yan. The timing of re-institution of good blood glucose control affects apoptosis and expression of Bax and Bcl-2 in the retina of diabetic rats. Molecular biology reports. vol 36. issue 7. 2009-10-01. PMID:18991018. |
good blood glucose control at early stage can decrease the number of apoptotic cells in the retina; the decreased apoptosis is correlated with the down-regulation of bax to bcl-2 ratio. |
2009-10-01 |
2023-08-12 |
rat |
| Patrick Imesch, Konstantin J Dedes, Michele Furlato, Daniel Fink, Andre Fedie. MLH1 protects from resistance acquisition by the histone deacetylase inhibitor trichostatin A in colon tumor cells. International journal of oncology. vol 35. issue 3. 2009-10-01. PMID:19639184. |
whereas the absence of acetyl-histone accumulation did not correlate with altered hdac activity, the absence of apoptosis correlated with reduced expression of (pro-apoptotic) bax. |
2009-10-01 |
2023-08-12 |
Not clear |
| Surajit Karmakar, Kristin A Davis, Subhasree Roy Choudhury, Anurag Deeconda, Naren L Banik, Swapan K Ra. Bcl-2 inhibitor and apigenin worked synergistically in human malignant neuroblastoma cell lines and increased apoptosis with activation of extrinsic and intrinsic pathways. Biochemical and biophysical research communications. vol 388. issue 4. 2009-10-01. PMID:19695221. |
alterations in bax and bcl-2 levels resulted in an increase in bax:bcl-2 ratio to activate intrinsic pathway of apoptosis with mitochondrial release of cytochrome c into the cytosol and activation of proteases. |
2009-10-01 |
2023-08-12 |
human |
| Xin Tian, Ying Luo, Yun-peng Liu, Ke-zuo Hou, Bo Jin, Jing-dong Zhang, Su Wan. [Downregulation of Bcl-2 and survivin expression and release of Smac/DIABLO involved in bufalin-induced HL-60 cell apoptosis]. Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi. vol 27. issue 1. 2009-09-30. PMID:16732934. |
to investigate the expression of mitochondria-mediated apoptosis pathway related genes bcl-2, bax, survivin and smac/diablo in bufalin induced hl-60 cell apoptosis. |
2009-09-30 |
2023-08-12 |
Not clear |
| Paolete Soto, Lawrence C Smit. BH4 peptide derived from Bcl-xL and Bax-inhibitor peptide suppresses apoptotic mitochondrial changes in heat stressed bovine oocytes. Molecular reproduction and development. vol 76. issue 7. 2009-09-30. PMID:19062170. |
in conclusion, the present results show that hs-induced apoptosis in bovine oocytes involves bax and bh4 domain-dependent pathways. |
2009-09-30 |
2023-08-12 |
cattle |
| Shintaro Suemasu, Ken-Ichiro Tanaka, Takushi Namba, Tomoaki Ishihara, Takashi Katsu, Mitsuaki Fujimoto, Hiroaki Adachi, Gen Sobue, Koji Takeuchi, Akira Nakai, Tohru Mizushim. A role for HSP70 in protecting against indomethacin-induced gastric lesions. The Journal of biological chemistry. vol 284. issue 29. 2009-09-25. PMID:19439408. |
both nsaid-dependent cyclooxygenase inhibition and gastric mucosal apoptosis are involved in nsaid-produced gastric lesions, and this apoptosis is mediated by the endoplasmic reticulum stress response and resulting activation of bax. |
2009-09-25 |
2023-08-12 |
mouse |
| Shintaro Suemasu, Ken-Ichiro Tanaka, Takushi Namba, Tomoaki Ishihara, Takashi Katsu, Mitsuaki Fujimoto, Hiroaki Adachi, Gen Sobue, Koji Takeuchi, Akira Nakai, Tohru Mizushim. A role for HSP70 in protecting against indomethacin-induced gastric lesions. The Journal of biological chemistry. vol 284. issue 29. 2009-09-25. PMID:19439408. |
suppression of hsp70 expression in vitro stimulated indomethacin-induced apoptosis and activation of bax but not the endoplasmic reticulum stress response. |
2009-09-25 |
2023-08-12 |
mouse |
| G Vinothini, R Senthil Murugan, S Nagin. Evaluation of molecular markers in a rat model of mammary carcinogenesis. Oncology research. vol 17. issue 10. 2009-09-25. PMID:19725228. |
we analyzed dmba-induced changes in the expression of cyp isoforms (cyp1a1 and 1b1) involved in dmba metabolism, markers of oxidative stress (4hne, hel, and 8-ohdg), cell survival and proliferation (pcna, nf-kappab-p50, nf-kappab-p65, gst-p, and p53), apoptosis (bcl-2, bax, caspases, apaf-1, cytochrome c, and fas), invasion (upa, mmp-2, mmp-9, timp-2, and reck), and angiogenesis (vegf, vegf-r1, hif-1alpha, and plgf) by immunohistochemical localization, western blot, and reverse transcriptase-polymerase chain reaction (rt-pcr) analysis. |
2009-09-25 |
2023-08-12 |
human |
| Junya Kuroda, Masafumi Taniwak. Involvement of BH3-only proteins in hematologic malignancies. Critical reviews in oncology/hematology. vol 71. issue 2. 2009-09-24. PMID:19022681. |
in this context, bh3-only proteins (such as bim), members of the pro-apoptotic bcl-2 family proteins, act as key initiators of apoptosis by activating bax and bak through liberating them from anti-apoptotic bcl-2 members. |
2009-09-24 |
2023-08-12 |
Not clear |
| Tetsuji Miura, Takayuki Mik. GSK-3beta, a therapeutic target for cardiomyocyte protection. Circulation journal : official journal of the Japanese Circulation Society. vol 73. issue 7. 2009-09-24. PMID:19506320. |
apoptosis of cardiomyocytes by pressure overload or ischemia/reperfusion is also suppressed by inactivation of gsk-3beta, in which reduced phosphorylation of p53, heat shock factor-1 and myeloid cell leukemia sequence-1 and inhibition of bax translocation might be involved. |
2009-09-24 |
2023-08-12 |
Not clear |
| Peng Wang, Andy Lo, J Bryce Young, Jin H Song, Raymond Lai, Norman M Kneteman, Chunhai Hao, Liang L. Targeted quantitative mass spectrometric identification of differentially expressed proteins between Bax-expressing and deficient colorectal carcinoma cells. Journal of proteome research. vol 8. issue 7. 2009-09-23. PMID:19425606. |
bax, a bcl-2 interacting protein, plays a central role in several stimuli-induced apoptosis pathways through its functional and physical interactions with various biologically important proteins. |
2009-09-23 |
2023-08-12 |
Not clear |