| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Lu Zhang, Li Li, Heather W Leavesley, Xun Zhang, Joseph L Borowitz, Gary E Iso. Cyanide-induced apoptosis of dopaminergic cells is promoted by BNIP3 and Bax modulation of endoplasmic reticulum-mitochondrial Ca2+ levels. The Journal of pharmacology and experimental therapeutics. vol 332. issue 1. 2010-01-26. PMID:19841471. |
cyanide-induced apoptosis of dopaminergic cells is promoted by bnip3 and bax modulation of endoplasmic reticulum-mitochondrial ca2+ levels. |
2010-01-26 |
2023-08-12 |
mouse |
| Nicholas M George, Natalie Targy, Jacquelynn J D Evans, Liqiang Zhang, Xu Lu. Bax contains two functional mitochondrial targeting sequences and translocates to mitochondria in a conformational change- and homo-oligomerization-driven process. The Journal of biological chemistry. vol 285. issue 2. 2010-01-26. PMID:19880508. |
the apoptosis gateway protein bax normally exists in the cytosol as a globular shaped monomer composed of nine alpha-helices. |
2010-01-26 |
2023-08-12 |
Not clear |
| Nicholas M George, Natalie Targy, Jacquelynn J D Evans, Liqiang Zhang, Xu Lu. Bax contains two functional mitochondrial targeting sequences and translocates to mitochondria in a conformational change- and homo-oligomerization-driven process. The Journal of biological chemistry. vol 285. issue 2. 2010-01-26. PMID:19880508. |
during apoptosis, bax translocates to the mitochondria, forms homo-oligomers, and subsequently induces mitochondrial damage. |
2010-01-26 |
2023-08-12 |
Not clear |
| Anoushiravan Vakili Zarch, Hamidreza Pazoki Toroudi, Mansooreh Soleimani, Azam Bakhtiarian, Majid Katebi, Bijan Djahanguir. Neuroprotective effects of diazoxide and its antagonism by glibenclamide in pyramidal neurons of rat hippocampus subjected to ischemia-reperfusion-induced injury. The International journal of neuroscience. vol 119. issue 9. 2010-01-26. PMID:19922361. |
apoptosis was assessed by measuring the amount of protein expressed by bax and bcl-2 genes. |
2010-01-26 |
2023-08-12 |
rat |
| Davor Toma. [Apoptosis, UV-radiation, precancerosis and skin tumors]. Acta medica Croatica : casopis Hravatske akademije medicinskih znanosti. vol 63 Suppl 2. 2010-01-26. PMID:19999548. |
uv-induced dna damage activates the mechanisms for removal of dna damage, delay in cell cycle progression, dna repair, or apoptosis by transcriptional activation of p-53 related genes, such as p21 and bax. |
2010-01-26 |
2023-08-12 |
human |
| Jian Hua Liang, Jing Du, Lian Deng Xu, Tao Jiang, Shuang Hao, Jing Bi, Bo Jian. Catalpol protects primary cultured cortical neurons induced by Abeta(1-42) through a mitochondrial-dependent caspase pathway. Neurochemistry international. vol 55. issue 8. 2010-01-25. PMID:19631247. |
by exposure to abeta(1-42) (5 microm) for 72 h in cultures, neuronal apoptosis occurred characterized by enhancement of activities of caspases and reactive oxygen species (ros) as well as bax increase, loss of mitochondrial membrane potential and cytochrome c release. |
2010-01-25 |
2023-08-12 |
Not clear |
| Jian Hua Liang, Jing Du, Lian Deng Xu, Tao Jiang, Shuang Hao, Jing Bi, Bo Jian. Catalpol protects primary cultured cortical neurons induced by Abeta(1-42) through a mitochondrial-dependent caspase pathway. Neurochemistry international. vol 55. issue 8. 2010-01-25. PMID:19631247. |
pretreatment with catalpol (0.5mm) for 30 min prior to abeta(1-42) treatment attenuated neuronal apoptosis not only by reversing intracellular ros accumulation, bax level, mitochondrial membrane potential and, cytochrome c release to some extent, but also through regulating the activity and cleavage of caspase-3 and caspase-9. |
2010-01-25 |
2023-08-12 |
Not clear |
| Irina Tsoy Nizamutdinova, Yong Chun Jin, Jong Il Chung, Sung Chul Shin, Sung Joong Lee, Han Geuk Seo, Jae Heun Lee, Ki Churl Chang, Hye Jung Ki. The anti-diabetic effect of anthocyanins in streptozotocin-induced diabetic rats through glucose transporter 4 regulation and prevention of insulin resistance and pancreatic apoptosis. Molecular nutrition & food research. vol 53. issue 11. 2010-01-21. PMID:19785000. |
moreover, ant protected pancreatic tissue from stz-induced apoptosis through regulation of caspase-3, bax, and bcl-2 proteins. |
2010-01-21 |
2023-08-12 |
rat |
| Chia-Wen Chang, Wan-Hua Tsai, Woei-Jer Chuang, Yee-Shin Lin, Jiunn-Jong Wu, Ching-Chuan Liu, Pei-Jane Tsai, Ming T Li. Procaspase 8 and Bax are up-regulated by distinct pathways in Streptococcal pyrogenic exotoxin B-induced apoptosis. The Journal of biological chemistry. vol 284. issue 48. 2010-01-21. PMID:19801665. |
procaspase 8 and bax are up-regulated by distinct pathways in streptococcal pyrogenic exotoxin b-induced apoptosis. |
2010-01-21 |
2023-08-12 |
Not clear |
| Xiu Fen Liu, Tapan K Bera, Lisa J Liu, Ira Pasta. A primate-specific POTE-actin fusion protein plays a role in apoptosis. Apoptosis : an international journal on programmed cell death. vol 14. issue 10. 2010-01-19. PMID:19669888. |
using wild-type and mutant mouse embryo cells, we find apoptosis induced by over-expression of pote-2gammac is decreased in bak ( -/- ) or bak ( -/- ) bax ( -/- ) cells indicating pote is acting through a mitochondrial pathway. |
2010-01-19 |
2023-08-12 |
mouse |
| Tianpeng Zhang, Dan Yang, Yongna Fan, Ping Xie, Huihua L. Epigallocatechin-3-gallate enhances ischemia/reperfusion-induced apoptosis in human umbilical vein endothelial cells via AKT and MAPK pathways. Apoptosis : an international journal on programmed cell death. vol 14. issue 10. 2010-01-19. PMID:19669889. |
moreover, treatment of cells with egcg resulted in increase of caspase-3 and bax and decrease of bcl-2, enhancing i/r-induced apoptosis. |
2010-01-19 |
2023-08-12 |
human |
| Séverine Hamann, Daniel F Schorderet, Sandra Cotte. Bax-induced apoptosis in Leber's congenital amaurosis: a dual role in rod and cone degeneration. PloS one. vol 4. issue 8. 2010-01-19. PMID:19672311. |
we then challenged the direct role of pro-apoptotic bax protein in triggering apoptosis of rod and cone photoreceptors.quantitative pcr analysis showed that increased expression of pro-apoptotic bax and decreased level of anti-apoptotic bcl-2 were restored in rpe65(-/-)/gnat1(-/-) mice lacking the gnat1 gene encoding rod transducin. |
2010-01-19 |
2023-08-12 |
mouse |
| Alwin Scharstuhl, Henricus A M Mutsaers, Sebastiaan W C Pennings, Frans G M Russel, Frank A D T G Wagene. Involvement of VDAC, Bax and ceramides in the efflux of AIF from mitochondria during curcumin-induced apoptosis. PloS one. vol 4. issue 8. 2010-01-19. PMID:19693275. |
involvement of vdac, bax and ceramides in the efflux of aif from mitochondria during curcumin-induced apoptosis. |
2010-01-19 |
2023-08-12 |
Not clear |
| P Maiso, E Colado, E M Ocio, M Garayoa, J Martín, P Atadja, A Pandiella, J F San-Migue. The synergy of panobinostat plus doxorubicin in acute myeloid leukemia suggests a role for HDAC inhibitors in the control of DNA repair. Leukemia. vol 23. issue 12. 2010-01-14. PMID:19812608. |
the combination induced aml cell death by an increase in the mitochondrial outer membrane permeability and release of cytochrome c from the mitochondria, resulting in caspase-dependent apoptosis and accompanied by the upregulation of bax, bak and, particularly, bad. |
2010-01-14 |
2023-08-12 |
Not clear |
| D G Morris, S M Waters, S D McCarthy, J Patton, B Earley, R Fitzpatrick, J J Murphy, M G Diskin, D A Kenny, A Brass, D C Wathe. Pleiotropic effects of negative energy balance in the postpartum dairy cow on splenic gene expression: repercussions for innate and adaptive immunity. Physiological genomics. vol 39. issue 1. 2010-01-13. PMID:19567785. |
network analysis using ingenuity pathway analysis revealed that sneb was associated with nrf2-mediated oxidative stress, mitochondrial dysfunction, endoplasmic reticulum stress, natural killer cell signaling, p53 signaling, downregulation of il-15, bcl-2, and ifn-gamma; upregulation of bax and chop and increased apoptosis with a potential negative impact on innate and adaptive immunity. |
2010-01-13 |
2023-08-12 |
cattle |
| D V Jeyaraju, G Cisbani, O M De Brito, E V Koonin, L Pellegrin. Hax1 lacks BH modules and is peripherally associated to heavy membranes: implications for Omi/HtrA2 and PARL activity in the regulation of mitochondrial stress and apoptosis. Cell death and differentiation. vol 16. issue 12. 2010-01-13. PMID:19680265. |
a recent report (chao et al., nature, 2008) proposed that the bcl-2-family-related protein, hax1, suppresses apoptosis in lymphocytes and neurons through a mechanism that involves its association to the inner mitochondrial membrane rhomboid protease parl, to proteolytically activate the serine protease omi/htra2 and eliminate active bax. |
2010-01-13 |
2023-08-12 |
Not clear |
| Xi-Min Fang, Yuan Li, Jiang-Chao Qian, Hai-Xia Zhou, Ju-Xiang Wan. [Effect of total saponins of Panaxginseng on bax and bcl-xl gene expression in HL-60 cells]. Zhongguo shi yan xue ye xue za zhi. vol 16. issue 4. 2010-01-12. PMID:18718060. |
the aim of this study was to investigate the effect of the total saponins of panaxginseng (tspg) on cells expression of apoptosis-related genes bax and bcl-xl in hl-60 cells and its mechanism inducing apoptosis of hl-60 cells. |
2010-01-12 |
2023-08-12 |
Not clear |
| Xi-Min Fang, Yuan Li, Jiang-Chao Qian, Hai-Xia Zhou, Ju-Xiang Wan. [Effect of total saponins of Panaxginseng on bax and bcl-xl gene expression in HL-60 cells]. Zhongguo shi yan xue ye xue za zhi. vol 16. issue 4. 2010-01-12. PMID:18718060. |
the effect on up-regulation of bax mrna and down-regulation of bcl-xl mrna probably play an important role in apoptosis of hl-60 cells induced by tspg. |
2010-01-12 |
2023-08-12 |
Not clear |
| Yi He, Jian-Min Yang, Jian-Min Wang, Hong Zhou, Shu-Qing Lü, Xiao-Xia H. [Synergistic effects of arsenic trioxide and proteasome inhibitor bortezomib on apoptosis induction in Raji cell line]. Zhongguo shi yan xue ye xue za zhi. vol 16. issue 4. 2010-01-12. PMID:18718063. |
the apoptosis related elements such as caspase-3, bcl-2, bax, jnk2 and ikappab-alpha, were measured with western blot. |
2010-01-12 |
2023-08-12 |
Not clear |
| Hai-Yan Hu, Zhao-Yang Song, Lan Deng, Mei-Xia Zhan. Immunoregulatory effect of evodiamine in mice of various germlines. Zhongguo shi yan xue ye xue za zhi. vol 16. issue 4. 2010-01-12. PMID:18718084. |
cell proliferation was detected by mtt method, while the concentration of il-2 was detected by elisa, mrna levels of bcl-2 and cdk2 in cells treated with evodiamine were detected by rt-pcr, the apoptosis rate and intracellular reactive oxygen species (ros) concentration were analyzed by fcm, and the protein levels of bcl-2, cdk2 and bax were determined by fluorescence microscope. |
2010-01-12 |
2023-08-12 |
mouse |