| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ajit Sodhi, Gautam Seth. Caspase-9 and Bax/Bcl-2 regulation in ultraviolet B-induced apoptosis of murine peritoneal macrophages. Toxicology mechanisms and methods. vol 14. issue 6. 2010-04-30. PMID:20021098. |
uvb (100 mj/cm2) irradiation induced apoptosis in murine peritoneal macrophages concurrent with expression of p53, apaf-1, upregulation of bax, downregulation of bcl-2, activation of caspases-9, -3, -2 and dna fragmentation. |
2010-04-30 |
2023-08-12 |
Not clear |
| Hui Yuan, Youtian Deng, Liyun Yuan, Jing Wu, Zhihang Yuan, Jine Yi, Ming Zhang, Chengzhi Guo, Lixin Wen, Rongfang Li, Li Zhu, Zuping H. Gynostemma pentaphyllum protects mouse male germ cells against apoptosis caused by zearalenone via Bax and Bcl-2 regulation. Toxicology mechanisms and methods. vol 20. issue 3. 2010-04-30. PMID:20163293. |
gynostemma pentaphyllum protects mouse male germ cells against apoptosis caused by zearalenone via bax and bcl-2 regulation. |
2010-04-30 |
2023-08-12 |
mouse |
| Hui Yuan, Youtian Deng, Liyun Yuan, Jing Wu, Zhihang Yuan, Jine Yi, Ming Zhang, Chengzhi Guo, Lixin Wen, Rongfang Li, Li Zhu, Zuping H. Gynostemma pentaphyllum protects mouse male germ cells against apoptosis caused by zearalenone via Bax and Bcl-2 regulation. Toxicology mechanisms and methods. vol 20. issue 3. 2010-04-30. PMID:20163293. |
it was found that gynostemma pentaphyllum has a marked effect on protecting male germ cells against zearalenone-induced apoptosis, as evidenced by a reduced apoptosis rate of male germ cells and bax expression as well as an enhancement of bcl-2 expression in gynostemma pentaphyllum-treated groups compared to the control. |
2010-04-30 |
2023-08-12 |
mouse |
| Daniel E Francés, María T Ronco, Juan A Monti, Paola I Ingaramo, Gerardo B Pisani, Juan P Parody, José M Pellegrino, Paloma Martín Sanz, María C Carrillo, Cristina E Carnoval. Hyperglycemia induces apoptosis in rat liver through the increase of hydroxyl radical: new insights into the insulin effect. The Journal of endocrinology. vol 205. issue 2. 2010-04-30. PMID:20164374. |
interestingly, the treatment of diabetic rats with desferoxamine or tempol (antioxidants/hydroxyl radical scavengers) significantly attenuated the increase in both hydroxyl radical production and in lpo produced by hyperglycemia, preventing apoptosis by reduction of mitochondrial bax and cytosolic cytochrome c levels. |
2010-04-30 |
2023-08-12 |
rat |
| Wei Wang, Ying Liu, Ying Chen, Cuiping Cao, Ying Xiang, Dan Zhang, Lingling Han, Hong Zhao, Guoliang Li. Inhibition of Foxo1 mediates protective effects of ghrelin against lipotoxicity in MIN6 pancreatic beta-cells. Peptides. vol 31. issue 2. 2010-04-29. PMID:19944124. |
ghrelin also inhibited the endoplasmic reticulum stress pathway of apoptosis in min6 cells, decreased expression of cytoplasmic triglyceride, and downregulated gene expression of bcl-2-associated x (bax), sterol-response element-binding protein 1c (srebp1c), and c/ebp homologous protein (chop-10). |
2010-04-29 |
2023-08-12 |
Not clear |
| Carolyn Ying Zhao, Laszlo Szekely, Wenjie Bao, Galina Selivanov. Rescue of p53 function by small-molecule RITA in cervical carcinoma by blocking E6-mediated degradation. Cancer research. vol 70. issue 8. 2010-04-28. PMID:20395210. |
rita activates the transcription of proapoptotic p53 targets noxa, puma, and bax, and repressed the expression of pro-proliferative factors cyclinb1, cdc2, and cdc25c, resulting in p53-dependent apoptosis and cell cycle arrest. |
2010-04-28 |
2023-08-12 |
human |
| Hua Niu, Vera Kozjak-Pavlovic, Thomas Rudel, Yasuko Rikihis. Anaplasma phagocytophilum Ats-1 is imported into host cell mitochondria and interferes with apoptosis induction. PLoS pathogens. vol 6. issue 2. 2010-04-27. PMID:20174550. |
bax redistribution was inhibited in both etoposide-induced and bax-induced apoptosis by ats-1. |
2010-04-27 |
2023-08-12 |
human |
| Xin-Wen Huang, Zheng-Yan Zhao, Chai J. [Effects of hypothyroidism on apoptosis and the expression of Bcl-2 and Bax gene in the neonatal rat hippocampus neurons]. Zhonghua er ke za zhi = Chinese journal of pediatrics. vol 43. issue 1. 2010-04-26. PMID:15796810. |
[effects of hypothyroidism on apoptosis and the expression of bcl-2 and bax gene in the neonatal rat hippocampus neurons]. |
2010-04-26 |
2023-08-12 |
rat |
| Xin-Wen Huang, Zheng-Yan Zhao, Chai J. [Effects of hypothyroidism on apoptosis and the expression of Bcl-2 and Bax gene in the neonatal rat hippocampus neurons]. Zhonghua er ke za zhi = Chinese journal of pediatrics. vol 43. issue 1. 2010-04-26. PMID:15796810. |
this study was designed to investigate the effects of hypothyroidism on apoptosis and the expression of bcl-2 and bax gene in the developing rat hippocampus neurons and to explore the mechanism of brain development regulated by thyroid hormone. |
2010-04-26 |
2023-08-12 |
rat |
| Dean A Wiseman, Shruti Sharma, Stephen M Blac. Elevated zinc induces endothelial apoptosis via disruption of glutathione metabolism: role of the ADP translocator. Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine. vol 23. issue 1. 2010-04-26. PMID:19768661. |
inhibition of ant causes increased mitochondrial oxidation, loss of adp uptake, mitochondrial translocation of bax, and apoptosis. |
2010-04-26 |
2023-08-12 |
Not clear |
| Weihua Hu, Jungang Xie, Jianping Zhao, Yongjian Xu, Shifang Yang, Wang N. Involvement of Bcl-2 family in apoptosis and signal pathways induced by cigarette smoke extract in the human airway smooth muscle cells. DNA and cell biology. vol 28. issue 1. 2010-04-22. PMID:19090673. |
further, the expression of bax, bad, and fas was increased but bcl-2 and nuclear factor-kappab (nf-kappab) was decreased in a dose- and time-dependent fashion in cse-induced apoptosis in hasmcs. |
2010-04-22 |
2023-08-12 |
human |
| Valeria Rodriguez, Gabriela Diaz de Barboza, Ruben Ponce, Valeria Merico, Silvia Garagna, Nori Tolosa de Talamon. Spermatocyte apoptosis, which involves both intrinsic and extrinsic pathways, explains the sterility of Graomys griseoflavus x Graomys centralis male hybrids. Reproduction, fertility, and development. vol 22. issue 2. 2010-04-22. PMID:20047733. |
terminal transferase-mediated dutp nick-end labelling assay (tunel), fas, bax and cytochrome c labelling were used for apoptosis evaluation, and calbindin d(28k) staining as an anti-apoptotic molecule. |
2010-04-22 |
2023-08-12 |
Not clear |
| Bernhard Gillissen, Jana Wendt, Antje Richter, Anja Richter, Annika Müer, Tim Overkamp, Nina Gebhardt, Robert Preissner, Claus Belka, Bernd Dörken, Peter T Danie. Endogenous Bak inhibitors Mcl-1 and Bcl-xL: differential impact on TRAIL resistance in Bax-deficient carcinoma. The Journal of cell biology. vol 188. issue 6. 2010-04-22. PMID:20308427. |
consequently, bax deficiency confers resistance against trail-induced apoptosis. |
2010-04-22 |
2023-08-12 |
Not clear |
| Bernhard Gillissen, Jana Wendt, Antje Richter, Anja Richter, Annika Müer, Tim Overkamp, Nina Gebhardt, Robert Preissner, Claus Belka, Bernd Dörken, Peter T Danie. Endogenous Bak inhibitors Mcl-1 and Bcl-xL: differential impact on TRAIL resistance in Bax-deficient carcinoma. The Journal of cell biology. vol 188. issue 6. 2010-04-22. PMID:20308427. |
in this study, we show that the bax dependency of trail-induced apoptosis is determined by mcl-1 but not bcl-xl. |
2010-04-22 |
2023-08-12 |
Not clear |
| You Ah Kim, Chang-Suk Kong, Sung Su Yea, Youngwan Se. Constituents of Corydalis heterocarpa and their anti-proliferative effects on human cancer cells. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. vol 48. issue 2. 2010-04-21. PMID:20026161. |
the potent inhibitory effect of compound 2 was produced by induction of apoptosis through activating bax, p53 and p21 expressions. |
2010-04-21 |
2023-08-12 |
human |
| G Vinothini, C Balachandran, S Nagin. Evaluation of molecular markers in canine mammary tumors: correlation with histological grading. Oncology research. vol 18. issue 5-6. 2010-04-20. PMID:20225757. |
we analyzed changes in the expression of markers of hormone and receptor status (estradiol, estrogen receptor; er and her-2/neu), hormone metabolism (cyp1a1 and cyp1b1), cell proliferation and survival [proliferating cell nuclear antigen (pcna), glutathione s-transferase-p (gst-p), nuclear factor-kappab (nf-kappab-p50, nf-kappab-p65), phosphorylated-inhibitor of kappab-alpha (p-ikappab-alpha) and ikappab], apoptosis (bcl-2, bax, caspases, apaf-1, cytochrome-c, and parp), invasion [matrix metalloproteinases-2 and -9 (mmp-2, mmp-9), tissue inhibitor of matrix metalloproteinase-2 (timp-2), and reversion-inducing cysteine-rich protein with kazal motifs (reck)], angiogenesis [vascular endothelial growth factor (vegf)], and epigenetics [dna methyltransferase (dnmt-1), histone deacetylase (hdac-1)] by immunohistochemical localization and western blot analysis and correlated these with histological grade. |
2010-04-20 |
2023-08-12 |
human |
| Mizuki Sudo, Yutaka Kan. Myofiber apoptosis occurs in the inflammation and regeneration phase following eccentric contractions in rats. The journal of physiological sciences : JPS. vol 59. issue 6. 2010-04-16. PMID:19636670. |
the expression of proteins related to apoptosis (bcl-2 and bax) was examined by western blot assay. |
2010-04-16 |
2023-08-12 |
rat |
| Meng-Liang Lin, Yao-Cheng Lu, Jing-Gung Chung, Yi-Chen Li, Shyang-Guang Wang, Sue-Hwee N G, Chia-Yin Wu, Hong-Lin Su, Shih-Shun Che. Aloe-emodin induces apoptosis of human nasopharyngeal carcinoma cells via caspase-8-mediated activation of the mitochondrial death pathway. Cancer letters. vol 291. issue 1. 2010-04-16. PMID:19942342. |
in addition, suppression of caspase-8 with the specific inhibitor z-ietd-fmk inhibited ae-induced the activation of bax, the cleavage of bid, the translocation of tbid to the mitochondria and the release of cytochrome c, apoptosis-inducing factor (aif) and endo g from the mitochondria and subsequent apoptosis. |
2010-04-16 |
2023-08-12 |
human |
| Reika Takamatsu, Eriko Takeshima, Chie Ishikawa, Kei Yamamoto, Hiromitsu Teruya, Klaus Heuner, Futoshi Higa, Jiro Fujita, Naoki Mor. Inhibition of Akt/GSK3beta signalling pathway by Legionella pneumophila is involved in induction of T-cell apoptosis. The Biochemical journal. vol 427. issue 1. 2010-04-15. PMID:20102336. |
it also caused the activation of the pro-apoptotic protein bax and inhibited the expression of the anti-apoptotic protein xiap (x-linked inhibitor of apoptosis) via inhibition of the akt pathway. |
2010-04-15 |
2023-08-12 |
human |
| Jung-Min Oh, Su-Hyeong Kim, Eun-Ah Cho, Yong-Sang Song, Woo-Ho Kim, Yong-Sung Juhn. Human papillomavirus type 16 E5 protein inhibits hydrogen-peroxide-induced apoptosis by stimulating ubiquitin-proteasome-mediated degradation of Bax in human cervical cancer cells. Carcinogenesis. vol 31. issue 3. 2010-04-14. PMID:20015862. |
human papillomavirus type 16 e5 protein inhibits hydrogen-peroxide-induced apoptosis by stimulating ubiquitin-proteasome-mediated degradation of bax in human cervical cancer cells. |
2010-04-14 |
2023-08-12 |
human |