| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Simone M Schoenwaelder, Yuping Yuan, Emma C Josefsson, Michael J White, Yu Yao, Kylie D Mason, Lorraine A O'Reilly, Katya J Henley, Akiko Ono, Sarah Hsiao, Abbey Willcox, Andrew W Roberts, David C S Huang, Hatem H Salem, Benjamin T Kile, Shaun P Jackso. Two distinct pathways regulate platelet phosphatidylserine exposure and procoagulant function. Blood. vol 114. issue 3. 2009-09-09. PMID:19387006. |
to clarify this, we investigated the consequence of removing the essential mediators of apoptosis, bak and bax, or directly inducing apoptosis with the bh3 mimetic compound abt-737. |
2009-09-09 |
2023-08-12 |
Not clear |
| Jun-Yu Lu, Wei Yao, Gui-Sheng Qian, Xiao-Jing Yang, Wei-Zhong Chen, Shu-Ping L. [Role of bcl-2 and bax expression in apoptosis of hypoxic pulmonary artery smooth muscle cells of rats induced by Na+/H+ exchanger isoform-1 inhibition in vitro]. Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue. vol 16. issue 7. 2009-09-08. PMID:15238173. |
[role of bcl-2 and bax expression in apoptosis of hypoxic pulmonary artery smooth muscle cells of rats induced by na+/h+ exchanger isoform-1 inhibition in vitro]. |
2009-09-08 |
2023-08-12 |
rat |
| Jun-Yu Lu, Wei Yao, Gui-Sheng Qian, Xiao-Jing Yang, Wei-Zhong Chen, Shu-Ping L. [Role of bcl-2 and bax expression in apoptosis of hypoxic pulmonary artery smooth muscle cells of rats induced by Na+/H+ exchanger isoform-1 inhibition in vitro]. Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue. vol 16. issue 7. 2009-09-08. PMID:15238173. |
to investigate the role of bcl-2 and bax expression in apoptosis of hypoxic pulmonary artery smooth muscle cells (pasmcs) of rats induced by na+/h+ exchanger isoform-1 (nhe-1) inhibition in vitro. |
2009-09-08 |
2023-08-12 |
rat |
| Jeffrey E McLean, Emmanuel Datan, Demetrius Matassov, Zahra F Zaker. Lack of Bax prevents influenza A virus-induced apoptosis and causes diminished viral replication. Journal of virology. vol 83. issue 16. 2009-09-08. PMID:19494020. |
lack of bax prevents influenza a virus-induced apoptosis and causes diminished viral replication. |
2009-09-08 |
2023-08-12 |
mouse |
| Jeffrey E McLean, Emmanuel Datan, Demetrius Matassov, Zahra F Zaker. Lack of Bax prevents influenza A virus-induced apoptosis and causes diminished viral replication. Journal of virology. vol 83. issue 16. 2009-09-08. PMID:19494020. |
bax, however, is activated and translocates from the cytosol to the mitochondria; this activation is required for the efficient induction of apoptosis and virus replication. |
2009-09-08 |
2023-08-12 |
mouse |
| Jeffrey E McLean, Emmanuel Datan, Demetrius Matassov, Zahra F Zaker. Lack of Bax prevents influenza A virus-induced apoptosis and causes diminished viral replication. Journal of virology. vol 83. issue 16. 2009-09-08. PMID:19494020. |
the knockout of bax in mouse embryonic fibroblasts blocks the induction of apoptosis, restricts the infection-mediated activation of executioner caspases, and inhibits virus propagation. |
2009-09-08 |
2023-08-12 |
mouse |
| Andrew J Steele, Archibald G Prentice, A Victor Hoffbrand, Birunthini C Yogashangary, Stephen M Hart, Mark W Lowdell, Edward R Samuel, Janet M North, Elisabeth P Nacheva, Anastasios Chanalaris, Panagiotis Kottaridis, Kate Cwynarski, R Gitendra Wickremasingh. 2-Phenylacetylenesulfonamide (PAS) induces p53-independent apoptotic killing of B-chronic lymphocytic leukemia (CLL) cells. Blood. vol 114. issue 6. 2009-09-08. PMID:19515722. |
pas treatment induced bax proapoptotic conformational change, bax movement from the cytosol to the mitochondria, and cytochrome c release, indicating that pas induced apoptosis via the mitochondrial pathway. |
2009-09-08 |
2023-08-12 |
Not clear |
| H J Li, D J Liu, M Cang, L M Wang, M Z Jin, Y Z Ma, B Shorga. Early apoptosis is associated with improved developmental potential in bovine oocytes. Animal reproduction science. vol 114. issue 1-3. 2009-09-04. PMID:19008057. |
meanwhile, group iii oocytes exhibited the highest bax (initiating apoptosis) transcriptional level and the lowest bcl-2 (preventing apoptosis) transcriptional level. |
2009-09-04 |
2023-08-12 |
cattle |
| H J Li, D J Liu, M Cang, L M Wang, M Z Jin, Y Z Ma, B Shorga. Early apoptosis is associated with improved developmental potential in bovine oocytes. Animal reproduction science. vol 114. issue 1-3. 2009-09-04. PMID:19008057. |
this is the first time that bax and bcl-2 transcripts were characterized in the immature bovine oocyte, and results indicated that the genes are good markers of early apoptosis and embryo development. |
2009-09-04 |
2023-08-12 |
cattle |
| Jin Wang, Aibin Wu, Yufang Xu, Jianwen Liu, Xuhong Qia. M(2)-A induces apoptosis and G(2)-M arrest via inhibiting PI3K/Akt pathway in HL60 cells. Cancer letters. vol 283. issue 2. 2009-09-04. PMID:19435648. |
on the other hand we observed the inhibition of nf-kappab nuclear translocation, up-regulation of bax and down-regulation of bcl-2, the caspase -3, -9 activity increase in hl60 cells after treated with m(2)-a, which indicated that the mitochondrial pathway was involved in the apoptosis signal pathway. |
2009-09-04 |
2023-08-12 |
Not clear |
| Andreas Jeron, Susanne Pfoertner, Dunja Bruder, Robert Geffers, Peter Hammerer, Rainer Hofmann, Jan Buer, Andres Jan Schrade. Frequency and gene expression profile of regulatory T cells in renal cell carcinoma. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. vol 30. issue 3. 2009-09-04. PMID:19609102. |
gene ontology identified an association of significantly up-/downregulated genes to six functional classes, particularly genes involved in apoptosis control such as lgals1, lgals3, bax, il7r and tnfrsf25. |
2009-09-04 |
2023-08-12 |
Not clear |
| Julie Roy, Pragathi Pallepati, Ahmed Bettaieb, André Tanel, Diana A Averill-Bate. Acrolein induces a cellular stress response and triggers mitochondrial apoptosis in A549 cells. Chemico-biological interactions. vol 181. issue 2. 2009-09-03. PMID:19596284. |
acrolein (3-27microm, 30-60min) activated early stage processes in the mitochondrial pathway of apoptosis, such as bax translocation to mitochondria, cytochrome c release, caspase-9 activation, and translocation of apoptosis-inducing factor to the nucleus. |
2009-09-03 |
2023-08-12 |
human |
| Rui Guo, Heng Ma, Feng Gao, Li Zhong, Jun Re. Metallothionein alleviates oxidative stress-induced endoplasmic reticulum stress and myocardial dysfunction. Journal of molecular and cellular cardiology. vol 47. issue 2. 2009-09-02. PMID:19344729. |
bso treatment led to apoptosis manifested as elevated expression of chop/gadd153, caspase-12 and bax as well as caspase-3 activity, reduced bcl-2 expression and jnk phosphorylation, all of which was ablated by mt. |
2009-09-02 |
2023-08-12 |
mouse |
| Hua Tian, Xiping Zhang, Chengjun Wu, Li Chen, Rongchao Ying, Jing Ye, Bingyan Yu, Qian Ye, Yan Pan, Meili Ma, Feibo Zh. Effects of Baicalin and Octreotide on the serum TNF-alpha level and apoptosis in multiple organs of rats with severe acute pancreatitis. Inflammation. vol 32. issue 3. 2009-09-01. PMID:19387806. |
at 3, 6 and 12 h after operation, the mortality rate of rats, endotoxin and tnf-alpha levels in blood as well as the pathological severity scores, expression levels of bax protein and apoptosis indexes in multiple organs were determined. |
2009-09-01 |
2023-08-12 |
rat |
| Hua Tian, Xiping Zhang, Chengjun Wu, Li Chen, Rongchao Ying, Jing Ye, Bingyan Yu, Qian Ye, Yan Pan, Meili Ma, Feibo Zh. Effects of Baicalin and Octreotide on the serum TNF-alpha level and apoptosis in multiple organs of rats with severe acute pancreatitis. Inflammation. vol 32. issue 3. 2009-09-01. PMID:19387806. |
compared to model control group (1),both drugs can relieve the pathological injuries of multiple organs and decrease significantly the levels of endotoxin and tnf-alpha in blood and the mortality rate of rats in treated groups (p < 0.05 or p < 0.01); (2) the expression of bax protein was upregulated in pancreas, lung, intestinal mucosa (p < 0.05 or p < 0.01) but downregulated in spleen and lymph nodes (p < 0.001 and p < 0.05, respectively) in baicalin treated group; the apoptosis indexes significantly increased in pancreas, intestinal mucosa, lymph nodes and spleen (p < 0.05 or p < 0.01). |
2009-09-01 |
2023-08-12 |
rat |
| Hua Tian, Xiping Zhang, Chengjun Wu, Li Chen, Rongchao Ying, Jing Ye, Bingyan Yu, Qian Ye, Yan Pan, Meili Ma, Feibo Zh. Effects of Baicalin and Octreotide on the serum TNF-alpha level and apoptosis in multiple organs of rats with severe acute pancreatitis. Inflammation. vol 32. issue 3. 2009-09-01. PMID:19387806. |
(3) the expression of bax protein was upregulated in pancreas and lung but downregulated in spleen and lymph nodes (p < 0.05 or p < 0.01) in octreotide treated group; the apoptosis indexes significantly increased in lymph nodes and spleen in octreotide treated group (p < 0.05 or p < 0.01). |
2009-09-01 |
2023-08-12 |
rat |
| Xiaoyan Jiang, Baoming Nie, Saili Fu, Jianguo Hu, Lan Yin, Lin Lin, Xiaofei Wang, Peihua Lu, Xiao-Ming X. EGb761 protects hydrogen peroxide-induced death of spinal cord neurons through inhibition of intracellular ROS production and modulation of apoptotic regulating genes. Journal of molecular neuroscience : MN. vol 38. issue 2. 2009-08-31. PMID:19148782. |
thus, our study provided evidence showing that the protective effect of egb761 on spinal cord neuronal apoptosis after oxidative stress is mediated, at least in part, by its anti-oxidative action and regulation of apoptosis-related genes bcl-2 and bax. |
2009-08-31 |
2023-08-12 |
rat |
| Wei-Bing Xu, Gang Lv, Yan-Feng Wang, Xu-Hua Lu, Tao Huang, Yue Zhu, Lian-Shun Ji. Combination of dexamethasone and aminoguanidine reduces secondary damage in compression spinal cord injury. Cellular and molecular neurobiology. vol 29. issue 5. 2009-08-28. PMID:19373550. |
compared to the control group, the combination therapy group with ag (75 mg/kg) and dex (0.025 mg/kg) significantly reduced the degree of (1) spinal cord edema, (2) the permeability of blood spinal cord barrier (measured by (99m)tc-albumin), (3) infiltration of neutrophils (mpo evaluation), (4) cytokines expression (tumor necrosis factor-alpha and interleukin-1 beta), and (5) apoptosis (measured by bax and bcl-2 expression). |
2009-08-28 |
2023-08-12 |
rat |
| Sarah Gagiannis, Martina Müller, Sebastian Uhlemann, Andreas Koch, Gerry Melino, Peter H Krammer, Peter P Nawroth, Maik Brune, Tobias Schillin. Parathyroid hormone-related protein confers chemoresistance by blocking apoptosis signaling via death receptors and mitochondria. International journal of cancer. vol 125. issue 7. 2009-08-28. PMID:19507249. |
inhibition of cd95- and bax gene transactivation is a mechanism by which pthrp reduced the apoptosis response and treatment sensitivity of tumor cells. |
2009-08-28 |
2023-08-12 |
human |
| Yu Chen, Xufeng Wei, Pengfei Yan, Ying Han, Shiren Sun, Kaichun Wu, Daiming Fa. Human mitochondrial Mrs2 protein promotes multidrug resistance in gastric cancer cells by regulating p27, cyclin D1 expression and cytochrome C release. Cancer biology & therapy. vol 8. issue 7. 2009-08-27. PMID:19242098. |
its upregulation inhibited adriamycin-induced apoptosis, probably by suppressing bax induced cytochrome c release from mitochondria. |
2009-08-27 |
2023-08-12 |
mouse |