| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Peter E Czabotar, Erinna F Lee, Geoff V Thompson, Ahmad Z Wardak, W Douglas Fairlie, Peter M Colma. Mutation to Bax beyond the BH3 domain disrupts interactions with pro-survival proteins and promotes apoptosis. The Journal of biological chemistry. vol 286. issue 9. 2011-05-04. PMID:21199865. |
mutations in bax that promote apoptosis can provide insight into how bax is regulated. |
2011-05-04 |
2023-08-12 |
mouse |
| Peter E Czabotar, Erinna F Lee, Geoff V Thompson, Ahmad Z Wardak, W Douglas Fairlie, Peter M Colma. Mutation to Bax beyond the BH3 domain disrupts interactions with pro-survival proteins and promotes apoptosis. The Journal of biological chemistry. vol 286. issue 9. 2011-05-04. PMID:21199865. |
these results support a model in which direct restraint of bax by pro-survival bcl-2 proteins is a barrier to apoptosis. |
2011-05-04 |
2023-08-12 |
mouse |
| Won-Hyung Choi, Jong-Phil Chu, Mei-Hua Jiang, Seung-Hwa Baek, Hyun-do Par. Effects of fraction obtained from Korean Corni Fructus extracts causing anti-proliferation and p53-dependent apoptosis in A549 lung cancer cells. Nutrition and cancer. vol 63. issue 1. 2011-05-03. PMID:21132604. |
consistently, cm/f3 effectively induced the activation of bax, cytochrome-c, caspase-3, -8, -9, p53, and p21 causing apoptosis, and caused the suppression of cdk2, prb, and e2f1 related to cell arrest in a549 cells. |
2011-05-03 |
2023-08-12 |
Not clear |
| Tiziana Genovese, Emanuela Mazzon, Irene Paterniti, Emanuela Esposito, Placido Bramanti, Salvatore Cuzzocre. Modulation of NADPH oxidase activation in cerebral ischemia/reperfusion injury in rats. Brain research. vol 1372. 2011-05-03. PMID:21138737. |
we also demonstrated that apocynin reduces levels of apoptosis (tunel, bax and bcl-2 expression) resulting in a reduction in the infarct volume in ischemia-reperfusion brain injury. |
2011-05-03 |
2023-08-12 |
rat |
| Jeremie Boucher, Yazmin Macotela, Olivier Bezy, Marcelo A Mori, Kristina Kriauciunas, C Ronald Kah. A kinase-independent role for unoccupied insulin and IGF-1 receptors in the control of apoptosis. Science signaling. vol 3. issue 151. 2011-05-03. PMID:21139139. |
this resistance to apoptosis was associated with decreased abundance of the proapoptotic protein bax and increases in abundance of the antiapoptotic proteins bcl-2, bcl-xl, xiap, and flip. |
2011-05-03 |
2023-08-12 |
Not clear |
| Lisa Chakrabarti, Jeremiah Eng, Nishi Ivanov, Gwenn A Garden, Albert R La Spad. Autophagy activation and enhanced mitophagy characterize the Purkinje cells of pcd mice prior to neuronal death. Molecular brain. vol 2. 2011-05-02. PMID:19640278. |
bax null status did not suppress purkinje neuron death in pcd mice, indicating that classic apoptosis is not responsible for purkinje cell loss. |
2011-05-02 |
2023-08-12 |
mouse |
| Rosanna Di Paola, Emanuela Mazzon, Irene Paterniti, Daniela Impellizzeri, Placido Bramanti, Salvatore Cuzzocre. Olprinone, a PDE3 inhibitor, modulates the inflammation associated with myocardial ischemia-reperfusion injury in rats. European journal of pharmacology. vol 650. issue 2-3. 2011-05-02. PMID:21035441. |
the olprinone administration significantly reduced the: (1) histological evidence of myocardial injury, (2) pro-inflammatory cytokines: tumor necrosis factor-α (tnf-α) and interleukin-1β (il-1β), (3) adhesion molecules: inter-cellular adhesion molecule 1 (icam-1) and p-selectin, (4) nitrotyrosine formation, (5) nuclear factor kappa-b (nf-κb) expression, (6) poly (adp-ribose) (par) formation, and (7) apoptosis (bax, bcl-2, fas-l and terminal deoxynucleotidyl transferase-mediated utp end labeling (tunel). |
2011-05-02 |
2023-08-12 |
rat |
| Arabinda Das, Misty McDowell, Casey M O'Dell, Megan E Busch, Joshua A Smith, Swapan K Ray, Naren L Bani. Post-treatment with voltage-gated Na(+) channel blocker attenuates kainic acid-induced apoptosis in rat primary hippocampal neurons. Neurochemical research. vol 35. issue 12. 2011-04-28. PMID:21127971. |
analyses showed increases in expression and activity of cysteine proteases, production of reactive oxygen species (ros), intracellular free [ca(2+)], and bax:bcl-2 ratio during apoptosis. |
2011-04-28 |
2023-08-12 |
human |
| Kukhuon Jeong, Yong-Cheol Shin, Sunju Park, Jeong-Su Park, Namil Kim, Jae-Young Um, Hoyeon Go, Seungho Sun, Sundong Lee, Wansu Park, Youkyung Choi, Yunkyung Song, Gyungjun Kim, Chanyong Jeon, Jonghyeong Park, Keysang Lee, Oksun Bang, Seong-Gyu K. Ethanol extract of Scutellaria baicalensis Georgi prevents oxidative damage and neuroinflammation and memorial impairments in artificial senescense mice. Journal of biomedical science. vol 18. 2011-04-28. PMID:21299906. |
ros, neuroinflammation and apoptosis related molecules expression such as cox-2, inos, procaspase-3, cleaved caspase-3, 8 and 9, bcl-2 and bax protein and the products of inos and cox-2, no, pge2, were studied using lps-activated raw 264.7 cells and microglia bv2 cells. |
2011-04-28 |
2023-08-12 |
mouse |
| Jong-Lyel Roh, Sung Koo Kang, Il Minn, Joseph A Califano, David Sidransky, Wayne M Koc. p53-Reactivating small molecules induce apoptosis and enhance chemotherapeutic cytotoxicity in head and neck squamous cell carcinoma. Oral oncology. vol 47. issue 1. 2011-04-27. PMID:21109480. |
cell-cycle arrest and apoptosis induced by p53ra small molecules were associated with upregulation of p21 and bax, and cleavage of caspase-3. |
2011-04-27 |
2023-08-12 |
human |
| F Allagnat, D Cunha, F Moore, J M Vanderwinden, D L Eizirik, A K Cardoz. Mcl-1 downregulation by pro-inflammatory cytokines and palmitate is an early event contributing to β-cell apoptosis. Cell death and differentiation. vol 18. issue 2. 2011-04-25. PMID:20798690. |
knocking down mcl-1 using small interference rnas increased apoptosis and caspase-3 cleavage induced by cytokines, palmitate or thapsigargin, whereas mcl-1 overexpression partly prevented bax translocation to the mitochondria, cytochrome c release, caspase-3 cleavage and apoptosis induced by the β-cell death effectors. |
2011-04-25 |
2023-08-12 |
Not clear |
| Jae-Sik Shin, Seung-Woo Hong, Jin-Gyun Lee, Young-Min Lee, Dae-Won Kim, Jee-Eun Kim, Da-Jung Jung, Sung-Kwan An, Nam-Joo Hong, Daejin Kim, Dong-Hoon Jin, Sok-Young Le. An ethanol extract of Iris nertschinskia induces p53-dependent apoptosis in the MCF7 human breast cancer cell line. International journal of molecular medicine. vol 27. issue 3. 2011-04-25. PMID:21240456. |
our results suggest that p53 sensitizes tumor cells to the ethanol extract of iris nertschinskia by bax protein induction and caspase-dependent apoptosis. |
2011-04-25 |
2023-08-12 |
human |
| Debashree Mukherjea, Sarvesh Jajoo, Tejbeer Kaur, Kelly E Sheehan, Vickram Ramkumar, Leonard P Ryba. Transtympanic administration of short interfering (si)RNA for the NOX3 isoform of NADPH oxidase protects against cisplatin-induced hearing loss in the rat. Antioxidants & redox signaling. vol 13. issue 5. 2011-04-22. PMID:20214492. |
also, transtympanic nox3 sirna reduced the expression of bax, abolished the decrease in expression of bcl2, and reduced apoptosis induced by cisplatin in the cochlea. |
2011-04-22 |
2023-08-12 |
rat |
| Xiu-ying Xiao, Miao Hao, Xin-ying Yang, Qian Ba, Mian Li, Shu-juan Ni, Li-Sha Wang, Xiang D. Licochalcone A inhibits growth of gastric cancer cells by arresting cell cycle progression and inducing apoptosis. Cancer letters. vol 302. issue 1. 2011-04-22. PMID:21216524. |
in addition, lca-induced apoptosis by its effects on the expression of parp, caspase-3, bcl-2 and bax. |
2011-04-22 |
2023-08-12 |
human |
| Changwei Liu, Yu Wang, Sirou Xie, Yijing Zhou, Xiangmei Ren, Xiaoting Li, Yunqing Ca. Liquiritigenin induces mitochondria-mediated apoptosis via cytochrome c release and caspases activation in HeLa Cells. Phytotherapy research : PTR. vol 25. issue 2. 2011-04-21. PMID:20658471. |
the apoptosis induction with liquiritigenin is associated with the up-regulation of p53 and bax, along with down-regulation of bcl-2 and survivin. |
2011-04-21 |
2023-08-12 |
human |
| Craig Brooks, Sung-Gyu Cho, Cong-Yi Wang, Tianxin Yang, Zheng Don. Fragmented mitochondria are sensitized to Bax insertion and activation during apoptosis. American journal of physiology. Cell physiology. vol 300. issue 3. 2011-04-20. PMID:21160028. |
fragmented mitochondria are sensitized to bax insertion and activation during apoptosis. |
2011-04-20 |
2023-08-12 |
mouse |
| Craig Brooks, Sung-Gyu Cho, Cong-Yi Wang, Tianxin Yang, Zheng Don. Fragmented mitochondria are sensitized to Bax insertion and activation during apoptosis. American journal of physiology. Cell physiology. vol 300. issue 3. 2011-04-20. PMID:21160028. |
these mefs were more sensitive to cisplatin-induced bax activation, release of cytochrome c, and apoptosis. |
2011-04-20 |
2023-08-12 |
mouse |
| Craig Brooks, Sung-Gyu Cho, Cong-Yi Wang, Tianxin Yang, Zheng Don. Fragmented mitochondria are sensitized to Bax insertion and activation during apoptosis. American journal of physiology. Cell physiology. vol 300. issue 3. 2011-04-20. PMID:21160028. |
mechanistically, mitochondrial fragmentation may sensitize the cells to bax insertion and activation in mitochondria, facilitating the release of apoptogenic factors and consequent apoptosis. |
2011-04-20 |
2023-08-12 |
mouse |
| Feng Wu, Ze-Yong Shao, Bao-Jin Zhai, Chun-Liang Zhao, Ding-Ming She. Ultrasound reverses multidrug resistance in human cancer cells by altering gene expression of ABC transporter proteins and Bax protein. Ultrasound in medicine & biology. vol 37. issue 1. 2011-04-19. PMID:21084157. |
the percentage of bax(+) cells was significantly higher in us-exposed hepg2/adm cells (p < 0.05), suggesting that us exposure could lead to cellular apoptosis in hepg2/adm cells. |
2011-04-19 |
2023-08-12 |
human |
| Min Ho Han, Gi Young Kim, Sung-Kwon Moon, Wun-Jae Kim, Taek-Jeong Nam, Yung Hyun Cho. Apoptosis induction by glycoprotein isolated from Laminaria japonica is associated with down-regulation of telomerase activity and prostaglandin E2 synthesis in AGS human gastric cancer cells. International journal of oncology. vol 38. issue 2. 2011-04-19. PMID:21132266. |
the increase in apoptosis was associated with up-regulation of pro-apoptotic bax expression, down-regulation of anti-apoptotic bcl-2 and iap family members, and activation of caspase-3 and -9. |
2011-04-19 |
2023-08-12 |
human |