| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Pankaj Chaudhary, Rajendra Sharma, Abha Sharma, Rit Vatsyayan, Sushma Yadav, Sharad S Singhal, Navin Rauniyar, Laszlo Prokai, Sanjay Awasthi, Yogesh C Awasth. Mechanisms of 4-hydroxy-2-nonenal induced pro- and anti-apoptotic signaling. Biochemistry. vol 49. issue 29. 2010-08-23. PMID:20565132. |
parallel treatment of 4-hne to hepg2 cells also induces apoptosis by the p53 pathway through activation of bax, p21, jnk, and caspase-3. |
2010-08-23 |
2023-08-12 |
Not clear |
| Jianxiong Yang, Guanbo Zhang, Jingwei Tian, Chunmei Li, Wanglin Jiang, Yanli Xing, Haibo Zhu, Jian Hou, Hong Xu, Juan W. Cardioprotective effect of SMND-309, a novel derivate of salvianolic acid B on acute myocardial infarction in rats. Basic & clinical pharmacology & toxicology. vol 106. issue 4. 2010-08-20. PMID:19912162. |
meanwhile, smnd-309 significantly increased the activities of superoxide dismutase, catalase and glutathione peroxidase, decreased the content of malondialdehyde in myocardium, and reduced the myocardium necrosis scores and the number of apoptosis cardiocytes in accordance with the up-regulated expression of anti-apoptotic protein, bcl-2 and the down-regulated expression of proapoptotic protein, bax. |
2010-08-20 |
2023-08-12 |
rat |
| Hyung-Gyoo Kang, Jasmine M Jenabi, Xian Fang Liu, C Patrick Reynolds, Timothy J Triche, Poul H B Sorense. Inhibition of the insulin-like growth factor I receptor by epigallocatechin gallate blocks proliferation and induces the death of Ewing tumor cells. Molecular cancer therapeutics. vol 9. issue 5. 2010-08-20. PMID:20423994. |
apoptosis in eft cells by egcg correlated with altered expression of bcl-2 family proteins, including increased expression of proapoptotic bax and decreased expression of prosurvival bcl2, bcl-xl, and mcl-1 proteins. |
2010-08-20 |
2023-08-12 |
human |
| Hsu-Feng Lu, Yu-Jie Chie, Ming-Sung Yang, Ching-Sung Lee, Jene-John Fu, Jai-Sing Yang, Tzu-Wei Tan, Shin-Hwar Wu, Yi-Shih Ma, Siu-Wan Ip, Jing-Gung Chun. Apigenin induces caspase-dependent apoptosis in human lung cancer A549 cells through Bax- and Bcl-2-triggered mitochondrial pathway. International journal of oncology. vol 36. issue 6. 2010-08-20. PMID:20428772. |
we investigated the role of ros, ca2+, caspases and bax proteins and mitochondria membrane potential in apigenin-induced apoptosis in a549 cells. |
2010-08-20 |
2023-08-12 |
human |
| Hsu-Feng Lu, Yu-Jie Chie, Ming-Sung Yang, Ching-Sung Lee, Jene-John Fu, Jai-Sing Yang, Tzu-Wei Tan, Shin-Hwar Wu, Yi-Shih Ma, Siu-Wan Ip, Jing-Gung Chun. Apigenin induces caspase-dependent apoptosis in human lung cancer A549 cells through Bax- and Bcl-2-triggered mitochondrial pathway. International journal of oncology. vol 36. issue 6. 2010-08-20. PMID:20428772. |
western blot analysis was used to determined the levels of bax and bcl-2 and apoptosis associated proteins, and confocal laser microscope for examining the translocation of associated protein after exposed to apigenin. |
2010-08-20 |
2023-08-12 |
human |
| Asfar S Azmi, Philip A Philip, A Aboukameel, Zhiwei Wang, Sanjeev Banerjee, Syed F Zafar, Anton-Scott Goustin, K Almhanna, Dajun Yang, Fazlul H Sarkar, Ramzi M Mohamma. Reactivation of p53 by novel MDM2 inhibitors: implications for pancreatic cancer therapy. Current cancer drug targets. vol 10. issue 3. 2010-08-16. PMID:20370686. |
ku70 is a key component of non-homologous end joining machinery in the dna damage pathway and is known to regulate apoptosis by blocking bax entry into mitochondria. |
2010-08-16 |
2023-08-12 |
Not clear |
| Longnan Jin, Vishwa Jeet Amatya, Yukio Takeshima, Looniva Shrestha, Kei Kushitani, Kouki Ina. Evaluation of apoptosis and immunohistochemical expression of the apoptosis-related proteins in mesothelioma. Hiroshima journal of medical sciences. vol 59. issue 2. 2010-08-16. PMID:20632685. |
apoptosis was evaluated by the tunel method, while expression of the apoptosis-related proteins, bax, bcl-2, survivin, caspase-3 and cleaved caspase-3 was evaluated by immunohistochemical staining. |
2010-08-16 |
2023-08-12 |
Not clear |
| Longnan Jin, Vishwa Jeet Amatya, Yukio Takeshima, Looniva Shrestha, Kei Kushitani, Kouki Ina. Evaluation of apoptosis and immunohistochemical expression of the apoptosis-related proteins in mesothelioma. Hiroshima journal of medical sciences. vol 59. issue 2. 2010-08-16. PMID:20632685. |
three mesothelioma cell lines also showed high cytoplasmic expression of bax, caspase-3 and survivin, while there was no expression of bcl-2, and apoptosis and cytoplasmic expression of cleaved caspase-3 were limited. |
2010-08-16 |
2023-08-12 |
Not clear |
| Qingyan Fei, Douglas W Ethel. Maneb potentiates paraquat neurotoxicity by inducing key Bcl-2 family members. Journal of neurochemistry. vol 105. issue 6. 2010-08-13. PMID:18266926. |
we recently reported that pq induces neuronal apoptosis through bak activation, in contrast to mpp(+), the toxic metabolite of mptp, which relies on bax and p53. |
2010-08-13 |
2023-08-12 |
Not clear |
| Qingyan Fei, Douglas W Ethel. Maneb potentiates paraquat neurotoxicity by inducing key Bcl-2 family members. Journal of neurochemistry. vol 105. issue 6. 2010-08-13. PMID:18266926. |
sirna knockdown of bax and bak confirmed that individually pq and maneb induce bak-dependent cell death, but together they block the bak pathway and activate apoptosis through bax. |
2010-08-13 |
2023-08-12 |
Not clear |
| Irene Paterniti, Emanuela Mazzon, Esposito Emanuela, Rosanna Di Paola, Maria Galuppo, Placido Bramanti, Salvatore Cuzzocre. Modulation of inflammatory response after spinal cord trauma with deferoxamine, an iron chelator. Free radical research. vol 44. issue 6. 2010-08-13. PMID:20370565. |
deferoxamine treatment 30 min before and 1 and 6 h after the sci significantly reduced: (1) gfap immunoreactivity, (2) neutrophil infiltration, (3) nf-kappab activation, (4) inos expression, (5) nitrotyrosine and mda formation, (6) dna damage (methyl green pyronin staining and par formation and (7) apoptosis (tunel staining, fasl, bax and bcl-2 expression, s-100 expression). |
2010-08-13 |
2023-08-12 |
mouse |
| Mi-Ae Lyu, Deepak Rai, Kwang Seok Ahn, Bokyung Sung, Lawrence H Cheung, John W Marks, Bharat B Aggarwal, Ricardo C T Aguiar, Varsha Gandhi, Michael G Rosenblu. The rGel/BLyS fusion toxin inhibits diffuse large B-cell lymphoma growth in vitro and in vivo. Neoplasia (New York, N.Y.). vol 12. issue 5. 2010-08-13. PMID:20454508. |
treatment also induced up-regulation of bax and apoptosis through caspase-3 activation and poly adp-ribose polymerase cleavage. |
2010-08-13 |
2023-08-12 |
Not clear |
| Feng Fang, Yijun Tang, Zhe Gao, Qiang X. A novel regulatory mechanism of naringenin through inhibition of T lymphocyte function in contact hypersensitivity suppression. Biochemical and biophysical research communications. vol 397. issue 2. 2010-08-10. PMID:20471963. |
meanwhile, naringenin also induced t cell apoptosis by upregulation of bax, bad, parp, cleaved-caspase 3 and downregulation of phosphorylated akt, bcl-2. |
2010-08-10 |
2023-08-12 |
Not clear |
| Bruna Pucci, Manuela Indelicato, Valentina Paradisi, Valentina Reali, Laura Pellegrini, Michele Aventaggiato, Natalie O Karpinich, Massimo Fini, Matteo A Russo, John L Farber, Marco Tafan. ERK-1 MAP kinase prevents TNF-induced apoptosis through bad phosphorylation and inhibition of Bax translocation in HeLa Cells. Journal of cellular biochemistry. vol 108. issue 5. 2010-08-09. PMID:19777442. |
erk-1 map kinase prevents tnf-induced apoptosis through bad phosphorylation and inhibition of bax translocation in hela cells. |
2010-08-09 |
2023-08-12 |
Not clear |
| Francesco Esposito, Mara Tornincasa, Paolo Chieffi, Ivana De Martino, Giovanna Maria Pierantoni, Alfredo Fusc. High-mobility group A1 proteins regulate p53-mediated transcription of Bcl-2 gene. Cancer research. vol 70. issue 13. 2010-08-09. PMID:20530667. |
by this mechanism, hmga1 modulates the transcription of p53 target genes such as mdm2, p21(waf1), and bax, inhibiting apoptosis. |
2010-08-09 |
2023-08-12 |
human |
| Rohan K Humphrey, Christina J Newcomb, Shu-Mei A Yu, Ergeng Hao, Doris Yu, Stan Krajewski, Keyong Du, Ulupi S Jhal. Mixed lineage kinase-3 stabilizes and functionally cooperates with TRIBBLES-3 to compromise mitochondrial integrity in cytokine-induced death of pancreatic beta cells. The Journal of biological chemistry. vol 285. issue 29. 2010-08-06. PMID:20421299. |
accordingly, attenuation of mlk3 or trb3 expression each prevented cytokine-induced bax conformational change and attenuated the progression to apoptosis. |
2010-08-06 |
2023-08-12 |
mouse |
| Mee-Sun Hyun, Jung-Mu Hur, Yeun-Ja Mun, Dongho Kim, Won-Hong Wo. BBR induces apoptosis in HepG2 cell through an Akt-ASK1-ROS-p38MAPKs-linked cascade. Journal of cellular biochemistry. vol 109. issue 2. 2010-08-05. PMID:19950206. |
nac treatment, a scavenger of ros, reversed bbr-induced apoptosis effects via inhibition of bax activation and bcl-2 inactivation. |
2010-08-05 |
2023-08-12 |
human |
| Chang-Suk Kong, Young-Eun Bahn, Boh-Kyung Kim, Kang-Yoon Lee, Kun-Young Par. Antiproliferative effect of chitosan-added kimchi in HT-29 human colon carcinoma cells. Journal of medicinal food. vol 13. issue 1. 2010-08-05. PMID:20136430. |
treatment with sk and nk induced apoptosis, as determined by 4,6-diamidino-2-phenylindole staining, and resulted in the up-regulation of bax expression and down-regulation of bcl-2, ciap-1, cellular inhibitor of apoptosis-2, cyclooxygenase-2, inhibitory nitric oxide synthase, and nuclear factor kappab (nf-kappab) expressions when compared to ck. |
2010-08-05 |
2023-08-12 |
human |
| Altaf A Dar, Shahana Majid, Mehdi Nosrati, David de Semir, Scot Federman, Mohammed Kashani-Sabe. Functional modulation of IGF-binding protein-3 expression in melanoma. The Journal of investigative dermatology. vol 130. issue 8. 2010-08-05. PMID:20357812. |
overexpression of igfbp3 in melanoma cells in vitro suppressed tumor cell survival, induced apoptosis, reduced colony formation and invasion, and induced expression of the proapoptotic genes p21, puma, and bax. |
2010-08-05 |
2023-08-12 |
human |
| Kirsten C Lucas, David A Hart, Rolf W Becke. Porcine proximal tubular cells (LLC-PK1) are able to tolerate high levels of lithium chloride in vitro: assessment of the influence of 1-20 mM LiCl on cell death and alterations in cell biology and biochemistry. Cell biology international. vol 34. issue 2. 2010-08-04. PMID:19947924. |
no evidence of apoptosis was observed based on cell morphology or dna fragmentation studies, or evidence of protein expression changes for bax, bcl-2, and p53 proteins using immunocytochemistry. |
2010-08-04 |
2023-08-12 |
Not clear |