| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Shengbing Huang, Frank A Sinicrop. Celecoxib-induced apoptosis is enhanced by ABT-737 and by inhibition of autophagy in human colorectal cancer cells. Autophagy. vol 6. issue 2. 2010-07-06. PMID:20104024. |
celecoxib was shown to induce apoptosis that was attenuated by ectopic bcl-2 or bax knockout. |
2010-07-06 |
2023-08-12 |
human |
| Chang-Dong Wang, Jian-Guo Huang, Xuan Gao, Yi Li, Shi-Yi Zhou, Xu Yan, An Zou, Jun-Li Chang, Yue-Sheng Wang, Guang-Xiao Yang, Guang-Yuan H. Fangchinoline induced G1/S arrest by modulating expression of p27, PCNA, and cyclin D in human prostate carcinoma cancer PC3 cells and tumor xenograft. Bioscience, biotechnology, and biochemistry. vol 74. issue 3. 2010-07-01. PMID:20208355. |
increased exposure time to fan caused apoptosis of pc3 cells, which was associated with up-regulation of pro-apoptotic proteins bax and caspase 3, and down-regulation of anti-apoptotic protein bcl-2. |
2010-07-01 |
2023-08-12 |
mouse |
| A Vichalkovski, E Gresko, D Hess, D F Restuccia, B A Hemming. PKB/AKT phosphorylation of the transcription factor Twist-1 at Ser42 inhibits p53 activity in response to DNA damage. Oncogene. vol 29. issue 24. 2010-07-01. PMID:20400976. |
this influenced the activation of p53 target genes such as p21(waf1) and bax and led to aberrant cell-cycle regulation and the inhibition of apoptosis. |
2010-07-01 |
2023-08-12 |
human |
| Arnaud Desfeux, Faiza El Ghazi, Sylvie Jégou, Hélène Legros, Stéphane Marret, Vincent Laudenbach, Bruno J Gonzale. Dual effect of glutamate on GABAergic interneuron survival during cerebral cortex development in mice neonates. Cerebral cortex (New York, N.Y. : 1991). vol 20. issue 5. 2010-06-28. PMID:19759125. |
in vivo bax small interfering ribonucleic acid and a caspase-9 inhibitor abrogated mk801-induced apoptosis and pyknotic nucleus formation. |
2010-06-28 |
2023-08-12 |
mouse |
| Chun Hui Lan, Jian Qiu Sheng, Dian Chun Fang, Qing Zhuang Meng, Li Lin Fan, Zeng Rong Huan. Involvement of VDAC1 and Bcl-2 family of proteins in VacA-induced cytochrome c release and apoptosis of gastric epithelial carcinoma cells. Journal of digestive diseases. vol 11. issue 1. 2010-06-24. PMID:20132430. |
the aim of this study is to investigate the role of bcl family of proteins (bcl-2 and bax) and the mitochondrial voltage-dependent anion channel (vdac) in vaca-induced apoptosis of ags cells. |
2010-06-24 |
2023-08-12 |
Not clear |
| Lei Shi, Wenbin Yue, Chunxiang Zhang, Youshe Ren, Xiaomin Zhu, Qian Wang, Liguang Shi, Fulin Le. Effects of maternal and dietary selenium (Se-enriched yeast) on oxidative status in testis and apoptosis of germ cells during spermatogenesis of their offspring in goats. Animal reproduction science. vol 119. issue 3-4. 2010-06-24. PMID:20226605. |
the results show that mrna expression of apoptosis genes (bcl-2, bax and caspase 8) were significantly higher in groups 1 and 4 than that in groups 2 and 3. |
2010-06-24 |
2023-08-12 |
Not clear |
| Yiyi Ye, Jianwen Liu, Jianhe Xu, Lijuan Sun, Mingcang Chen, Minbo La. Nano-SiO2 induces apoptosis via activation of p53 and Bax mediated by oxidative stress in human hepatic cell line. Toxicology in vitro : an international journal published in association with BIBRA. vol 24. issue 3. 2010-06-22. PMID:20060462. |
nano-sio2 induces apoptosis via activation of p53 and bax mediated by oxidative stress in human hepatic cell line. |
2010-06-22 |
2023-08-12 |
human |
| Yiyi Ye, Jianwen Liu, Jianhe Xu, Lijuan Sun, Mingcang Chen, Minbo La. Nano-SiO2 induces apoptosis via activation of p53 and Bax mediated by oxidative stress in human hepatic cell line. Toxicology in vitro : an international journal published in association with BIBRA. vol 24. issue 3. 2010-06-22. PMID:20060462. |
furthermore, apoptosis related proteins such as p53, bax and bcl-2 were analyzed by using western blot analysis. |
2010-06-22 |
2023-08-12 |
human |
| Junye Liu, Jing Zhang, Xiaowu Wang, Yan Li, Yongbin Chen, Kangchu Li, Jian Zhang, Libo Yao, Guozhen Gu. HIF-1 and NDRG2 contribute to hypoxia-induced radioresistance of cervical cancer Hela cells. Experimental cell research. vol 316. issue 12. 2010-06-22. PMID:20206160. |
moreover, ndrg2 was proved to protect hela cells from radiation-induced apoptosis and abolish radiation-induced upregulation of bax. |
2010-06-22 |
2023-08-12 |
human |
| Robert W Nickell. Variations in the rheostat model of apoptosis: what studies of retinal ganglion cell death tell us about the functions of the Bcl2 family proteins. Experimental eye research. vol 91. issue 1. 2010-06-22. PMID:20230818. |
studies of the functions of members of the bcl2 gene family suggested that apoptosis was controlled by a rheostat in which anti-apoptotic proteins like bcl2 bound and sequestered pro-apoptotic proteins like bax. |
2010-06-22 |
2023-08-12 |
Not clear |
| Robert W Nickell. Variations in the rheostat model of apoptosis: what studies of retinal ganglion cell death tell us about the functions of the Bcl2 family proteins. Experimental eye research. vol 91. issue 1. 2010-06-22. PMID:20230818. |
studies of retinal ganglion cell apoptosis indicate that a threshold of bax expression is required for its successful activation, which is independent of the overall concentration of anti-apoptotic proteins in these cells. |
2010-06-22 |
2023-08-12 |
Not clear |
| Q L Zhang, Q Niu, P Y Niu, Y T Shi, C Y Liu, M Di Gioacchino, L Zhang, C Zhang, M Brag. Bax gene silencing: a potential intervention in aluminum-induced neural cell death. Journal of biological regulators and homeostatic agents. vol 24. issue 1. 2010-06-22. PMID:20385067. |
the optimal concentration of the transfection agent was 20 nm and the optimal incubation period was 72 h. the transfection and knockdown efficiencies were 95 percent and 62 percent, respectively, which closely correlated with bax protein expression and also the cell apoptosis intervention. |
2010-06-22 |
2023-08-12 |
Not clear |
| Q L Zhang, Q Niu, P Y Niu, Y T Shi, C Y Liu, M Di Gioacchino, L Zhang, C Zhang, M Brag. Bax gene silencing: a potential intervention in aluminum-induced neural cell death. Journal of biological regulators and homeostatic agents. vol 24. issue 1. 2010-06-22. PMID:20385067. |
taken together, bax is essential for apoptosis induced by aluminum. |
2010-06-22 |
2023-08-12 |
Not clear |
| Q L Zhang, Q Niu, P Y Niu, Y T Shi, C Y Liu, M Di Gioacchino, L Zhang, C Zhang, M Brag. Bax gene silencing: a potential intervention in aluminum-induced neural cell death. Journal of biological regulators and homeostatic agents. vol 24. issue 1. 2010-06-22. PMID:20385067. |
inactivation of the bax gene could be an effective strategy for delaying the onset of apoptosis induced by al. |
2010-06-22 |
2023-08-12 |
Not clear |
| Weiming Ouyang, Omar Beckett, Qian Ma, Ming O L. Transforming growth factor-beta signaling curbs thymic negative selection promoting regulatory T cell development. Immunity. vol 32. issue 5. 2010-06-21. PMID:20471291. |
enhanced apoptosis of tgf-beta receptor-deficient ntreg cells was associated with high expression of proapoptotic proteins bim, bax, and bak and low expression of the antiapoptotic protein bcl-2. |
2010-06-21 |
2023-08-12 |
mouse |
| Bin Zhang, Haiyun Wang, Bimei Jiang, Pengfei Liang, Meidong Liu, Gonghua Deng, Xianzhong Xia. Nucleolin/C23 is a negative regulator of hydrogen peroxide-induced apoptosis in HUVECs. Cell stress & chaperones. vol 15. issue 3. 2010-06-18. PMID:19757191. |
all these results indicate an important negative regulatory role for nucleolin in the apoptosis of endothelial cells, likely involving the bax pathway. |
2010-06-18 |
2023-08-12 |
human |
| Tetsuya Kurosu, Nan Wu, Gaku Oshikawa, Hiroyuki Kagechika, Osamu Miur. Enhancement of imatinib-induced apoptosis of BCR/ABL-expressing cells by nutlin-3 through synergistic activation of the mitochondrial apoptotic pathway. Apoptosis : an international journal on programmed cell death. vol 15. issue 5. 2010-06-18. PMID:20094798. |
nutlin-3 and imatinib synergistically induced bax activation, mitochondrial membrane depolarization, and caspase-3 cleavage leading to caspase-dependent apoptosis, which was inhibited by overexpression of bcl-xl. |
2010-06-18 |
2023-08-12 |
Not clear |
| Jia-Jun Liu, Yong Zhang, Wei-Bin Guang, Hong-Zhi Yang, Dong-Jun Lin, Ruo-Zhi Xia. Ponicidin inhibits monocytic leukemia cell growth by induction of apoptosis. International journal of molecular sciences. vol 9. issue 11. 2010-06-17. PMID:19330074. |
marked morphological changes of cell apoptosis were observed clearly after the cells were treated with ponicidin for 48 approximately 72 h. rt-pcr and western blot analysis demonstrated that both survivin and bcl-2 expressions were down-regulated remarkably while bax expression remained constant before and after apoptosis occurred. |
2010-06-17 |
2023-08-12 |
Not clear |
| B Liebelt, P Papapetrou, A Ali, M Guo, X Ji, C Peng, R Rogers, A Curry, D Jimenez, Y Din. Exercise preconditioning reduces neuronal apoptosis in stroke by up-regulating heat shock protein-70 (heat shock protein-72) and extracellular-signal-regulated-kinase 1/2. Neuroscience. vol 166. issue 4. 2010-06-17. PMID:20083167. |
we investigated the beneficial role of heat shock protein-70 (hsp-70) and phosphorylated extracellular-signal-regulated-kinase 1/2 (perk 1/2), as they pertain to reducing apoptosis and their influence on bcl-x(l), bax, and apoptosis-inducing factor (aif) in rats subjected to ischemia and reperfusion. |
2010-06-17 |
2023-08-12 |
rat |
| Damijan Nipic, Ales Pirc, Blaz Banic, Dusan Suput, Irina Milisa. Preapoptotic cell stress response of primary hepatocytes. Hepatology (Baltimore, Md.). vol 51. issue 6. 2010-06-17. PMID:20513000. |
we propose that the translocation of procaspase-9 and bax into the nuclei reduces the ability to trigger apoptosis through the intrinsic apoptotic pathway. |
2010-06-17 |
2023-08-12 |
Not clear |