| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Nobutaka Matsumura, Toru Tsuji, Takeshi Sumida, Masahito Kokubo, Michiko Onimaru, Nobuhide Doi, Hideaki Takashima, Etsuko Miyamoto-Sato, Hiroshi Yanagaw. mRNA display selection of a high-affinity, Bcl-X(L)-specific binding peptide. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 24. issue 7. 2010-08-03. PMID:20181936. |
bcl-x(l), an antiapoptotic member of the bcl-2 family, is a mitochondrial protein that inhibits activation of bax and bak, which commit the cell to apoptosis, and it therefore represents a potential target for drug discovery. |
2010-08-03 |
2023-08-12 |
Not clear |
| Stéphane Heitz, Nancy J Grant, Raphael Leschiera, Anne-Marie Haeberlé, Valérie Demais, Guy Bombarde, Yannick Baill. Autophagy and cell death of Purkinje cells overexpressing Doppel in Ngsk Prnp-deficient mice. Brain pathology (Zurich, Switzerland). vol 20. issue 1. 2010-07-30. PMID:19055638. |
np(0/0) pc death is partly prevented by either knocking-out the apoptotic factor bax or overexpressing the anti-apoptotic factor bcl-2 suggesting that apoptosis is involved in dpl-induced death. |
2010-07-30 |
2023-08-12 |
mouse |
| Fabio Ghiotto, Franco Fais, Claudya Tenca, Valeria Tomati, Fortunato Morabito, Salvatore Casciaro, Anna Mumot, Gabriele Zoppoli, Ermanno Ciccone, Silvio Parodi, Silvia Brun. Apoptosis of B-cell chronic lymphocytic leukemia cells induced by a novel BH3 peptidomimetic. Cancer biology & therapy. vol 8. issue 3. 2010-07-30. PMID:19164937. |
apoptosis was demonstrated by activation of bak and bax, externalization of plasma membranes phosphadydilserines, appearance of hypodiploid events in dna flow cytometry histograms and was accompanied by dissipation of the mitochondrial transmembrane potential. |
2010-07-30 |
2023-08-12 |
human |
| Hung-Li Wang, An-Hsun Chou, An-Chi Lin, Si-Ying Chen, Yi-Hshin Weng, Tu-Hsueh Ye. Polyglutamine-expanded ataxin-7 upregulates Bax expression by activating p53 in cerebellar and inferior olivary neurons. Experimental neurology. vol 224. issue 2. 2010-07-30. PMID:20546728. |
in response to various cellular stresses, transcription factor p53 promotes neuronal apoptosis by enhancing the transcription of proapoptotic genes including bax and puma. |
2010-07-30 |
2023-08-12 |
mouse |
| Qiao Niu, Lin-ping Wang, Yi-lan Chen, Hong-mei Zhan. [Relationship between apoptosis of rat hippocampus cells induced by aluminum and the copy of the bcl-2 as well as bax mRNA]. Wei sheng yan jiu = Journal of hygiene research. vol 34. issue 6. 2010-07-29. PMID:16535832. |
[relationship between apoptosis of rat hippocampus cells induced by aluminum and the copy of the bcl-2 as well as bax mrna]. |
2010-07-29 |
2023-08-12 |
rat |
| Qiao Niu, Lin-ping Wang, Yi-lan Chen, Hong-mei Zhan. [Relationship between apoptosis of rat hippocampus cells induced by aluminum and the copy of the bcl-2 as well as bax mRNA]. Wei sheng yan jiu = Journal of hygiene research. vol 34. issue 6. 2010-07-29. PMID:16535832. |
to explore the effects of aluminum chloride (alcl3) on the apoptosis of rat hippocampus cells and the relationship between the apoptosis and the expression of the bcl-2 as well as bax mrna. |
2010-07-29 |
2023-08-12 |
rat |
| Qin Hu, Ruile Pan, Liwei Wang, Bo Peng, Jingtian Tang, Xinmin Li. Platycodon grandiflorum induces apoptosis in SKOV3 human ovarian cancer cells through mitochondrial-dependent pathway. The American journal of Chinese medicine. vol 38. issue 2. 2010-07-29. PMID:20387232. |
our result showed that pge-induced apoptosis was associated with activation of caspase-3, -8 and -9, down-regulation of bcl-2, up-regulation of bax and release of mitochondrial cytochrome c to cytosol. |
2010-07-29 |
2023-08-12 |
human |
| Yan-Li Zhang, Yong-Jie Wan, Zi-Yu Wang, Wei-Wei Qi, Zheng-Rong Zhou, Rong Huang, Feng Wan. Cell cycle distribution, cellular viability and mRNA expression of hGCase-gene-transfected cells in dairy goat. Cell biology international. vol 34. issue 6. 2010-07-28. PMID:20192919. |
the expression of genes involved in imprinting [igf2 (insulin-like growth factor 2), igf2r (igf2 receptor)], apoptosis (bax), stress (heat-shock protein, hsp70.1), cellular connections [cx43 (connexin 43)] and dna methylation [dnmt1 (dna methyltransferase 1)] in transgenic fetal cells has been investigated. |
2010-07-28 |
2023-08-12 |
human |
| Roberta F Saldanha-Gama, João A Moraes, Andrea Mariano-Oliveira, Ana Lucia Coelho, Erin M Walsh, Cezary Marcinkiewicz, Christina Barja-Fidalg. alpha(9)beta(1) integrin engagement inhibits neutrophil spontaneous apoptosis: involvement of Bcl-2 family members. Biochimica et biophysica acta. vol 1803. issue 7. 2010-07-27. PMID:20362630. |
vlo5 also inhibited the early steps of neutrophil spontaneous apoptosis by preventing bax translocation to the outer mitochondrial membrane and consequent cytochrome c release. |
2010-07-27 |
2023-08-12 |
human |
| Manal Mohamed Elhassan Taha, Ahmad Bustamam Abdul, Rasedee Abdullah, Tengku Azmi Tengku Ibrahim, Siddig Ibrahim Abdelwahab, Syam Moha. Potential chemoprevention of diethylnitrosamine-initiated and 2-acetylaminofluorene-promoted hepatocarcinogenesis by zerumbone from the rhizomes of the subtropical ginger (Zingiber zerumbet). Chemico-biological interactions. vol 186. issue 3. 2010-07-27. PMID:20452335. |
zerumbone treatment had also increased bax and decreased bcl-2 protein expression in the livers of den/aaf rats, which suggested increased apoptosis. |
2010-07-27 |
2023-08-12 |
rat |
| Wei Wang, Dan Zhang, Hong Zhao, Ying Chen, Ying Liu, Cuiping Cao, Lingling Han, Guoliang Li. Ghrelin inhibits cell apoptosis induced by lipotoxicity in pancreatic beta-cell line. Regulatory peptides. vol 161. issue 1-3. 2010-07-26. PMID:20079380. |
ghrelin also inhibited the mitochondrial pathway of apoptosis and it down-regulated bax in min6 cells. |
2010-07-26 |
2023-08-12 |
Not clear |
| Junsheng Ye, Juan Li, Yuming Yu, Qiang Wei, Wenfeng Deng, Lixin Y. L-carnitine attenuates oxidant injury in HK-2 cells via ROS-mitochondria pathway. Regulatory peptides. vol 161. issue 1-3. 2010-07-26. PMID:20093144. |
furthermore, mitochondrial dysfunction associated with cell apoptosis including membrane potential loss, down-regulation of bcl-2 and up-regulation of bax and the release of cytochrome c were abrogated in the presence of l-carnitine. |
2010-07-26 |
2023-08-12 |
human |
| Isabelle Mader, Martin Wabitsch, Klaus-Michael Debatin, Pamela Fischer-Posovszky, Simone Fuld. Identification of a novel proapoptotic function of resveratrol in fat cells: SIRT1-independent sensitization to TRAIL-induced apoptosis. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 24. issue 6. 2010-07-21. PMID:20097879. |
mechanistic studies reveal that resveratrol inhibits pi3k-driven phosphorylation of akt, leading to increased bax activation, loss of mitochondrial membrane potential, cytochrome c release, and caspase-dependent apoptosis. |
2010-07-21 |
2023-08-12 |
human |
| F Farabegoli, A Papi, G Bartolini, R Ostan, M Orland. (-)-Epigallocatechin-3-gallate downregulates Pg-P and BCRP in a tamoxifen resistant MCF-7 cell line. Phytomedicine : international journal of phytotherapy and phytopharmacology. vol 17. issue 5. 2010-07-21. PMID:20149610. |
egcg treatment (10-100 microg/ml for 24-72 hours) caused cell growth inhibition and dose-dependent apoptosis: after 100 microg/ml egcg treatment for 24 hours, bax expression increased and bcl2 expression decreased (p<0.05). |
2010-07-21 |
2023-08-12 |
human |
| Jiwei Huang, Jun Gao, Xiang Lv, Guilin Li, Delong Hao, Xiaoying Yao, Liquan Zhou, Depei Liu, Renzhi Wan. Target gene therapy of glioma: overexpression of BAX gene under the control of both tissue-specific promoter and hypoxia-inducible element. Acta biochimica et biophysica Sinica. vol 42. issue 4. 2010-07-21. PMID:20383466. |
we constructed 4opthbs-msi1/gfap promoters and tested their ability to mediate bax expression to induce apoptosis in glioma cell lines. |
2010-07-21 |
2023-08-12 |
Not clear |
| Xiaoning Li, Navjotsingh Pabla, Qingqing Wei, Guie Dong, Robert O Messing, Cong-Yi Wang, Zheng Don. PKC-delta promotes renal tubular cell apoptosis associated with proteinuria. Journal of the American Society of Nephrology : JASN. vol 21. issue 7. 2010-07-21. PMID:20395372. |
in addition, bcl-2 transfection inhibited apoptosis and attenuated albumin-induced bax translocation to mitochondria and cytochrome c release from the organelles, further confirming a role for the intrinsic pathway of apoptosis in albuminuria-associated tubular apoptosis. |
2010-07-21 |
2023-08-12 |
mouse |
| Xiaoning Li, Navjotsingh Pabla, Qingqing Wei, Guie Dong, Robert O Messing, Cong-Yi Wang, Zheng Don. PKC-delta promotes renal tubular cell apoptosis associated with proteinuria. Journal of the American Society of Nephrology : JASN. vol 21. issue 7. 2010-07-21. PMID:20395372. |
rottlerin, a pharmacologic inhibitor of pkc-delta, suppressed albumin-induced bax translocation, cytochrome c release, and apoptosis. |
2010-07-21 |
2023-08-12 |
mouse |
| Stéphan Hardivillé, Esthelle Hoedt, Christophe Mariller, Monique Benaïssa, Annick Pierc. O-GlcNAcylation/phosphorylation cycling at Ser10 controls both transcriptional activity and stability of delta-lactoferrin. The Journal of biological chemistry. vol 285. issue 25. 2010-07-21. PMID:20404350. |
delta-lactoferrin (deltalf) is a transcription factor that up-regulates dcps, skp1, and bax genes, provoking cell cycle arrest and apoptosis. |
2010-07-21 |
2023-08-12 |
Not clear |
| Melissa R Dent, Paramjit S Tappia, Naranjan S Dhall. Gender differences in apoptotic signaling in heart failure due to volume overload. Apoptosis : an international journal on programmed cell death. vol 15. issue 4. 2010-07-19. PMID:20041302. |
these data suggest that downregulation of phospho-bcl-2 and an upregulation of bax may play a major role in cardiomyocyte apoptosis in heart failure due to volume overload in male rats. |
2010-07-19 |
2023-08-12 |
rat |
| Manikandan Subramanian, Chandrima Shah. Oestrogen modulates human macrophage apoptosis via differential signalling through oestrogen receptor-alpha and beta. Journal of cellular and molecular medicine. vol 13. issue 8B. 2010-07-19. PMID:20141615. |
intracellular alkalinization accompanied by concomitant bcl-2 increase and bax migration does not cause cellular apoptosis; however, sirna mediated down-regulation of er-alpha during e2 exposure leads to inhibition of bcl-2 increase and consequently apoptosis due to the unopposed action of mitochondrial bax. |
2010-07-19 |
2023-08-12 |
human |