| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Eldi Schonfeld-Dado, Menahem Sega. Activity-dependent survival of neurons in culture: a model of slow neurodegeneration. Journal of neural transmission (Vienna, Austria : 1996). vol 116. issue 11. 2010-02-12. PMID:19565182. |
eventually, neurons activate p53, caspase-3 and bax, hallmarks of neuronal apoptosis, before they die. |
2010-02-12 |
2023-08-12 |
Not clear |
| Sahdeo Prasad, Esha Madan, Nidhi Nigam, Preeti Roy, Jasmine George, Yogeshwer Shukl. Induction of apoptosis by lupeol in human epidermoid carcinoma A431 cells through regulation of mitochondrial, Akt/PKB and NFkappaB signaling pathways. Cancer biology & therapy. vol 8. issue 17. 2010-02-12. PMID:19625778. |
the rt-pcr and western blot analysis showed that lupeol-induced apoptosis was associated with caspase dependent mitochondrial cell death pathway through activation of bax, caspases, apaf1, decrease in bcl-2 expression and subsequent cleavage of parp. |
2010-02-12 |
2023-08-12 |
human |
| Jung-Chou Chen, Kung-Wen Lu, Ming-Li Tsai, Shu-Chun Hsu, Chao-Lin Kuo, Jai-Sing Yang, Te-Chun Hsia, Chun-Shu Yu, Su-Tze Chou, Ming-Ching Kao, Jing-Gung Chung, W Gibson Woo. Gypenosides induced G0/G1 arrest via CHk2 and apoptosis through endoplasmic reticulum stress and mitochondria-dependent pathways in human tongue cancer SCC-4 cells. Oral oncology. vol 45. issue 3. 2010-02-09. PMID:18674953. |
in conclusion, gyp induced er stress and production of reactive oxygen species and ca(2+), change the ratio of bcl-2 and bax, followed by the dysfunction of mitochondria, caused cytochrome c release, activation of caspase-3 before leading to apoptosis. |
2010-02-09 |
2023-08-12 |
human |
| Danielle Resende Camisasca, Júlia Honorato, Vagner Bernardo, Licínio Esmeraldo da Silva, Eliene Carvalho da Fonseca, Paulo Antônio Silvestre de Faria, Fernando Luiz Dias, Simone de Queiroz Chaves Lourenç. Expression of Bcl-2 family proteins and associated clinicopathologic factors predict survival outcome in patients with oral squamous cell carcinoma. Oral oncology. vol 45. issue 3. 2010-02-09. PMID:18715811. |
the aims of this study were to assess the expression levels of three proteins involved in apoptosis--bcl-2, bcl-x, and bax--and evaluate their relationship with clinicopathologic features and survival in oral squamous cell carcinoma (oscc). |
2010-02-09 |
2023-08-12 |
Not clear |
| Yue Jia, Kuk-Wha Lee, Ronald Swerdloff, David Hwang, Laura J Cobb, Amiya Sinha Hikim, Yan He Lue, Pinchas Cohen, Christina Wan. Interaction of insulin-like growth factor-binding protein-3 and BAX in mitochondria promotes male germ cell apoptosis. The Journal of biological chemistry. vol 285. issue 3. 2010-02-08. PMID:19887447. |
interaction of insulin-like growth factor-binding protein-3 and bax in mitochondria promotes male germ cell apoptosis. |
2010-02-08 |
2023-08-12 |
rat |
| Yue Jia, Kuk-Wha Lee, Ronald Swerdloff, David Hwang, Laura J Cobb, Amiya Sinha Hikim, Yan He Lue, Pinchas Cohen, Christina Wan. Interaction of insulin-like growth factor-binding protein-3 and BAX in mitochondria promotes male germ cell apoptosis. The Journal of biological chemistry. vol 285. issue 3. 2010-02-08. PMID:19887447. |
our data demonstrate that the igfbp-3 and bax interaction activates germ cell apoptosis via the mitochondria-dependent pathway. |
2010-02-08 |
2023-08-12 |
rat |
| J-J Lee, J-H Lee, Y-G Ko, S I Hong, J-S Le. Prevention of premature senescence requires JNK regulation of Bcl-2 and reactive oxygen species. Oncogene. vol 29. issue 4. 2010-02-05. PMID:19855432. |
bax did not change their localization to the mitochondria, which is required for apoptosis. |
2010-02-05 |
2023-08-12 |
human |
| Jun Chen, Dan Xia, Jin-Dan Luo, Ping Wan. Exogenous p27KIP1 expression induces anti-tumour effects and inhibits the EGFR/PI3K/Akt signalling pathway in PC3 cells. Asian journal of andrology. vol 11. issue 6. 2010-02-04. PMID:19734935. |
moreover, p27-transfected pc3 cells underwent apoptosis, as shown by flow cytometric analysis and western blotting analysis of bcl-2, bax, bad, caspase-3 and poly(adp-ribose)polymerase expression. |
2010-02-04 |
2023-08-12 |
human |
| b' Ewa Og\\xc5\\x82odek, Beata Augusty\\xc5\\x84ska, Aleksander Araszkiewicz, Danuta Mo\\xc5\\x9. [The bile acids as an example of patogens destructive hepatocytes in alcoholic liver injury]. Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego. vol 27. issue 160. 2010-02-04. PMID:19928668.' |
the proteins bcl-x(l) and bcl-w inhibit apoptosis, while bax and bad protein promotes it. |
2010-02-04 |
2023-08-12 |
Not clear |
| b' Ewa Og\\xc5\\x82odek, Beata Augusty\\xc5\\x84ska, Aleksander Araszkiewicz, Danuta Mo\\xc5\\x9. [The bile acids as an example of patogens destructive hepatocytes in alcoholic liver injury]. Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego. vol 27. issue 160. 2010-02-04. PMID:19928668.' |
the bax protein interacts with mitochondrial pores inducing cytochrome c, which contributes to the release of caspase-activated proteins and starts the apoptosis. |
2010-02-04 |
2023-08-12 |
Not clear |
| Li Li Zhou, Fan Fan Hou, Guo Bao Wang, Fang Yang, Di Xie, Yong Ping Wang, Jian Wei Tia. Accumulation of advanced oxidation protein products induces podocyte apoptosis and deletion through NADPH-dependent mechanisms. Kidney international. vol 76. issue 11. 2010-02-02. PMID:19727064. |
increasing the amount of aopps in the media of conditionally immortalized podocytes rapidly triggered the production of intracellular superoxide by activation of nadph oxidase and this, in turn, led to an upregulation of p53, bax, caspase 3 activity, and apoptosis. |
2010-02-02 |
2023-08-12 |
rat |
| Paola Palozza, Rossella Simone, Assunta Catalano, Alma Boninsegna, Volker Böhm, Kati Fröhlich, Maria Cristina Mele, Giovanni Monego, Franco O Ranellett. Lycopene prevents 7-ketocholesterol-induced oxidative stress, cell cycle arrest and apoptosis in human macrophages. The Journal of nutritional biochemistry. vol 21. issue 1. 2010-02-01. PMID:19157829. |
concomitantly, it inhibited 7-kc-induced apoptosis, by limiting caspase-3 activation and the modulatory effects of 7-kc on akt, bcl-2, bcl-xl and bax. |
2010-02-01 |
2023-08-12 |
human |
| Anne-Françoise Rénert, Pierre Leprince, Marc Dieu, Jenny Renaut, Martine Raes, Vincent Bours, Jean-Paul Chapelle, Jacques Piette, Marie-Paule Merville, Marianne Fille. The proapoptotic C16-ceramide-dependent pathway requires the death-promoting factor Btf in colon adenocarcinoma cells. Journal of proteome research. vol 8. issue 10. 2010-02-01. PMID:19705920. |
in adenocarcinoma cells, btf regulates apoptosis related proteins such as mdm2, p53, bax and pbcl-2 and thus plays an important role in the ceramide mediated cell death. |
2010-02-01 |
2023-08-12 |
Not clear |
| Yanqing Guan, Lili Qiu, Wenwen Wan. [Expression of Bax, Bcl-2 and P53 in the HeLa apoptosis induced by co-immobilized cytokines]. Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi. vol 26. issue 1. 2010-01-28. PMID:19334572. |
[expression of bax, bcl-2 and p53 in the hela apoptosis induced by co-immobilized cytokines]. |
2010-01-28 |
2023-08-12 |
Not clear |
| Yanqing Guan, Lili Qiu, Wenwen Wan. [Expression of Bax, Bcl-2 and P53 in the HeLa apoptosis induced by co-immobilized cytokines]. Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi. vol 26. issue 1. 2010-01-28. PMID:19334572. |
the results suggest that hela apoptosis was induced by tumor necrosis factor-a and interferon -gamma, and the increasing expression of p53 may induce the expression of bax and prevent the expression of bcl-2, via the mitochondrial induction of cell apoptosis. |
2010-01-28 |
2023-08-12 |
Not clear |
| Jun Peng, Suzanne M Lapolla, Zhi Zhang, Jialing Li. The cytosolic domain of Bcl-2 forms small pores in model mitochondrial outer membrane after acidic pH-induced membrane association. Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi. vol 26. issue 1. 2010-01-28. PMID:19334571. |
therefore, bcl-2 and bax may form different size pores in mom, and while the large pore formed by bax may release cytochrome c during apoptosis, the small pore formed by bcl-2 may maintain the normal mom permeability. |
2010-01-28 |
2023-08-12 |
Not clear |
| Bian Li-juan, Liao Bing, Li Zhi, Li Yang, Liang Ying-ji. Hepatocyte growth factor suppresses tumor cell apoptosis in nasopharyngeal carcinoma by upregulating Bcl-2 protein expression. Pathology, research and practice. vol 205. issue 12. 2010-01-28. PMID:19625133. |
npc cells were treated with hgf (25 ng/ml), followed by an assay for cell viability and apoptosis, as well as by an expression analysis of bcl-2 and bax using immunostaining and western blot. |
2010-01-28 |
2023-08-12 |
Not clear |
| Jae-Hee Hyun, Sang-Cheol Kim, Jung-Il Kang, Min-Kyoung Kim, Hye-Jin Boo, Jung-Mi Kwon, Young-Sang Koh, Jin-Won Hyun, Deok-Bae Park, Eun-Sook Yoo, Hee-Kyoung Kan. Apoptosis inducing activity of fucoidan in HCT-15 colon carcinoma cells. Biological & pharmaceutical bulletin. vol 32. issue 10. 2010-01-28. PMID:19801840. |
in the mechanism of fucoidan-induced apoptosis, we examined changes in bcl-2 and bax protein expression levels and activation of caspases. |
2010-01-28 |
2023-08-12 |
human |
| Yuan-yuan Jiang, Hong-jun Wang, Jing Wang, Shin-ichi Tashiro, Satoshi Onodera, Takashi Ikejim. The protective effect of silibinin against mitomycin C-induced intrinsic apoptosis in human melanoma A375-S2 cells. Journal of pharmacological sciences. vol 111. issue 2. 2010-01-28. PMID:19834285. |
however, preincubation with silibinin prior to mitomycin c treatment substantially suppressed cell apoptosis, attenuated the change of p53 and bcl-2 expressions, blocked the translocation of bax to mitochondrial outer membrane, and ameliorated the loss of mitochondrial membrane potential, but mitomycin c stimuli led to few changes in the protein levels of caspase 8, fas ligand, and fas-associated death domain protein, indicating that silibinin protected cells from mitomycin c-induced apoptosis mainly via suppressing the mitochondria-mediated intrinsic apoptosis pathway, but not in an extrinsic manner. |
2010-01-28 |
2023-08-12 |
human |
| K Kojima, M Konopleva, T Tsao, M Andreeff, H Ishida, Y Shiotsu, L Jin, Y Tabe, H Nakakum. Selective FLT3 inhibitor FI-700 neutralizes Mcl-1 and enhances p53-mediated apoptosis in AML cells with activating mutations of FLT3 through Mcl-1/Noxa axis. Leukemia. vol 24. issue 1. 2010-01-27. PMID:19946262. |
the fi-700/nutlin-3 combination profoundly activated bax and induced apoptosis. |
2010-01-27 |
2023-08-12 |
Not clear |