| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ming-Yue Li, Jackie Leung, Angel W Y Kong, Nian Ci Liang, Kefeng Wu, Michael K Y Hsin, Yi Feng Deng, Xianling Gong, Yingnian Lv, Tony S K Mok, Malcolm J Underwood, George G Che. Anticancer efficacy of 5F in NNK-induced lung cancer development of A/J mice and human lung cancer cells. Journal of molecular medicine (Berlin, Germany). vol 88. issue 12. 2011-04-04. PMID:20830463. |
cell culture experiments showed that 5f translocated bax into the mitochondria, downregulated bcl-2, activated caspase-9 and caspase-3, released cytochrome c into the cytosol, and translocated aif from the mitochondria to the nucleus, which leading to g2-m cell cycle arrest and cell apoptosis. |
2011-04-04 |
2023-08-12 |
mouse |
| Ki Seong Eom, Hyung-Jin Kim, Hong-Seob So, Raekil Park, Tae Young Ki. Berberine-induced apoptosis in human glioblastoma T98G cells is mediated by endoplasmic reticulum stress accompanying reactive oxygen species and mitochondrial dysfunction. Biological & pharmaceutical bulletin. vol 33. issue 10. 2011-04-04. PMID:20930370. |
the inhibition of er stress using salubrinal led to an increased the level of bcl-2, whereas the level of bax, cleavage of procaspase-9 and -3, and parp were decreased when compared with cells treated with berberine alone, indicating that berberine-induced apoptosis is associated with mitochondrial dysfunction. |
2011-04-04 |
2023-08-12 |
human |
| Logan Banadyga, Sing-Chi Lam, Toru Okamoto, Marc Kvansakul, David C Huang, Michele Barr. Deerpox virus encodes an inhibitor of apoptosis that regulates Bak and Bax. Journal of virology. vol 85. issue 5. 2011-04-04. PMID:21159883. |
deerpox virus encodes an inhibitor of apoptosis that regulates bak and bax. |
2011-04-04 |
2023-08-12 |
Not clear |
| Logan Banadyga, Sing-Chi Lam, Toru Okamoto, Marc Kvansakul, David C Huang, Michele Barr. Deerpox virus encodes an inhibitor of apoptosis that regulates Bak and Bax. Journal of virology. vol 85. issue 5. 2011-04-04. PMID:21159883. |
we confirmed the ability of dpv022 to interact with bak and bax by immunoprecipitation and showed that dpv022 prevented apoptosis induced by bak and bax overexpression. |
2011-04-04 |
2023-08-12 |
Not clear |
| Xin Liu, Yang Xue, Jiao Su. Indirect induction of endothelial cell injury by PU- or PTFE-mediated activation of monocytes. Journal of biomaterials science. Polymer edition. vol 21. issue 13. 2011-04-01. PMID:20557688. |
then, we assessed the apoptosis rate of the huvecs and determined the expression of no, inducible nitric oxide synthase (inos), and apoptosis-related proteins (p53, bax, bcl-2) in the huvecs. |
2011-04-01 |
2023-08-12 |
human |
| Xin Liu, Yang Xue, Jiao Su. Indirect induction of endothelial cell injury by PU- or PTFE-mediated activation of monocytes. Journal of biomaterials science. Polymer edition. vol 21. issue 13. 2011-04-01. PMID:20557688. |
after culturing with the supernatants of the pu- or ptfe-stimulated thp-1 cells, the apoptosis rate, no production and expression of inos, p53 and bax in the huvecs were up-regulated, while bcl-2 expression was down-regulated. |
2011-04-01 |
2023-08-12 |
human |
| Xin Liu, Yang Xue, Jiao Su. Indirect induction of endothelial cell injury by PU- or PTFE-mediated activation of monocytes. Journal of biomaterials science. Polymer edition. vol 21. issue 13. 2011-04-01. PMID:20557688. |
in conclusion, the release of ros by pu- or ptfe-treated thp-1 cells may induce inos expression and cause apoptosis in huvecs via the p53, bax and bcl-2 proteins. |
2011-04-01 |
2023-08-12 |
human |
| Juan Cen, Yan Qi, Yi-fu Tao, Yan Deng, Wei-rong Fang, Yun-man Li, Lu-yong Zhang, Wen-long Huan. HZ08, a great regulator to reverse multidrug resistance via cycle arrest and apoptosis sensitization in MCF-7/ADM. European journal of pharmacology. vol 647. issue 1-3. 2011-04-01. PMID:20816813. |
then we found hz08 could increase cells in g(0)/g(1) phase and regulate apoptosis related proteins (bcl-2, bax) as well as upstream functional molecules (c-myc and c-fos), which are usually abnormal in malignancy and responsible for multidrug resistance in mcf-7/adm. |
2011-04-01 |
2023-08-12 |
Not clear |
| Daniela Impellizzeri, Emanuela Esposito, Emanuela Mazzon, Irene Paterniti, Rosanna Di Paola, Placido Bramanti, Salvatore Cuzzocre. Effect of apocynin, a NADPH oxidase inhibitor, on acute lung inflammation. Biochemical pharmacology. vol 81. issue 5. 2011-04-01. PMID:21147071. |
furthermore, carrageenan induced the expression of nuclear factor-κb (nf-κb) inducible nitric oxide synthase (inos), nitrotyrosine, poly-adp-ribosyl polymerase (parp) as well as induced apoptosis (tunel staining, fas-ligand expression, bax and bcl-2 expression) and mitogen-activated protein kinase (mapk) activation in the lung tissues. |
2011-04-01 |
2023-08-12 |
mouse |
| Seamus J Marti. Mitochondrial fusion: bax to the fussure. Developmental cell. vol 20. issue 2. 2011-04-01. PMID:21316581. |
(2011) published in molecular cell now suggests that bax, more commonly known for its role in apoptosis, can promote mitochondrial fusion in a mitofusin 2-dependent manner. |
2011-04-01 |
2023-08-12 |
Not clear |
| Alissa Armstrong, Yun Kyoung Ryu, Deanna Chieco, Rejji Kuruvill. Frizzled3 is required for neurogenesis and target innervation during sympathetic nervous system development. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 31. issue 7. 2011-04-01. PMID:21325504. |
fz3(-/-) sympathetic neuroblasts also undergo enhanced apoptosis, which could not be rescued by eliminating the proapoptotic factor, bax. |
2011-04-01 |
2023-08-12 |
mouse |
| Alexander Wree, Alisan Kahraman, Guido Gerken, Ali Canba. Obesity affects the liver - the link between adipocytes and hepatocytes. Digestion. vol 83. issue 1-2. 2011-03-31. PMID:21042023. |
jnk activates the proapoptotic protein bim, resulting in bax activation and enhanced apoptosis, termed 'lipoapoptosis'. |
2011-03-31 |
2023-08-12 |
Not clear |
| Senping Cheng, Ning Gao, Zhuo Zhang, Gang Chen, Amit Budhraja, Zunji Ke, Young-ok Son, Xin Wang, Jia Luo, Xianglin Sh. Quercetin induces tumor-selective apoptosis through downregulation of Mcl-1 and activation of Bax. Clinical cancer research : an official journal of the American Association for Cancer Research. vol 16. issue 23. 2011-03-31. PMID:21138867. |
quercetin induces tumor-selective apoptosis through downregulation of mcl-1 and activation of bax. |
2011-03-31 |
2023-08-12 |
human |
| Senping Cheng, Ning Gao, Zhuo Zhang, Gang Chen, Amit Budhraja, Zunji Ke, Young-ok Son, Xin Wang, Jia Luo, Xianglin Sh. Quercetin induces tumor-selective apoptosis through downregulation of Mcl-1 and activation of Bax. Clinical cancer research : an official journal of the American Association for Cancer Research. vol 16. issue 23. 2011-03-31. PMID:21138867. |
to investigate the in vivo antitumor efficacy of quercetin in u937 xenografts and the functional roles of mcl-1 and bax in quercetin-induced apoptosis in human leukemia. |
2011-03-31 |
2023-08-12 |
human |
| Satish Babu, Rohit Anthony Sinha, Vishwa Mohan, Geeta Rao, Amit Pal, Amrita Pathak, Manish Singh, Madan M Godbol. Effect of hypothyroxinemia on thyroid hormone responsiveness and action during rat postnatal neocortical development. Experimental neurology. vol 228. issue 1. 2011-03-30. PMID:21185833. |
the resultant downregulation of nuclear myelin binding protein (mbp) and mitochondrial transcripts cytochrome oxidase iii (cox iii) as well as significantly enhanced mitochondrial localization of bax and reduced bcl-2 and bcl-xl accompanied by enhanced release of cytochrome c and smac with activation of caspase-3 indicates pronounced apoptosis leading to compromised cellular survival. |
2011-03-30 |
2023-08-12 |
rat |
| Hyang Ae Shin, Yun Yi Cha, Mun Su Park, Jae Myeong Kim, Young Chang Li. Diallyl sulfide induces growth inhibition and apoptosis of anaplastic thyroid cancer cells by mitochondrial signaling pathway. Oral oncology. vol 46. issue 4. 2011-03-29. PMID:20219414. |
in addition, das-induced apoptosis was associated with a decrease in the level of bcl-2 expression and an increase in the level of bax expression, and cytochrome c was remarkably released from mitochondrial into the cytosol by das. |
2011-03-29 |
2023-08-12 |
Not clear |
| Evita B Henderson-Jackson, James Helm, Masoumeh Ghayouri, Ardeshir Hakam, Aejaz Nasir, Marino Leon, Marilyn Bui, Timothy Yeatman, Domenico Coppol. Correlation between Mcl-1 and pAKT protein expression in colorectal cancer. International journal of clinical and experimental pathology. vol 3. issue 8. 2011-03-29. PMID:21151390. |
mcl-1 inhibits apoptosis in well-differentiated cells by sequestering bad, bid, and bax and other apoptotic molecules. |
2011-03-29 |
2023-08-12 |
Not clear |
| Eunjin Park, Insun Hwang, Jie-Young Song, Youngheun Je. Acidic polysaccharide of Panax ginseng as a defense against small intestinal damage by whole-body gamma irradiation of mice. Acta histochemica. vol 113. issue 1. 2011-03-25. PMID:19767060. |
in addition, apg significantly inhibited irradiation-induced apoptosis by decreasing the amount of pro-apoptotic p53 and bax as well as augmenting that of anti-apoptotic bcl-2 at 24h after irradiation. |
2011-03-25 |
2023-08-12 |
mouse |
| Wen-Feng Chu, Dong-Mei Wu, Wei Liu, Li-Jun Wu, De-Zhi Li, Dong-Yang Xu, Xiao-Feng Wan. Sulforaphane induces G2-M arrest and apoptosis in high metastasis cell line of salivary gland adenoid cystic carcinoma. Oral oncology. vol 45. issue 11. 2011-03-24. PMID:19589718. |
in terms of apoptosis, sfn increased the expression of bax and decreased the level of bcl-2 and subsequently triggered release of cytochrome c from mitochondria and activation of caspase-3, but fas level and caspase-8 activity remained unchanged at all time points. |
2011-03-24 |
2023-08-12 |
human |
| Feng-Lang Lin, Jue-Liang Hsu, Chang-Hung Chou, Wen-Jun Wu, Chi-I Chang, Hung-Jen Li. Activation of p38 MAPK by damnacanthal mediates apoptosis in SKHep 1 cells through the DR5/TRAIL and TNFR1/TNF-α and p53 pathways. European journal of pharmacology. vol 650. issue 1. 2011-03-24. PMID:20951126. |
this is first demonstration that damnacanthal-mediated apoptosis involves the sustained activation of the p38 mapk pathway, leading to the transcription of the death receptor family genes encoding dr5/trail and tnf-r1/tnf-α genes as well as the p53-regulated bax gene. |
2011-03-24 |
2023-08-12 |
Not clear |