| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ying-Jung Chen, Wen-Hsin Liu, Pei-Hsiu Kao, Jeh-Jeng Wang, Long-Sen Chan. Involvement of p38 MAPK- and JNK-modulated expression of Bcl-2 and Bax in Naja nigricollis CMS-9-induced apoptosis of human leukemia K562 cells. Toxicon : official journal of the International Society on Toxinology. vol 55. issue 7. 2010-07-19. PMID:20144638. |
involvement of p38 mapk- and jnk-modulated expression of bcl-2 and bax in naja nigricollis cms-9-induced apoptosis of human leukemia k562 cells. |
2010-07-19 |
2023-08-12 |
human |
| Rosanna Di Paola, Concetta Crisafulli, Emanuela Mazzon, Emanuela Esposito, Irene Paterniti, Maria Galuppo, Tiziana Genovese, Christoph Thiemermann, Salvatore Cuzzocre. GW0742, a high-affinity PPAR -beta/delta agonist, inhibits acute lung injury in mice. Shock (Augusta, Ga.). vol 33. issue 4. 2010-07-19. PMID:20407409. |
furthermore, car induced lung apoptosis (bax and bcl-2 expression), and nitrotyrosine formation was determined by immunohistochemical analysis of lung tissues. |
2010-07-19 |
2023-08-12 |
mouse |
| Su-Chee Chen, Tien-Ling Liao, Yau-Huei Wei, Chii-Reuy Tzeng, Shu-Huei Ka. Endocrine disruptor, dioxin (TCDD)-induced mitochondrial dysfunction and apoptosis in human trophoblast-like JAR cells. Molecular human reproduction. vol 16. issue 5. 2010-07-15. PMID:20083559. |
furthermore, we observed increased apoptosis, p53 accumulation, bax overexpression, cytochrome c release and sequential caspase 3 activation after tcdd exposure. |
2010-07-15 |
2023-08-12 |
human |
| Andromachi Kotsafti, Fabio Farinati, Romilda Cardin, Patrizia Burra, Marina Bortolam. Bax inhibitor-1 down-regulation in the progression of chronic liver diseases. BMC gastroenterology. vol 10. 2010-07-15. PMID:20359348. |
bax inhibitor-1 (bi-1) is an evolutionary conserved endoplasmic reticulum protein that, when overexpressed in mammalian cells, suppresses the apoptosis induced by bax, a pro-apoptotic member of the bcl-2 family. |
2010-07-15 |
2023-08-12 |
Not clear |
| Xing Du, Richard J Youle, David J FitzGerald, Ira Pasta. Pseudomonas exotoxin A-mediated apoptosis is Bak dependent and preceded by the degradation of Mcl-1. Molecular and cellular biology. vol 30. issue 14. 2010-07-14. PMID:20457813. |
pe induced a rapid and dose-dependent induction of apoptosis in wild-type (wt) and bax knockout (bax(-/-)) mefs but failed in bak knockout (bak(-/-)) and bax/bak double-knockout (dko) mefs. |
2010-07-14 |
2023-08-12 |
mouse |
| Yue-ming Shen, Xuan Zhu, Kun-he Zhang, Yong Xie, Jiang Chen, Ying Dai, Can-hui Ou-Yang, Bi-min L. [Effect of ursolic acid on proliferation and apoptosis of hepatic stellate cells in vitro]. Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology. vol 16. issue 4. 2010-07-13. PMID:18423155. |
to investigate the effect of ursolic acid on proliferation and apoptosis of hepatic stellate cells (hsc) in vitro and explore the mechanisms of apoptosis of hsc induced by ursolic acid by studying the expressions of apoptosis-regulating proteins bcl-2, bax and caspase 3 in hsc. |
2010-07-13 |
2023-08-12 |
Not clear |
| S Luo, D C Rubinsztei. Apoptosis blocks Beclin 1-dependent autophagosome synthesis: an effect rescued by Bcl-xL. Cell death and differentiation. vol 17. issue 2. 2010-07-13. PMID:19713971. |
apoptosis induced by the proapoptotic protein bax reduced autophagy by enhancing caspase-mediated cleavage of beclin 1 at d149. |
2010-07-13 |
2023-08-12 |
Not clear |
| H Düssmann, M Rehm, C G Concannon, S Anguissola, M Würstle, S Kacmar, P Völler, H J Huber, J H M Preh. Single-cell quantification of Bax activation and mathematical modelling suggest pore formation on minimal mitochondrial Bax accumulation. Cell death and differentiation. vol 17. issue 2. 2010-07-13. PMID:19745831. |
mitochondrial outer membrane permeabilisation (momp) during apoptosis is triggered by the activation and oligomerisation of bax and bak, but a quantification of these processes in individual cells has not yet been performed. |
2010-07-13 |
2023-08-12 |
Not clear |
| L Lindenboim, E Blacher, C Borner, R Stei. Regulation of stress-induced nuclear protein redistribution: a new function of Bax and Bak uncoupled from Bcl-x(L). Cell death and differentiation. vol 17. issue 2. 2010-07-13. PMID:19816507. |
re-expression of bax or bak in bax/bak-deficient mefs restores nuclear redistribution during apoptosis. |
2010-07-13 |
2023-08-12 |
mouse |
| Yang Liu, Fuyuki Sato, Takeshi Kawamoto, Katsumi Fujimoto, Satoko Morohashi, Harue Akasaka, Jun Kondo, Yunyan Wu, Mitsuhide Noshiro, Yukio Kato, Hiroshi Kijim. Anti-apoptotic effect of the basic helix-loop-helix (bHLH) transcription factor DEC2 in human breast cancer cells. Genes to cells : devoted to molecular & cellular mechanisms. vol 15. issue 4. 2010-07-13. PMID:20236182. |
knockdown of dec2 affected the expression of mrna or proteins related to apoptosis, such as fas, c-myc, caspase-8, poly (adp-ribose) polymerase (parp) and bax. |
2010-07-13 |
2023-08-12 |
human |
| Jung Mogg Kim, Joo Sung Kim, Jin Young Lee, Young-Suk Sim, Young-Jeon Kim, Yu-Kyoung Oh, Ho Joo Yoon, Ju Seop Kang, Jeehee Youn, Nayoung Kim, Hyun Chae Jung, Sunil Ki. Dual effects of Helicobacter pylori vacuolating cytotoxin on human eosinophil apoptosis in early and late periods of stimulation. European journal of immunology. vol 40. issue 6. 2010-07-13. PMID:20333629. |
furthermore, apoptosis facilitated by bax and cytochrome c was primarily regulated by p38 mapk in vaca-treated eosinophils. |
2010-07-13 |
2023-08-12 |
human |
| Jung Mogg Kim, Joo Sung Kim, Jin Young Lee, Young-Suk Sim, Young-Jeon Kim, Yu-Kyoung Oh, Ho Joo Yoon, Ju Seop Kang, Jeehee Youn, Nayoung Kim, Hyun Chae Jung, Sunil Ki. Dual effects of Helicobacter pylori vacuolating cytotoxin on human eosinophil apoptosis in early and late periods of stimulation. European journal of immunology. vol 40. issue 6. 2010-07-13. PMID:20333629. |
these results suggest that the exposure of human eosinophils to h. pylori vaca induces the early upregulation of c-iap2 and a relatively late apoptotic response, with the apoptosis progressing through a sequential pathway that includes p38 mapk activation, bax translocation, and cytochrome c release. |
2010-07-13 |
2023-08-12 |
human |
| Fengjie Guo, Yalin Li, Yan Liu, Jiajia Wang, Guancheng L. ARL6IP1 mediates cisplatin-induced apoptosis in CaSki cervical cancer cells. Oncology reports. vol 23. issue 5. 2010-07-13. PMID:20372863. |
these novel findings collectively suggest that arl6ip1 may play a key role in cisplatin-induced apoptosis in caski cervical cancer cells by regulating the expression of apoptosis-associated proteins such as caspase-3, -9, p53, nf-kappab, mapk, bcl-2, bcl-xl, and bax. |
2010-07-13 |
2023-08-12 |
Not clear |
| Sung-Gyu Cho, Quansheng Du, Shuang Huang, Zheng Don. Drp1 dephosphorylation in ATP depletion-induced mitochondrial injury and tubular cell apoptosis. American journal of physiology. Renal physiology. vol 299. issue 1. 2010-07-13. PMID:20410216. |
importantly, cyclosporine a and fk506 could also prevent mitochondrial fragmentation, bax accumulation, cytochrome c release, and apoptosis following atp depletion in rptc. |
2010-07-13 |
2023-08-12 |
rat |
| Shiva Nasiraei-Moghadam, Behrang Kazeminezhad, Leila Dargahi, Abolhassan Ahmadian. Maternal oral consumption of morphine increases Bax/Bcl-2 ratio and caspase 3 activity during early neural system development in rat embryos. Journal of molecular neuroscience : MN. vol 41. issue 1. 2010-07-12. PMID:19936637. |
these findings suggest that morphine exposure during the first embryonic days may enhance the susceptibility of neuroblasts to apoptosis by upregulating the ratio of bax to bcl-2 protein expression and increasing downstream caspase-3 activity. |
2010-07-12 |
2023-08-12 |
rat |
| Ze-Fen Wang, Jun Yin, Yao Zhang, Ling-Qiang Zhu, Qing Tian, Xiao-Chuan Wang, Hong-Lian Li, Jian-Zhi Wan. Overexpression of tau proteins antagonizes amyloid-beta-potentiated apoptosis through mitochondria-caspase-3 pathway in N2a cells. Journal of Alzheimer's disease : JAD. vol 20. issue 1. 2010-07-08. PMID:20164595. |
here, we observed that the cells bearing high level of abeta were more vulnerable than the controls to h2o2-induced apoptosis, and this effect of abeta was associated with decrease of bcl-2, elevation of bax and cytosolic cytochrome-c, as well as activation of caspase-3, suggesting that abeta could potentiate the oxidant-induced cell apoptosis with involvement of mitochondria-caspase-3 pathway. |
2010-07-08 |
2023-08-12 |
Not clear |
| Ze-Fen Wang, Jun Yin, Yao Zhang, Ling-Qiang Zhu, Qing Tian, Xiao-Chuan Wang, Hong-Lian Li, Jian-Zhi Wan. Overexpression of tau proteins antagonizes amyloid-beta-potentiated apoptosis through mitochondria-caspase-3 pathway in N2a cells. Journal of Alzheimer's disease : JAD. vol 20. issue 1. 2010-07-08. PMID:20164595. |
more importantly, we also found that expression of tau that became hyperphosphorylated could reduce the abeta-potentiated apoptosis with simultaneous preservation of bcl-2 and suppression of bax, cytosolic cytochrome-c, and caspase-3 activity, implying that overexpression of tau that became hyperphosphorylated can attenuate the abeta-potentiated cell apoptosis through mitochondria-caspase-3 pathway. |
2010-07-08 |
2023-08-12 |
Not clear |
| J Hasnan, M I Yusof, T D Damitri, A R Faridah, A S Adenan, T H Norbain. Relationship between apoptotic markers (Bax and Bcl-2) and biochemical markers in type 2 diabetes mellitus. Singapore medical journal. vol 51. issue 1. 2010-07-08. PMID:20200776. |
bax is essential for apoptosis in normal cells. |
2010-07-08 |
2023-08-12 |
Not clear |
| Vermont P Dia, Elvira Gonzalez de Meji. Lunasin promotes apoptosis in human colon cancer cells by mitochondrial pathway activation and induction of nuclear clusterin expression. Cancer letters. vol 295. issue 1. 2010-07-08. PMID:20206442. |
lunasin-induced apoptosis as evidenced by a twofold increase in the percentage of cells undergoing apoptosis, decreased bcl-2:bax ratio from 8.5 to 0.4, increased caspase-3 activity by 77% and increased expression of pro-apoptotic nuclear clusterin by five fold when compared to untreated cells. |
2010-07-08 |
2023-08-12 |
human |
| D Haller, M Mackiewicz, S Gerber, D Beyer, B Kullmann, I Schneider, J S Ahmed, U Seitze. Cytoplasmic sequestration of p53 promotes survival in leukocytes transformed by Theileria. Oncogene. vol 29. issue 21. 2010-07-07. PMID:20208567. |
although buparvaquone treatment led to apoptosis of the host cell, inhibition of either p53 or bax significantly reduced buparvaquone-induced apoptosis of the transformed cells. |
2010-07-07 |
2023-08-12 |
cattle |