| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Shengnan Wu, Feifan Zhou, Zhenzhen Zhang, Da Xin. Bax is essential for Drp1-mediated mitochondrial fission but not for mitochondrial outer membrane permeabilization caused by photodynamic therapy. Journal of cellular physiology. vol 226. issue 2. 2011-01-06. PMID:20683914. |
further study revealed that bax knockdown only slowed down the speed of cell death induced by pdt, indicating that bax is not essential for pdt-induced apoptosis. |
2011-01-06 |
2023-08-12 |
human |
| Shengnan Wu, Feifan Zhou, Zhenzhen Zhang, Da Xin. Bax is essential for Drp1-mediated mitochondrial fission but not for mitochondrial outer membrane permeabilization caused by photodynamic therapy. Journal of cellular physiology. vol 226. issue 2. 2011-01-06. PMID:20683914. |
the fact that bax knockdown totally inhibited the mitochondrial accumulation of dynamin-related protein (drp1) and drp1 knockdown attenuated cell apoptosis suggest that bax can promote pdt-induced apoptosis through promoting drp1 activation. |
2011-01-06 |
2023-08-12 |
human |
| Shengnan Wu, Feifan Zhou, Zhenzhen Zhang, Da Xin. Bax is essential for Drp1-mediated mitochondrial fission but not for mitochondrial outer membrane permeabilization caused by photodynamic therapy. Journal of cellular physiology. vol 226. issue 2. 2011-01-06. PMID:20683914. |
taken together, bax activation is not essential for momp but essential for drp1-mediated mitochondrial fission during the apoptosis caused by photofrin-pdt. |
2011-01-06 |
2023-08-12 |
human |
| Subhrajit Biswas, Qiong Shi, Lauren Matise, Susan Cleveland, Utpal Dave, Sandra Zinke. A role for proapoptotic Bax and Bak in T-cell differentiation and transformation. Blood. vol 116. issue 24. 2011-01-06. PMID:20813900. |
proapoptotic bax and bak are the key b-cell lymphoma-2 family members mediating apoptosis through the intrinsic pathway. |
2011-01-06 |
2023-08-12 |
mouse |
| Subhrajit Biswas, Qiong Shi, Lauren Matise, Susan Cleveland, Utpal Dave, Sandra Zinke. A role for proapoptotic Bax and Bak in T-cell differentiation and transformation. Blood. vol 116. issue 24. 2011-01-06. PMID:20813900. |
bax and bak, key regulators of the intrinsic pathway of apoptosis, are thus required to prevent t-cell malignancy, and for normal t-cell differentiation, regulating early t-cell development at the stage of early t-lineage progenitor cells. |
2011-01-06 |
2023-08-12 |
mouse |
| Rebecca A Kirkland, Geraldine M Saavedra, Brian S Cummings, James L Frankli. Bax regulates production of superoxide in both apoptotic and nonapoptotic neurons: role of caspases. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 30. issue 48. 2011-01-06. PMID:21123558. |
these data indicate that bax lies upstream of most o(2)(·-) produced in neurons, that caspase 3 is required for increased o(2)(·-) production during neuronal apoptosis, that caspase 3 is partially involved in o(2)(·-) production in nonapoptotic neurons, and that other caspases may also be involved in bax-dependent o(2)(·-) production in nonapoptotic cells. |
2011-01-06 |
2023-08-12 |
mouse |
| Sung-Yup Cho, Jin-Haeng Lee, Han-Dong Bae, Eui Man Jeong, Gi-Yong Jang, Chai-Wan Kim, Dong-Myung Shin, Ju-Hong Jeon, In-Gyu Ki. Transglutaminase 2 inhibits apoptosis induced by calcium- overload through down-regulation of Bax. Experimental & molecular medicine. vol 42. issue 9. 2011-01-04. PMID:20676023. |
transglutaminase 2 inhibits apoptosis induced by calcium- overload through down-regulation of bax. |
2011-01-04 |
2023-08-12 |
Not clear |
| Zhengyi Li, Yufeng Xie, Weihua Sheng, Jingcheng Miao, Jim Xiang, Jicheng Yan. Tumor-suppressive effect of adenovirus-mediated inhibitor of growth 4 gene transfer in breast carcinoma cells in vitro and in vivo. Cancer biotherapy & radiopharmaceuticals. vol 25. issue 4. 2011-01-04. PMID:20707719. |
this study further demonstrates that ad-ing4 gene transfer resulted in g2/m phase arrest and apoptosis, upregulated p21, p27, and bax, downregulated bcl-2, il-8, and ang-1, promoted cytochrome c release from mitochondria into cytosol, and activated caspase-9, caspase-3, and parp in mutant p53 mda-mb-231 breast carcinoma cells. |
2011-01-04 |
2023-08-12 |
mouse |
| Xinjing Luo, Baoguo Chen, Rui Zheng, Peng Lin, Jicheng Li, Haixiao Che. Hydrogen peroxide induces apoptosis through the mitochondrial pathway in rat Schwann cells. Neuroscience letters. vol 485. issue 1. 2011-01-04. PMID:20813162. |
we demonstrated that h(2)o(2) induces apoptosis in scs, and is associated with increased release of cytochrome c from mitochondria and the activation of caspase-3 and -9 by up-regulation of bax and down-regulation of bcl-2. |
2011-01-04 |
2023-08-12 |
rat |
| Sheila J Semaan, Elaine K Murray, Matthew C Poling, Sangeeta Dhamija, Nancy G Forger, Alexander S Kauffma. BAX-dependent and BAX-independent regulation of Kiss1 neuron development in mice. Endocrinology. vol 151. issue 12. 2011-01-04. PMID:20926580. |
the role of bax-mediated apoptosis in generating this sex difference was tested in adult bax knockout (ko) and wild-type mice. |
2011-01-04 |
2023-08-12 |
mouse |
| Sheila J Semaan, Elaine K Murray, Matthew C Poling, Sangeeta Dhamija, Nancy G Forger, Alexander S Kauffma. BAX-dependent and BAX-independent regulation of Kiss1 neuron development in mice. Endocrinology. vol 151. issue 12. 2011-01-04. PMID:20926580. |
in the arc, kiss1 cell number was markedly increased in bax ko mice of both sexes, indicating that although bax-dependent apoptosis does not generate the sex difference in either kiss1 or th expression in avpv/pen, bax does importantly regulate kiss1 cell number in the arc. |
2011-01-04 |
2023-08-12 |
mouse |
| Lara Cattaruzza, Dolores Fregona, Maurizio Mongiat, Luca Ronconi, Ambrogio Fassina, Alfonso Colombatti, Donatella Aldinucc. Antitumor activity of gold(III)-dithiocarbamato derivatives on prostate cancer cells and xenografts. International journal of cancer. vol 128. issue 1. 2010-12-30. PMID:20209498. |
in addition, it induces apoptosis, caspase activation, bcl-2 downregulation and bax upregulation, reduces the expression of the phosphorylated form of the egfr, and it inhibits pc3 cell migration. |
2010-12-30 |
2023-08-12 |
mouse |
| Tom Juncker, Claudia Cerella, Marie-Hélène Teiten, Franck Morceau, Marc Schumacher, Jenny Ghelfi, François Gaascht, Michael Schnekenburger, Estelle Henry, Mario Dicato, Marc Diederic. UNBS1450, a steroid cardiac glycoside inducing apoptotic cell death in human leukemia cells. Biochemical pharmacology. vol 81. issue 1. 2010-12-30. PMID:20849830. |
our results show that unbs1450 inhibits nf-κb transactivation and triggers apoptosis by cleavage of pro-caspases 8, 9 and 3/7, by decreasing expression of anti-apoptotic mcl-1 and by recruitment of pro-apoptotic bak and bax protein eventually resulting in cell death. |
2010-12-30 |
2023-08-12 |
human |
| Anja Berger, Sandra-Annika Quast, Michael Plötz, Martin Hein, Manfred Kunz, Peter Langer, Jürgen Eberl. Sensitization of melanoma cells for death ligand-induced apoptosis by an indirubin derivative--Enhancement of both extrinsic and intrinsic apoptosis pathways. Biochemical pharmacology. vol 81. issue 1. 2010-12-30. PMID:20858462. |
furthermore, indirubin activated intrinsic apoptosis pathways, seen in loss of mitochondrial membrane potential and release of cytochrome c. the mitochondrial response appeared as related to upregulation of bax and bad and to downregulation of mcl-1. |
2010-12-30 |
2023-08-12 |
Not clear |
| Zhanxiong Fang, Pei-Chun Liao, Yu-Liang Yang, Feng-Ling Yang, Yi-Lin Chen, Yulin Lam, Kuo-Feng Hua, Shih-Hsiung W. Synthesis and biological evaluation of polyenylpyrrole derivatives as anticancer agents acting through caspases-dependent apoptosis. Journal of medicinal chemistry. vol 53. issue 22. 2010-12-30. PMID:20964408. |
the underlying mechanisms for the anticancer activity were demonstrated as caspases activation dependent apoptosis induction through loss of mitochondrial membrane potential, release of cytochrome c, increase in b-cell lymphoma-2-associated x protein (bax) level, and decrease in b-cell lymphoma-2 (bcl-2) level. |
2010-12-30 |
2023-08-12 |
mouse |
| Decheng Ren, Ho-Chou Tu, Hyungjin Kim, Gary X Wang, Gregory R Bean, Osamu Takeuchi, John R Jeffers, Gerard P Zambetti, James J-D Hsieh, Emily H-Y Chen. BID, BIM, and PUMA are essential for activation of the BAX- and BAK-dependent cell death program. Science (New York, N.Y.). vol 330. issue 6009. 2010-12-28. PMID:21127253. |
although the proteins bax and bak are required for initiation of apoptosis at the mitochondria, how bax and bak are activated remains unsettled. |
2010-12-28 |
2023-08-12 |
mouse |
| Decheng Ren, Ho-Chou Tu, Hyungjin Kim, Gary X Wang, Gregory R Bean, Osamu Takeuchi, John R Jeffers, Gerard P Zambetti, James J-D Hsieh, Emily H-Y Chen. BID, BIM, and PUMA are essential for activation of the BAX- and BAK-dependent cell death program. Science (New York, N.Y.). vol 330. issue 6009. 2010-12-28. PMID:21127253. |
thus, many forms of apoptosis require direct activation of bax and bak at the mitochondria by a member of the bid, bim, or puma family of proteins. |
2010-12-28 |
2023-08-12 |
mouse |
| Jing-Hua Li, Xue Xiao, Yao-Nan Zhang, Ya-Mei Wang, Li-Min Feng, Yu-Mei Wu, Yu-Xiang Zhan. MicroRNA miR-886-5p inhibits apoptosis by down-regulating Bax expression in human cervical carcinoma cells. Gynecologic oncology. vol 120. issue 1. 2010-12-23. PMID:20947150. |
microrna mir-886-5p inhibits apoptosis by down-regulating bax expression in human cervical carcinoma cells. |
2010-12-23 |
2023-08-12 |
human |
| Taoufik Khalfaoui, Nuria Basora, Amel Ouertani-Medde. Apoptotic factors (Bcl-2 and Bax) and diabetic retinopathy in type 2 diabetes. Journal of molecular histology. vol 41. issue 2-3. 2010-12-22. PMID:20532811. |
bax was always localized in tissues characterized by a high rate of apoptosis, whereas, bcl-2 was absent. |
2010-12-22 |
2023-08-12 |
human |
| Lei Shi, Jian Chen, Jian Yang, Tianhong Pan, Shuguang Zhang, Zhimin Wan. MiR-21 protected human glioblastoma U87MG cells from chemotherapeutic drug temozolomide induced apoptosis by decreasing Bax/Bcl-2 ratio and caspase-3 activity. Brain research. vol 1352. 2010-12-22. PMID:20633539. |
pro-apoptotic bax and anti-apoptotic bcl-2 proteins are known to regulate the apoptosis of glioma cells. |
2010-12-22 |
2023-08-12 |
human |