| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jung-Min Oh, Su-Hyeong Kim, Eun-Ah Cho, Yong-Sang Song, Woo-Ho Kim, Yong-Sung Juhn. Human papillomavirus type 16 E5 protein inhibits hydrogen-peroxide-induced apoptosis by stimulating ubiquitin-proteasome-mediated degradation of Bax in human cervical cancer cells. Carcinogenesis. vol 31. issue 3. 2010-04-14. PMID:20015862. |
knockdown of e5 by small interfering rna sensitized caski cervical cancer cells to hydrogen peroxide-induced apoptosis with concurrent increase in bax expression. |
2010-04-14 |
2023-08-12 |
human |
| Jung-Min Oh, Su-Hyeong Kim, Eun-Ah Cho, Yong-Sang Song, Woo-Ho Kim, Yong-Sung Juhn. Human papillomavirus type 16 E5 protein inhibits hydrogen-peroxide-induced apoptosis by stimulating ubiquitin-proteasome-mediated degradation of Bax in human cervical cancer cells. Carcinogenesis. vol 31. issue 3. 2010-04-14. PMID:20015862. |
treatment with pge(2) decreased the expression of bax and inhibited hydrogen peroxide-induced apoptosis of c-33a cells. |
2010-04-14 |
2023-08-12 |
human |
| Jung-Min Oh, Su-Hyeong Kim, Eun-Ah Cho, Yong-Sang Song, Woo-Ho Kim, Yong-Sung Juhn. Human papillomavirus type 16 E5 protein inhibits hydrogen-peroxide-induced apoptosis by stimulating ubiquitin-proteasome-mediated degradation of Bax in human cervical cancer cells. Carcinogenesis. vol 31. issue 3. 2010-04-14. PMID:20015862. |
we concluded that hpv16 e5 protein inhibits hydrogen peroxide-induced apoptosis of cervical cancer cells by stimulating the ubiquitin-proteasome-mediated degradation of bax protein, and the pathway involves cox-2, pge(2) and pka. |
2010-04-14 |
2023-08-12 |
human |
| Amit Kunwar, P Bansal, S Jaya Kumar, P P Bag, P Paul, N D Reddy, L B Kumbhare, V K Jain, R C Chaubey, M K Unnikrishnan, K I Priyadarsin. In vivo radioprotection studies of 3,3'-diselenodipropionic acid, a selenocystine derivative. Free radical biology & medicine. vol 48. issue 3. 2010-04-13. PMID:19931386. |
dsepa also inhibited radiation-induced apoptosis in the spleen and reversed radiation-induced alterations in the expression of the proapoptotic bax and the antiapoptotic bcl-2 genes. |
2010-04-13 |
2023-08-12 |
mouse |
| Na Zhao, Yu-Ying Liu, Fang Wang, Bai-He Hu, Kai Sun, Xin Chang, Chun-Shui Pan, Jing-Yu Fan, Xiao-Hong Wei, Xiang Li, Chuan-She Wang, Zhi-Xin Guo, Jing-Yan Ha. Cardiotonic pills, a compound Chinese medicine, protects ischemia-reperfusion-induced microcirculatory disturbance and myocardial damage in rats. American journal of physiology. Heart and circulatory physiology. vol 298. issue 4. 2010-04-12. PMID:20118406. |
in addition, the drug significantly ameliorated the i/r-induced myocardial damage and apoptosis indicated by increased malondialdehyde, infarct size, myocardial ultrastructural changes, terminal deoxynucleotidyl transferase-mediated dutp nick-end labeling-positive myocardial cells, inhibitor-kappabalpha degradation, and expression of bcl-2, bax, and caspase-3 in myocardial tissues. |
2010-04-12 |
2023-08-12 |
rat |
| Yiying Zhang, Yuanlin Dong, Xu Wu, Yan Lu, Zhipeng Xu, Andrew Knapp, Yun Yue, Tiejun Xu, Zhongcong Xi. The mitochondrial pathway of anesthetic isoflurane-induced apoptosis. The Journal of biological chemistry. vol 285. issue 6. 2010-04-09. PMID:20007710. |
here we show for the first time that treatment with 2% isoflurane for 6 h can increase pro-apoptotic factor bax levels, decrease anti-apoptotic factor bcl-2 levels, increase ros accumulation, facilitate cytochrome c release from the mitochondria to the cytosol, induce activation of caspase-9 and caspase-3, and finally cause apoptosis as compared with the control condition. |
2010-04-09 |
2023-08-12 |
mouse |
| Ming Ding, James J Potter, Xiaopu Liu, Michael S Torbenson, Esteban Meze. Selenium supplementation decreases hepatic fibrosis in mice after chronic carbon tetrachloride administration. Biological trace element research. vol 133. issue 1. 2010-04-08. PMID:19488682. |
se increased hepatocyte apoptosis after ccl(4) and the pro-apoptotic bax and bcl xs/l proteins. |
2010-04-08 |
2023-08-12 |
mouse |
| Hashemitabar Mahmoud, Orazizadeh Mahmoud, Khorsandi Layasadat, Albughobeish Naei. Dexamethasone effects on Bax expression in the mouse testicular germ cells. Folia histochemica et cytobiologica. vol 47. issue 2. 2010-04-08. PMID:19995710. |
the aim of the present study was to find out whether dexamethasone (dex), a widely used gc, would influence the apoptosis and expression of bax, an important proapoptotic protein, in the mouse testicular germ cells. |
2010-04-08 |
2023-08-12 |
mouse |
| Lorenzo Galluzzi, Eugenia Morselli, Ilio Vitale, Oliver Kepp, Laura Senovilla, Alfredo Criollo, Nicolas Servant, Caroline Paccard, Philippe Hupé, Thomas Robert, Hugues Ripoche, Vladimir Lazar, Annick Harel-Bellan, Philippe Dessen, Emmanuel Barillot, Guido Kroeme. miR-181a and miR-630 regulate cisplatin-induced cancer cell death. Cancer research. vol 70. issue 5. 2010-04-08. PMID:20145152. |
pre-mir-181a and pre-mir-630 consistently modulated mitochondrial/postmitochondrial steps of the intrinsic pathway of apoptosis, including bax oligomerization, mitochondrial transmembrane potential dissipation, and the proteolytic maturation of caspase-9 and caspase-3. |
2010-04-08 |
2023-08-12 |
Not clear |
| Wang Chun-Guang, Yang Jun-Qing, Liu Bei-Zhong, Jin Dan-Ting, Wang Chong, Zhong Liang, Zhu Dan, Wu Ya. Anti-tumor activity of emodin against human chronic myelocytic leukemia K562 cell lines in vitro and in vivo. European journal of pharmacology. vol 627. issue 1-3. 2010-04-05. PMID:19857484. |
the increased bax concurrent with the decreased of bcl-2 indicated that emodin treatment might result in apoptosis of k562 cells. |
2010-04-05 |
2023-08-12 |
mouse |
| Maria T Ronco, Daniel E Francés, Paola I Ingaramo, Ariel D Quiroga, Maria L Alvarez, Gerardo B Pisani, Silvia S Revelli, Cristina E Carnoval. Tumor necrosis factor alpha induced by Trypanosoma cruzi infection mediates inflammation and cell death in the liver of infected mice. Cytokine. vol 49. issue 1. 2010-04-05. PMID:19892564. |
our results suggest that t. cruzi infection induces programmed cell death in the host liver by increase of tnfalpha production, associated with tnf-r1 over-expression, that set in motion the bid cleavage and mitochondrial translocation, bax mitochondrial translocation, cytochrome c release, and ultimately apoptosis induction. |
2010-04-05 |
2023-08-12 |
mouse |
| Lingai Hu, Yukun Sun, Jian H. Catalpol inhibits apoptosis in hydrogen peroxide-induced endothelium by activating the PI3K/Akt signaling pathway and modulating expression of Bcl-2 and Bax. European journal of pharmacology. vol 628. issue 1-3. 2010-04-05. PMID:19962976. |
catalpol inhibits apoptosis in hydrogen peroxide-induced endothelium by activating the pi3k/akt signaling pathway and modulating expression of bcl-2 and bax. |
2010-04-05 |
2023-08-12 |
human |
| Lingai Hu, Yukun Sun, Jian H. Catalpol inhibits apoptosis in hydrogen peroxide-induced endothelium by activating the PI3K/Akt signaling pathway and modulating expression of Bcl-2 and Bax. European journal of pharmacology. vol 628. issue 1-3. 2010-04-05. PMID:19962976. |
apoptosis in huvecs was associated with increased bax, decreased bcl-2 activity and inactivated phosphorylation of akt and bad after 24h of h(2)o(2) exposure. |
2010-04-05 |
2023-08-12 |
human |
| Lingai Hu, Yukun Sun, Jian H. Catalpol inhibits apoptosis in hydrogen peroxide-induced endothelium by activating the PI3K/Akt signaling pathway and modulating expression of Bcl-2 and Bax. European journal of pharmacology. vol 628. issue 1-3. 2010-04-05. PMID:19962976. |
catalpol not only increased the expression of bcl-2, while decreasing bax expression, but also induced akt activation and bad phosphorylation, and ultimately reduced h(2)o(2)-induced apoptosis. |
2010-04-05 |
2023-08-12 |
human |
| Lingai Hu, Yukun Sun, Jian H. Catalpol inhibits apoptosis in hydrogen peroxide-induced endothelium by activating the PI3K/Akt signaling pathway and modulating expression of Bcl-2 and Bax. European journal of pharmacology. vol 628. issue 1-3. 2010-04-05. PMID:19962976. |
taken together, these results suggest that pre-treatment of huvecs with catalpol can block h(2)o(2)-induced apoptosis, and that the underlying mechanism involves reactive oxygen species scavenging, activation of the pi3k/akt-bad signaling pathway and increased bcl-2 and decreased bax expression. |
2010-04-05 |
2023-08-12 |
human |
| Bokkee Eun, Bongki Cho, Younghye Moon, Soo Young Kim, Kyungjin Kim, Hyun Kim, Woong Su. Induction of neuronal apoptosis by expression of Hes6 via p53-dependent pathway. Brain research. vol 1313. 2010-04-05. PMID:19968968. |
in addition, neuronal apoptosis by hes6 overexpression was markedly blunted in p53(-/-) or bax(-/-) cortical neurons, suggesting that these pro-apoptotic effects are mediated by p53- and bax-dependent pathway. |
2010-04-05 |
2023-08-12 |
Not clear |
| Jun Zhao, Tao Liu, Long Ma, Ming Yan, Yu Zhao, Zhengyi Gu, Yi Huan. Protective effect of acteoside on immunological liver injury induced by Bacillus Calmette-Guerin plus lipopolysaccharide. Planta medica. vol 75. issue 14. 2010-04-02. PMID:19548187. |
moreover, the modulation influence of acteoside on the expression of b cell lymphoma/leukemia-2 (bcl-2, hepatocyte apoptosis inhibitor) and bcl-2 associated x protein (bax, hepatocyte apoptosis promoter) in the mice liver with immunological hepatic injury was studied also. |
2010-04-02 |
2023-08-12 |
mouse |
| Tsung-Lang Chiu, Chin-Cheng S. Tanshinone IIA induces apoptosis in human lung cancer A549 cells through the induction of reactive oxygen species and decreasing the mitochondrial membrane potential. International journal of molecular medicine. vol 25. issue 2. 2010-04-02. PMID:20043132. |
the outcome of western blotting showed that protein expressions of p53 and bax were increased, but proto-oncogene bcl-2 was notably decreased, after culturing with tan-iia (5 microg/ml) for 6, 12 and 24 h. tan-iia inhibited the proliferation of non-small cell lung cancer a549 cells, possibly by decreasing the mmp and inducing apoptosis due to the induction of a higher ratio of bax/bcl-2. |
2010-04-02 |
2023-08-12 |
human |
| Xuebin Liu, Stewart Leung, Chunxia Wang, Zhu Tan, Ji Wang, Taylor B Guo, Lei Fang, Yonggang Zhao, Bing Wan, Xia Qin, Limin Lu, Runsheng Li, Heng Pan, Mingjuan Song, Ailian Liu, Jian Hong, Hongtao Lu, Jingwu Z Zhan. Crucial role of interleukin-7 in T helper type 17 survival and expansion in autoimmune disease. Nature medicine. vol 16. issue 2. 2010-04-02. PMID:20062065. |
il-7r antagonism rendered differentiated t(h)17 cells susceptible to apoptosis through the inhibition of janus kinase-signal transducer and activator of transcription-5 (jak-stat5) pathway and altered expression of the prosurvival protein bcl-2 and the proapoptotic protein bax, leading to decreased severity of eae. |
2010-04-02 |
2023-08-12 |
human |
| Soo Yeon Park, Ha Young Kim, Jung Hwan Lee, Kyoung Ho Yoon, Mun Seog Chang, Seong Kyu Par. The age-dependent induction of apoptosis-inducing factor (AIF) in the human semitendinosus skeletal muscle. Cellular & molecular biology letters. vol 15. issue 1. 2010-03-30. PMID:19685011. |
to assess the dependence on age of the expression of apoptosis regulatory proteins in the human semitendinosus muscle, we measured the expression levels of several apoptosis-related genes, including apoptosis-inducing factor (aif), bax, bcl-2, caspase-3 and heat shock protein 70 (hsp70), using rt-pcr, immunohistochemistry and tunel assays. |
2010-03-30 |
2023-08-12 |
human |