| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Heather M Berens, Kenneth L Tyle. The proapoptotic Bcl-2 protein Bax plays an important role in the pathogenesis of reovirus encephalitis. Journal of virology. vol 85. issue 8. 2011-05-18. PMID:21307199. |
our studies suggest that bax is important for reovirus growth and pathogenesis in neurons and that the intrinsic pathway of apoptosis, mediated by bax, is important for full expression of disease, cns tissue injury, apoptosis, and viral growth in the cns of reovirus-infected mice. |
2011-05-18 |
2023-08-12 |
mouse |
| Saurabh Chattopadhyay, Michifumi Yamashita, Ying Zhang, Ganes C Se. The IRF-3/Bax-mediated apoptotic pathway, activated by viral cytoplasmic RNA and DNA, inhibits virus replication. Journal of virology. vol 85. issue 8. 2011-05-18. PMID:21307205. |
independent of irf-3's transcriptional role, a novel irf-3 activation pathway causes its interaction with the proapoptotic protein bax and its mitochondrial translocation to induce apoptosis. |
2011-05-18 |
2023-08-12 |
mouse |
| Yadong Liu, Shiping Ma, Rong Q. SCLM, total saponins extracted from Chaihu-jia-longgu-muli-tang, reduces chronic mild stress-induced apoptosis in the hippocampus in mice. Pharmaceutical biology. vol 48. issue 8. 2011-05-17. PMID:20673169. |
the present results suggest that sclm possesses a significant antidepressant-like property, and this effect may be through protection against stress-induced neuronal apoptosis by affecting the expression of bax and caspase-3 proteins in the hippocampus. |
2011-05-17 |
2023-08-12 |
mouse |
| Jennefer Lindsay, Mauro Degli Esposti, Andrew P Gilmor. Bcl-2 proteins and mitochondria--specificity in membrane targeting for death. Biochimica et biophysica acta. vol 1813. issue 4. 2011-05-17. PMID:21056595. |
anti-apoptotic bcl-2 proteins reside on the outer mitochondrial membrane (omm) and prevent apoptosis by inhibiting the activation of the pro-apoptotic family members bax and bak. |
2011-05-17 |
2023-08-12 |
Not clear |
| Aisha Shamas-Din, Hetal Brahmbhatt, Brian Leber, David W Andrew. BH3-only proteins: Orchestrators of apoptosis. Biochimica et biophysica acta. vol 1813. issue 4. 2011-05-17. PMID:21146563. |
bh3-only proteins promote apoptosis by both directly activating bax and bak and by suppressing the anti-apoptotic proteins at the mitochondria and the endoplasmic reticulum. |
2011-05-17 |
2023-08-12 |
Not clear |
| Dana Westphal, Grant Dewson, Peter E Czabotar, Ruth M Kluc. Molecular biology of Bax and Bak activation and action. Biochimica et biophysica acta. vol 1813. issue 4. 2011-05-17. PMID:21195116. |
bax and bak are two nuclear-encoded proteins present in higher eukaryotes that are able to pierce the mitochondrial outer membrane to mediate cell death by apoptosis. |
2011-05-17 |
2023-08-12 |
Not clear |
| Justin M Fear, Peter J Hanse. Developmental changes in expression of genes involved in regulation of apoptosis in the bovine preimplantation embryo. Biology of reproduction. vol 84. issue 1. 2011-05-16. PMID:20811013. |
thus, transcription of bax or other proteins is required for acquisition of the capacity for apoptosis. |
2011-05-16 |
2023-08-12 |
cattle |
| Aslamuzzaman Kazi, Jiazhi Sun, Kenichiro Doi, Shen-Shu Sung, Yoshinori Takahashi, Hang Yin, Johanna M Rodriguez, Jorge Becerril, Norbert Berndt, Andrew D Hamilton, Hong-Gang Wang, Saïd M Sebt. The BH3 alpha-helical mimic BH3-M6 disrupts Bcl-X(L), Bcl-2, and MCL-1 protein-protein interactions with Bax, Bak, Bad, or Bim and induces apoptosis in a Bax- and Bim-dependent manner. The Journal of biological chemistry. vol 286. issue 11. 2011-05-16. PMID:21148306. |
the bh3 alpha-helical mimic bh3-m6 disrupts bcl-x(l), bcl-2, and mcl-1 protein-protein interactions with bax, bak, bad, or bim and induces apoptosis in a bax- and bim-dependent manner. |
2011-05-16 |
2023-08-12 |
human |
| Aslamuzzaman Kazi, Jiazhi Sun, Kenichiro Doi, Shen-Shu Sung, Yoshinori Takahashi, Hang Yin, Johanna M Rodriguez, Jorge Becerril, Norbert Berndt, Andrew D Hamilton, Hong-Gang Wang, Saïd M Sebt. The BH3 alpha-helical mimic BH3-M6 disrupts Bcl-X(L), Bcl-2, and MCL-1 protein-protein interactions with Bax, Bak, Bad, or Bim and induces apoptosis in a Bax- and Bim-dependent manner. The Journal of biological chemistry. vol 286. issue 11. 2011-05-16. PMID:21148306. |
using several approaches, we demonstrate that bh3-m6 is a pan-bcl-2 antagonist that inhibits the binding of bcl-x(l), bcl-2, and mcl-1 to multi-domain bax or bak, or bh3-only bim or bad in cell-free systems and in intact human cancer cells, freeing up pro-apoptotic proteins to induce apoptosis. |
2011-05-16 |
2023-08-12 |
human |
| Aslamuzzaman Kazi, Jiazhi Sun, Kenichiro Doi, Shen-Shu Sung, Yoshinori Takahashi, Hang Yin, Johanna M Rodriguez, Jorge Becerril, Norbert Berndt, Andrew D Hamilton, Hong-Gang Wang, Saïd M Sebt. The BH3 alpha-helical mimic BH3-M6 disrupts Bcl-X(L), Bcl-2, and MCL-1 protein-protein interactions with Bax, Bak, Bad, or Bim and induces apoptosis in a Bax- and Bim-dependent manner. The Journal of biological chemistry. vol 286. issue 11. 2011-05-16. PMID:21148306. |
using caspase inhibitors and bax and bak sirnas, we demonstrate that bh3-m6-induced apoptosis is caspase- and bax-, but not bak-dependent. |
2011-05-16 |
2023-08-12 |
human |
| Meenakshi Tiwari, Marisa Lopez-Cruzan, William W Morgan, Brian Herma. Loss of caspase-2-dependent apoptosis induces autophagy after mitochondrial oxidative stress in primary cultures of young adult cortical neurons. The Journal of biological chemistry. vol 286. issue 10. 2011-05-11. PMID:21216964. |
the loss of caspase-2 significantly inhibited rotenone-induced activation of bid and bax and the release of cytochrome c and apoptosis inducing factor from mitochondria. |
2011-05-11 |
2023-08-12 |
mouse |
| Sai-Nan Xu, Yu Feng, Yu Zhang, Yi-Fei Zhou, Lei Yang, Yong-Guo Ji. [Effect of erythromycin on apoptosis of epithelial cell in nasal polyps]. Zhonghua er bi yan hou tou jing wai ke za zhi = Chinese journal of otorhinolaryngology head and neck surgery. vol 41. issue 7. 2011-05-10. PMID:17007374. |
to study the effect of erythromycin on apoptosis and expression of bax and bcl-2 of epithelial cell in nasal polyps. |
2011-05-10 |
2023-08-12 |
Not clear |
| Jo-Hua Chiang, Jai-Sing Yang, Chia-Yu Ma, Mei-Due Yang, Hui-Ying Huang, Te-Chun Hsia, Hsiu-Maan Kuo, Ping-Ping Wu, Tsung-Han Lee, Jing-Gung Chun. Danthron, an anthraquinone derivative, induces DNA damage and caspase cascades-mediated apoptosis in SNU-1 human gastric cancer cells through mitochondrial permeability transition pores and Bax-triggered pathways. Chemical research in toxicology. vol 24. issue 1. 2011-05-10. PMID:21126053. |
this study investigated the roles of caspase cascades, ros, dna damage, mitochondrial disruption, and bax and bcl-2 proteins in danthron-induced apoptosis of snu-1 human gastric cancer cells, a commonly used cell culture system for in vitro studies. |
2011-05-10 |
2023-08-12 |
human |
| Elliott M McMillan, Joe Quadrilater. Differential apoptosis-related protein expression, mitochondrial properties, proteolytic enzyme activity, and DNA fragmentation between skeletal muscles. American journal of physiology. Regulatory, integrative and comparative physiology. vol 300. issue 3. 2011-05-09. PMID:21148478. |
the protein content of apoptosis-inducing factor (aif), apoptosis repressor with caspase recruitment domain (arc), bax, bcl-2, cytochrome c, heat shock protein 70 (hsp70), and second mitochondria-derived activator of caspases (smac) were significantly (p < 0.05) higher in rg vs. wg muscle. |
2011-05-09 |
2023-08-12 |
rat |
| Zhengshun Xu, Hongtao Liu, Xinquan Lv, Yuqiong Liu, Shenglei Li, Huixiang L. Knockdown of the Bmi-1 oncogene inhibits cell proliferation and induces cell apoptosis and is involved in the decrease of Akt phosphorylation in the human breast carcinoma cell line MCF-7. Oncology reports. vol 25. issue 2. 2011-05-09. PMID:21152871. |
our results demonstrated that bmi-1 sirna effectively down-regulated the expression of bmi-1, inhibited cell proliferation in vitro and in vivo, evoked cell cycle arrest in the g0/g1 phase and induced cell apoptosis in mcf-7 cells, coupled with decrease in cyclin d1, cyclin e, cdk2, bcl-2 and ki-67 expression and akt phosphorylation levels and an increase of p21 and bax expression and activities of caspase-3/-9. |
2011-05-09 |
2023-08-12 |
human |
| Wei-Jiunn Lee, Yun-Ru Chen, Tsui-Hwa Tsen. Quercetin induces FasL-related apoptosis, in part, through promotion of histone H3 acetylation in human leukemia HL-60 cells. Oncology reports. vol 25. issue 2. 2011-05-09. PMID:21165570. |
quercetin triggered the extrinsic apoptosis pathway through activation of caspase-8 and induction of bid cleavage, bax conformation change and cytochrome c release. |
2011-05-09 |
2023-08-12 |
human |
| Ming Yan, Yun Zhang, Kedi Xu, Tao Fu, Haiyan Qin, Xiaoxiang Zhen. An in vitro study of vascular endothelial toxicity of CdTe quantum dots. Toxicology. vol 282. issue 3. 2011-05-06. PMID:21291946. |
moreover, upon 24h exposure to 10μg/ml cdte qds, the apoptotic huvecs dramatically increased by 402.01%, accompanied with alternative expression of apoptosis proteins, which were upregulation of bax, downregulation of bcl-2, release of mitochondrial cytochrome c and cleavage of caspase-9/caspase-3. |
2011-05-06 |
2023-08-12 |
human |
| Dae-Hee Lee, Cuk-Seong Kim, Yong J Le. Astaxanthin protects against MPTP/MPP+-induced mitochondrial dysfunction and ROS production in vivo and in vitro. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. vol 49. issue 1. 2011-05-05. PMID:21056612. |
our results suggest that the protective effects of ast on mpp+-induced apoptosis may be due to its anti-oxidative properties and anti-apoptotic activity via induction of expression of superoxide dismutase (sod) and catalase and regulating the expression of bcl-2 and bax. |
2011-05-05 |
2023-08-12 |
mouse |
| Dae-Hee Lee, Cuk-Seong Kim, Yong J Le. Astaxanthin protects against MPTP/MPP+-induced mitochondrial dysfunction and ROS production in vivo and in vitro. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. vol 49. issue 1. 2011-05-05. PMID:21056612. |
in summary, ast shows protection from mpp+/mptp-induced apoptosis in the sh-sy5y cells and pd model mouse sn neurons, and this effect may be attributable to upregulation of the expression of bcl-2 protein, downregulation of the expression of bax and α-synuclein, and inhibition of the activation of caspase-3. |
2011-05-05 |
2023-08-12 |
mouse |
| Peter E Czabotar, Erinna F Lee, Geoff V Thompson, Ahmad Z Wardak, W Douglas Fairlie, Peter M Colma. Mutation to Bax beyond the BH3 domain disrupts interactions with pro-survival proteins and promotes apoptosis. The Journal of biological chemistry. vol 286. issue 9. 2011-05-04. PMID:21199865. |
mutation to bax beyond the bh3 domain disrupts interactions with pro-survival proteins and promotes apoptosis. |
2011-05-04 |
2023-08-12 |
mouse |