| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ying Geng, K C Walls, Arindam P Ghosh, Rizwan S Akhtar, Barbara J Klocke, Kevin A Rot. Cytoplasmic p53 and activated Bax regulate p53-dependent, transcription-independent neural precursor cell apoptosis. The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society. vol 58. issue 3. 2010-03-09. PMID:19901272. |
cytoplasmic p53 and activated bax regulate p53-dependent, transcription-independent neural precursor cell apoptosis. |
2010-03-09 |
2023-08-12 |
mouse |
| Ying Geng, K C Walls, Arindam P Ghosh, Rizwan S Akhtar, Barbara J Klocke, Kevin A Rot. Cytoplasmic p53 and activated Bax regulate p53-dependent, transcription-independent neural precursor cell apoptosis. The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society. vol 58. issue 3. 2010-03-09. PMID:19901272. |
these observations suggest that cytoplasmic p53 can trigger transcription-independent npc apoptosis through its potential interaction with npm and activated bax. |
2010-03-09 |
2023-08-12 |
mouse |
| John P Wiebe, Michel Beausoleil, Guihua Zhang, Valentin Cialac. Opposing actions of the progesterone metabolites, 5alpha-dihydroprogesterone (5alphaP) and 3alpha-dihydroprogesterone (3alphaHP) on mitosis, apoptosis, and expression of Bcl-2, Bax and p21 in human breast cell lines. The Journal of steroid biochemistry and molecular biology. vol 118. issue 1-2. 2010-03-09. PMID:19931389. |
opposing actions of the progesterone metabolites, 5alpha-dihydroprogesterone (5alphap) and 3alpha-dihydroprogesterone (3alphahp) on mitosis, apoptosis, and expression of bcl-2, bax and p21 in human breast cell lines. |
2010-03-09 |
2023-08-12 |
human |
| John P Wiebe, Michel Beausoleil, Guihua Zhang, Valentin Cialac. Opposing actions of the progesterone metabolites, 5alpha-dihydroprogesterone (5alphaP) and 3alpha-dihydroprogesterone (3alphaHP) on mitosis, apoptosis, and expression of Bcl-2, Bax and p21 in human breast cell lines. The Journal of steroid biochemistry and molecular biology. vol 118. issue 1-2. 2010-03-09. PMID:19931389. |
the studies were conducted on tumorigenic (mcf-7, mda-mb-231, t47d) and non-tumorigenic (mcf-10a) human breast cell lines, employing several methods to assess the effects of the hormones on cell proliferation, mitosis, apoptosis and expression of bcl-2, bax and p21. |
2010-03-09 |
2023-08-12 |
human |
| Yang Gao, Xin-guo Deng, Qian-na Sun, Zhi-qiang Zhon. Ganoderma spore lipid inhibits N-methyl-N-nitrosourea-induced retinal photoreceptor apoptosis in vivo. Experimental eye research. vol 90. issue 3. 2010-03-09. PMID:20003911. |
expressions of bax, bcl-xl and caspase-3 were detected by rt-pcr and immunofluorescence assays, then photoreceptor cell apoptosis was confirmed by terminal deoxynucleotidyl transferase-mediated deoxyuridine triphosphate-digoxigenin nick-end labeling (tunel) signals. |
2010-03-09 |
2023-08-12 |
rat |
| Yang Gao, Xin-guo Deng, Qian-na Sun, Zhi-qiang Zhon. Ganoderma spore lipid inhibits N-methyl-N-nitrosourea-induced retinal photoreceptor apoptosis in vivo. Experimental eye research. vol 90. issue 3. 2010-03-09. PMID:20003911. |
taken together, these data suggest that gsl may regulate the expressions of bax, bcl-xl and caspases-3, inhibiting mnu-induced rat photoreceptor cell apoptosis and protecting retinal function. |
2010-03-09 |
2023-08-12 |
rat |
| Xiaoli Zhu, Hongming Zhang, Yong Lin, Pingsheng Chen, Jie Min, Zhengzhong Wang, Wei Xiao, Bao'an Che. Mechanisms of gambogic acid-induced apoptosis in non-small cell lung cancer cells in relation to transferrin receptors. Journal of chemotherapy (Florence, Italy). vol 21. issue 6. 2010-03-09. PMID:20071291. |
we found that ga uptake into spc-a1 cells was higher than into sk-mes-1 cells; apoptosis-related proteins caspase 2, caspase 9, caspase 10, bax and p53 were involved in ga-induced apoptosis. |
2010-03-09 |
2023-08-12 |
human |
| Julie Garibal, Emilie Hollville, Benjamin Renouf, Cécile Tétaud, Joëlle Wiel. Caspase-8-mediated cleavage of Bid and protein phosphatase 2A-mediated activation of Bax are necessary for Verotoxin-1-induced apoptosis in Burkitt's lymphoma cells. Cellular signalling. vol 22. issue 3. 2010-03-08. PMID:19895884. |
caspase-8-mediated cleavage of bid and protein phosphatase 2a-mediated activation of bax are necessary for verotoxin-1-induced apoptosis in burkitt's lymphoma cells. |
2010-03-08 |
2023-08-12 |
Not clear |
| Alexander V Sirotkin, Marcela Lauková, Dmitriy Ovcharenko, Pauline Brenaut, Milos Mlynce. Identification of microRNAs controlling human ovarian cell proliferation and apoptosis. Journal of cellular physiology. vol 223. issue 1. 2010-03-08. PMID:20039279. |
the effect of transfection of cultured primary ovarian granulosa cells with 80 different constructs encoding human pre-mirnas on the expression of the proliferation marker, pcna, and the apoptosis marker, bax was evaluated by immunocytochemistry. |
2010-03-08 |
2023-08-12 |
human |
| Katja Janssen, Sibylle Horn, Mathis T Niemann, Peter T Daniel, Klaus Schulze-Osthoff, Ute Fische. Inhibition of the ER Ca2+ pump forces multidrug-resistant cells deficient in Bak and Bax into necrosis. Journal of cell science. vol 122. issue Pt 24. 2010-03-05. PMID:19920074. |
in the presence of bak and bax, thapsigargin eliminates cells by release of mitochondrial cytochrome c and subsequent caspase activation, which leads to the proteolytic inactivation of the molecular necrosis switch parp-1 and results in apoptosis. |
2010-03-05 |
2023-08-12 |
Not clear |
| Katja Janssen, Sibylle Horn, Mathis T Niemann, Peter T Daniel, Klaus Schulze-Osthoff, Ute Fische. Inhibition of the ER Ca2+ pump forces multidrug-resistant cells deficient in Bak and Bax into necrosis. Journal of cell science. vol 122. issue Pt 24. 2010-03-05. PMID:19920074. |
thus, even though deficiency in bak and bax protects these cells against apoptosis, it does not compromise necrosis induced by serca inhibitors. |
2010-03-05 |
2023-08-12 |
Not clear |
| Hae-Ree Seo, Ji-Young Kim, Jeong-Hwan Kim, Kun-Young Par. Identification of Bacillus cereus in a chungkukjang that showed high anticancer effects against AGS human gastric adenocarcinoma cells. Journal of medicinal food. vol 12. issue 6. 2010-03-05. PMID:20041781. |
k-chungkukjang induced apoptosis as determined by 4,6-diamidino-2-phenylindole staining and exhibited increased bax and decreased bcl-2 mrna expression. |
2010-03-05 |
2023-08-12 |
human |
| Sang Kyu Lee, Yong Chan Kim, Seok Bean Song, Young Sang Ki. Stabilization and translocation of p53 to mitochondria is linked to Bax translocation to mitochondria in simvastatin-induced apoptosis. Biochemical and biophysical research communications. vol 391. issue 4. 2010-03-05. PMID:20043868. |
stabilization and translocation of p53 to mitochondria is linked to bax translocation to mitochondria in simvastatin-induced apoptosis. |
2010-03-05 |
2023-08-12 |
Not clear |
| Sang Kyu Lee, Yong Chan Kim, Seok Bean Song, Young Sang Ki. Stabilization and translocation of p53 to mitochondria is linked to Bax translocation to mitochondria in simvastatin-induced apoptosis. Biochemical and biophysical research communications. vol 391. issue 4. 2010-03-05. PMID:20043868. |
moreover, knockdown or deficiency of p53 expression reduced both bax translocation to mitochondria and mmp disruption in simvastatin-induced apoptosis. |
2010-03-05 |
2023-08-12 |
Not clear |
| Sang Kyu Lee, Yong Chan Kim, Seok Bean Song, Young Sang Ki. Stabilization and translocation of p53 to mitochondria is linked to Bax translocation to mitochondria in simvastatin-induced apoptosis. Biochemical and biophysical research communications. vol 391. issue 4. 2010-03-05. PMID:20043868. |
taken together, these all indicate that stabilization and translocation of p53 to mitochondria is involved in bax translocation to mitochondria in simvastatin-induced apoptosis. |
2010-03-05 |
2023-08-12 |
Not clear |
| Jie Cao, Jie Xia, Hui Wang, Hong DU, Wang-Lin L. [Fragile histidine triad protein expression and correlation with apoptosis in rectal carcinoma]. Zhonghua wei chang wai ke za zhi = Chinese journal of gastrointestinal surgery. vol 10. issue 2. 2010-03-04. PMID:17380463. |
the relationship between fhit protein expression and bcl-2, bax and survivin expression, as well as cell apoptosis in rectal carcinoma were explored. |
2010-03-04 |
2023-08-12 |
Not clear |
| D D Cui, Y Huang, S H Mao, S C Chen, M Qiu, L L Ji, C Y. Synergistic antitumor effect of TRAIL and adriamycin on the human breast cancer cell line MCF-7. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas. vol 42. issue 9. 2010-03-03. PMID:19738990. |
in addition, the combined treatment with trail and adm significantly increased cell apoptosis from 9.8% (trail) or 17% (adm) to 38.7%, resulting in a synergistic apoptotic effect, which is proposed to be mediated by up-regulation of dr4 and dr5 mrna expression and increased expression of bax and caspase-9 proteins. |
2010-03-03 |
2023-08-12 |
human |
| Meihong Zhang, Xiangyong Li, Yuefei Zhang, Keyuan Zho. Bax inhibitor-1 mediates apoptosis-resistance in human nasopharyngeal carcinoma cells. Molecular and cellular biochemistry. vol 333. issue 1-2. 2010-03-02. PMID:19579059. |
bax inhibitor-1 (bi-1), a newly identified apoptosis inhibitor, has recently been found to be overexpressed in several human carcinomas and its specific down-regulation by rna interference (rnai) could lead to cell death. |
2010-03-02 |
2023-08-12 |
human |
| Seung-Ju Cho, Seung-Soo Lee, Young-Jong Kim, Byoung-Duck Park, Joon-Seok Choi, Linhua Liu, Young-Mi Ham, B Moon Kim, Seung-Ki Le. Xylocydine, a novel Cdk inhibitor, is an effective inducer of apoptosis in hepatocellular carcinoma cells in vitro and in vivo. Cancer letters. vol 287. issue 2. 2010-03-02. PMID:19616371. |
the effects on apoptosis are concomitant with changes in the levels of anti-apoptotic proteins, bcl-2, xiap, and survivin, which are markedly down-regulated, and pro-apoptotic molecules, p53 and bax, which are elevated in hcc cells after treatment with xylocydine. |
2010-03-02 |
2023-08-12 |
mouse |
| Soon Young Shin, Yeonjoong Yong, Chang Gun Kim, Young Han Lee, Yoongho Li. Deoxypodophyllotoxin induces G2/M cell cycle arrest and apoptosis in HeLa cells. Cancer letters. vol 287. issue 2. 2010-03-02. PMID:19616373. |
together, these data suggest that dppt induces g(2)/m cell-cycle arrest followed by apoptosis through multiple cellular processes, involving the activation of atm, upregulation of p53 and bax, activation of caspase-3 and -7, and accumulation of pten resulting in the inhibition of the akt pathway. |
2010-03-02 |
2023-08-12 |
Not clear |