| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Michelle Yan, Karin Hardin, Emily H. Differential response to zinc-induced apoptosis in benign prostate hyperplasia and prostate cancer cells. The Journal of nutritional biochemistry. vol 21. issue 8. 2010-12-02. PMID:19576751. |
apoptosis was assessed by phosphatidylserine externalization, caspase activation and protein expression of b-cell cll/lymphoma 2 (bcl-2)-associated x protein (bax):bcl-2. |
2010-12-02 |
2023-08-12 |
Not clear |
| Daniel R Premkumar, Esther P Jane, Ian F Pollac. Co-administration of NVP-AEW541 and dasatinib induces mitochondrial-mediated apoptosis through Bax activation in malignant human glioma cell lines. International journal of oncology. vol 37. issue 3. 2010-11-30. PMID:20664932. |
co-administration of nvp-aew541 and dasatinib induces mitochondrial-mediated apoptosis through bax activation in malignant human glioma cell lines. |
2010-11-30 |
2023-08-12 |
human |
| Daniel R Premkumar, Esther P Jane, Ian F Pollac. Co-administration of NVP-AEW541 and dasatinib induces mitochondrial-mediated apoptosis through Bax activation in malignant human glioma cell lines. International journal of oncology. vol 37. issue 3. 2010-11-30. PMID:20664932. |
our data indicate that activation of bax plays a critical role in mediating nvp-aew541 and dasatinib-induced apoptosis, and suggest the potential value of combining igfr inhibition with other classes of tyrosine kinase inhibitors to potentiate therapeutic efficacy. |
2010-11-30 |
2023-08-12 |
human |
| N Ozaki, K A Matheis, M Gamber, T Feidl, T Nolte, A Kalkuhl, U Desch. Identification of genes involved in gentamicin-induced nephrotoxicity in rats--a toxicogenomic investigation. Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie. vol 62. issue 5. 2010-11-29. PMID:19664912. |
renal cell apoptosis was indicated by up-regulated genes as tp53 and bax. |
2010-11-29 |
2023-08-12 |
rat |
| Ning Zhang, Xiaoli Kong, Shi Yan, Cunzhong Yuan, Qifeng Yan. Huaier aqueous extract inhibits proliferation of breast cancer cells by inducing apoptosis. Cancer science. vol 101. issue 11. 2010-11-29. PMID:20718753. |
decreased mitochondrial membrane potential by rhodamine 123 assay and down-regulation of bcl-2 and up-regulation of bcl2-associated x protein (bax) indicated that huaier induced apoptosis through the mitochondrial pathway. |
2010-11-29 |
2023-08-12 |
Not clear |
| Xing-Ding Zhang, Ye Wang, Yan Wang, Xuan Zhang, Rong Han, Jun-Chao Wu, Zhong-Qin Liang, Zhen-Lun Gu, Feng Han, Kohji Fukunaga, Zheng-Hong Qi. p53 mediates mitochondria dysfunction-triggered autophagy activation and cell death in rat striatum. Autophagy. vol 5. issue 3. 2010-11-26. PMID:19305162. |
3-np upregulated the expression of tumor suppressor protein 53 (p53) and its target genes including bax, p53-upregulated modulator of apoptosis (puma) and damage-regulated autophagy modulator (dram). |
2010-11-26 |
2023-08-12 |
rat |
| Yun-Chih Hsieh, Yerra Koteswara Rao, Chun-Chi Wu, Chi-Ying F Huang, Madamanchi Geethangili, Shih-Lan Hsu, Yew-Min Tzen. Methyl antcinate A from Antrodia camphorata induces apoptosis in human liver cancer cells through oxidant-mediated cofilin- and Bax-triggered mitochondrial pathway. Chemical research in toxicology. vol 23. issue 7. 2010-11-26. PMID:20557081. |
additionally, pretreatment of huh7 cells with antioxidants ascorbic acid and n-acetyl cysteine markedly attenuated the maa-induced apoptosis by upregulation of bax, bak, and puma, mitochondrial translocation of cofilin, activation of caspase-3, and cell death. |
2010-11-26 |
2023-08-12 |
human |
| Juni Chakraborty, Shuvomoy Banerjee, Pallab Ray, Dewan Md Sakib Hossain, Sankar Bhattacharyya, Arghya Adhikary, Sreya Chattopadhyay, Tanya Das, Gaurisankar S. Gain of cellular adaptation due to prolonged p53 impairment leads to functional switchover from p53 to p73 during DNA damage in acute myeloid leukemia cells. The Journal of biological chemistry. vol 285. issue 43. 2010-11-24. PMID:20675383. |
we adopted multiple experimental approaches to demonstrate that in p53-impaired cancer cells, dna damage caused accumulation of p53 paralogue p73 via chk-1 that strongly impacted bax expression and p53-independent apoptosis. |
2010-11-24 |
2023-08-12 |
Not clear |
| Irene Paterniti, Maria Galuppo, Emanuela Mazzon, Daniela Impellizzeri, Emanuela Esposito, Placido Bramanti, Salvatore Cuzzocre. Protective effects of apocynin, an inhibitor of NADPH oxidase activity, in splanchnic artery occlusion and reperfusion. Journal of leukocyte biology. vol 88. issue 5. 2010-11-24. PMID:20807703. |
10% dmso) 5 min before reperfusion significantly reduced the (1) histological evidence of tissue injury, (2) proinflammatory cytokine production (tnf-α, il-1β), (3) adhesion molecules (icam-1, p-selectin), (4) nitrotyrosine formation, (5) nf-κb expression, and (6) apoptosis (bax, bcl-2, fas-l, and tunel). |
2010-11-24 |
2023-08-12 |
rat |
| Feng-Hua Wu, Ye Yuan, Dong Li, Zhang Lei, Chuan-Wang Song, Yan-Yan Liu, Bo Li, Bo Huang, Zuo-Hua Feng, Gui-Mei Zhan. Endothelial cell-expressed Tim-3 facilitates metastasis of melanoma cells by activating the NF-kappaB pathway. Oncology reports. vol 24. issue 3. 2010-11-23. PMID:20664975. |
the activated nf-kappab not only promoted the proliferation of b16 cells, but also enhanced apoptosis resistance of b16 cells by up-regulating bcl-2 and bcl-xl and down-regulating bax. |
2010-11-23 |
2023-08-12 |
Not clear |
| Jung-Chen Su, Kuei-Li Lin, Ching-Ming Chien, Pei-Wen Chuang, Long-Sen Chang, Shinne-Ren Li. Concomitant inactivation of the epidermal growth factor receptor, phosphatidylinositol 3-kinase/Akt and Janus tyrosine kinase 2/signal transducer and activator of transcription 3 signalling pathways in cardiotoxin III-treated A549 cells. Clinical and experimental pharmacology & physiology. vol 37. issue 8. 2010-11-22. PMID:20456425. |
these actions were correlated with upregulation of bax and bad and downregulation of various anti-apoptotic proteins, including bcl-2, bcl-x(l), mcl-1, x-linked inhibitor of apoptosis protein (xiap) and p-bad in ctx iii-treated cells. |
2010-11-22 |
2023-08-12 |
human |
| Stella Pesakhov, Marina Khanin, George P Studzinski, Michael Danilenk. Distinct combinatorial effects of the plant polyphenols curcumin, carnosic acid, and silibinin on proliferation and apoptosis in acute myeloid leukemia cells. Nutrition and cancer. vol 62. issue 6. 2010-11-22. PMID:20661831. |
early stage of curcumin/carnosic acid-induced apoptosis was associated with cleavage (activation) of caspase-8, caspase-9, and caspase-3 and the proapoptotic protein bid, but not with oxidative stress or altered levels of other bcl-2 family proteins (bcl-2, bcl-xl, mcl-1, bax, and bak). |
2010-11-22 |
2023-08-12 |
human |
| b' Ljiljana Markovi\\xc4\\x87, Jasna Todorovi\\xc4\\x87, Gordana Stankovi\\xc4\\x87, Sanja Radojevi\\xc4\\x87, Eleonora Gvozdenovi\\xc4\\x87, Jelena Aritonovi\\xc4\\x87, Nada Stupar, Gordana Vojinovi\\xc4\\x87 Magli\\xc4\\x8. Expression of Bcl-2 and Bax proteins in thyroid glands of rats in experimental thyroiditis. Folia biologica. vol 58. issue 3-4. 2010-11-16. PMID:20968180.' |
these data suggest that the increased expression of bax may contribute to the role of apoptosis in the pathogenesis of experimental thyroiditis. |
2010-11-16 |
2023-08-12 |
rat |
| Kinnosuke Yahiro, Naoko Morinaga, Joel Moss, Masatoshi Nod. Subtilase cytotoxin induces apoptosis in HeLa cells by mitochondrial permeabilization via activation of Bax/Bak, independent of C/EBF-homologue protein (CHOP), Ire1alpha or JNK signaling. Microbial pathogenesis. vol 49. issue 4. 2010-11-12. PMID:20561923. |
silencing using sirna of both bax and bak genes, but not bax, bak, or bim alone, resulted in reduction of cytochrome c release, caspase-3 activation, dna ladder formation and cytotoxicity, indicating that bax and bak were involved in apoptosis. |
2010-11-12 |
2023-08-12 |
Not clear |
| Hyo-Soon Jeong, Jung-Hyun Kim, Hye Yeon Choi, Eung-Ryoung Lee, Ssang-Goo Ch. Induction of cell growth arrest and apoptotic cell death in human breast cancer MCF-7 cells by the COX-1 inhibitor FR122047. Oncology reports. vol 24. issue 2. 2010-11-10. PMID:20596620. |
upon fr122047 treatment, there were apparent increases in the ratio of bax to bcl-2, mitochondrial cytochrome c release, and apoptosis in mcf-7 cells. |
2010-11-10 |
2023-08-12 |
human |
| Paola Palozza, Maria Colangelo, Rossella Simone, Assunta Catalano, Alma Boninsegna, Paola Lanza, Giovanni Monego, Franco O Ranellett. Lycopene induces cell growth inhibition by altering mevalonate pathway and Ras signaling in cancer cell lines. Carcinogenesis. vol 31. issue 10. 2010-11-10. PMID:20699249. |
these effects were also accompanied by an arrest of cell cycle progression and by apoptosis induction, as evidenced by a decrease in cyclin d1 and phospho-akt levels and by an increase in p21, p27 and p53 levels and in bax:bcl-2 ratio. |
2010-11-10 |
2023-08-12 |
Not clear |
| Chyi Lo, Tung-Yuan Lai, Jen-Hung Yang, Jai-Sing Yang, Yi-Shih Ma, Shu-Wen Weng, Ya-Yin Chen, Jaung-Geng Lin, Jing-Gung Chun. Gallic acid induces apoptosis in A375.S2 human melanoma cells through caspase-dependent and -independent pathways. International journal of oncology. vol 37. issue 2. 2010-11-09. PMID:20596665. |
observation of the molecular mechanism of apoptosis in a375.s2 cells showed that ga up-regulated the proapoptotic proteins such as bax, and induced caspase cascade activity, but down-regulated antiapoptotic proteins such as bcl-2. |
2010-11-09 |
2023-08-12 |
human |
| Weiping Yu, Richa Tiwary, Jing Li, Sook-Kyung Park, Li Jia, Ailian Xiong, Marla Simmons-Menchaca, Bob G Sanders, Kimberly Klin. α-TEA induces apoptosis of human breast cancer cells via activation of TRAIL/DR5 death receptor pathway. Molecular carcinogenesis. vol 49. issue 11. 2010-11-09. PMID:20886583. |
dr5/trail induced apoptosis involves downregulation of c-flip (l), caspase-8 activation, activated proapoptotic mediators tbid and bax, mitochondrial permeability transition, and activation of caspase-9. |
2010-11-09 |
2023-08-12 |
human |
| Lan V Pham, Archito T Tamayo, Changping Li, William Bornmann, Waldemar Priebe, Richard J For. Degrasyn potentiates the antitumor effects of bortezomib in mantle cell lymphoma cells in vitro and in vivo: therapeutic implications. Molecular cancer therapeutics. vol 9. issue 7. 2010-11-04. PMID:20606045. |
the apoptosis in these cells was correlated with the downregulation of constitutive nf-kappab and phosphorylated stat3 activation, leading to the inhibition of c-myc, cyclin d1, and bcl-2 protein expression and the upregulation of bax protein expression. |
2010-11-04 |
2023-08-12 |
mouse |
| Bunliang Suphim, Auemduan Prawan, Upa Kukongviriyapan, Sarinya Kongpetch, Benjaporn Buranrat, Veerapol Kukongviriyapa. Redox modulation and human bile duct cancer inhibition by curcumin. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. vol 48. issue 8-9. 2010-11-03. PMID:20510329. |
up-regulation of p53 and bax was associated with marked oxidative stress and apoptosis. |
2010-11-03 |
2023-08-12 |
human |