| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jiraporn Saekoo, Potchanapond Graidist, Wilairat Leeanansaksiri, Chavaboon Dechsukum, Arunporn Ithara. Dioscorealide B from the traditional Thai medicine Hua-Khao-Yen induces apoptosis in MCF-7 human breast cancer cells via modulation of Bax, Bak and Bcl-2 protein expression. Natural product communications. vol 5. issue 12. 2011-03-08. PMID:21299121. |
dioscorealide b from the traditional thai medicine hua-khao-yen induces apoptosis in mcf-7 human breast cancer cells via modulation of bax, bak and bcl-2 protein expression. |
2011-03-08 |
2023-08-12 |
human |
| Jiraporn Saekoo, Potchanapond Graidist, Wilairat Leeanansaksiri, Chavaboon Dechsukum, Arunporn Ithara. Dioscorealide B from the traditional Thai medicine Hua-Khao-Yen induces apoptosis in MCF-7 human breast cancer cells via modulation of Bax, Bak and Bcl-2 protein expression. Natural product communications. vol 5. issue 12. 2011-03-08. PMID:21299121. |
dioscorealide b-induced apoptosis was associated with modulation of the multidomain bcl-2 family members bax, bak and bcl-2. |
2011-03-08 |
2023-08-12 |
human |
| Qinhong Wang, Shi-Yong Sun, Fadlo Khuri, Walter J Curran, Xingming Den. Mono- or double-site phosphorylation distinctly regulates the proapoptotic function of Bax. PloS one. vol 5. issue 10. 2011-03-07. PMID:20976235. |
bax is the major multidomain proapoptotic molecule that is required for apoptosis. |
2011-03-07 |
2023-08-12 |
Not clear |
| Ramarao Malla, Sreelatha Gopinath, Kiranmai Alapati, Christopher S Gondi, Meena Gujrati, Dzung H Dinh, Sanjeeva Mohanam, Jasti S Ra. Downregulation of uPAR and cathepsin B induces apoptosis via regulation of Bcl-2 and Bax and inhibition of the PI3K/Akt pathway in gliomas. PloS one. vol 5. issue 10. 2011-03-07. PMID:21060833. |
downregulation of upar and cathepsin b induces apoptosis via regulation of bcl-2 and bax and inhibition of the pi3k/akt pathway in gliomas. |
2011-03-07 |
2023-08-12 |
Not clear |
| Qin-Sheng Dai, Wei Liu, Xiao-Bing Wang, Na Lu, Dan-Dan Gong, Ling-Yi Kong, Qing-Long Gu. NCPMF-60 induces G2/M cell cycle arrest and apoptosis in human hepatocellular carcinoma HepG2 cells. Anti-cancer drugs. vol 22. issue 1. 2011-03-04. PMID:20948430. |
moreover, upregulation of p21, p53-upregulated modifier of apoptosis, and bax, three p53-target gene products, and the downregulation of bcl-2 and mdm2, were observed in ncpmf-60-treated cells. |
2011-03-04 |
2023-08-12 |
human |
| Lulu Mao, Qi Cheng, Béatrice Guardiola-Lemaître, Carole Schuster-Klein, Chunmin Dong, Ling Lai, Steven M Hil. In vitro and in vivo antitumor activity of melatonin receptor agonists. Journal of pineal research. vol 49. issue 3. 2011-03-03. PMID:20609073. |
furthermore, at this dosage, s23478-1 is more effective than melatonin at suppressing the estrogen-signaling pathway and promoting tumor cell apoptosis, significantly increasing the expression of the pro-apoptotic protein bax, while decreasing the expression of erα and the anti-apoptotic protein bcl-2. |
2011-03-03 |
2023-08-12 |
human |
| Katherine Forman, Elena Vara, Cruz García, Roman Kireev, Sara Cuesta, Darío Acuña-Castroviejo, J A F Tresguerre. Beneficial effects of melatonin on cardiological alterations in a murine model of accelerated aging. Journal of pineal research. vol 49. issue 3. 2011-03-03. PMID:20738757. |
after 30 days of treatment, the expression of inflammatory mediators (tumor necrosis factor-alpha, interleukin 1 and 10, nfkbp50 and nfkbp52), apoptosis markers (bad, bax and bcl2) and parameters related to oxidative stress (heme oxygenases 1 and 2, endothelial and inducible nitric oxide synthases) were determined in the heart by real-time reverse transcription polymerase chain reaction (rt-pcr). |
2011-03-03 |
2023-08-12 |
mouse |
| Michelle E Schober, Benjamin Block, Joanna C Beachy, Kimberly D Statler, Christopher C Giza, Robert H Lan. Early and sustained increase in the expression of hippocampal IGF-1, but not EPO, in a developmental rodent model of traumatic brain injury. Journal of neurotrauma. vol 27. issue 11. 2011-03-03. PMID:20822461. |
we used the controlled cortical impact (cci) model and measured hippocampal mrna levels of epo, igf-1, epor, igf-1r, and markers of caspase-dependent apoptosis (bcl2, bax, and p53) at post-injury days (pid) 1, 2, 3, 7, and 14. |
2011-03-03 |
2023-08-12 |
rat |
| Eun Kyeong Lee, Kyung Jin Jung, Jehun Choi, Hyun Jung Kim, Yu Kyeong Han, Kyu-Shik Jeong, Ae-Ri Ji, Jin-Kyu Park, Byung Pal Yu, Hae Young Chun. Molecular basis for age-related changes in ileum: involvement of Bax/caspase-dependent mitochondrial apoptotic signaling. Experimental gerontology. vol 45. issue 12. 2011-03-03. PMID:20840861. |
in conclusion, our findings indicate that the mitochondrial translocation of bax by increased oxidative stress may result in cell death through caspase-dependent apoptosis in aged ileum, thereby leading to a decrease in intestinal mucosal thickness during aging. |
2011-03-03 |
2023-08-12 |
rat |
| Ze J Lu, Yan Zhou, Qi Song, Zhao Qin, Hong Zhang, Yong J Zhou, Lan T Gou, Jin L Yang, Feng Lu. Periplocin inhibits growth of lung cancer in vitro and in vivo by blocking AKT/ERK signaling pathways. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology. vol 26. issue 4-5. 2011-03-02. PMID:21063098. |
moreover, periplocin induced apoptosis by downregulating bcl-2 and upregulating bax, leading to activation of caspase-3 and caspase-9. |
2011-03-02 |
2023-08-12 |
mouse |
| Subash C Gupta, Simone Reuter, Kanokkarn Phromnoi, Byoungduck Park, Padmanabhan S Hema, Mangalam Nair, Bharat B Aggarwa. Nimbolide sensitizes human colon cancer cells to TRAIL through reactive oxygen species- and ERK-dependent up-regulation of death receptors, p53, and Bax. The Journal of biological chemistry. vol 286. issue 2. 2011-03-02. PMID:21078664. |
in addition, nimbolide down-regulated cell survival proteins, including i-flice, ciap-1, ciap-2, bcl-2, bcl-xl, survivin, and x-linked inhibitor of apoptosis protein, and up-regulated the pro-apoptotic proteins p53 and bax. |
2011-03-02 |
2023-08-12 |
human |
| Subash C Gupta, Simone Reuter, Kanokkarn Phromnoi, Byoungduck Park, Padmanabhan S Hema, Mangalam Nair, Bharat B Aggarwa. Nimbolide sensitizes human colon cancer cells to TRAIL through reactive oxygen species- and ERK-dependent up-regulation of death receptors, p53, and Bax. The Journal of biological chemistry. vol 286. issue 2. 2011-03-02. PMID:21078664. |
overall, our results indicate that nimbolide can sensitize colon cancer cells to trail-induced apoptosis through three distinct mechanisms: reactive oxygen species- and erk-mediated up-regulation of dr5 and dr4, down-regulation of cell survival proteins, and up-regulation of p53 and bax. |
2011-03-02 |
2023-08-12 |
human |
| N V Ryazanceva, V V Novickiy, O B Zhukova, A K Biktasova, O E Chechina, E V Sazonova, M V Belkina, N Yu Chasovskih, Z K Khaitov. Role of reactive oxygen species and Bcl-2 family proteins in TNF-α-induced apoptosis of lymphocytes. Bulletin of experimental biology and medicine. vol 149. issue 2. 2011-03-02. PMID:21113486. |
rtnf-α-induced apoptosis was accompanied by an increase in the number of cells with low mitochondrial transmembrane potential, increased intracellular content of reactive oxygen species, reduced content of bcl-2, bcl-xl, and bax proteins, and elevated bad content. |
2011-03-02 |
2023-08-12 |
Not clear |
| Juliette Martin, Pamela Romanque, Olivier Maurhofer, Karin Schmitter, Caroline Hora, Gisèle Ferrand, Jean-François Dufou. Ablation of the tumor suppressor histidine triad nucleotide binding protein 1 is protective against hepatic ischemia/reperfusion injury. Hepatology (Baltimore, Md.). vol 53. issue 1. 2011-03-02. PMID:21140474. |
the serum aminotransferase levels, histological lesions, apoptosis, reactive oxygen species, and expression of b cell lymphoma 2-associated x protein (bax), heme oxygenase 1 (ho-1), interleukin-6 (il-6), il-10, tumor necrosis factor-a, src, nuclear factor kappa b (p65/rela), and c-jun were quantified. |
2011-03-02 |
2023-08-12 |
mouse |
| Wei-Ting Lee, Chia-Wen Chan. Bax is upregulated by p53 signal pathway in the SPE B-induced apoptosis. Molecular and cellular biochemistry. vol 343. issue 1-2. 2011-03-01. PMID:20567883. |
bax is upregulated by p53 signal pathway in the spe b-induced apoptosis. |
2011-03-01 |
2023-08-12 |
Not clear |
| Wei-Ting Lee, Chia-Wen Chan. Bax is upregulated by p53 signal pathway in the SPE B-induced apoptosis. Molecular and cellular biochemistry. vol 343. issue 1-2. 2011-03-01. PMID:20567883. |
this is consistent with the findings that spe b upregulates bax expression through p38/p53 signal pathways that enhance cell apoptosis. |
2011-03-01 |
2023-08-12 |
Not clear |
| Xiaohua Chen, Peng Zhao, Fengsheng Chen, Libo Li, Rongcheng Lu. Effect and mechanism of 5-aminolevulinic acid-mediated photodynamic therapy in esophageal cancer. Lasers in medical science. vol 26. issue 1. 2011-03-01. PMID:20676910. |
this study investigated the effect of ala-pdt on esophageal squamous carcinoma cell line eca-109 in vitro and vivo to explore optimal parameters, and evaluated the significance of cell apoptosis, cell cycle, ala-protoporphyrin ix (ala-ppix) subcellular localization, and expression of bcl-2 and bax mrna in cells to understand the mechanism of ala-pdt for esophageal cancer. |
2011-03-01 |
2023-08-12 |
mouse |
| I Kostic, B Toffoletto, M Toller, C A Beltrami, F S Ambesi-Impiombato, F Curci. UVC radiation-induced effect on human primary thyroid cell proliferation and HLA-DR expression. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme. vol 42. issue 12. 2011-03-01. PMID:20886415. |
apoptosis was detected measuring annexin v, proteins involved in apoptotic process (p53, bax, bcl-2, caspase 3, and 9) by immunoblot analysis and hla-dr expression by facs. |
2011-03-01 |
2023-08-12 |
human |
| Xi-Ling Fan, Hui Zhou, Zhi-Min Xia, Hai-Xin Niu, Jun-Jun Lu. [Effects of Huoxuezhitong recipe on the pathway of mitochondrial apoptosis and the expression of related gene in epidural scar tissue]. Zhongguo gu shang = China journal of orthopaedics and traumatology. vol 23. issue 10. 2011-03-01. PMID:21137294. |
to study the effect of huoxuezhitong recipe on the pathway of mitochondrial apoptosis and the expression of related gene (caspase-3, -9, bax, bcl-2) in epidural scar tissue. |
2011-03-01 |
2023-08-12 |
Not clear |
| A S Azmi, P A Philip, F W J Beck, Z Wang, S Banerjee, S Wang, D Yang, F H Sarkar, R M Mohamma. MI-219-zinc combination: a new paradigm in MDM2 inhibitor-based therapy. Oncogene. vol 30. issue 1. 2011-02-28. PMID:20818437. |
zncl(2) enhanced mi-219 activity (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (mtt), apoptosis and colony formation), and chelation of zinc not only blocked the activity of mi-219, but also suppressed reactivation of the p53 and its downstream effector molecules p21(waf1) and bax. |
2011-02-28 |
2023-08-12 |
Not clear |