| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Basilia Zingarelli, Ranjit Chima, Michael O'Connor, Giovanna Piraino, Alvin Denenberg, Paul W Hak. Liver apoptosis is age dependent and is reduced by activation of peroxisome proliferator-activated receptor-gamma in hemorrhagic shock. American journal of physiology. Gastrointestinal and liver physiology. vol 298. issue 1. 2010-09-09. PMID:19926821. |
the ratio between the antiapoptotic protein bcl-2 and the proapoptotic protein bax was lower, whereas activity of caspase-3, the executioner of apoptosis, was higher in liver of mature rats compared with young rats. |
2010-09-09 |
2023-08-12 |
rat |
| Raymond R Tjandrawinata, Poppy Firzani Arifin, Olivia M Tandrasasmita, Dina Rahmi, Asep Aripi. DLBS1425, a Phaleria macrocarpa (Scheff.) Boerl. extract confers anti proliferative and proapoptosis effects via eicosanoid pathway. Journal of experimental therapeutics & oncology. vol 8. issue 3. 2010-09-09. PMID:20734918. |
induction of apoptosis was shown by dna fragmentation, activation of caspase 9, and regulation of bax and bcl-2 at the mrna level. |
2010-09-09 |
2023-08-12 |
Not clear |
| Rosanna Di Paola, Emanuela Esposito, Emanuela Mazzon, Irene Paterniti, Maria Galuppo, Salvatore Cuzzocre. GW0742, a selective PPAR-beta/delta agonist, contributes to the resolution of inflammation after gut ischemia/reperfusion injury. Journal of leukocyte biology. vol 88. issue 2. 2010-09-08. PMID:20430778. |
), 5 min prior to reperfusion, significantly reduced the (1) mortality rate, (2) histological evidence of gut injury, (3) mpo activity, (4) proinflammatory cytokines (tnf-alpha, il-1beta), (5) adhesion molecules (icam-1, p-selectin), (6) nitrotyrosine formation, (7) nf-kappab expression, (8) par formation, and (9) apoptosis (bax, bcl-2, fas-l, and tunel). |
2010-09-08 |
2023-08-12 |
mouse |
| Aldo Andreani, Stefania Bellini, Silvia Burnelli, Massimiliano Granaiola, Alberto Leoni, Alessandra Locatelli, Rita Morigi, Mirella Rambaldi, Lucilla Varoli, Natalia Calonghi, Concettina Cappadone, Maddalena Zini, Claudio Stefanelli, Lanfranco Masotti, Robert H Shoemake. Substituted E-3-(3-indolylmethylene)-1,3-dihydroindol-2-ones with antitumor activity. In depth study of the effect on growth of breast cancer cells. Journal of medicinal chemistry. vol 53. issue 15. 2010-09-08. PMID:20684599. |
the ability of these derivatives to inhibit cellular proliferation was accompanied by increased level of p53 and its transcriptional targets p21 and bax, interference in the cell cycle progression with cell accumulation in the g2/m phase, and activation of apoptosis. |
2010-09-08 |
2023-08-12 |
Not clear |
| Ning Kang, Jing-Hai Zhang, Feng Qiu, Shin-Ichi Tashiro, Satoshi Onodera, Takashi Ikejim. Inhibition of EGFR signaling augments oridonin-induced apoptosis in human laryngeal cancer cells via enhancing oxidative stress coincident with activation of both the intrinsic and extrinsic apoptotic pathways. Cancer letters. vol 294. issue 2. 2010-09-07. PMID:20202741. |
the enhanced apoptotic effect correlates with high expression and activation of bax, fadd, caspase-8 as well as caspase-3 and decreased protein levels of bcl(2) and sirt1, suggesting that both the extrinsic and intrinsic apoptosis pathways are involved in the apoptotic processes. |
2010-09-07 |
2023-08-12 |
human |
| Alessandra Rossi, Silvia Schenone, Adriano Angelucci, Martina Cozzi, Valentina Caracciolo, Francesca Pentimalli, Andrew Puca, Biagio Pucci, Raffaele La Montagna, Mauro Bologna, Maurizio Botta, Antonio Giordan. New pyrazolo-[3,4-d]-pyrimidine derivative Src kinase inhibitors lead to cell cycle arrest and tumor growth reduction of human medulloblastoma cells. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 24. issue 8. 2010-09-07. PMID:20354138. |
moreover, the exposure to pyrimidine derivatives induces apoptosis, assayed by the supravital propidium iodide assay, through modulation of the apoptotic proteins bax and bcl2, and inhibits tumor growth in vivo in a mouse model. |
2010-09-07 |
2023-08-12 |
mouse |
| Zhicong He, Donna Lai, Laurence P G Wakeli. [Co(III)(cyclen)Cl2]Cl is selectively cytotoxic to human leukaemia cells. European journal of pharmacology. vol 637. issue 1-3. 2010-09-07. PMID:20385117. |
the nmr data indicate increasing lactate production during apoptosis, which implies involvement of the intrinsic mitochondrial pathway, a notion supported by down-regulation of bcl-2 and up-regulation of bax levels as detected by western blotting. |
2010-09-07 |
2023-08-12 |
human |
| J Zaraza, A Oropeza, M A Velazquez, K Korsawe, D Herrmann, J W Carnwath, H Nieman. Developmental competence and mRNA expression of preimplantation in vitro-produced embryos from prepubertal and postpubertal cattle and their relationship with apoptosis after intraovarian administration of IGF-1. Theriogenology. vol 74. issue 1. 2010-09-03. PMID:20138354. |
recombinant human insulin-like growth factor-i (higf-1) was administered to one ovary of prepubertal and postpubertal cattle to determine its effects on (1) oocyte developmental competence, (2) the expression pattern of six developmentally important genes (glut3, glut8, akt1, bcl-xl, bad, and bax), and (3) its relationship with apoptosis (female holstein-friesian). |
2010-09-03 |
2023-08-12 |
human |
| b' A V Sirotkin, M Meszarosov\\xc3\\xa. Comparison of effects of leptin and ghrelin on porcine ovarian granulosa cells. Domestic animal endocrinology. vol 39. issue 1. 2010-09-03. PMID:20452167.' |
leptin stimulated proliferation (pcna, cyclin b1, mapk), apoptosis (bax, p53), and progesterone secretion. |
2010-09-03 |
2023-08-12 |
Not clear |
| b' A V Sirotkin, M Meszarosov\\xc3\\xa. Comparison of effects of leptin and ghrelin on porcine ovarian granulosa cells. Domestic animal endocrinology. vol 39. issue 1. 2010-09-03. PMID:20452167.' |
ghrelin promoted proliferation (pcna, cyclin b1, mapk) and progesterone secretion but suppressed apoptosis (bax, caspase 3, p53). |
2010-09-03 |
2023-08-12 |
Not clear |
| Mei Lin Tan, Peter F M Choong, Crispin R Das. Anti-chondrosarcoma effects of PEDF mediated via molecules important to apoptosis, cell cycling, adhesion and invasion. Biochemical and biophysical research communications. vol 398. issue 4. 2010-09-03. PMID:20501323. |
in this report, pigment epithelium-derived factor (pedf) induced apoptosis in the chondrosarcoma cell line - jj012, with upregulation of bax, fas, caspase-3 and -6 and downregulation of bcl-2. |
2010-09-03 |
2023-08-12 |
Not clear |
| Mariela Bilotas, Gabriela Meresman, Ricardo Buquet, Carlos Sueldo, Rosa Inés Baraña. Effect of vascular endothelial growth factor and interleukin-1beta on apoptosis in endometrial cell cultures from patients with endometriosis and controls. Journal of reproductive immunology. vol 84. issue 2. 2010-09-02. PMID:20137818. |
our results show that vegf and il-1beta reduce apoptosis and decrease bax expression in endometrial epithelial cells from patients with endometriosis. |
2010-09-02 |
2023-08-12 |
human |
| Alexander V Sirotki. Effect of two types of stress (heat shock/high temperature and malnutrition/serum deprivation) on porcine ovarian cell functions and their response to hormones. The Journal of experimental biology. vol 213. issue Pt 12. 2010-09-01. PMID:20511527. |
for this purpose, we compared the expression of markers of proliferation (pcna, cyclin b1), of apoptosis (bax, caspase-3) and secretory activity (release of progesterone, p(4), and insulin-like growth factor, igf-i) in whole ovarian follicles and granulosa cells cultured in conditions of normal temperature (37.5 degrees c) and feeding (with serum), high temperature (41.5 degrees c, with serum) and malnutrition (37.5 degrees c, without serum), with and without hormones [igf-i, leptin and follicle-stimulating hormone (fsh)]. |
2010-09-01 |
2023-08-12 |
Not clear |
| Alexander V Sirotki. Effect of two types of stress (heat shock/high temperature and malnutrition/serum deprivation) on porcine ovarian cell functions and their response to hormones. The Journal of experimental biology. vol 213. issue Pt 12. 2010-09-01. PMID:20511527. |
serum deprivation increased accumulation of cyclin b1 but not other markers of proliferation (pcna) and apoptosis (bax, caspase-3) or p(4) release in ovarian follicles. |
2010-09-01 |
2023-08-12 |
Not clear |
| Alexander V Sirotki. Effect of two types of stress (heat shock/high temperature and malnutrition/serum deprivation) on porcine ovarian cell functions and their response to hormones. The Journal of experimental biology. vol 213. issue Pt 12. 2010-09-01. PMID:20511527. |
adding igf-i, leptin and fsh affected proliferation, apoptosis and secretory activity of ovarian cell functions but also prevented an inhibitory effect of high temperature on the expression of bax and pcna and an inhibitory action of serum deprivation on pcna in ovarian follicles. |
2010-09-01 |
2023-08-12 |
Not clear |
| Qinli Zhang, Yingtao Shi, Qiao Ni. [Selection of bax siRNA sequences and its influence on aluminum induced glioma cell apoptosis]. Wei sheng yan jiu = Journal of hygiene research. vol 37. issue 3. 2010-08-31. PMID:18646519. |
[selection of bax sirna sequences and its influence on aluminum induced glioma cell apoptosis]. |
2010-08-31 |
2023-08-12 |
Not clear |
| Qinli Zhang, Yingtao Shi, Qiao Ni. [Selection of bax siRNA sequences and its influence on aluminum induced glioma cell apoptosis]. Wei sheng yan jiu = Journal of hygiene research. vol 37. issue 3. 2010-08-31. PMID:18646519. |
to decrease bax expression by rna interference, and inhibite the apoptosis in glioma cells induced by aluminum. |
2010-08-31 |
2023-08-12 |
Not clear |
| Zhenmin Ye, Meiqing Shi, Shulin Xu, Jim Xian. LFA-1 defect-induced effector/memory CD8+ T cell apoptosis is mediated via Bcl-2/Caspase pathways and associated with downregulation of CD27 and IL-15R. Molecular immunology. vol 47. issue 14. 2010-08-30. PMID:20569988. |
we found that survival of transferred effector and memory cd8(+) t cells in cd54(-/-) mice significantly decreased (p<0.05) compared to that in c57bl/6 mice due to an increased t cell apoptosis, which is mediated via downregulation of proapoptotic bid, anti-apoptotic bcl-2, bcl-x(l) and pro-caspase-8, and up-regulation of apoptotic bax and cleaved caspase-3 and -7 by rna array and western blotting analyses. |
2010-08-30 |
2023-08-12 |
mouse |
| Geetha M Habi. Arsenite causes down-regulation of Akt and c-Fos, cell cycle dysfunction and apoptosis in glutathione-deficient cells. Journal of cellular biochemistry. vol 110. issue 2. 2010-08-27. PMID:20336670. |
apoptosis involved down-regulation of anti-apoptotic proteins bcl-2, bcl-xl, survivin, and inhibitor of apoptosis protein (iap) and up-regulation of pro-apoptotic protein bax. |
2010-08-27 |
2023-08-12 |
Not clear |
| Yinyuan Wu, Yinyin Wang, Yang Sun, Liying Zhang, Dianjun Wang, Fangli Ren, Donald Chang, Zhijie Chang, Baoqing Ji. RACK1 promotes Bax oligomerization and dissociates the interaction of Bax and Bcl-XL. Cellular signalling. vol 22. issue 10. 2010-08-25. PMID:20541605. |
together, these results indicate that rack1 promotes apoptosis by promoting bax oligomerization and dissociating the complex of bax and bcl-xl. |
2010-08-25 |
2023-08-12 |
Not clear |