| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Chong-Feng Bai, Jin-Cheng Liu, Rong Zhao, Wei Cao, Shui-Bin Liu, Xiao-Nan Zhang, Hong-Ju Guo, Qi Yang, Ding-Hua Yi, Ming-Gao Zha. Role of 5-HT 2B receptors in cardiomyocyte apoptosis in noradrenaline-induced cardiomyopathy in rats. Clinical and experimental pharmacology & physiology. vol 37. issue 7. 2010-11-02. PMID:20374255. |
in addition, sb 204741 notably attenuated myocardial apoptosis, as evidenced by downregulation of bax and caspase 3 (p < 0.05) and upregulation of the anti-apoptotic bcl-2 protein (p < 0.05). |
2010-11-02 |
2023-08-12 |
rat |
| Benoît Busser, Lucie Sancey, Véronique Josserand, Carole Niang, Marie C Favrot, Jean-Luc Coll, Amandine Hurbi. Amphiregulin promotes BAX inhibition and resistance to gefitinib in non-small-cell lung cancers. Molecular therapy : the journal of the American Society of Gene Therapy. vol 18. issue 3. 2010-10-29. PMID:19826406. |
thus, in the presence of areg, gefitinib-mediated apoptosis is reduced because bax is sequestered in the cytoplasm. |
2010-10-29 |
2023-08-12 |
Not clear |
| Benoît Busser, Lucie Sancey, Véronique Josserand, Carole Niang, Saadi Khochbin, Marie C Favrot, Jean-Luc Coll, Amandine Hurbi. Amphiregulin promotes resistance to gefitinib in nonsmall cell lung cancer cells by regulating Ku70 acetylation. Molecular therapy : the journal of the American Society of Gene Therapy. vol 18. issue 3. 2010-10-29. PMID:19826407. |
we previously demonstrated that amphiregulin (areg) inhibits gefitinib-induced apoptosis in nsclc cells by inactivating the proapoptotic protein bax. |
2010-10-29 |
2023-08-12 |
Not clear |
| Benoît Busser, Lucie Sancey, Véronique Josserand, Carole Niang, Saadi Khochbin, Marie C Favrot, Jean-Luc Coll, Amandine Hurbi. Amphiregulin promotes resistance to gefitinib in nonsmall cell lung cancer cells by regulating Ku70 acetylation. Molecular therapy : the journal of the American Society of Gene Therapy. vol 18. issue 3. 2010-10-29. PMID:19826407. |
accordingly, areg or ku70 knock down restore bax activation and apoptosis in gefitinib-treated h358 cells in vitro. |
2010-10-29 |
2023-08-12 |
Not clear |
| Masahiro Yoshikawa, Keiichi Hishikawa, Mana Idei, Toshiro Fujit. Trichostatin a prevents TGF-beta1-induced apoptosis by inhibiting ERK activation in human renal tubular epithelial cells. European journal of pharmacology. vol 642. issue 1-3. 2010-10-28. PMID:20553909. |
tgf-beta1-induced apoptosis via the activation of both caspase-8 and caspase-9 but did not activate the fas receptor and did not alter bcl-2 or bax protein expression. |
2010-10-28 |
2023-08-12 |
human |
| Lu Yang, Xiaozhuo Liu, Zengbing Lu, Judy Yuet-Wa Chan, Linli Zhou, Kwok-Pui Fung, Ping Wu, Shihua W. Ursolic acid induces doxorubicin-resistant HepG2 cell death via the release of apoptosis-inducing factor. Cancer letters. vol 298. issue 1. 2010-10-28. PMID:20630652. |
ua could activate bak but not bax, which implied that bak may play an important role in ua-induced apoptosis. |
2010-10-28 |
2023-08-12 |
mouse |
| Marcel Benadiba, Renata Rolim Prudente Dos Santos, Denise de Oliveira Silva, Alison Colquhou. Inhibition of C6 rat glioma proliferation by [Ru2Cl(Ibp)4] depends on changes in p21, p27, Bax/Bcl2 ratio and mitochondrial membrane potential. Journal of inorganic biochemistry. vol 104. issue 9. 2010-10-27. PMID:20605638. |
the marked decrease in mitochondrial membrane potential (p<0.01) and modest increase in apoptosis was accompanied by a decrease in anti-apoptotic bcl2 expression and an increase in pro-apoptotic bax expression (p<0.05). |
2010-10-27 |
2023-08-12 |
human |
| F Zhu, P Wang, A Kontrogianni-Konstantopoulos, K Konstantopoulo. Prostaglandin (PG)D(2) and 15-deoxy-Delta(12,14)-PGJ(2), but not PGE(2), mediate shear-induced chondrocyte apoptosis via protein kinase A-dependent regulation of polo-like kinases. Cell death and differentiation. vol 17. issue 8. 2010-10-26. PMID:20150912. |
plks target p53, which controls the transcription of p53 effectors (tp53inps, fas and bax) involved in chondrocyte apoptosis. |
2010-10-26 |
2023-08-12 |
human |
| Lin Jiang, Florent Allagnat, Evrard Nguidjoe, Adama Kamagate, Nathalie Pachera, Jean-Marie Vanderwinden, Marisa Brini, Ernesto Carafoli, Décio L Eizirik, Alessandra K Cardozo, André Herchuel. Plasma membrane Ca2+-ATPase overexpression depletes both mitochondrial and endoplasmic reticulum Ca2+ stores and triggers apoptosis in insulin-secreting BRIN-BD11 cells. The Journal of biological chemistry. vol 285. issue 40. 2010-10-26. PMID:20660595. |
this was followed by bax translocation to the mitochondria with subsequent cytochrome c release, opening of the permeability transition pore, and apoptosis. |
2010-10-26 |
2023-08-12 |
Not clear |
| Jiang Zhu, Lei Zhang, Xiaoming Jin, Xinying Han, Chuanhui Sun, Jinglong Ya. beta-Ionone-induced apoptosis in human osteosarcoma (U2os) cells occurs via a p53-dependent signaling pathway. Molecular biology reports. vol 37. issue 6. 2010-10-25. PMID:19757179. |
in addition, beta-ionone upregulated bax protein and downregulated bcl2 protein which led to bax translocation and cytochrome c release, subsequently activated caspase 3, thus resulting in apoptosis. |
2010-10-25 |
2023-08-12 |
human |
| Jia-Jun Liu, Wen-Da Liu, Hong-Zhi Yang, Yong Zhang, Zhi-Gang Fang, Pei-Qing Liu, Dong-Jun Lin, Ruo-Zhi Xiao, Yuan Hu, Chun-Zhi Wang, Xu-Dong Li, Yi He, Ren-Wei Huan. Inactivation of PI3k/Akt signaling pathway and activation of caspase-3 are involved in tanshinone I-induced apoptosis in myeloid leukemia cells in vitro. Annals of hematology. vol 89. issue 11. 2010-10-25. PMID:20512574. |
tan i-induced apoptosis was accompanied by a significant decrease in survivin and an increase in bax. |
2010-10-25 |
2023-08-12 |
human |
| Jia-Jun Liu, Wen-Da Liu, Hong-Zhi Yang, Yong Zhang, Zhi-Gang Fang, Pei-Qing Liu, Dong-Jun Lin, Ruo-Zhi Xiao, Yuan Hu, Chun-Zhi Wang, Xu-Dong Li, Yi He, Ren-Wei Huan. Inactivation of PI3k/Akt signaling pathway and activation of caspase-3 are involved in tanshinone I-induced apoptosis in myeloid leukemia cells in vitro. Annals of hematology. vol 89. issue 11. 2010-10-25. PMID:20512574. |
we therefore conclude that the induction of apoptosis by tan i in these leukemia cells is mainly related to the disruption of Δψm, the upregulation of bax expression, and the activation of caspase-3. |
2010-10-25 |
2023-08-12 |
human |
| Thomas Decker, Christian Bogner, Madlen Oelsner, Christian Peschel, Ingo Ringshause. Antiapoptotic effect of interleukin-2 (IL-2) in B-CLL cells with low and high affinity IL-2 receptors. Annals of hematology. vol 89. issue 11. 2010-10-25. PMID:20544350. |
while only limited regulation of apoptosis controlling proteins was observed in resting b-cll cells, il-2 had strong effects on mcl-1, bcl-xl, and survivin expression and inhibited bax cleavage in cd25 high cells. |
2010-10-25 |
2023-08-12 |
Not clear |
| Yolanda Sánchez, Gloria P Simón, Eva Calviño, Elena de Blas, Patricio Alle. Curcumin stimulates reactive oxygen species production and potentiates apoptosis induction by the antitumor drugs arsenic trioxide and lonidamine in human myeloid leukemia cell lines. The Journal of pharmacology and experimental therapeutics. vol 335. issue 1. 2010-10-21. PMID:20605902. |
curcumin plus ato or lonidamine stimulates typical events of the mitochondrial executioner pathway (bax and bid activation, cytochrome c release, x-linked inhibitor of apoptosis down-regulation, and caspase-9/-3 activation) and causes mitochondrial transmembrane potential dissipation, which nevertheless represents a late event in the apoptotic response. |
2010-10-21 |
2023-08-12 |
human |
| Ying-Ying Lu, Tong-Sheng Chen, Xiao-Ping Wang, Jun-Le Qu, Min Che. The JNK inhibitor SP600125 enhances dihydroartemisinin-induced apoptosis by accelerating Bax translocation into mitochondria in human lung adenocarcinoma cells. FEBS letters. vol 584. issue 18. 2010-10-21. PMID:20709060. |
the jnk inhibitor sp600125 enhances dihydroartemisinin-induced apoptosis by accelerating bax translocation into mitochondria in human lung adenocarcinoma cells. |
2010-10-21 |
2023-08-12 |
human |
| Ying-Ying Lu, Tong-Sheng Chen, Xiao-Ping Wang, Jun-Le Qu, Min Che. The JNK inhibitor SP600125 enhances dihydroartemisinin-induced apoptosis by accelerating Bax translocation into mitochondria in human lung adenocarcinoma cells. FEBS letters. vol 584. issue 18. 2010-10-21. PMID:20709060. |
the c-jun n-terminal kinase (jnk) inhibitor sp600125 is widely used to inhibit the jnk-mediated bax activation and cell apoptosis. |
2010-10-21 |
2023-08-12 |
human |
| Ying-Ying Lu, Tong-Sheng Chen, Xiao-Ping Wang, Jun-Le Qu, Min Che. The JNK inhibitor SP600125 enhances dihydroartemisinin-induced apoptosis by accelerating Bax translocation into mitochondria in human lung adenocarcinoma cells. FEBS letters. vol 584. issue 18. 2010-10-21. PMID:20709060. |
however, this report demonstrates that sp600125 synergistically enhances the dihydroartemisinin (dha)-induced human lung adenocarcinoma cell apoptosis by accelerating bax translocation and subsequent intrinsic apoptotic pathway involving mitochondrial membrane depolarization, cytochrome c release, caspase-9 and caspase-3 activation. |
2010-10-21 |
2023-08-12 |
human |
| Ming-Jyh Sheu, Pei-Yu Chou, Chin-Shiu Huang, I-Chun Tsai, Yi-Chung Chien, Sung-Yuan Lin, Huei-Yann Tsai, Hsu-Chen Cheng, Chieh-Hsi W. Pipoxolan inhibits proliferation of HL-60 human leukaemia cancer cells by arresting the cell cycle at the G0/G1 phase. Clinical and experimental pharmacology & physiology. vol 37. issue 5-6. 2010-10-20. PMID:20082627. |
the expression of factors affecting the cell cycle and apoptosis, including p53, p21, bax, bcl2, cytochrome c, caspase 3 and caspase 9, was examined by western blotting. |
2010-10-20 |
2023-08-12 |
human |
| Hua-Pei Song, Lei Zhang, Yong-Ming Dang, Hong Yan, Zhi-Gang Chu, Yue-Sheng Huan. The phosphatidylinositol 3-kinase-Akt pathway protects cardiomyocytes from ischaemic and hypoxic apoptosis via mitochondrial function. Clinical and experimental pharmacology & physiology. vol 37. issue 5-6. 2010-10-20. PMID:20082630. |
cardiomyocytes cultured under hypoxic conditions exhibited increased apoptosis, decreased cell viability, enhanced caspase 3 activity, a decreased mitochondrial membrane potential, increased cytoplasmic calcium transients and increased p53 and bax mrna expression. |
2010-10-20 |
2023-08-12 |
rat |
| Yuan-Yuan Liu, Zhen-Jue She, Ming-Hui Ya. Erythropoietin inhibits gamma-irradiation-induced apoptosis by upregulation of Bcl-2 and decreasing the activation of caspase 3 in human UT-7/erythropoietin cell line. Clinical and experimental pharmacology & physiology. vol 37. issue 5-6. 2010-10-20. PMID:20132233. |
the cell viability, cell apoptosis and the expression of apoptosis-related proteins bcl-2, bax and caspase 3 were examined. |
2010-10-20 |
2023-08-12 |
human |