| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| François Gonzalvez, Fabrizio Pariselli, Olivier Jalmar, Pauline Dupaigne, Franck Sureau, Marc Dellinger, Eric A Hendrickson, Sophie Bernard, Patrice X Peti. Mechanistic issues of the interaction of the hairpin-forming domain of tBid with mitochondrial cardiolipin. PloS one. vol 5. issue 2. 2010-09-30. PMID:20179769. |
the pro-apoptotic effector bid induces mitochondrial apoptosis in synergy with bax and bak. |
2010-09-30 |
2023-08-12 |
Not clear |
| Barkha P Patel, Adeel Safdar, Sandeep Raha, Mark A Tarnopolsky, Mazen J Hamade. Caloric restriction shortens lifespan through an increase in lipid peroxidation, inflammation and apoptosis in the G93A mouse, an animal model of ALS. PloS one. vol 5. issue 2. 2010-09-30. PMID:20195368. |
to investigate the long-term cr-induced pathology in g93a mice, we assessed the mitochondrial bioenergetic efficiency and oxidative capacity (cs--citrate synthase content and activity, cytochrome c oxidase--cox activity and protein content of cox subunit-i and iv and ucp3-uncoupling protein 3), oxidative damage (mda--malondialdehyde and pc--protein carbonyls), antioxidant enzyme capacity (mn-sod, cu/zn-sod and catalase), inflammation (tnf-alpha), stress response (hsp70) and markers of apoptosis (bax, bcl-2, caspase 9, cleaved caspase 9) in their skeletal muscle. |
2010-09-30 |
2023-08-12 |
mouse |
| Dong Xiao, Anna A Powolny, Michelle B Moura, Eric E Kelley, Ajay Bommareddy, Su-Hyeong Kim, Eun-Ryeong Hahm, Daniel Normolle, Bennett Van Houten, Shivendra V Sing. Phenethyl isothiocyanate inhibits oxidative phosphorylation to trigger reactive oxygen species-mediated death of human prostate cancer cells. The Journal of biological chemistry. vol 285. issue 34. 2010-09-30. PMID:20571029. |
furthermore, rna interference of bax and bak conferred significant protection against peitc-induced apoptosis. |
2010-09-30 |
2023-08-12 |
human |
| Xiaoming Li, Fang Han, Dongjuan Liu, Yuxiu Sh. Changes of Bax, Bcl-2 and apoptosis in hippocampus in the rat model of post-traumatic stress disorder. Neurological research. vol 32. issue 6. 2010-09-29. PMID:20092675. |
changes of bax, bcl-2 and apoptosis in hippocampus in the rat model of post-traumatic stress disorder. |
2010-09-29 |
2023-08-12 |
rat |
| Hongchi Jiang, Yong Ma, Xiaoning Chen, Shangha Pan, Bei Sun, Geoffrey W Krissansen, Xueying Su. Genistein synergizes with arsenic trioxide to suppress human hepatocellular carcinoma. Cancer science. vol 101. issue 4. 2010-09-29. PMID:20219070. |
cell viability, apoptosis, intracellular reactive oxygen species (ros), mitochondrial membrane potential (deltapsim), expression of bcl-2, bax, caspase-9, and -3, and release of cytochrome c into the cytosol were examined. |
2010-09-29 |
2023-08-12 |
mouse |
| Bodvaël Fraysse, Sadia M Nagi, Belinda Boher, Hélène Ragot, Jeanne Lainé, André Salmon, Marc Y Fiszman, Marcel Toussaint, Yves Frome. Ca2+ overload and mitochondrial permeability transition pore activation in living delta-sarcoglycan-deficient cardiomyocytes. American journal of physiology. Cell physiology. vol 299. issue 3. 2010-09-29. PMID:20592245. |
bax, bcl-2, and lc3 expression analysis by western blot indicated that the intrinsic apoptosis and the cell death associated to autophagy pathways were not significantly activated in chf147 hearts. |
2010-09-29 |
2023-08-12 |
Not clear |
| Guang-Hui Li, Hong Wei, Sheng-Qing Lv, Hua Ji, Dong-Lin Wan. Knockdown of STAT3 expression by RNAi suppresses growth and induces apoptosis and differentiation in glioblastoma stem cells. International journal of oncology. vol 37. issue 1. 2010-09-27. PMID:20514402. |
knockdown of stat3 induces apoptosis and reduces significantly expression of bcl-2 and cyclin-d in human primary gscs, whereas no significance was achieved in bax and caspase-3 expression. |
2010-09-27 |
2023-08-12 |
human |
| Alka Singh, Sushma Rathau. Combination of DEC plus aspirin induced mitochondrial mediated apoptosis in filarial parasite Setaria cervi. Biochimie. vol 92. issue 7. 2010-09-24. PMID:20362029. |
studies presented in this paper demonstrated that exposure of worms to the combination of dec plus aspirin (dec + a) at 100 microm concentration irreversibly paralyzed adult worms as well as microfilariae within 2 h. some of the apoptosis markers viz; dna fragmentation with accompanying ladder formation, upregulation of bax expression and decrease in bcl-2 have suggested that the parasite may be killed due to mitochondrial mediated apoptosis. |
2010-09-24 |
2023-08-12 |
human |
| Alka Singh, Sushma Rathau. Combination of DEC plus aspirin induced mitochondrial mediated apoptosis in filarial parasite Setaria cervi. Biochimie. vol 92. issue 7. 2010-09-24. PMID:20362029. |
no is known inducer of mitochondrial mediated apoptosis and acts by increasing the permeability of mitochondrial membrane through bax and allowing cytochrome c to release in cytosol, inducing caspases leading to apoptosis. |
2010-09-24 |
2023-08-12 |
human |
| Su Yeon Lee, Eui-Kyong Jeong, Hyun Min Jeon, Cho Hee Kim, Ho Sung Kan. Implication of necrosis-linked p53 aggregation in acquired apoptotic resistance to 5-FU in MCF-7 multicellular tumour spheroids. Oncology reports. vol 24. issue 1. 2010-09-23. PMID:20514446. |
5-fu (400 microm) induced apoptosis in mcf-7 cell monolayer as determined by ho/pi staining, parp cleavage, p53 induction, bax induction, and bcl-2 down-regulation. |
2010-09-23 |
2023-08-12 |
Not clear |
| Ali M Sharifi, Fotovat Eskandari Hoda, Amir Mozaffari Noo. Studying the effect of LPS on cytotoxicity and apoptosis in PC12 neuronal cells: role of Bax, Bcl-2, and Caspase-3 protein expression. Toxicology mechanisms and methods. vol 20. issue 6. 2010-09-17. PMID:20521854. |
studying the effect of lps on cytotoxicity and apoptosis in pc12 neuronal cells: role of bax, bcl-2, and caspase-3 protein expression. |
2010-09-17 |
2023-08-12 |
human |
| Ali M Sharifi, Fotovat Eskandari Hoda, Amir Mozaffari Noo. Studying the effect of LPS on cytotoxicity and apoptosis in PC12 neuronal cells: role of Bax, Bcl-2, and Caspase-3 protein expression. Toxicology mechanisms and methods. vol 20. issue 6. 2010-09-17. PMID:20521854. |
the purpose of this study was to investigate the cytotoxic effect of lps and also to examine the involvement of bax, pro-apoptotic, bcl-2, anti-apoptotic, and caspase-3, the executioner of apoptosis, protein expression, during lps-induced apoptosis in neuronal pc12 cells. |
2010-09-17 |
2023-08-12 |
human |
| Ali M Sharifi, Fotovat Eskandari Hoda, Amir Mozaffari Noo. Studying the effect of LPS on cytotoxicity and apoptosis in PC12 neuronal cells: role of Bax, Bcl-2, and Caspase-3 protein expression. Toxicology mechanisms and methods. vol 20. issue 6. 2010-09-17. PMID:20521854. |
from the present results, it might be concluded that lps can cause pc12 cell death, in which apoptosis plays an important role, possibly by the mitochondrial pathway through higher expression of the bax as well as caspase 3 protein. |
2010-09-17 |
2023-08-12 |
human |
| Sahdeo Prasad, Vivek R Yadav, Chitra Sundaram, Simone Reuter, Padmanabhan S Hema, Mangalam S Nair, Madan M Chaturvedi, Bharat B Aggarwa. Crotepoxide chemosensitizes tumor cells through inhibition of expression of proliferation, invasion, and angiogenic proteins linked to proinflammatory pathway. The Journal of biological chemistry. vol 285. issue 35. 2010-09-17. PMID:20576605. |
we found that crotepoxide potentiated tumor necrosis factor (tnf), and chemotherapeutic agents induced apoptosis and inhibited the expression of nf-kappab-regulated gene products involved in anti-apoptosis (bcl-2, bcl-xl, iap1,(2) mcl-1, survivin, and traf1), apoptosis (bax, bid), inflammation (cox-2), proliferation (cyclin d1 and c-myc), invasion (icam-1 and mmp-9), and angiogenesis (vegf). |
2010-09-17 |
2023-08-12 |
human |
| Jing Lin, Qingyuan Yang, Paul T Wilder, France Carrier, David J Webe. The calcium-binding protein S100B down-regulates p53 and apoptosis in malignant melanoma. The Journal of biological chemistry. vol 285. issue 35. 2010-09-17. PMID:20587415. |
sirna(s100b)-mediated apoptosis was independent of the mitochondria, because no changes were observed in mitochondrial membrane potential, cytochrome c release, caspase 9 activation, or ratios of pro- and anti-apoptotic proteins (bax, bcl-2, and bcl-x(l)). |
2010-09-17 |
2023-08-12 |
Not clear |
| Kris Nys, An Van Laethem, Carine Michiels, Noemi Rubio, Jacques G Piette, Maria Garmyn, Patrizia Agostini. A p38(MAPK)/HIF-1 pathway initiated by UVB irradiation is required to induce Noxa and apoptosis of human keratinocytes. The Journal of investigative dermatology. vol 130. issue 9. 2010-09-16. PMID:20393480. |
previously, we reported that in uvb-irradiated keratinocytes, p38(mapk) instigates bcl-2-associated x protein (bax) activation and mitochondrial apoptosis. |
2010-09-16 |
2023-08-12 |
human |
| Xiaoguang Cao, Xiaoxin Li, Jianxin Hu, Yongzhen Ba. Hydrogen peroxide-induced cellular apoptosis is mediated by TGF-beta2 signaling pathway in cultured human lens epithelial cells. International ophthalmology. vol 30. issue 3. 2010-09-15. PMID:19444386. |
hydrogen peroxide induced the accumulation of smad-4 in the nucleus of hlecs, and upregulated the expression of tgf-beta receptors (tbetars) mrna in hlecs, as well as upregulated the expression of the apoptotic gene bax, which leads hlecs to apoptosis. |
2010-09-15 |
2023-08-12 |
human |
| Chad M Kerksick, Richard B Kreider, Darryn S Willoughb. Intramuscular adaptations to eccentric exercise and antioxidant supplementation. Amino acids. vol 39. issue 1. 2010-09-14. PMID:19967420. |
markers of intramuscular mitochondrial and cytosolic apoptosis were assessed (e.g., bax, bcl-2, cytochrome c, caspase-3 content/enzyme activity, and total dna content). |
2010-09-14 |
2023-08-12 |
human |
| Vijay S Thakur, A R M Ruhul Amin, Rajib K Paul, Kalpana Gupta, Kedar Hastak, Mukesh K Agarwal, Mark W Jackson, David N Wald, Hasan Mukhtar, Munna L Agarwa. p53-Dependent p21-mediated growth arrest pre-empts and protects HCT116 cells from PUMA-mediated apoptosis induced by EGCG. Cancer letters. vol 296. issue 2. 2010-09-13. PMID:20444544. |
furthermore, we find that p53-dependent activation of puma in response to egcg directly leads to apoptosis with out requiring bax as is the case in response to agents that induce dna damage. |
2010-09-13 |
2023-08-12 |
Not clear |
| Stine M Andersen, Cecilia Rosada, Frederik Dagnaes-Hansen, Ina G Laugesen, Elisabeth de Darkó, Tomas N Dam, Karin Stenderu. Topical application of valrubicin has a beneficial effect on developing skin tumors. Carcinogenesis. vol 31. issue 8. 2010-09-13. PMID:20554745. |
cell viability was assessed by adenosine triphosphate presence, proliferation as proliferative cell nuclear antigen expression and apoptosis as cytokeratin 18 cleavage, caspase activation, poly-adenosine diphosphate-ribose-polymerase cleavage and bax and bcl-2 regulation. |
2010-09-13 |
2023-08-12 |
mouse |