| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jisheng Liu, Weihua Sheng, Yufeng Xie, Yunbo Shan, Jingcheng Miao, Jim Xiang, Jicheng Yan. The in vitro and in vivo antitumor activity of adenovirus-mediated interleukin-24 expression for laryngocarcinoma. Cancer biotherapy & radiopharmaceuticals. vol 25. issue 1. 2010-10-18. PMID:20187794. |
we demonstrated that ad-il-24 induced significant growth inhibition and apoptosis, upregulated the expression of p21, p27, and bax, downregulated bcl-2 expression, and activated caspase-3 in hep-2 laryngeal tumor cells, while it exerted no direct effect on the in vitro proliferation of wi-38 normal diploid cells. |
2010-10-18 |
2023-08-12 |
mouse |
| Jiru Chu, Shengnan Wu, Da Xin. Survivin mediates self-protection through ROS/cdc25c/CDK1 signaling pathway during tumor cell apoptosis induced by high fluence low-power laser irradiation. Cancer letters. vol 297. issue 2. 2010-10-15. PMID:20579806. |
in addition, activated survivin delays mitochondrial depolarization, cytochrome c release, caspase-9 and bax activation, all of which are typical pro-apoptotic events of cell apoptosis induced by hf-lpli. |
2010-10-15 |
2023-08-12 |
human |
| Connie J Kim, Jennifer A Kovacs-Nolan, Chengbo Yang, Tania Archbold, Ming Z Fan, Yoshinori Min. l-Tryptophan exhibits therapeutic function in a porcine model of dextran sodium sulfate (DSS)-induced colitis. The Journal of nutritional biochemistry. vol 21. issue 6. 2010-10-12. PMID:19428234. |
moreover, tryptophan reduced the expression of the pro-inflammatory cytokines tumor necrosis factor-alpha, interleukin (il)-6, interferon (ifn)-gamma, il-12p40, il-1beta and il-17, as well as il-8 and intracellular adhesion molecule-1, and resulted in increased expression of apoptosis initiators caspase-8 and bax. |
2010-10-12 |
2023-08-12 |
Not clear |
| Yanfeng Liu, Changqi Zhao, Hongxing Li, Miao Yu, Jiali Gao, Lei Wang, Yonggong Zha. Cytotoxicity and apoptosis induced by a new podophyllotoxin glucoside in human hepatoma (HepG2) cells. Canadian journal of physiology and pharmacology. vol 88. issue 4. 2010-10-12. PMID:20555416. |
these results suggest that 4' dpg has prominent cytotoxic activity and induces apoptosis by increasing the ratio of bax to bcl-2 in hepg2 cells. |
2010-10-12 |
2023-08-12 |
human |
| Kyoung Joon Oh, Pawan Singh, Kyungro Lee, Kelly Foss, Shinyoub Lee, Minji Park, Steffi Lee, Sreevidya Aluvila, Matthew Park, Puja Singh, Ryung-Suk Kim, Jindrich Symersky, D Eric Walter. Conformational changes in BAK, a pore-forming proapoptotic Bcl-2 family member, upon membrane insertion and direct evidence for the existence of BH3-BH3 contact interface in BAK homo-oligomers. The Journal of biological chemistry. vol 285. issue 37. 2010-10-07. PMID:20605789. |
during apoptosis, the pro-apoptotic bcl-2 family proteins bak and bax form large oligomeric pores in the mitochondrial outer membrane. |
2010-10-07 |
2023-08-12 |
Not clear |
| Huigang Liu, Jing Liu, Lihong Xu, Shanshan Zhou, Ling Li, Weiping Li. Enantioselective cytotoxicity of isocarbophos is mediated by oxidative stress-induced JNK activation in human hepatocytes. Toxicology. vol 276. issue 2. 2010-10-07. PMID:20688129. |
we found that (-)-icp, but not (+)-icp, up-regulated bax protein expression and down-regulated bcl-2 expression levels, which resulted in an increase in bax/bcl-2 ratio with the apoptosis co-ordination. |
2010-10-07 |
2023-08-12 |
human |
| Zhen-Hua Shi, Guangjun Nie, Xiang-Lin Duan, Tracey Rouault, Wen-Shuang Wu, Bo Ning, Nan Zhang, Yan-Zhong Chang, Bao-Lu Zha. Neuroprotective mechanism of mitochondrial ferritin on 6-hydroxydopamine-induced dopaminergic cell damage: implication for neuroprotection in Parkinson's disease. Antioxidants & redox signaling. vol 13. issue 6. 2010-10-06. PMID:20121342. |
importantly, mtft strongly inhibited mitochondrial damage, decreased production of the reactive oxygen species and lipid peroxidation, and dramatically rescued apoptosis by regulating bcl-2, bax and caspase-3 pathways. |
2010-10-06 |
2023-08-12 |
mouse |
| Guansong Wang, Deshan Zhou, Changzheng Wang, Yuqi Gao, Qiquan Zhou, Guisheng Qian, Mark A DeCoste. Hypoxic preconditioning suppresses group III secreted phospholipase A2-induced apoptosis via JAK2-STAT3 activation in cortical neurons. Journal of neurochemistry. vol 114. issue 4. 2010-10-06. PMID:20492356. |
our results suggest that spla(2) iii-induced neuronal apoptosis is likely because of its alterations in expression and activity of bcl-xl, bax, caspase 3, and its target gene fodrin; and that hpc-produced neuroprotection against the spla(2) iii toxicity is mediated via jak-stat signal pathways that regulate the expression of bcl-xl, bax, and cleaved caspase 3 in cultured cortical neurons. |
2010-10-06 |
2023-08-12 |
Not clear |
| Simendra Singh, Tatsunori Okamura, Francis Ali-Osma. Serine phosphorylation of glutathione S-transferase P1 (GSTP1) by PKCα enhances GSTP1-dependent cisplatin metabolism and resistance in human glioma cells. Biochemical pharmacology. vol 80. issue 9. 2010-10-06. PMID:20654585. |
although, cisplatin-induced apoptosis was associated with the translocation of bax to mitochondria, release of cytochrome c and caspase-3/7 activation, the levels of relocalized bax and cytochrome c were significantly greater following gstp1 knockdown. |
2010-10-06 |
2023-08-12 |
human |
| Laura M Plum, Lothar Rink, Hajo Haas. The essential toxin: impact of zinc on human health. International journal of environmental research and public health. vol 7. issue 4. 2010-10-05. PMID:20617034. |
here, zinc influences apoptosis by acting on several molecular regulators of programmed cell death, including caspases and proteins from the bcl and bax families. |
2010-10-05 |
2023-08-12 |
human |
| Ahmet Ateşşahin, Gaffari Türk, Seval Yilmaz, Mustafa Sönmez, Fatih Sakin, Ali Osman Ceribas. Modulatory effects of lycopene and ellagic acid on reproductive dysfunction induced by polychlorinated biphenyl (Aroclor 1254) in male rats. Basic & clinical pharmacology & toxicology. vol 106. issue 6. 2010-10-04. PMID:20074268. |
body and reproductive organ weights, epididymal sperm characteristics, testicular tissue lipid peroxidation levels, antioxidant enzyme activities, histopathological changes and apoptosis via bax and bcl-2 genes were investigated. |
2010-10-04 |
2023-08-12 |
rat |
| Yawei Liu, Bing Dai, Lili Fu, Jieshuang Jia, Changlin Me. Rosiglitazone inhibits cell proliferation by inducing G1 cell cycle arrest and apoptosis in ADPKD cyst-lining epithelia cells. Basic & clinical pharmacology & toxicology. vol 106. issue 6. 2010-10-04. PMID:20210794. |
rosiglitazone also induced apoptosis in cyst-lining epithelial cells, which was correlated with increased bax expression and decreased bcl-2 expression. |
2010-10-04 |
2023-08-12 |
human |
| Jane L Watson, Richard Hill, Paul B Yaffe, Anna Greenshields, Mark Walsh, Patrick W Lee, Carman A Giacomantonio, David W Hoski. Curcumin causes superoxide anion production and p53-independent apoptosis in human colon cancer cells. Cancer letters. vol 297. issue 1. 2010-10-04. PMID:20472336. |
in addition, curcumin-treated p53(+/+) hct-116 cells and mutant p53 ht-29 cells showed upregulation of total and activated p53, as well as increased expression of p53-regulated p21, puma (p53 upregulated modulator of apoptosis), and bax; however, an equivalent cytotoxic effect by curcumin was observed in p53(+/+) and p53(-/-) hct-116 cells, demonstrating that curcumin-induced cytotoxicity was independent of p53 status. |
2010-10-04 |
2023-08-12 |
human |
| Hong-Lei Tian, Ting Yu, Nai-Ning Xu, Chao Feng, Li-Ying Zhou, Hou-Wei Luo, Donald C Chang, Xiao-Feng Le, Kathy Qian Lu. A novel compound modified from tanshinone inhibits tumor growth in vivo via activation of the intrinsic apoptotic pathway. Cancer letters. vol 297. issue 1. 2010-10-04. PMID:20494511. |
ros-mediated bax activation should be the mechanism by which ata induces apoptosis and inhibits tumor growth. |
2010-10-04 |
2023-08-12 |
mouse |
| Jung Ok Ban, Dong Hoon Kwak, Ju Hoon Oh, Eun-Jung Park, Min-Chul Cho, Ho Seub Song, Min Jong Song, Sang Bae Han, Dong Cheul Moon, Keon Wook Kang, Jin Tae Hon. Suppression of NF-kappaB and GSK-3beta is involved in colon cancer cell growth inhibition by the PPAR agonist troglitazone. Chemico-biological interactions. vol 188. issue 1. 2010-10-04. PMID:20540935. |
cells were arrested in g(0)/g(1) phase followed by the induction of apoptosis after treatment of troglitazone with concomitant decrease in the expression of the g(0)/g(1) phase regulatory proteins; cdk2, cdk4, cyclin b1, d1, and e as well as in the anti-apoptosis protein bcl-2 along with an increase in the expression of the pro-apoptosis-associated proteins; caspase-3, caspase-9 and bax. |
2010-10-04 |
2023-08-12 |
human |
| X Shang, S A Vasudevan, Y Yu, N Ge, A D Ludwig, C L Wesson, K Wang, S M Burlingame, Y-J Zhao, P H Rao, X Lu, H V Russell, M F Okcu, M J Hicks, J M Shohet, L A Donehower, J G Nuchtern, J Yan. Dual-specificity phosphatase 26 is a novel p53 phosphatase and inhibits p53 tumor suppressor functions in human neuroblastoma. Oncogene. vol 29. issue 35. 2010-10-04. PMID:20562916. |
inhibiting dusp26 expression in the imr-32 neuroblastoma cell line enhanced doxorubicin-induced p53 phosphorylation at ser20 and ser37, p21, puma, bax expression as well as apoptosis. |
2010-10-04 |
2023-08-12 |
human |
| X Shang, S A Vasudevan, Y Yu, N Ge, A D Ludwig, C L Wesson, K Wang, S M Burlingame, Y-J Zhao, P H Rao, X Lu, H V Russell, M F Okcu, M J Hicks, J M Shohet, L A Donehower, J G Nuchtern, J Yan. Dual-specificity phosphatase 26 is a novel p53 phosphatase and inhibits p53 tumor suppressor functions in human neuroblastoma. Oncogene. vol 29. issue 35. 2010-10-04. PMID:20562916. |
in contrast, dusp26 overexpression in the sk-n-sh cell line inhibited doxorubicin-induced p53 phosphorylation at ser20 and ser37, p21, puma, bax expression and apoptosis. |
2010-10-04 |
2023-08-12 |
human |
| Shanshan Li, Wenjiao Tai, Yanchun Li, Liang Zhang, Weige Zhang, Enlong Ma, Jianchun L. 1-(3',4',5'-Trimethoxyphenyl)-3-(3'',4''-dimethoxy-2''-hydroxyphenyl)-propane with microtubule-depolymerizing ability induces G2/M phase arrest and apoptosis in HepG2 cells. Chemico-biological interactions. vol 188. issue 1. 2010-10-04. PMID:20674558. |
dp increased the levels of reactive oxygen species (ros) in hepg2 cells, and antioxidant n-acetylcysteine (nac) completely blocked dp-induced ros accumulation and the disruption of the balance between bax and bcl-2 proteins, and effectively blocked the decreased mmp and apoptosis, but had no effect on the activation of caspase-8 and the up-regulations of dr4 and dr5 induced by dp. |
2010-10-04 |
2023-08-12 |
human |
| Kenkichi Nozaki, Arabinda Das, Swapan K Ray, Naren L Bani. Calpain inhibition attenuates intracellular changes in muscle cells in response to extracellular inflammatory stimulation. Experimental neurology. vol 225. issue 2. 2010-10-01. PMID:20673830. |
in this study, we demonstrated that post-treatment with calpeptin (calpain inhibitor) attenuated intracellular changes to prevent apoptosis (wright staining) through both mitochondrial pathway (increase in bax:bcl-2 ratio) and endoplasmic reticulum stress pathway (activation of caspase-12), which were induced by interferon-gamma (ifn-γ) stimulation in rat l6 myoblast cells. |
2010-10-01 |
2023-08-12 |
rat |
| Hui Zhao, Wei Guo, Changliang Peng, Tao Ji, Xinchang L. Arsenic trioxide inhibits the growth of adriamycin resistant osteosarcoma cells through inducing apoptosis. Molecular biology reports. vol 37. issue 5. 2010-09-30. PMID:19701692. |
to elucidate the underlying mechanism of the apoptosis, related proteins bcl-2, bcl-xl, bax, bak, cleaved caspase-3 and cleaved caspase-9 were analyzed by western blotting. |
2010-09-30 |
2023-08-12 |
human |