| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xian Jiang, Hali Li, Haiquan Qiao, Hongchi Jiang, Ruian Xu, Xueying Su. Combining kallistatin gene therapy and meloxicam to treat hepatocellular carcinoma in mice. Cancer science. vol 100. issue 11. 2009-11-03. PMID:19709125. |
meloxicam therapy inhibited cell proliferation, induced cell apoptosis, reduced expression of proliferating cell nuclear antigen, increased activation of caspase-3, and upregulated bax. |
2009-11-03 |
2023-08-12 |
mouse |
| Shenglin Ma, Yunshan Yang, Chunmei Wang, Ning Hui, Linhui Gu, Haijun Zhong, Zhijian Cai, Qingqing Wang, Qinghua Zhang, Nan Li, Xuetao Ca. Endogenous human CaMKII inhibitory protein suppresses tumor growth by inducing cell cycle arrest and apoptosis through down-regulation of the phosphatidylinositide 3-kinase/Akt/HDM2 pathway. The Journal of biological chemistry. vol 284. issue 37. 2009-11-02. PMID:19586909. |
hcamkiinbeta blocked cell cycle progression and induced apoptosis of ho-8910pm cells, which was correlated with the up-regulation of p21, p53, and bax and the down-regulation of cyclin a, cyclin d1, cyclin e, cdk2, phosphorylated retinoblastoma, and bcl-2. |
2009-11-02 |
2023-08-12 |
mouse |
| Yingjie Zhang, Da Xing, Lei Li. PUMA promotes Bax translocation by both directly interacting with Bax and by competitive binding to Bcl-X L during UV-induced apoptosis. Molecular biology of the cell. vol 20. issue 13. 2009-10-27. PMID:19439449. |
puma promotes bax translocation by both directly interacting with bax and by competitive binding to bcl-x l during uv-induced apoptosis. |
2009-10-27 |
2023-08-12 |
human |
| Yingjie Zhang, Da Xing, Lei Li. PUMA promotes Bax translocation by both directly interacting with Bax and by competitive binding to Bcl-X L during UV-induced apoptosis. Molecular biology of the cell. vol 20. issue 13. 2009-10-27. PMID:19439449. |
however, the molecular mechanism through which puma regulates apoptosis, especially how puma activates bcl-2-associated x protein (bax) in response to uv irradiation is still controversial. |
2009-10-27 |
2023-08-12 |
human |
| Yingjie Zhang, Da Xing, Lei Li. PUMA promotes Bax translocation by both directly interacting with Bax and by competitive binding to Bcl-X L during UV-induced apoptosis. Molecular biology of the cell. vol 20. issue 13. 2009-10-27. PMID:19439449. |
in this study, by using real-time single-cell analysis and fluorescence resonance energy transfer, we investigated the tripartite nexus among puma, bax, and bcl-x(l) in living human lung adenocarcinoma cells (astc-a-1) to illustrate how puma promotes bax translocation to initiate apoptosis. |
2009-10-27 |
2023-08-12 |
human |
| Yingjie Zhang, Da Xing, Lei Li. PUMA promotes Bax translocation by both directly interacting with Bax and by competitive binding to Bcl-X L during UV-induced apoptosis. Molecular biology of the cell. vol 20. issue 13. 2009-10-27. PMID:19439449. |
in addition, pifithrin-alpha (a p53 inhibitor) and cycloheximide (a protein synthesis inhibitor) could inhibit puma-mediated bax translocation and cell apoptosis. |
2009-10-27 |
2023-08-12 |
human |
| Yingjie Zhang, Da Xing, Lei Li. PUMA promotes Bax translocation by both directly interacting with Bax and by competitive binding to Bcl-X L during UV-induced apoptosis. Molecular biology of the cell. vol 20. issue 13. 2009-10-27. PMID:19439449. |
together, these studies create an important conclusion that puma promotes bax translocation by both by directly interacting with bax and by competitive binding to bcl-x(l) in uv-induced apoptosis. |
2009-10-27 |
2023-08-12 |
human |
| Regalla Kumarswamy, Rakesh Kumar Seth, Bilikere Srinivasarao Dwarakanath, Sudhir Chandn. Mitochondrial regulation of insect cell apoptosis: evidence for permeability transition pore-independent cytochrome-c release in the Lepidopteran Sf9 cells. The international journal of biochemistry & cell biology. vol 41. issue 6. 2009-10-26. PMID:19146980. |
bax inhibitory peptide bip-p5 could effectively block both cytochrome-c release and apoptosis induction indicating dependence on bax-channel formation. |
2009-10-26 |
2023-08-12 |
drosophila_melanogaster |
| Ragini Kumari, Kamaleshwar P Singh, James W Dumon. Simulated microgravity decreases DNA repair capacity and induces DNA damage in human lymphocytes. Journal of cellular biochemistry. vol 107. issue 4. 2009-10-26. PMID:19415677. |
downregulation of genes involved in cell proliferation (cyclind1 and pcna) and apoptosis (bax) was also observed. |
2009-10-26 |
2023-08-12 |
human |
| Y Wang, T-Z Ha. Prenatal exposure to heroin in mice elicits memory deficits that can be attributed to neuronal apoptosis. Neuroscience. vol 160. issue 2. 2009-10-21. PMID:19272431. |
these findings suggest that prenatal heroin exposure during the e9-18 period enhances neuronal apoptosis by altering the expressions of caspase-3, bcl-2, and bax in the mouse hippocampus, and leads to impairment in hippocampus-dependent learning and memory. |
2009-10-21 |
2023-08-12 |
mouse |
| Nesrin Ozören, Naohiro Inohara, Gabriel Núñe. A putative role for human BFK in DNA damage-induced apoptosis. Biotechnology journal. vol 4. issue 7. 2009-10-21. PMID:19557800. |
the cleaved form of the protein is dependent on the presence of bax or bak for its ability to induce apoptosis, since bax(-/-)-bak(-/-) double-knockout mefs are completely resistant to bfk-induced apoptosis. |
2009-10-21 |
2023-08-12 |
mouse |
| Anna M Giammarioli, Rosa Vona, Lucrezia Gambardella, Barbara Ascione, Angela Maselli, Cristiana Barbati, Antonella Tinari, Walter Malorn. Interferon-gamma bolsters CD95/Fas-mediated apoptosis of astroglioma cells. The FEBS journal. vol 276. issue 20. 2009-10-20. PMID:19740103. |
the mechanism underlying this sensitization appeared to be associated with a framework of cell changes, including up-regulation of death receptor at the cell surface, pro-apoptotic molecule bax and bak over-expression and mitochondria hyperpolarization, as is known to be associated with cell sensitization to apoptosis. |
2009-10-20 |
2023-08-12 |
human |
| Seyed Hadi Mousavi, Jalil Tavakkol-Afshari, Azam Brook, Iraj Jafari-Anarkool. Role of caspases and Bax protein in saffron-induced apoptosis in MCF-7 cells. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. vol 47. issue 8. 2009-10-19. PMID:19457443. |
role of caspases and bax protein in saffron-induced apoptosis in mcf-7 cells. |
2009-10-19 |
2023-08-12 |
Not clear |
| Seyed Hadi Mousavi, Jalil Tavakkol-Afshari, Azam Brook, Iraj Jafari-Anarkool. Role of caspases and Bax protein in saffron-induced apoptosis in MCF-7 cells. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. vol 47. issue 8. 2009-10-19. PMID:19457443. |
therefore, we investigated the role of caspases and bax protein in saffron-induced apoptosis in mcf-7 cells, a commonly used cell culture system for in vitro studies on breast cancer. |
2009-10-19 |
2023-08-12 |
Not clear |
| Neal B Blatt, Anthony E Boitano, Costas A Lyssiotis, Anthony W Opipari, Gary D Glic. Bz-423 superoxide signals B cell apoptosis via Mcl-1, Bak, and Bax. Biochemical pharmacology. vol 78. issue 8. 2009-10-19. PMID:19481066. |
bz-423 superoxide signals b cell apoptosis via mcl-1, bak, and bax. |
2009-10-19 |
2023-08-12 |
Not clear |
| Neal B Blatt, Anthony E Boitano, Costas A Lyssiotis, Anthony W Opipari, Gary D Glic. Bz-423 superoxide signals B cell apoptosis via Mcl-1, Bak, and Bax. Biochemical pharmacology. vol 78. issue 8. 2009-10-19. PMID:19481066. |
following the generation of superoxide, bz-423-induced apoptosis requires the activation of bax and bak to induce mitochondrial outer membrane permeabilization and cytochrome c release. |
2009-10-19 |
2023-08-12 |
Not clear |
| Phillip Kaestner, Ailine Stolz, Holger Bastian. Determinants for the efficiency of anticancer drugs targeting either Aurora-A or Aurora-B kinases in human colon carcinoma cells. Molecular cancer therapeutics. vol 8. issue 7. 2009-10-19. PMID:19584233. |
subsequently, mln8054-treated cells exit from mitosis and activate a p53-dependent postmitotic g(1) checkpoint, which subsequently induces p21 and bax, leading to g(1) arrest followed by the induction of apoptosis. |
2009-10-19 |
2023-08-12 |
human |
| Grant Dewson, Ruth M Kluc. Mechanisms by which Bak and Bax permeabilise mitochondria during apoptosis. Journal of cell science. vol 122. issue Pt 16. 2009-10-19. PMID:19795525. |
mechanisms by which bak and bax permeabilise mitochondria during apoptosis. |
2009-10-19 |
2023-08-12 |
Not clear |
| Elke S Bergmann-Leitner, Wolfgang W Leitner, Elizabeth H Duncan, Tatyana Savranskaya, Evelina Ango. Molecular adjuvants for malaria DNA vaccines based on the modulation of host-cell apoptosis. Vaccine. vol 27. issue 41. 2009-10-16. PMID:19576940. |
a pro-apoptotic gene (bax) was used as a molecular adjuvant in an attempt to mimic the immunostimulatory apoptosis triggered by viral or virus-derived vaccines, while anti-apoptotic genes such as bcl-xl may increase the life span of transfected cells thus prolonging antigen production. |
2009-10-16 |
2023-08-12 |
Not clear |
| Enlong Ma, Yanchun Li, Weige Zhang, Xiaolong Wang, Wenjiao Tai, Te Li, Liang Zhang, Takashi Ikejim. 2(+/-)-7,8,3',4',5'-Pentamethoxyflavan induces G2/M phase arrest and apoptosis in HL60 cells. Toxicology in vitro : an international journal published in association with BIBRA. vol 23. issue 5. 2009-10-13. PMID:19450678. |
pmf also induced apoptosis of hl60 cells via death receptor and mitochondria apoptotic pathways, which was characterized by dna fragmentation, cleavage of poly (adp-ribose) polymerase, caspase-3, caspase-8 and caspase-9, changes of bcl-2 and bax expression, cytochrome c release from mitochondria and a decrease in the mitochondrial membrane potential (mmp). |
2009-10-13 |
2023-08-12 |
human |