| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ran Zhang, Naren L Banik, Swapan K Ra. Differential sensitivity of human glioblastoma LN18 (PTEN-positive) and A172 (PTEN-negative) cells to Taxol for apoptosis. Brain research. vol 1239. 2010-01-12. PMID:18804099. |
apoptosis occurred with an increase in bax:bcl-2 and mitochondrial release of cytochrome c into the cytosol leading to activation of mitochondria-dependent caspase cascade. |
2010-01-12 |
2023-08-12 |
human |
| Waldemar Bartchewsky, Mariana R Martini, Aline C Squassoni, Marisa C Alvarez, Marcelo S P Ladeira, Daisy M F Salvatore, Miriam A Trevisan, José Pedrazzoli, Marcelo L Ribeir. Effects of Helicobacter pylori infection on the expressions of Bax and Bcl-2 in patients with chronic gastritis and gastric cancer. Digestive diseases and sciences. vol 55. issue 1. 2010-01-12. PMID:19160045. |
our data showed that the up-regulationary effects of h. pylori infection on the pro-apoptotic gene, bax, were stronger than its induction of bcl-2; this effect may increase apoptosis in patients with chronic gastritis. |
2010-01-12 |
2023-08-12 |
Not clear |
| Chih-Jen Yang, Chuan-Sheng Wang, Jen-Yu Hung, Hurng-Wern Huang, Yi-Chen Chia, Pei-Hui Wang, Ching-Feng Weng, Ming-Shyan Huan. Pyrogallol induces G2-M arrest in human lung cancer cells and inhibits tumor growth in an animal model. Lung cancer (Amsterdam, Netherlands). vol 66. issue 2. 2010-01-12. PMID:19233505. |
moreover, the higher cleavage of poly (adp)-ribose polymerase (parp), the increased of bax concurrent with the decreased of bcl-2 indicated that pyrogallol treatment resulted in apoptosis of lung cancer cells. |
2010-01-12 |
2023-08-12 |
mouse |
| Ashok Kumar Pandey, Ajit Sodh. Recombinant YopJ induces apoptosis in murine peritoneal macrophages in vitro: involvement of mitochondrial death pathway. International immunology. vol 21. issue 11. 2010-01-12. PMID:19736292. |
the data further suggest that ryopj-induced apoptosis is mediated by molecules upstream of caspase-8 and relay through mitochondrial pathway involving bax, bcl-2, activation of caspase-8 and caspase-3, bid and polyadenosine diphosphate-ribose polymerase cleavage, cytochrome c release and dna fragmentation. |
2010-01-12 |
2023-08-12 |
Not clear |
| Beata Pajak, Arkadiusz Orzechowsk. Chapter 4: Regulation of Clusterin activity by calcium. Advances in cancer research. vol 104. 2010-01-08. PMID:19878772. |
if cells are about to survive, intrinsic apoptosis is abrogated by sclu interacting with activated bax. |
2010-01-08 |
2023-08-12 |
Not clear |
| Julie Y Djeu, Sheng We. Clusterin and chemoresistance. Advances in cancer research. vol 105. 2010-01-07. PMID:19879424. |
known as a protein chaperone, sclu appears to stabilize ku70/bax complexes, sequestering bax from its ability to induce mitochondrial release of cytochrome c that triggers cell apoptosis. |
2010-01-07 |
2023-08-12 |
Not clear |
| Elena Lomonosova, Jan Ryerse, G Chinnadura. BAX/BAK-independent mitoptosis during cell death induced by proteasome inhibition? Molecular cancer research : MCR. vol 7. issue 8. 2010-01-06. PMID:19671675. |
subsequent cell death is independent of bax, and probably bak, and proceeds through the intrinsic mitochondrial apoptosis pathway. |
2010-01-06 |
2023-08-12 |
Not clear |
| Hyungjin Kim, Ho-Chou Tu, Decheng Ren, Osamu Takeuchi, John R Jeffers, Gerard P Zambetti, James J-D Hsieh, Emily H-Y Chen. Stepwise activation of BAX and BAK by tBID, BIM, and PUMA initiates mitochondrial apoptosis. Molecular cell. vol 36. issue 3. 2010-01-06. PMID:19917256. |
stepwise activation of bax and bak by tbid, bim, and puma initiates mitochondrial apoptosis. |
2010-01-06 |
2023-08-12 |
Not clear |
| Yue-Qiang Fu, Zhong-Yi Lu, Fang Fang, Li-Ping Tan, Feng-Wu Kuang, Xing-Yong Wang, Feng X. [Oxidative stress induced the expression of Bax and p53 during the apoptosis of alveolar type II epithelial cell]. Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue. vol 20. issue 2. 2010-01-05. PMID:18279588. |
[oxidative stress induced the expression of bax and p53 during the apoptosis of alveolar type ii epithelial cell]. |
2010-01-05 |
2023-08-12 |
Not clear |
| Joshua A Smith, Ran Zhang, Abhay K Varma, Arabinda Das, Swapan K Ray, Naren L Bani. Estrogen partially down-regulates PTEN to prevent apoptosis in VSC4.1 motoneurons following exposure to IFN-gamma. Brain research. vol 1301. 2010-01-05. PMID:19748493. |
up-regulation of pten following ifn-gamma exposure was associated with decreased overall cell viability due to increased apoptosis, as assessed by wright staining and analysis of cell death markers including bax, bcl-2, calpain activity, and caspase-3 activity, indicating a prominent role for pten in suppression of the pi3k/akt survival pathway to promote motoneuron death. |
2010-01-05 |
2023-08-12 |
human |
| Jin Li, Qi-Xiong Li, Xian-Fei Xie, Ying Ao, Chao-Rong Tie, Ren-Jie Son. Differential roles of dihydropyridine calcium antagonist nifedipine, nitrendipine and amlodipine on gentamicin-induced renal tubular toxicity in rats. European journal of pharmacology. vol 620. issue 1-3. 2009-12-31. PMID:19698708. |
in addition to the biochemical changes, histopathological studies showed that gentamicin caused structural damages in the kidneys; renal tubular cell apoptosis, a decrease in bcl-2 expression and an increase in bax expression were observed in all rats treated with gentamicin, nifedipine and amlodipine effectively reversed the effect of gentamicin while nitrendipine worsened them. |
2009-12-31 |
2023-08-12 |
rat |
| Nathalie Produit-Zengaffinen, Constantin J Pournaras, Daniel F Schordere. Retinal ischemia-induced apoptosis is associated with alteration in Bax and Bcl-x(L) expression rather than modifications in Bak and Bcl-2. Molecular vision. vol 15. 2009-12-30. PMID:19862336. |
retinal ischemia-induced apoptosis is associated with alteration in bax and bcl-x(l) expression rather than modifications in bak and bcl-2. |
2009-12-30 |
2023-08-12 |
Not clear |
| Xiu-rong Huang, Ming-xin Qi, Zhao-yang Wang, Yi Che. [Inhibition effects of compound leech eye drops on apoptosis of lens epithelial cells and expressions of Bcl-2 and Bax genes in rats]. Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine. vol 5. issue 6. 2009-12-29. PMID:17997946. |
[inhibition effects of compound leech eye drops on apoptosis of lens epithelial cells and expressions of bcl-2 and bax genes in rats]. |
2009-12-29 |
2023-08-12 |
rat |
| Xiu-rong Huang, Ming-xin Qi, Zhao-yang Wang, Yi Che. [Inhibition effects of compound leech eye drops on apoptosis of lens epithelial cells and expressions of Bcl-2 and Bax genes in rats]. Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine. vol 5. issue 6. 2009-12-29. PMID:17997946. |
to investigate the inhibition effects of compound leech eye drops (co-sz) on apoptosis of lens epithelial cells (lecs) induced by hydrogen peroxide (h2o2) and the expressions of apoptosis-related genes bcl-2 and bax in rats. |
2009-12-29 |
2023-08-12 |
rat |
| Chun-Ying Xie, Wei Yang, Ming Li, Jun Ying, Shu-Juan Tao, Karen Li, Jin-Hua Dong, Xi-Sha Wan. Cell apoptosis induced by delta-elemene in colorectal adenocarcinoma cells via a mitochondrial-mediated pathway. Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan. vol 129. issue 11. 2009-12-29. PMID:19881213. |
in the process of the induction of apoptotic cell death, bax translocated into mitochondria, a reduction in deltapsim was observed and a release of cytochrome c and apoptosis inducing factor (aif) from mitochondria into the cytosol occurred, indicating that cell death induced by delta-elemene was through a mitochondrial-mediated pathway. |
2009-12-29 |
2023-08-12 |
human |
| Qiong Luo, Zhuoneng Li, Jun Yan, Fan Zhu, Ruo-Jun Xu, Yi-Zhong Ca. Lycium barbarum polysaccharides induce apoptosis in human prostate cancer cells and inhibits prostate cancer growth in a xenograft mouse model of human prostate cancer. Journal of medicinal food. vol 12. issue 4. 2009-12-22. PMID:19735167. |
the ratio of bcl-2/bax protein expression following lbp treatments decreased significantly with a dose-effect relationship, which suggested that lbp can regulate the expression of bcl-2 and bax to induce apoptosis of pc-3 and du-145 cells. |
2009-12-22 |
2023-08-12 |
mouse |
| Michael Erb, Sarina Meinen, Patrizia Barzaghi, Lazar T Sumanovski, Isabelle Courdier-Früh, Markus A Rüegg, Thomas Meie. Omigapil ameliorates the pathology of muscle dystrophy caused by laminin-alpha2 deficiency. The Journal of pharmacology and experimental therapeutics. vol 331. issue 3. 2009-12-22. PMID:19759319. |
transgenic overexpression of the apoptosis inhibitor protein bcl-2, or deletion of the proapoptotic bax gene in a mouse model for mdc1a prolongs survival and mitigates pathology, indicating that apoptotic events are involved in the pathology. |
2009-12-22 |
2023-08-12 |
mouse |
| Mohamed Rahmani, Anh Anderson, Joseph Reza Habibi, Timothy Ryan Crabtree, Mandy Mayo, Hisashi Harada, Andrea Ferreira-Gonzalez, Paul Dent, Steven Gran. The BH3-only protein Bim plays a critical role in leukemia cell death triggered by concomitant inhibition of the PI3K/Akt and MEK/ERK1/2 pathways. Blood. vol 114. issue 20. 2009-12-22. PMID:19773546. |
ectopic mcl-1 expression potently inhibited perifosine/pd184352-induced apoptosis, as did bak or bax knockdown. |
2009-12-22 |
2023-08-12 |
human |
| Mohamed Rahmani, Anh Anderson, Joseph Reza Habibi, Timothy Ryan Crabtree, Mandy Mayo, Hisashi Harada, Andrea Ferreira-Gonzalez, Paul Dent, Steven Gran. The BH3-only protein Bim plays a critical role in leukemia cell death triggered by concomitant inhibition of the PI3K/Akt and MEK/ERK1/2 pathways. Blood. vol 114. issue 20. 2009-12-22. PMID:19773546. |
notably, knockdown of bim, but not bad, blocked bak and bax conformational change, inhibited bax membrane translocation, diminished bax/bak binding, and sharply attenuated perifosine/pd184352-induced apoptosis. |
2009-12-22 |
2023-08-12 |
human |
| Tatiana K Rostovtseva, Hacène Boukari, Antonella Antignani, Brian Shiu, Soojay Banerjee, Albert Neutzner, Richard J Youl. Bax activates endophilin B1 oligomerization and lipid membrane vesiculation. The Journal of biological chemistry. vol 284. issue 49. 2009-12-22. PMID:19805544. |
endophilin b1 (endo b1) was identified to bind bax, a bcl-2 family member that promotes apoptosis, through yeast two-hybrid protein screens. |
2009-12-22 |
2023-08-12 |
Not clear |