| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Nagarajarao Shamaladevi, Dominic A Lyn, Diogo O Escudero, Bal L Lokeshwa. CXC receptor-1 silencing inhibits androgen-independent prostate cancer. Cancer research. vol 69. issue 21. 2009-11-23. PMID:19861539. |
cxcr1 depletion lead to increases in spontaneous apoptosis by mitochondria-mediated intrinsic mechanism and increases in proapoptotic proteins (bad, 40%; bax, 12%), but decreases in antiapoptotic proteins (bcl2, down 38%; bcl(xl), 20%). |
2009-11-23 |
2023-08-12 |
mouse |
| Zhi-qing Li, Guo-biao Liang, Yi-xue Xue, Yun-hui Li. Effects of combination treatment of dexamethasone and melatonin on brain injury in intracerebral hemorrhage model in rats. Brain research. vol 1264. 2009-11-17. PMID:19368815. |
compared to the control group, combination therapy group with melatonin (10 mg/kg) and dex (0.025 mg/kg) significantly reduced the degree of (1) brain edema, (2) the permeability of blood brain barrier (measured by evans blue), (3) oxidative stress (evaluated by malondialdehyde assay), (4) cytokines expression (tumor necrosis factor-alpha and interleukin-1beta), and (5) apoptosis (measured by bax and bcl-2 expression). |
2009-11-17 |
2023-08-12 |
rat |
| Tapio Nuutinen, Tiina Suuronen, Anu Kauppinen, Antero Salmine. Clusterin: a forgotten player in Alzheimer's disease. Brain research reviews. vol 61. issue 2. 2009-11-17. PMID:19651157. |
clusterin is a stress-induced chaperone which is normally secreted but in conditions of cellular stress, it can be transported to cytoplasm where it can bind to bax protein and inhibit neuronal apoptosis. |
2009-11-17 |
2023-08-12 |
Not clear |
| Fang Huang, Chunlai Nie, Yang Yang, Wen Yue, Yun Ren, Yingli Shang, Xiaohui Wang, Haijing Jin, Caimin Xu, Quan Che. Selenite induces redox-dependent Bax activation and apoptosis in colorectal cancer cells. Free radical biology & medicine. vol 46. issue 8. 2009-11-13. PMID:19439215. |
selenite induces redox-dependent bax activation and apoptosis in colorectal cancer cells. |
2009-11-13 |
2023-08-12 |
Not clear |
| Fang Huang, Chunlai Nie, Yang Yang, Wen Yue, Yun Ren, Yingli Shang, Xiaohui Wang, Haijing Jin, Caimin Xu, Quan Che. Selenite induces redox-dependent Bax activation and apoptosis in colorectal cancer cells. Free radical biology & medicine. vol 46. issue 8. 2009-11-13. PMID:19439215. |
we have investigated the role of bax, a bcl-2 family protein and a critical regulator of the mitochondrial apoptotic pathway, in selenite-induced apoptosis in colorectal cancer cells. |
2009-11-13 |
2023-08-12 |
Not clear |
| Fang Huang, Chunlai Nie, Yang Yang, Wen Yue, Yun Ren, Yingli Shang, Xiaohui Wang, Haijing Jin, Caimin Xu, Quan Che. Selenite induces redox-dependent Bax activation and apoptosis in colorectal cancer cells. Free radical biology & medicine. vol 46. issue 8. 2009-11-13. PMID:19439215. |
importantly, we show that the two conserved cysteine residues of bax seem to be critical for sensing the intracellular ros to initiate bax conformational changes and subsequent apoptosis. |
2009-11-13 |
2023-08-12 |
Not clear |
| Shohreh Amini, Nana Merabova, Kamel Khalili, Nune Darbinia. p38SJ, a novel DINGG protein protects neuronal cells from alcohol induced injury and death. Journal of cellular physiology. vol 221. issue 3. 2009-11-13. PMID:19739100. |
furthermore, pre-treatment of neuronal cells with p38sj diminishes the level of the pro-apoptotic protein bax and some events associated with apoptosis such as caspase 3 cleavage. |
2009-11-13 |
2023-08-12 |
Not clear |
| Liming Shen, Qiong Liu, Jiazuan Ni, Guangyan Hon. A proteomic investigation into the human cervical cancer cell line HeLa treated with dicitratoytterbium (III) complex. Chemico-biological interactions. vol 181. issue 3. 2009-11-10. PMID:19632212. |
western blot analysis showed that [ybcit2](3-)-induced apoptosis was accompanied by the activation of caspase-9 and specific proteolytic cleavage of parp, leading to an increase in the pro-apoptotic protein bax and a decrease in the anti-apoptotic protein bcl-2. |
2009-11-10 |
2023-08-12 |
human |
| Sonia Perales, M José Alejandre, Rogelio Palomino-Morales, Carolina Torres, Jose Iglesias, Ana Linare. Effect of oxysterol-induced apoptosis of vascular smooth muscle cells on experimental hypercholesterolemia. Journal of biomedicine & biotechnology. vol 2009. 2009-11-10. PMID:19727411. |
cells were exposed in vitro to 25-hydroxycholesterol to study levels of apoptosis and apoptotic proteins bcl-2, bcl-x(l) and bax and the expression of bcl-2 and bcl-x(l), genes. |
2009-11-10 |
2023-08-12 |
chicken |
| Sonia Perales, M José Alejandre, Rogelio Palomino-Morales, Carolina Torres, Jose Iglesias, Ana Linare. Effect of oxysterol-induced apoptosis of vascular smooth muscle cells on experimental hypercholesterolemia. Journal of biomedicine & biotechnology. vol 2009. 2009-11-10. PMID:19727411. |
the quantitative real-time reverse transcriptase-polymerase chain reaction and the immunoblotting western blot analysis showed that 25-hydroxycholesterol produces apoptosis in smcs, mediated by a high increase in bax protein and bax gene expression. |
2009-11-10 |
2023-08-12 |
chicken |
| Feng-Xiang Wei, Jun-Xing Liu, Lin Wang, Hong-Zhi Li, Jia-Bin Lu. [Expression of bcl-2 and bax genes in the liver cancer cell line HepG2 after apoptosis induced by essential oils from Rosmarinus officinalis]. Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials. vol 31. issue 6. 2009-11-09. PMID:18998574. |
[expression of bcl-2 and bax genes in the liver cancer cell line hepg2 after apoptosis induced by essential oils from rosmarinus officinalis]. |
2009-11-09 |
2023-08-12 |
Not clear |
| Feng-Xiang Wei, Jun-Xing Liu, Lin Wang, Hong-Zhi Li, Jia-Bin Lu. [Expression of bcl-2 and bax genes in the liver cancer cell line HepG2 after apoptosis induced by essential oils from Rosmarinus officinalis]. Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials. vol 31. issue 6. 2009-11-09. PMID:18998574. |
to investigate the expression of bcl-2 and bax genes in the liver cancer cell line hepg2 after apoptosis induced by essential oils from rosmarinus officinalis. |
2009-11-09 |
2023-08-12 |
Not clear |
| M Sohrabi, F A Kalati, S Vatansever, M M Abbasi, L Roshangar, A A Khaki, I M Tuglu, I Aydemir, Y Dustar, B Y Javadzadeh, J S Ra. Effect of dietary and topical Celecoxib on expression of bcl-2, bax, c-erb-B2 and Ki67 in carcinogen-induced tongue carcinoma in rat. Pakistan journal of biological sciences : PJBS. vol 12. issue 10. 2009-11-09. PMID:19806804. |
the aim of the study is to determine the effect of celecoxib administration, dietary or topical, on expression of ki-67, c-erb-b2, bcl-2 and bax genes in rat tongue by the immunohistochemistry methods and also tdt-mediated dupt-biotin nick end labeling assay in order to explore their role in malignant transformation and the proliferation rate, apoptosis rate in tongue squamous cell carcinoma. |
2009-11-09 |
2023-08-12 |
rat |
| Senthil Selvaraj, John A Watt, Brij B Sing. TRPC1 inhibits apoptotic cell degeneration induced by dopaminergic neurotoxin MPTP/MPP(+). Cell calcium. vol 46. issue 3. 2009-11-06. PMID:19695701. |
trpc1 overexpression also inhibited bax translocation to the mitochondria and thereby prevented cytochrome c release and mitochondrial-mediated apoptosis. |
2009-11-06 |
2023-08-12 |
Not clear |
| S M Schmidt, T König, A Bringmann, S Held, K von Schwarzenberg, A Heine, T A W Holderried, S Stevanovic, F Grünebach, P Brossar. Characterization of BAX inhibitor-1 as a novel leukemia-associated antigen. Leukemia. vol 23. issue 10. 2009-11-05. PMID:19609282. |
using this approach, an hla-a24-binding peptide derived from bax inhibitor-1 (bi-1), a regulator of apoptosis pathways, was identified as an epitope recognized by the generated ctls. |
2009-11-05 |
2023-08-12 |
Not clear |
| Igor Sukhotnik, Katya Voskoboinik, Michael Lurie, Yakov Bejar, Arnold G Coran, Jorge G Mogilne. Involvement of the bax and bcl-2 system in the induction of germ cell apoptosis is correlated with the time of reperfusion after testicular ischemia in a rat model. Fertility and sterility. vol 92. issue 4. 2009-11-03. PMID:19481735. |
involvement of the bax and bcl-2 system in the induction of germ cell apoptosis is correlated with the time of reperfusion after testicular ischemia in a rat model. |
2009-11-03 |
2023-08-12 |
rat |
| P E Czabotar, P M Colman, D C S Huan. Bax activation by Bim? Cell death and differentiation. vol 16. issue 9. 2009-11-03. PMID:19557009. |
the mechanism by which the cell death mediator bax becomes activated to cause mitochondrial damage, a key step for the intrinsic pathway to apoptosis, remain highly contentious. |
2009-11-03 |
2023-08-12 |
Not clear |
| Michio Kaneko, Setsuko Kaneko, Kenshi Suzuk. Prolonged low-dose administration of the cyclooxygenase-2 inhibitor celecoxib enhances the antitumor activity of irinotecan against neuroblastoma xenografts. Cancer science. vol 100. issue 11. 2009-11-03. PMID:19673886. |
induction of apoptosis by cpt-11 with and without celecoxib was associated with the up-regulation of bax expression and the down-regulation of bcl-2 expression. |
2009-11-03 |
2023-08-12 |
human |
| Pablo M Peixoto, Shin-Young Ryu, Agnes Bombrun, Bruno Antonsson, Kathleen W Kinnall. MAC inhibitors suppress mitochondrial apoptosis. The Biochemical journal. vol 423. issue 3. 2009-11-03. PMID:19691447. |
compounds that blocked the release of fluorescein from liposomes by recombinant bax were tested for their ability to directly close mac and suppress apoptosis in fl5.12 cells. |
2009-11-03 |
2023-08-12 |
Not clear |
| Xian Jiang, Hali Li, Haiquan Qiao, Hongchi Jiang, Ruian Xu, Xueying Su. Combining kallistatin gene therapy and meloxicam to treat hepatocellular carcinoma in mice. Cancer science. vol 100. issue 11. 2009-11-03. PMID:19709125. |
gene transfer of kallistatin inhibited tumor angiogenesis, and slightly inhibited cell proliferation and increased cell apoptosis in situ, but had no effect on expression of vascular endothelial growth factor, basic fibroblast growth factor, proliferating cell nuclear antigen, bcl-2, bax, or activation of caspase-3. |
2009-11-03 |
2023-08-12 |
mouse |