| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Zhigang Bai, Yingjiang Ye, Bin Liang, Feng Xu, Hui Zhang, Yanbin Zhang, Jiarou Peng, Danhua Shen, Zhirong Cui, Zhongtao Zhang, Shan Wan. Proteomics-based identification of a group of apoptosis-related proteins and biomarkers in gastric cancer. International journal of oncology. vol 38. issue 2. 2011-04-19. PMID:21165559. |
the identified proteins were functionally classified using bioinformatics methods, showing that the 9 proteins identified were related to bcl2, bax, erbb2 and casp3 proteins and involved in the process of apoptosis. |
2011-04-19 |
2023-08-12 |
Not clear |
| Elena Pichichero, Rosella Cicconi, Maurizio Mattei, Antonella Canin. Chrysin-induced apoptosis is mediated through p38 and Bax activation in B16-F1 and A375 melanoma cells. International journal of oncology. vol 38. issue 2. 2011-04-19. PMID:21170506. |
chrysin-induced apoptosis is mediated through p38 and bax activation in b16-f1 and a375 melanoma cells. |
2011-04-19 |
2023-08-12 |
human |
| Manujendra N Saha, Hua Jiang, Hong Chan. Molecular mechanisms of nutlin-induced apoptosis in multiple myeloma: evidence for p53-transcription-dependent and -independent pathways. Cancer biology & therapy. vol 10. issue 6. 2011-04-18. PMID:20595817. |
our data show that nutlin-induced apoptosis correlated with reduction in cell viability, upregulation of p53, p21 and mdm2 protein levels with a simultaneous increase in pro-apoptotic targets puma, bax and bak and downregulation of anti-apoptotic targets bcl2 and survivin and activation of caspase in mm cells harboring wild type p53. |
2011-04-18 |
2023-08-12 |
Not clear |
| Biao Yan, Men Kong, Yi-han Che. Prevention of apoptosis by the interaction between FIH1 and Bax. Molecular and cellular biochemistry. vol 348. issue 1-2. 2011-04-18. PMID:21069436. |
prevention of apoptosis by the interaction between fih1 and bax. |
2011-04-18 |
2023-08-12 |
Not clear |
| Biao Yan, Men Kong, Yi-han Che. Prevention of apoptosis by the interaction between FIH1 and Bax. Molecular and cellular biochemistry. vol 348. issue 1-2. 2011-04-18. PMID:21069436. |
bax induces mitochondrial-dependent cell apoptosis signals in mammalian cells. |
2011-04-18 |
2023-08-12 |
Not clear |
| Dong Xiao, Yan Zeng, Lakshmi Prakash, Vladmir Badmaev, Muhammed Majeed, Shivendra V Sing. Reactive oxygen species-dependent apoptosis by gugulipid extract of Ayurvedic medicine plant Commiphora mukul in human prostate cancer cells is regulated by c-Jun N-terminal kinase. Molecular pharmacology. vol 79. issue 3. 2011-04-18. PMID:21115635. |
the gl treatment caused the activation of jnk that functioned upstream of bax activation in apoptosis response. |
2011-04-18 |
2023-08-12 |
mouse |
| Dong Xiao, Yan Zeng, Lakshmi Prakash, Vladmir Badmaev, Muhammed Majeed, Shivendra V Sing. Reactive oxygen species-dependent apoptosis by gugulipid extract of Ayurvedic medicine plant Commiphora mukul in human prostate cancer cells is regulated by c-Jun N-terminal kinase. Molecular pharmacology. vol 79. issue 3. 2011-04-18. PMID:21115635. |
the gl-induced conformational change of bax and apoptosis were significantly suppressed by genetic suppression of jnk activation. |
2011-04-18 |
2023-08-12 |
mouse |
| Pablo M Peixoto, Jennifer K Lue, Shin-Young Ryu, Brian N Wroble, Jill C Sible, Kathleen W Kinnall. Mitochondrial apoptosis-induced channel (MAC) function triggers a Bax/Bak-dependent bystander effect. The American journal of pathology. vol 178. issue 1. 2011-04-18. PMID:21224042. |
time-lapse videos showed that neighboring cells also underwent apoptosis, but expression of bax and/or bak was essential to this effect, because no bystanders were observed in cells lacking both of these mac components. |
2011-04-18 |
2023-08-12 |
mouse |
| M C Ferrante, G Mattace Raso, E Esposito, G Bianco, A Iacono, M T Clausi, P Amero, A Santoro, R Simeoli, G Autore, R Mel. Effects of non-dioxin-like polychlorinated biphenyl congeners (PCB 101, PCB 153 and PCB 180) alone or mixed on J774A.1 macrophage cell line: modification of apoptotic pathway. Toxicology letters. vol 202. issue 1. 2011-04-18. PMID:21291966. |
also, bcl-2 and bax proteins were assessed to elucidate the apoptosis machinery induced in macrophage cultures by pcbs. |
2011-04-18 |
2023-08-12 |
Not clear |
| M C Ferrante, G Mattace Raso, E Esposito, G Bianco, A Iacono, M T Clausi, P Amero, A Santoro, R Simeoli, G Autore, R Mel. Effects of non-dioxin-like polychlorinated biphenyl congeners (PCB 101, PCB 153 and PCB 180) alone or mixed on J774A.1 macrophage cell line: modification of apoptotic pathway. Toxicology letters. vol 202. issue 1. 2011-04-18. PMID:21291966. |
our results indicate that the increase in pcb-induced apoptosis correlates with a reduction in the expression of antiapoptotic bcl-2 and an increase in the expression of proapoptotic bax. |
2011-04-18 |
2023-08-12 |
Not clear |
| Zhongbin Lai, Satyan Kalkunte, Surendra Sharm. A critical role of interleukin-10 in modulating hypoxia-induced preeclampsia-like disease in mice. Hypertension (Dallas, Tex. : 1979). vol 57. issue 3. 2011-04-14. PMID:21263114. |
hypoxia-induced elevation of p53 was associated with marked induction of proapoptotic protein bax, downregulation of bcl-2, and trophoblast-specific apoptosis in utero-placental tissue. |
2011-04-14 |
2023-08-12 |
mouse |
| b' Barbara Zapa\\xc5\\x82a, \\xc5\\x81ukasz Kaczy\\xc5\\x84ski, Beata Kie\\xc4\\x87-Wilk, Teresa Staszel, Anna Knapp, G Hege Thoresen, Iwona Wybra\\xc5\\x84ska, Aldona Dembi\\xc5\\x84ska-Kie\\xc4\\x8. Humanins, the neuroprotective and cytoprotective peptides with antiapoptotic and anti-inflammatory properties. Pharmacological reports : PR. vol 62. issue 5. 2011-04-13. PMID:21098860.' |
it has been demonstrated that hn plays a protective role through its antiapoptotic activity that interferes with bax activation, which suppresses bax-dependent apoptosis. |
2011-04-13 |
2023-08-12 |
human |
| Sakhila K Banu, Jone A Stanley, Jehoon Lee, Sam D Stephen, Joe A Arosh, Patricia B Hoyer, Robert C Burghard. Hexavalent chromium-induced apoptosis of granulosa cells involves selective sub-cellular translocation of Bcl-2 members, ERK1/2 and p53. Toxicology and applied pharmacology. vol 251. issue 3. 2011-04-13. PMID:21262251. |
our data indicated that crvi: (i) induced dna fragmentation and increased apoptosis, (ii) increased cytochrome c release from the mitochondria to cytosol, (iii) downregulated anti-apoptotic bcl-2, bcl-xl, hsp70 and hsp90; upregulated pro-apoptotic bax and bad, (iv) altered translocation of bcl-2, bcl-xl, bax, bad, hsp70 and hsp90 to the mitochondria, (v) upregulated p-erk and p-jnk, and selectively translocated p-erk to the mitochondria and nucleus, (vi) activated caspase-3 and parp, and (vii) increased phosphorylation of p53 at ser-6, ser-9, ser-15, ser-20, ser-37, ser-46 and ser-392, increased p53 transcriptional activation, and downregulated mdm-2. |
2011-04-13 |
2023-08-12 |
rat |
| Chitra Subramanian, Jason A Jarzembowski, Sonja M Halsey, Rork Kuick, Anthony W Opipari, Valerie P Castle, Roland P S Kwo. CLU blocks HDACI-mediated killing of neuroblastoma. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. vol 32. issue 2. 2011-04-11. PMID:21042904. |
clusterin blocks apoptosis by binding to activated bax and sequestering it in the cytoplasm, thereby preventing bax from entering mitochondria, releasing cytochrome c, and triggering apoptosis. |
2011-04-11 |
2023-08-12 |
Not clear |
| Jia-Wang Ding, Xiao-Hong Tong, Jun Yang, Zhao-Qi Liu, Yan Zhang, Jian Yang, Song Li, Li L. Activated protein C protects myocardium via activation of anti-apoptotic pathways of survival in ischemia-reperfused rat heart. Journal of Korean medical science. vol 25. issue 11. 2011-04-07. PMID:21060750. |
myocardial infarct size, apoptosis index, the phosphorylation of erk1/2, bcl-2, bax and cytochrome c genes and proteins were assessed. |
2011-04-07 |
2023-08-12 |
rat |
| Wen Ji Li, Mi-Kyung Shin, Seung-June O. Time dependent bladder apoptosis induced by acute bladder outlet obstruction and subsequent emptying is associated with decreased MnSOD expression and Bcl-2/Bax ratio. Journal of Korean medical science. vol 25. issue 11. 2011-04-07. PMID:21060756. |
we examined the extent of bladder apoptosis, expression of mn-superoxide dismutase (mn-sod), bcl-2, bax, caspase 3 and poly (adp-ribose) (par) in the bladder. |
2011-04-07 |
2023-08-12 |
rat |
| Hyunho Yoon, Jeong-Ki Min, Jung Whoi Lee, Dae-Ghon Kim, Hyo Jeong Hon. Acquisition of chemoresistance in intrahepatic cholangiocarcinoma cells by activation of AKT and extracellular signal-regulated kinase (ERK)1/2. Biochemical and biophysical research communications. vol 405. issue 3. 2011-04-06. PMID:21130731. |
inhibition of akt activation by phosphoinocitide 3-kinase (pi3k) inhibitor ly294002 resulted in reduced bcl-2 expression and enhanced bax expression and thus induced apoptosis in the resistant cells, whereas inhibition of erk1/2 activation by mitogen-activated protein kinase (mek) inhibitor u0126 did not induce apoptosis without affecting the expression of bcl-2 and bax but decreased cell growth. |
2011-04-06 |
2023-08-12 |
Not clear |
| Najuan Zhang, Fei Pei, Huaying Wei, Tongtong Zhang, Chao Yang, Gang Ma, Chunlei Yan. Isorhamnetin protects rat ventricular myocytes from ischemia and reperfusion injury. Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie. vol 63. issue 1-2. 2011-04-04. PMID:19815400. |
corresponding to the reduced apoptosis rate in the i/r+/isor+ group, western blotting assay showed increased amount of bcl-2 and p53, decreased amount of bax, and nuclear accumulation of nf-κb/p65. |
2011-04-04 |
2023-08-12 |
rat |
| Zhichao Zhang, Ting Song, Tiantai Zhang, Jin Gao, Guiye Wu, Lijia An, Guanhua D. A novel BH3 mimetic S1 potently induces Bax/Bak-dependent apoptosis by targeting both Bcl-2 and Mcl-1. International journal of cancer. vol 128. issue 7. 2011-04-04. PMID:20503275. |
the results of fluorescence polarization assays, coimmunoprecipitation, fluorescent resonance energy transfer, and shrna indicated that s1 can disrupt bcl-2/bax, mcl-1/bak and bcl-2/bim heterodimerization in multiple cell lines, activate bax accompanied by its translocation to mitochondrial, activate caspase 3 completely dependent on bax/bak, and in turn induce a bim-independent apoptosis. |
2011-04-04 |
2023-08-12 |
mouse |
| Ming-Yue Li, Jackie Leung, Angel W Y Kong, Nian Ci Liang, Kefeng Wu, Michael K Y Hsin, Yi Feng Deng, Xianling Gong, Yingnian Lv, Tony S K Mok, Malcolm J Underwood, George G Che. Anticancer efficacy of 5F in NNK-induced lung cancer development of A/J mice and human lung cancer cells. Journal of molecular medicine (Berlin, Germany). vol 88. issue 12. 2011-04-04. PMID:20830463. |
cell proliferation and apoptosis were determined through expression of pcna, bcl-2, bax, and tunel assay in in vivo animal model. |
2011-04-04 |
2023-08-12 |
mouse |