| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Gregory J Cost, Yevgeniy Freyvert, Annamaria Vafiadis, Yolanda Santiago, Jeffrey C Miller, Edward Rebar, Trevor N Collingwood, Andrew Snowden, Philip D Gregor. BAK and BAX deletion using zinc-finger nucleases yields apoptosis-resistant CHO cells. Biotechnology and bioengineering. vol 105. issue 2. 2010-03-02. PMID:19777580. |
apoptosis in cell culture involves mitochondrial permeabilization by the pro-apoptotic bak and bax proteins; activity of either protein is sufficient to permit apoptosis. |
2010-03-02 |
2023-08-12 |
Not clear |
| C Esposito, G Fasoli, T Rampino, A Dal Canto. [Hepatocyte growth factor and kidney]. Giornale italiano di nefrologia : organo ufficiale della Societa italiana di nefrologia. vol 23. issue 4. 2010-03-01. PMID:17063438. |
hgf inhibits apoptosis by upregulating the protooncogene bcl-2 and downregulating bax. |
2010-03-01 |
2023-08-12 |
Not clear |
| Jose A Gomez, Weiyon Sun, Vivian Gama, Dagmar Hajkova, Tomoyuki Yoshida, Zhengrong Wu, Masaru Miyagi, John J Pink, Mark W Jackson, David Danielpour, Shigemi Matsuyam. The C-terminus of interferon gamma receptor beta chain (IFNgammaR2) has antiapoptotic activity as a Bax inhibitor. Cancer biology & therapy. vol 8. issue 18. 2010-02-25. PMID:19657228. |
ifngammar2(296-337) rescued human cells from apoptosis induced by overexpression of bax but not bak. |
2010-02-25 |
2023-08-12 |
human |
| Jose A Gomez, Weiyon Sun, Vivian Gama, Dagmar Hajkova, Tomoyuki Yoshida, Zhengrong Wu, Masaru Miyagi, John J Pink, Mark W Jackson, David Danielpour, Shigemi Matsuyam. The C-terminus of interferon gamma receptor beta chain (IFNgammaR2) has antiapoptotic activity as a Bax inhibitor. Cancer biology & therapy. vol 8. issue 18. 2010-02-25. PMID:19657228. |
interestingly, ifngammar2 inhibited apoptosis induced by the bh3-only protein bim-el, suggesting that ifngammar2 inhibits bax activation through a bh3-only protein. |
2010-02-25 |
2023-08-12 |
human |
| Concetta Crisafulli, Rosanna Di Paola, Emanuela Mazzon, Irene Paterniti, Maria Galuppo, Tiziana Genovese, Placido Bramanti, Alessandro Cappellani, Salvatore Cuzzocre. Liver X receptor agonist treatment reduced splanchnic ischemia and reperfusion injury. Journal of leukocyte biology. vol 87. issue 2. 2010-02-25. PMID:20028773. |
this study provides the evidence that t0901317, lxr agonist, modulates: the development of sao shock; the infiltration of the tissue with pmns; the expression of tnf-alpha and il-1beta; the nitration of tyrosine residues; nf-kappab expression; the mapk phosphorylation (erk, jnk, and p38); fasl; apoptosis; bax and bcl-2 expression; and the degree of tissue injury caused by sao shock. |
2010-02-25 |
2023-08-12 |
mouse |
| S Romano, A D'Angelillo, R Pacelli, S Staibano, E De Luna, R Bisogni, E-L Eskelinen, M Mascolo, G Calì, C Arra, M F Roman. Role of FK506-binding protein 51 in the control of apoptosis of irradiated melanoma cells. Cell death and differentiation. vol 17. issue 1. 2010-02-24. PMID:19696786. |
fkbp51 was required for the activation of rx-induced nf-kappab, which in turn inhibited apoptosis by stimulating x-linked inhibitor of apoptosis protein and promoting authophagy-mediated bax degradation. |
2010-02-24 |
2023-08-12 |
mouse |
| Huibo Wang, Shu-Yu Zhang, Shuai Wang, Juan Lu, Wenting Wu, Lin Weng, Dan Chen, Yu Zhang, Zhipeng Lu, Jingmin Yang, Yuanyuan Chen, Xu Zhang, Xiaofeng Chen, Caihua Xi, Daru Lu, Shiguang Zha. REV3L confers chemoresistance to cisplatin in human gliomas: the potential of its RNAi for synergistic therapy. Neuro-oncology. vol 11. issue 6. 2010-02-23. PMID:19289490. |
downregulation of rev3l expression significantly enhanced the sensitivity of glioma cells to cisplatin, as evidenced by the increased apoptosis rate and marked alterations in the anti-apoptotic proteins b-cell lymphoma 2 (bcl-2) and b-cell lymphoma-extra large (bcl-xl) and proapoptotic bcl-2-associated x protein (bax) expression levels, and reduced mutation frequencies in surviving glioma cells. |
2010-02-23 |
2023-08-12 |
human |
| Han Jin Cho, Gyoo Taik Kwon, Jung Han Yoon Par. trans-10,cis-12 Conjugated linoleic acid induces depolarization of mitochondrial membranes in HT-29 human colon cancer cells: a possible mechanism for induction of apoptosis. Journal of medicinal food. vol 12. issue 5. 2010-02-23. PMID:19857056. |
these findings indicate that physiological levels of t10c12 induce apoptosis in ht-29 colon cancer cells, which is mediated via mitochondrion-mediated events associated with a decline in akt activity, an increase in the translocation of the pro-apototic bad and bax to the mitochondria, and the subsequent disruption of normal mitochondrial membrane potential. |
2010-02-23 |
2023-08-12 |
human |
| D E Zamora-Avila, P Zapata-Benavides, M A Franco-Molina, S Saavedra-Alonso, L M Trejo-Avila, D Reséndez-Pérez, J L Méndez-Vázquez, J Isaias-Badillo, C Rodríguez-Padill. WT1 gene silencing by aerosol delivery of PEI-RNAi complexes inhibits B16-F10 lung metastases growth. Cancer gene therapy. vol 16. issue 12. 2010-02-22. PMID:19461674. |
furthermore, the treated lung tissue showed cells in the tumor infiltrations undergoing apoptosis and elevated expression of the proapoptotic genes bcl-xs and bax, suggesting an activation of the intrinsic apoptotic pathway. |
2010-02-22 |
2023-08-12 |
mouse |
| Hai-yan Xiong, Xian-ling Guo, Xin-xin Bu, Shan-shan Zhang, Nan-nan Ma, Jian-rui Song, Fei Hu, Shuang-fen Tao, Kai Sun, Rong Li, Meng-chao Wu, Li-xin We. Autophagic cell death induced by 5-FU in Bax or PUMA deficient human colon cancer cell. Cancer letters. vol 288. issue 1. 2010-02-22. PMID:19660860. |
bax or puma deficient cells had similar chemosensitivity to wt cells but were defective in undergoing apoptosis. |
2010-02-22 |
2023-08-12 |
human |
| Alexandra Berdichevski, Gideon Meiry, Felix Milman, Irena Reiter, Oshra Sedan, Sivan Eliyahu, Heather S Duffy, Moussa B Youdim, Ofer Bina. TVP1022 protects neonatal rat ventricular myocytes against doxorubicin-induced functional derangements. The Journal of pharmacology and experimental therapeutics. vol 332. issue 2. 2010-02-19. PMID:19915070. |
studies on structure-activity relationship revealed that their neuroprotective effect is associated with the propargylamine moiety, which protects mitochondrial viability and prevents apoptosis by activating bcl-2 and protein kinase c-epsilon and by down-regulating the proapoptotic protein bax. |
2010-02-19 |
2023-08-12 |
rat |
| Yea-Tzy Deng, Hsiu-Chen Huang, Jen-Kun Li. Rotenone induces apoptosis in MCF-7 human breast cancer cell-mediated ROS through JNK and p38 signaling. Molecular carcinogenesis. vol 49. issue 2. 2010-02-18. PMID:19777565. |
the antiapoptotic protein, bcl-2, was decreased, whereas the apoptotic protein, bax, was increased in a time-dependent manner in rotenone-induced apoptosis. |
2010-02-18 |
2023-08-12 |
human |
| Li Kai, Shirley K Samuel, Anait S Levenso. Resveratrol enhances p53 acetylation and apoptosis in prostate cancer by inhibiting MTA1/NuRD complex. International journal of cancer. vol 126. issue 7. 2010-02-18. PMID:19810103. |
furthermore, mta1 silencing maximized the levels of res-induced apoptosis and pro-apoptotic bax accumulation. |
2010-02-18 |
2023-08-12 |
Not clear |
| Marco Arlorio, Consuelo Bottini, Fabiano Travaglia, Monica Locatelli, Matteo Bordiga, Jean Daniel Coïsson, Aldo Martelli, Luciana Tessitor. Protective activity of Theobroma cacao L. phenolic extract on AML12 and MLP29 liver cells by preventing apoptosis and inducing autophagy. Journal of agricultural and food chemistry. vol 57. issue 22. 2010-02-18. PMID:19883072. |
death prevented by cocoa had hallmarks of apoptosis such as the sub-g1 peak at flow cytometry and activation of bax expression, together with down-regulation of bcl-2, released cytochrome c in the cytosol with activation of caspase 3, indicating that components of the apoptotic pathway such as bax or upstream are major targets of cocoa phytochemicals. |
2010-02-18 |
2023-08-12 |
Not clear |
| Jaiprakash R Patil, K N Chidambara Murthy, G K Jayaprakasha, Mahadev B Chetti, Bhimanagouda S Pati. Bioactive compounds from Mexican lime ( Citrus aurantifolia ) juice induce apoptosis in human pancreatic cells. Journal of agricultural and food chemistry. vol 57. issue 22. 2010-02-18. PMID:19919125. |
the meoh extract exhibited the maximum activity, with an ic50 value of 81.20 microg/ml after 72 h. the inhibition of panc-28 cells was in the range of 73-89%, at 100 microg/ml at 96 h. the involvement of apoptosis in induction of cytotoxicity was confirmed by expression of bax, bcl-2, casapase-3, and p53. |
2010-02-18 |
2023-08-12 |
human |
| Morris Schweitzer, Benjamin Mitmaker, Daniel Obrand, Nathan Sheiner, Cherrie Abraham, Stevan Dostanic, Lorraine E Chalifou. Atorvastatin mediates increases in intralesional BAX and BAK expression in human end-stage abdominal aortic aneurysms. Canadian journal of physiology and pharmacology. vol 87. issue 11. 2010-02-18. PMID:19935899. |
thus, the increase in bax and bak in at-treated aaas did not activate the mitochondria or endoplasmic reticulum mediated apoptosis pathways. |
2010-02-18 |
2023-08-12 |
human |
| Emmanuelle Ménoret, Patricia Gomez-Bougie, Sylvanie Surget, Valérie Trichet, Lisa Oliver, Catherine Pellat-Deceunynck, Martine Amio. Mcl-1(128-350) fragment induces apoptosis through direct interaction with Bax. FEBS letters. vol 584. issue 3. 2010-02-18. PMID:19968986. |
mcl-1(128-350) fragment induces apoptosis through direct interaction with bax. |
2010-02-18 |
2023-08-12 |
Not clear |
| Emmanuelle Ménoret, Patricia Gomez-Bougie, Sylvanie Surget, Valérie Trichet, Lisa Oliver, Catherine Pellat-Deceunynck, Martine Amio. Mcl-1(128-350) fragment induces apoptosis through direct interaction with Bax. FEBS letters. vol 584. issue 3. 2010-02-18. PMID:19968986. |
the silencing of bax, but not of bak, prevented mcl-1(128-350) induced apoptosis. |
2010-02-18 |
2023-08-12 |
Not clear |
| Irene Paterniti, Tiziana Genovese, Emanuela Mazzon, Concetta Crisafulli, Rosanna Di Paola, Maria Galuppo, Placido Bramanti, Salvatore Cuzzocre. Liver X receptor agonist treatment regulates inflammatory response after spinal cord trauma. Journal of neurochemistry. vol 112. issue 3. 2010-02-16. PMID:19891733. |
treatment with t0901317, 1 and 6 h after the sci, significantly decreased (i) the degree of spinal cord inflammation and tissue injury (histological score); (ii) neutrophil infiltration (myeloperoxidase activity); (iii) inducible nitric oxide synthase expression; (iv) nitrotyrosine, lipid peroxidation, and poly-adp-ribose formation; (v) pro-inflammatory cytokines expression; (vi) nuclear factor-kappa b activation; and (vii) apoptosis (terminal deoxynucleotidyltransferase-mediated utp end labeling staining, fas ligand, bax, and bcl-2 expression). |
2010-02-16 |
2023-08-12 |
mouse |
| Yong-fie Li, Zhao-xia Wang, Xu-guang Gao, Dao-jun Hong, Yun Yua. [Expressions of PDCD5 and other apoptosis-related proteins in muscle of patients with mitochondrial cytopathy]. Zhonghua yi xue za zhi. vol 89. issue 23. 2010-02-16. PMID:19957502. |
to investigate the expression of pdcds, caspase-3, bcl-2 and bax in skeletal muscle of patients with mitochondrial encephalomyopathies with lactate acidosis and stroke like episodes (melas), limb-girdle type mitochondrial myopathy (lgmm) and chronic progressive external ophthalmoplegia (cpeo), and to explore the correlation between apoptosis and the pathogenesis of mitochondrial cytopathy. |
2010-02-16 |
2023-08-12 |
Not clear |