| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Bing Wu, Hong Jiang, Rong Lin, Bo Cui, Huazhi Wen, Zhibing L. Pretreatment with B-type natriuretic peptide protects the heart from ischemia-reperfusion injury by inhibiting myocardial apoptosis. The Tohoku journal of experimental medicine. vol 219. issue 2. 2009-12-09. PMID:19776527. |
the bnp-mediated attenuation of apoptosis was associated with the increased expression of an anti-apoptotic protein bcl-2 and the reduced expression of a pro-apoptotic protein bax. |
2009-12-09 |
2023-08-12 |
Not clear |
| Bo Liu, Qing-Xian Bai, Xie-Qun Chen, Guang-Xun Gao, Hong-Tao G. [Effect of curcumin on expression of survivin, Bcl-2 and Bax in human multiple myeloma cell line]. Zhongguo shi yan xue ye xue za zhi. vol 15. issue 4. 2009-12-08. PMID:17708799. |
to explore the mechanisms of suppression growth and induction apoptosis of curcumin on human multiple myeloma cell line rpmi8226, the suppressive effect of curcumin on rpmi8226 was examined by mtt assay; the induction apoptosis and cell cycle arrest of curcumin on rpmi8226 were determined by flow cytometry (fcm); the changes of survivin, bcl-2, bax mrna levels were detected by rt-pcr. |
2009-12-08 |
2023-08-12 |
human |
| E D Bazhanova, K I Pavlov, I G Popovich, V N Anisimo. [Ontogenetic peculiarities of regulation of apoptosis in hypothalamic neurosecretory cells in thf-knockout mice]. Zhurnal evoliutsionnoi biokhimii i fiziologii. vol 45. issue 5. 2009-12-08. PMID:19886200. |
bax, bcl2, mcl1, neuropeptide vasopressin, and the apoptosis level in hypothalamus in tnf-knockout mice of different ages as compared with mice with unchanged level of tnf synthesis. |
2009-12-08 |
2023-08-12 |
mouse |
| E D Bazhanova, K I Pavlov, I G Popovich, V N Anisimo. [Ontogenetic peculiarities of regulation of apoptosis in hypothalamic neurosecretory cells in thf-knockout mice]. Zhurnal evoliutsionnoi biokhimii i fiziologii. vol 45. issue 5. 2009-12-08. PMID:19886200. |
thus, in supraoptic nucleus (son), in all studied animal groups, animal groups, an important cause of the nsc apoptosis is bax. |
2009-12-08 |
2023-08-12 |
mouse |
| Subhra Mohapatra, Baoky Chu, Xiuhua Zhao, Julie Djeu, Jin Q Cheng, W Jackson Pledge. Apoptosis of metastatic prostate cancer cells by a combination of cyclin-dependent kinase and AKT inhibitors. The international journal of biochemistry & cell biology. vol 41. issue 3. 2009-12-07. PMID:18708158. |
collectively, our data show apoptosis of prostate cancer cells by a drug combination and identify bax activation as a basis of cooperation. |
2009-12-07 |
2023-08-12 |
Not clear |
| Igor Sukhotnik, Jorge G Mogilner, Dan Shteinberg, Rahel Karry, Michael Lurie, Benno M Ure, Ron Shaoul, Arnold G Cora. Leptin accelerates enterocyte turnover during methotrexate-induced intestinal mucositis in a rat. Cancer biology & therapy. vol 8. issue 10. 2009-12-07. PMID:19276673. |
mtx-lep rats also showed a trend toward an increase in enterocyte apoptosis that was accompanied by an increase in bax mrna and decrease in bcl-2 mrna expression. |
2009-12-07 |
2023-08-12 |
rat |
| Minglun Li, Anke Jung, Ute Ganswindt, Patrizia Marini, Anna Friedl, Peter T Daniel, Kirsten Lauber, Verena Jendrossek, Claus Belk. Aurora kinase inhibitor ZM447439 induces apoptosis via mitochondrial pathways. Biochemical pharmacology. vol 79. issue 2. 2009-12-07. PMID:19686703. |
to precisely define key components for zm-induced apoptosis, knockout cells lacking p53, bak, bax or both bak and bax were used. |
2009-12-07 |
2023-08-12 |
Not clear |
| Minglun Li, Anke Jung, Ute Ganswindt, Patrizia Marini, Anna Friedl, Peter T Daniel, Kirsten Lauber, Verena Jendrossek, Claus Belk. Aurora kinase inhibitor ZM447439 induces apoptosis via mitochondrial pathways. Biochemical pharmacology. vol 79. issue 2. 2009-12-07. PMID:19686703. |
lack of p53 reduced zm-induced apoptosis and breakdown of deltapsim, while lack of bak, bax or both almost completely inhibited apoptosis and breakdown of deltapsim. |
2009-12-07 |
2023-08-12 |
Not clear |
| Minglun Li, Anke Jung, Ute Ganswindt, Patrizia Marini, Anna Friedl, Peter T Daniel, Kirsten Lauber, Verena Jendrossek, Claus Belk. Aurora kinase inhibitor ZM447439 induces apoptosis via mitochondrial pathways. Biochemical pharmacology. vol 79. issue 2. 2009-12-07. PMID:19686703. |
since no difference in apoptosis induction was detectable between hct-116 cells lacking bak, bax or both, apoptosis induction depended non-redundantly on both bak and bax. |
2009-12-07 |
2023-08-12 |
Not clear |
| Diana Hippe, Arnim Weber, Liying Zhou, Donald C Chang, Georg Häcker, Carsten G K Lüde. Toxoplasma gondii infection confers resistance against BimS-induced apoptosis by preventing the activation and mitochondrial targeting of pro-apoptotic Bax. Journal of cell science. vol 122. issue Pt 19. 2009-12-04. PMID:19737817. |
toxoplasma gondii infection confers resistance against bims-induced apoptosis by preventing the activation and mitochondrial targeting of pro-apoptotic bax. |
2009-12-04 |
2023-08-12 |
Not clear |
| Tomoko Suzuki, Cory Yamashita, Rachel L Zemans, Natalie Briones, Annemie Van Linden, Gregory P Downe. Leukocyte elastase induces lung epithelial apoptosis via a PAR-1-, NF-kappaB-, and p53-dependent pathway. American journal of respiratory cell and molecular biology. vol 41. issue 6. 2009-12-03. PMID:19307610. |
elastase-induced apoptosis of lung epithelial cells correlated temporally with activation of nf-kappab, phosphorylation, and nuclear translocation of p53, increased p53 up-regulated modulator of apoptosis (puma) expression, and mitochondrial translocation of bax resulting in enhanced permeability. |
2009-12-03 |
2023-08-12 |
Not clear |
| Tomoko Suzuki, Cory Yamashita, Rachel L Zemans, Natalie Briones, Annemie Van Linden, Gregory P Downe. Leukocyte elastase induces lung epithelial apoptosis via a PAR-1-, NF-kappaB-, and p53-dependent pathway. American journal of respiratory cell and molecular biology. vol 41. issue 6. 2009-12-03. PMID:19307610. |
these inhibitors prevented elastase-induced puma expression, mitochondrial translocation of bax, increased mitochondrial permeability, and attenuated apoptosis. |
2009-12-03 |
2023-08-12 |
Not clear |
| Martin Chopra, Arunasalam M Dharmarajan, Gregor Meiss, Dieter Schren. Inhibition of UV-C light-induced apoptosis in liver cells by 2,3,7,8-tetrachlorodibenzo-p-dioxin. Toxicological sciences : an official journal of the Society of Toxicology. vol 111. issue 1. 2009-12-03. PMID:19520675. |
apoptosis induced by uv-c light in these cells is caspase-dependent and is accompanied by alterations in apoptosis-related gene expression such as up-regulation of proapoptotic bcl-2 family genes like bak and bax, and a marked down regulation of the expression of the antiapoptotic bcl-2. |
2009-12-03 |
2023-08-12 |
human |
| Francesca Pellicano, Mhairi Copland, Heather G Jorgensen, Joanne Mountford, Brian Leber, Tessa L Holyoak. BMS-214662 induces mitochondrial apoptosis in chronic myeloid leukemia (CML) stem/progenitor cells, including CD34+38- cells, through activation of protein kinase Cbeta. Blood. vol 114. issue 19. 2009-12-03. PMID:19738029. |
apoptosis proceeded via the intrinsic pathway: bax conformational changes, loss of mitochondrial membrane potential, generation of reactive oxygen species, release of cytochrome c, and caspase-9/3 activation were noted. |
2009-12-03 |
2023-08-12 |
Not clear |
| S Savion, E Shtelman, H Orenstein, A Torchinsky, A Fein, V Tode. Bax-associated mechanisms underlying the response of embryonic cells to methotrexate. Toxicology in vitro : an international journal published in association with BIBRA. vol 23. issue 6. 2009-11-30. PMID:19524032. |
bax was shown previously to regulate apoptotic cell death in various experimental systems, however, its involvement in teratogen-induced apoptosis is not clear yet. |
2009-11-30 |
2023-08-12 |
mouse |
| Rui Guo, Li Zhong, Jun Re. Overexpression of aldehyde dehydrogenase-2 attenuates chronic alcohol exposure-induced apoptosis, change in Akt and Pim signalling in liver. Clinical and experimental pharmacology & physiology. vol 36. issue 5-6. 2009-11-24. PMID:19215238. |
pro- and anti-apoptotic proteins, including p53, omi/htra2, bcl-2, bax, x-linked inhibitor of apoptosis protein (xiap), akt, phosphorylated (p) akt, the akt downstream signalling molecule pim and ppim, were examined using immunoblot analysis. |
2009-11-24 |
2023-08-12 |
mouse |
| Valery G Veresov, Alexander I Davidovski. Activation of Bax by joint action of tBid and mitochondrial outer membrane: Monte Carlo simulations. European biophysics journal : EBJ. vol 38. issue 7. 2009-11-24. PMID:19466402. |
bax, a member of the bcl-2 protein family, plays a pivotal role in mitochondrion-mediated apoptosis. |
2009-11-24 |
2023-08-12 |
Not clear |
| Biman B Mandal, S C Kund. Self-assembled silk sericin/poloxamer nanoparticles as nanocarriers of hydrophobic and hydrophilic drugs for targeted delivery. Nanotechnology. vol 20. issue 35. 2009-11-24. PMID:19671963. |
up-regulation of pro-apoptotic protein bax, down-regulation of anti-apoptotic protein bcl-2 and cleavage of regulatory protein parp through western blot analysis suggested further drug-induced apoptosis in cells. |
2009-11-24 |
2023-08-12 |
Not clear |
| Binod Kumar, Amit Kumar, B N Pandey, K P Mishra, Banasri Hazr. Role of mitochondrial oxidative stress in the apoptosis induced by diospyrin diethylether in human breast carcinoma (MCF-7) cells. Molecular and cellular biochemistry. vol 320. issue 1-2. 2009-11-23. PMID:18836818. |
taken together, the results of our study clearly suggested that the apoptosis induced by d7 would involve alteration of mpt, cardiolipin peroxidation, migration of bax from cytosol to mitochondria, decreased expression of bcl-2, and release of cytochrome c, indicating oxidative mechanism at the mitochondrial level in the tumor cells. |
2009-11-23 |
2023-08-12 |
human |
| Sanjeev Kumar, David A Allen, Julius E Kieswich, Nimesh S A Patel, Steven Harwood, Emanuela Mazzon, Salvatore Cuzzocrea, Martin J Raftery, Christoph Thiemermann, Muhammad M Yaqoo. Dexamethasone ameliorates renal ischemia-reperfusion injury. Journal of the American Society of Nephrology : JASN. vol 20. issue 11. 2009-11-23. PMID:19797168. |
in rat renal iri, a single dose of dexamethasone administered before ischemia, or at the onset of reperfusion, ameliorated biochemical and histologic acute kidney injury after 24 h. dexamethasone upregulated bcl-xl, downregulated ischemia-induced bax, inhibited caspase-9 and caspase-3 activation, and reduced apoptosis and necrosis of proximal tubular cells. |
2009-11-23 |
2023-08-12 |
mouse |