| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Mark D McKenzie, Emma Jamieson, Elisa S Jansen, Clare L Scott, David C S Huang, Philippe Bouillet, Janette Allison, Thomas W H Kay, Andreas Strasser, Helen E Thoma. Glucose induces pancreatic islet cell apoptosis that requires the BH3-only proteins Bim and Puma and multi-BH domain protein Bax. Diabetes. vol 59. issue 3. 2010-03-30. PMID:19959756. |
glucose induces pancreatic islet cell apoptosis that requires the bh3-only proteins bim and puma and multi-bh domain protein bax. |
2010-03-30 |
2023-08-12 |
mouse |
| Takayuki Ikezoe, Jing Yang, Chie Nishioka, Akihito Yokoyam. p53 is critical for the Aurora B kinase inhibitor-mediated apoptosis in acute myelogenous leukemia cells. International journal of hematology. vol 91. issue 1. 2010-03-30. PMID:20013323. |
azd1152-hqpa (10-100 nm, 48 h) strikingly induced apoptosis of mv4-11 cells, as assessed by annexin v binding, loss of mitochondrial outer membrane potential, and activation of caspase cascade, in parallel with up-regulation of p53 and its target molecules bax and noxa. |
2010-03-30 |
2023-08-12 |
human |
| Mohammed O Altonsy, Simon C Andrews, Kieran M Tuoh. Differential induction of apoptosis in human colonic carcinoma cells (Caco-2) by Atopobium, and commensal, probiotic and enteropathogenic bacteria: mediation by the mitochondrial pathway. International journal of food microbiology. vol 137. issue 2-3. 2010-03-30. PMID:20036023. |
instead, in all cases, apoptosis was induced through the mitochondrial pathway as indicated by bax translocation, cytochrome c release, and caspase-9 and -3 cleavage. |
2010-03-30 |
2023-08-12 |
human |
| Jiao Zhang, Jian-Ping Lu, David M Suter, Karl-Heinz Krause, M Elizabeth Fini, Baoan Chen, Qun L. Isoform- and dose-sensitive feedback interactions between paired box 6 gene and delta-catenin in cell differentiation and death. Experimental cell research. vol 316. issue 6. 2010-03-30. PMID:20074565. |
furthermore, sustained high expression of pax6(+5a) triggered apoptosis as determined by the reduction of phospho-bad, bcl-2, survivin and procaspases, as well as the increases in bax and cleaved poly(adp-ribose) polymerase. |
2010-03-30 |
2023-08-12 |
drosophila_melanogaster |
| Yan Wang, Xiao-Xia Dong, Yi Cao, Zhong-Qin Liang, Rong Han, Jun-Chao Wu, Zhen-Lun Gu, Zhen-Hong Qi. p53 induction contributes to excitotoxic neuronal death in rat striatum through apoptotic and autophagic mechanisms. The European journal of neuroscience. vol 30. issue 12. 2010-03-30. PMID:20092569. |
rats were intrastriatally administered the n-methyl-d-aspartate (nmda) receptor agonist quinolinic acid (qa), the changes in the expression of p53 and its target genes involved in apoptosis and autophagy, including p53-upregulated modulator of apoptosis (puma), bax, bcl-2, damage-regulated autophagy modulator (dram) and other autophagic proteins including microtubule-associated protein 1 light chain 3 (lc3) and beclin 1 were assessed. |
2010-03-30 |
2023-08-12 |
rat |
| Stephanie Bleicken, Mirjam Classen, Pulagam V L Padmavathi, Takashi Ishikawa, Kornelius Zeth, Heinz-Jürgen Steinhoff, Enrica Bordigno. Molecular details of Bax activation, oligomerization, and membrane insertion. The Journal of biological chemistry. vol 285. issue 9. 2010-03-26. PMID:20008353. |
activated bax inserts into the mitochondrial outer membrane forming oligomers which lead to membrane poration, release of cytochrome c, and apoptosis. |
2010-03-26 |
2023-08-12 |
Not clear |
| Ildete L Ferreira, Maria V Nascimento, Márcio Ribeiro, Sandra Almeida, Sandra M Cardoso, Manuela Grazina, João Pratas, Maria João Santos, Cristina Januário, Catarina R Oliveira, A Cristina Reg. Mitochondrial-dependent apoptosis in Huntington's disease human cybrids. Experimental neurology. vol 222. issue 2. 2010-03-26. PMID:20079354. |
3-np-evoked apoptosis in hd cybrids involved cytochrome c and aif release from mitochondria, which was associated with mitochondrial bax translocation. |
2010-03-26 |
2023-08-12 |
human |
| Joseph George, Naren L Banik, Swapan K Ra. Genistein induces receptor and mitochondrial pathways and increases apoptosis during BCL-2 knockdown in human malignant neuroblastoma SK-N-DZ cells. Journal of neuroscience research. vol 88. issue 4. 2010-03-25. PMID:19813266. |
apoptosis was associated with increases in bax:bcl-2 ratio, mitochondrial release of cytochrome c, and activation of caspases through the mitochondria-mediated apoptotic pathway. |
2010-03-25 |
2023-08-12 |
human |
| Junfei Jin, Thomas D Mullen, Qi Hou, Jacek Bielawski, Alicja Bielawska, Xiaoming Zhang, Lina M Obeid, Yusuf A Hannun, Yi-Te Hs. AMPK inhibitor Compound C stimulates ceramide production and promotes Bax redistribution and apoptosis in MCF7 breast carcinoma cells. Journal of lipid research. vol 50. issue 12. 2010-03-23. PMID:19528633. |
ampk inhibitor compound c stimulates ceramide production and promotes bax redistribution and apoptosis in mcf7 breast carcinoma cells. |
2010-03-23 |
2023-08-12 |
Not clear |
| Takayuki Kojima, Takanari Norose, Keita Tsuchiya, Kazuichi Sakamot. Mouse 3T3-L1 cells acquire resistance against oxidative stress as the adipocytes differentiate via the transcription factor FoxO. Apoptosis : an international journal on programmed cell death. vol 15. issue 1. 2010-03-23. PMID:19842039. |
god remarkably increased the levels of bad, bax, and bim-the genes that are actively involved in cell apoptosis. |
2010-03-23 |
2023-08-12 |
mouse |
| R Di Paola, C Crisafulli, E Mazzon, T Genovese, I Paterniti, P Bramanti, S Cuzzocre. Effect of PD98059, a selective MAPK3/MAPK1 inhibitor, on acute lung injury in mice. International journal of immunopathology and pharmacology. vol 22. issue 4. 2010-03-22. PMID:20074457. |
furthermore, carrageenan induced lung apoptosis (bax and bcl-2 expression) as well as nitrotyrosine formation, nf-kb activation, and pjnk expression, as determined by immunohistochemical analysis of lung tissues and the degree of lung inflammation and tissue injury (histological score). |
2010-03-22 |
2023-08-12 |
mouse |
| Surajit Sinha, Sunil Kumar Malonia, Smriti P K Mittal, Kamini Singh, Sreenath Kadreppa, Rohan Kamat, Robin Mukhopadhyaya, Jayanta K Pal, Samit Chattopadhya. Coordinated regulation of p53 apoptotic targets BAX and PUMA by SMAR1 through an identical MAR element. The EMBO journal. vol 29. issue 4. 2010-03-22. PMID:20075864. |
this facilitates p53 acetylation and restricts smar1 binding to bax and puma mar leading to apoptosis. |
2010-03-22 |
2023-08-12 |
Not clear |
| Zhuoshun Yang, Zhang Lei, Bo Li, Yu Zhou, Gui-Mei Zhang, Zuo-Hua Feng, Biao Zhang, Guan-Xin Shen, Bo Huan. Rapamycin inhibits lung metastasis of B16 melanoma cells through down-regulating alphav integrin expression and up-regulating apoptosis signaling. Cancer science. vol 101. issue 2. 2010-03-16. PMID:19922502. |
second, rapamycin promotes apoptosis by up-regulating the proapoptotic molecules bid and bax and down-regulating bcl-xl. |
2010-03-16 |
2023-08-12 |
Not clear |
| Zhiyong Wang, Andrea Havasi, Jonathan Gall, Ramon Bonegio, Zhijian Li, Haiping Mao, John H Schwartz, Steven C Borka. GSK3beta promotes apoptosis after renal ischemic injury. Journal of the American Society of Nephrology : JASN. vol 21. issue 2. 2010-03-16. PMID:20093356. |
exposure of renal epithelial cells to metabolic stress activated gsk3beta, bax, and caspase 3 and induced apoptosis. |
2010-03-16 |
2023-08-12 |
rat |
| Zhiyong Wang, Andrea Havasi, Jonathan Gall, Ramon Bonegio, Zhijian Li, Haiping Mao, John H Schwartz, Steven C Borka. GSK3beta promotes apoptosis after renal ischemic injury. Journal of the American Society of Nephrology : JASN. vol 21. issue 2. 2010-03-16. PMID:20093356. |
taken together, gsk3beta-mediated bax activation induces apoptosis and tubular damage that contribute to acute ischemic kidney injury. |
2010-03-16 |
2023-08-12 |
rat |
| Eunjin Sohn, Junghyun Kim, Chan-Sik Kim, Young Sook Kim, Dae Sik Jang, Jin Sook Ki. Extract of the aerial parts of Aster koraiensis reduced development of diabetic nephropathy via anti-apoptosis of podocytes in streptozotocin-induced diabetic rats. Biochemical and biophysical research communications. vol 391. issue 1. 2010-03-15. PMID:19944074. |
kidney histopathology, ages accumulation, apoptosis, and expression of bax and bcl-2 also were examined. |
2010-03-15 |
2023-08-12 |
rat |
| Maria Anzaldi, Chiara Macciò, Mauro Mazzei, Maria Bertolotto, Luciano Ottonello, Franco Dallegri, Alessandro Balb. Antiproliferative and proapoptotic activities of a new class of pyrazole derivatives in HL-60 cells. Chemistry & biodiversity. vol 6. issue 10. 2010-03-12. PMID:19842131. |
the inhibition of cell growth mainly reflects a compound-induced reduction in the number of cells in phases from s to m, whereas the induction of apoptosis involves inhibition of expression of bcl-2 and enhanced expression of bax with consequent reduced activation of the proapoptotic caspase 3. |
2010-03-12 |
2023-08-12 |
Not clear |
| Dana Westphal, Elizabeth C Ledgerwood, Joel D A Tyndall, Merilyn H Hibma, Norihito Ueda, Stephen B Fleming, Andrew A Merce. The orf virus inhibitor of apoptosis functions in a Bcl-2-like manner, binding and neutralizing a set of BH3-only proteins and active Bax. Apoptosis : an international journal on programmed cell death. vol 14. issue 11. 2010-03-09. PMID:19779821. |
the orf virus inhibitor of apoptosis functions in a bcl-2-like manner, binding and neutralizing a set of bh3-only proteins and active bax. |
2010-03-09 |
2023-08-12 |
Not clear |
| Dana Westphal, Elizabeth C Ledgerwood, Joel D A Tyndall, Merilyn H Hibma, Norihito Ueda, Stephen B Fleming, Andrew A Merce. The orf virus inhibitor of apoptosis functions in a Bcl-2-like manner, binding and neutralizing a set of BH3-only proteins and active Bax. Apoptosis : an international journal on programmed cell death. vol 14. issue 11. 2010-03-09. PMID:19779821. |
we conclude that orfv125's mechanism of action is bcl-2-like and propose that the viral protein's combined ability to bind to a range of bh3-only proteins as well as the active form of bax provides significant protection against apoptosis. |
2010-03-09 |
2023-08-12 |
Not clear |
| Lan Hu, Temple F Smith, Gabriel Goldberge. LFG: a candidate apoptosis regulatory gene family. Apoptosis : an international journal on programmed cell death. vol 14. issue 11. 2010-03-09. PMID:19784873. |
for example the transmembrane bax inhibitor 1 (bi1) motif family has been reported to play a role in apoptosis and to consist of at least seven mammalian protein genes, grina, bi1, lfg/faim2, ghitm, resc1/tmbim1, gaap/tmbim4, and tmbm1b. |
2010-03-09 |
2023-08-12 |
human |