| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Damijan Nipic, Ales Pirc, Blaz Banic, Dusan Suput, Irina Milisa. Preapoptotic cell stress response of primary hepatocytes. Hepatology (Baltimore, Md.). vol 51. issue 6. 2010-06-17. PMID:20513000. |
the shifts of procaspase-9 and bax are reversible in the absence of the apoptotic trigger; the spontaneous reversion was confirmed experimentally for procaspase-9, whereas bax shifted from the nuclei to the cytosol and mitochondria after the initiation of apoptosis. |
2010-06-17 |
2023-08-12 |
Not clear |
| M Cam, W Handke, M Picard-Maureau, W Brun. Cytomegaloviruses inhibit Bak- and Bax-mediated apoptosis with two separate viral proteins. Cell death and differentiation. vol 17. issue 4. 2010-06-15. PMID:19816509. |
like bcl-2, the viral analogs inhibit apoptosis by preventing activation and/or oligomerization of the proapoptotic mitochondrial proteins bax and bak. |
2010-06-15 |
2023-08-12 |
rat |
| Luciano A Castro, Larissa S A Elias, Angélica F Oton-Leite, José V de Spíndula-Filho, Claudio R Leles, Aline C Batista, Elismauro F Mendonç. Long-term effects of nifedipine on human gingival epithelium: a histopathological and immunohistochemical study. Journal of oral science. vol 52. issue 1. 2010-06-15. PMID:20339233. |
proliferation (ki67 and cyclin b1) and apoptosis (bcl2, bax and p53) markers were identified by immunohistochemistry in twenty-one samples of gingival tissue from patients undergoing chronic treatment with nifedipine and in eleven samples of gingival tissue from healthy patients who did not use drugs associated with go (control). |
2010-06-15 |
2023-08-12 |
human |
| Rita Rezzani, Enzo Porteri, Carolina De Ciuceis, Francesca Bonomini, Luigi F Rodella, Silvia Paiardi, Gianluca E M Boari, Caterina Platto, Annamaria Pilu, Daniele Avanzi, Damiano Rizzoni, Enrico Agabiti Rose. Effects of melatonin and Pycnogenol on small artery structure and function in spontaneously hypertensive rats. Hypertension (Dallas, Tex. : 1979). vol 55. issue 6. 2010-06-15. PMID:20421515. |
aortic contents of metalloproteinase 2, bax, inducible no synthase, and cyclooxygenase 2 were evaluated, together with the aortic content of total collagen and collagen subtypes and apoptosis rate. |
2010-06-15 |
2023-08-12 |
rat |
| Tan Li, Wei Wang, Hong Chen, Tong Li, Lu Y. Evaluation of anti-leukemia effect of resveratrol by modulating STAT3 signaling. International immunopharmacology. vol 10. issue 1. 2010-06-14. PMID:19796711. |
our data indicate that resveratrol contributes to inhibiting growth, inducing apoptosis and cell cycle arrest in the three leukemia cell lines (jurkat, sup-b15, and kasumi-1), and reducing the phosphorylation of stat3, meanwhile modulating the expression of bcl-2 and bax. |
2010-06-14 |
2023-08-12 |
mouse |
| Yuriy Shapovalov, David Benavidez, Daniel Zuch, Roman A Elisee. Proteasome inhibition with bortezomib suppresses growth and induces apoptosis in osteosarcoma. International journal of cancer. vol 127. issue 1. 2010-06-14. PMID:19894220. |
in this study, we hypothesized that proteasome inhibition will induce runx2 and runx2-dependent bax expression sensitizing osteosarcoma cells to apoptosis. |
2010-06-14 |
2023-08-12 |
mouse |
| Seong-Jun Cho, Suhkneung Py. Interferon-gamma enhances the apoptosis of macrophages under trophic stress through activation of p53 and the JAK1 pathway. Archives of pharmacal research. vol 33. issue 2. 2010-06-14. PMID:20195830. |
in addition, we showed that enhancement of apoptosis by ifn-gamma is caused by a decrease in mitochondrial membrane potential due to upregulation of p53 and bax and down-regulation of bcl-xl. |
2010-06-14 |
2023-08-12 |
Not clear |
| Saurabh Chattopadhyay, Joao T Marques, Michifumi Yamashita, Kristi L Peters, Kevin Smith, Avanti Desai, Bryan R G Williams, Ganes C Se. Viral apoptosis is induced by IRF-3-mediated activation of Bax. The EMBO journal. vol 29. issue 10. 2010-06-14. PMID:20360684. |
viral apoptosis is induced by irf-3-mediated activation of bax. |
2010-06-14 |
2023-08-12 |
mouse |
| Saurabh Chattopadhyay, Joao T Marques, Michifumi Yamashita, Kristi L Peters, Kevin Smith, Avanti Desai, Bryan R G Williams, Ganes C Se. Viral apoptosis is induced by IRF-3-mediated activation of Bax. The EMBO journal. vol 29. issue 10. 2010-06-14. PMID:20360684. |
apoptosis was triggered by the direct interaction of irf-3, through a newly identified bh3 domain, with the pro-apoptotic protein bax, their co-translocation to the mitochondria and the resulting activation of the mitochondrial apoptotic pathway. |
2010-06-14 |
2023-08-12 |
mouse |
| Madhulika Tripathi, Brijesh Kumar Singh, Chetna Mishra, Sheikh Raisuddin, Poonam Kakka. Involvement of mitochondria mediated pathways in hepatoprotection conferred by Fumaria parviflora Lam. extract against nimesulide induced apoptosis in vitro. Toxicology in vitro : an international journal published in association with BIBRA. vol 24. issue 2. 2010-06-02. PMID:19772912. |
nimesulide exposure increased intracellular ros, translocation of bax and bcl2 followed by mitochondrial depolarization and cytochrome c (cyt c) release along with caspase-9/-3 activity confirming involvement of mitochondria in nimesulide induced apoptosis. |
2010-06-02 |
2023-08-12 |
rat |
| Giovanni Benard, Albert Neutzner, Guihong Peng, Chunxin Wang, Ferenc Livak, Richard J Youle, Mariusz Karbowsk. IBRDC2, an IBR-type E3 ubiquitin ligase, is a regulatory factor for Bax and apoptosis activation. The EMBO journal. vol 29. issue 8. 2010-06-02. PMID:20300062. |
ibrdc2, an ibr-type e3 ubiquitin ligase, is a regulatory factor for bax and apoptosis activation. |
2010-06-02 |
2023-08-12 |
Not clear |
| Giovanni Benard, Albert Neutzner, Guihong Peng, Chunxin Wang, Ferenc Livak, Richard J Youle, Mariusz Karbowsk. IBRDC2, an IBR-type E3 ubiquitin ligase, is a regulatory factor for Bax and apoptosis activation. The EMBO journal. vol 29. issue 8. 2010-06-02. PMID:20300062. |
bax, a pro-apoptotic protein from the bcl-2 family, is central to apoptosis regulation. |
2010-06-02 |
2023-08-12 |
Not clear |
| Giovanni Benard, Albert Neutzner, Guihong Peng, Chunxin Wang, Ferenc Livak, Richard J Youle, Mariusz Karbowsk. IBRDC2, an IBR-type E3 ubiquitin ligase, is a regulatory factor for Bax and apoptosis activation. The EMBO journal. vol 29. issue 8. 2010-06-02. PMID:20300062. |
to suppress spontaneous apoptosis, bax must be under stringent control that may include regulation of bax conformation and expression levels. |
2010-06-02 |
2023-08-12 |
Not clear |
| Giovanni Benard, Albert Neutzner, Guihong Peng, Chunxin Wang, Ferenc Livak, Richard J Youle, Mariusz Karbowsk. IBRDC2, an IBR-type E3 ubiquitin ligase, is a regulatory factor for Bax and apoptosis activation. The EMBO journal. vol 29. issue 8. 2010-06-02. PMID:20300062. |
although mostly cytosolic in healthy cells, upon induction of apoptosis, ibrdc2 accumulates in mitochondrial domains enriched with bax. |
2010-06-02 |
2023-08-12 |
Not clear |
| Yongli Shi, Feng Wang, Jibao He, Santosh Yadav, He Wan. Titanium dioxide nanoparticles cause apoptosis in BEAS-2B cells through the caspase 8/t-Bid-independent mitochondrial pathway. Toxicology letters. vol 196. issue 1. 2010-06-02. PMID:20362650. |
the levels of bax, cytochrome c, p53 and bcl-2 also changed reflecting the activation of intrinsic apoptosis pathway. |
2010-06-02 |
2023-08-12 |
human |
| Xinya Lu, Aleksandar Masic, Yang Li, YeunKyung Shin, Qiang Liu, Yan Zho. The PI3K/Akt pathway inhibits influenza A virus-induced Bax-mediated apoptosis by negatively regulating the JNK pathway via ASK1. The Journal of general virology. vol 91. issue Pt 6. 2010-06-01. PMID:20130137. |
here, it is reported that, although both wt and pr8-sh3-mf-1 viruses induced apoptosis, the pr8-sh3-mf-1 virus consistently showed greater potential to induce mitochondrial membrane disruption, cytochrome c release, and translocation and conformational change of bax than the wt virus. |
2010-06-01 |
2023-08-12 |
Not clear |
| Xinya Lu, Aleksandar Masic, Yang Li, YeunKyung Shin, Qiang Liu, Yan Zho. The PI3K/Akt pathway inhibits influenza A virus-induced Bax-mediated apoptosis by negatively regulating the JNK pathway via ASK1. The Journal of general virology. vol 91. issue Pt 6. 2010-06-01. PMID:20130137. |
blocking jnk activity could inhibit virus-induced bax activation and apoptosis. |
2010-06-01 |
2023-08-12 |
Not clear |
| Akane Suzuki, Chiaki Iwamura, Kenta Shinoda, Damon J Tumes, Motoko Y Kimura, Hiroyuki Hosokawa, Yusuke Endo, Shu Horiuchi, Koji Tokoyoda, Haruhiko Koseki, Masakatsu Yamashita, Toshinori Nakayam. Polycomb group gene product Ring1B regulates Th2-driven airway inflammation through the inhibition of Bim-mediated apoptosis of effector Th2 cells in the lung. Journal of immunology (Baltimore, Md. : 1950). vol 184. issue 8. 2010-05-27. PMID:20237291. |
the in vitro experiments revealed that the expression of bim was increased at both the transcriptional and protein levels in ring1b(-/-) effector th2 cells, and the enhanced apoptosis in ring1b(-/-) th2 cells was rescued by the knockdown of bim but not the other proapoptotic genes, such as perp, noxa, or bax. |
2010-05-27 |
2023-08-12 |
mouse |
| Dessie Salilew-Wondim, Micheal Hölker, Franca Rings, Chirawath Phatsara, Abdollah Mohammadi-Sangcheshmeh, Ernst Tholen, Karl Schellander, Dawit Tesfay. Depletion of BIRC6 leads to retarded bovine early embryonic development and blastocyst formation in vitro. Reproduction, fertility, and development. vol 22. issue 3. 2010-05-26. PMID:20188030. |
moreover, the apoptotic cell ratio, caspase 3 and 7 activity, bax to bcl-2 ratio and levels of smac and caspase 9 were higher in blastocysts derived from the ldsrna and shrna groups, suggesting increased apoptosis in those blastocysts. |
2010-05-26 |
2023-08-12 |
cattle |
| Wei Chen, Jie Hou, Yan Yin, Jongchol Jang, Zhongliang Zheng, Handong Fan, Guolin Zo. alpha-Bisabolol induces dose- and time-dependent apoptosis in HepG2 cells via a Fas- and mitochondrial-related pathway, involves p53 and NFkappaB. Biochemical pharmacology. vol 80. issue 2. 2010-05-26. PMID:20346922. |
preparation of mitochondrial/cytosol fraction followed with immunoblot analysis showed the release of chromosome c from mitochondria, down-regulated expression of bcl-2 and translocation of bax, bak and bid, suggesting the mitochondrial-related pathway might be involved in alpha-bisabolol-induced apoptosis either. |
2010-05-26 |
2023-08-12 |
human |