| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| N Pasupuleti, S Matsuyama, O Voss, A I Doseff, K Song, D Danielpour, R H Nagara. The anti-apoptotic function of human αA-crystallin is directly related to its chaperone activity. Cell death & disease. vol 1. 2011-06-23. PMID:21364639. |
in cho cells, it inhibited apoptosis induced by the overexpression of human proapoptotic proteins, bim and bax. |
2011-06-23 |
2023-08-12 |
human |
| J K Sanzari, C Wambi, J S Lewis-Wambi, A R Kenned. Antioxidant dietary supplementation in mice exposed to proton radiation attenuates expression of programmed cell death-associated genes. Radiation research. vol 175. issue 5. 2011-06-23. PMID:21443425. |
these data confirm high-energy proton-induced gene expression of classical apoptosis markers including bax, caspase-3 and parp-1. |
2011-06-23 |
2023-08-12 |
mouse |
| Cornelia Amalinei, Corina Cianga, Raluca Balan, Petru Cianga, Simona Giusca, Irina-Draga Carunt. Immunohistochemical analysis of steroid receptors, proliferation markers, apoptosis related molecules, and gelatinases in non-neoplastic and neoplastic endometrium. Annals of anatomy = Anatomischer Anzeiger : official organ of the Anatomische Gesellschaft. vol 193. issue 1. 2011-06-22. PMID:21145716. |
our study was designed to investigate steroid receptor (er, pr) expression and its correlation with proliferative activity (pcna), apoptosis (fas, fasl, bcl-2, bax, and p53), gelatinases (mmp-2 and mmp-9) and their tissue specific inhibitor (timp-1 and timp-2) immunoexpression in endometrial carcinogenesis. |
2011-06-22 |
2023-08-12 |
Not clear |
| Ayako Matsumoto, Hajime Isomoto, Masaaki Nakayama, Junzo Hisatsune, Yoshito Nishi, Yujiro Nakashima, Kayoko Matsushima, Hisao Kurazono, Kazuhiko Nakao, Toshiya Hirayama, Shigeru Kohn. Helicobacter pylori VacA reduces the cellular expression of STAT3 and pro-survival Bcl-2 family proteins, Bcl-2 and Bcl-XL, leading to apoptosis in gastric epithelial cells. Digestive diseases and sciences. vol 56. issue 4. 2011-06-21. PMID:20927590. |
vaca induces apoptosis via activation of the pro-apoptotic b-cell lymphoma (bcl)-2 family proteins, bcl-2-associated x protein (bax) and bcl-2 homologous antagonist/killer (bak), while the implication of such pro-survival bcl-2 family members as bcl-2 and bcl-xl in the vaca-induced apoptosis remains unknown. |
2011-06-21 |
2023-08-12 |
Not clear |
| Ahmed Malki, Stephen C Bergmeie. Novel quinuclidinone derivative 8a induced apoptosis in human MCF-7 breast cancer cell lines. Anticancer research. vol 31. issue 3. 2011-06-21. PMID:21498708. |
8a induced g(1) phase arrest, presumably sensitizing the breast cancer cells to apoptosis by increasing expression level of p21 and cyclin e. moreover, 8a increased expression level of erk1, p53 and bax, and it reduced expression level of akt and bcl-2. |
2011-06-21 |
2023-08-12 |
human |
| Juan Garcia Valero, Lucie Sancey, Jérôme Kucharczak, Yannis Guillemin, Diana Gimenez, Julien Prudent, Germain Gillet, Jesús Salgado, Jean-Luc Coll, Abdel Aouacheri. Bax-derived membrane-active peptides act as potent and direct inducers of apoptosis in cancer cells. Journal of cell science. vol 124. issue Pt 4. 2011-06-20. PMID:21245196. |
we show that membrane-active segments of bax can directly induce the release of mitochondria-residing apoptogenic factors and commit tumor cells promptly and irreversibly to caspase-dependent apoptosis. |
2011-06-20 |
2023-08-12 |
mouse |
| Juan Garcia Valero, Lucie Sancey, Jérôme Kucharczak, Yannis Guillemin, Diana Gimenez, Julien Prudent, Germain Gillet, Jesús Salgado, Jean-Luc Coll, Abdel Aouacheri. Bax-derived membrane-active peptides act as potent and direct inducers of apoptosis in cancer cells. Journal of cell science. vol 124. issue Pt 4. 2011-06-20. PMID:21245196. |
on this basis, we designed a peptide encompassing part of the bax pore-forming domain, which can target mitochondria, induce cytochrome c release and trigger caspase-dependent apoptosis. |
2011-06-20 |
2023-08-12 |
mouse |
| Ali M Sharifi, Roshanak Ghazanfari, Neda Tekiyehmaroof, Mohammad A Sharif. Investigating the effect of lead acetate on rat bone marrow-derived mesenchymal stem cells toxicity: role of apoptosis. Toxicology mechanisms and methods. vol 21. issue 3. 2011-06-17. PMID:21244221. |
finally, it might be concluded that lead acetate could induce cell toxicity and apoptosis in mscs, causing instability in mitochondria and in turn activation of the intrinsic pathway including over-expression of bax, caspase 9 and caspase 3, leading to dna damage and activation of p53. |
2011-06-17 |
2023-08-12 |
rat |
| Ahyoung Kim, Mira Park, Tae Ki Yoon, Woo Sik Lee, Jeong-Jae Ko, Kangseok Lee, Jeehyeon Ba. Maternal exposure to benzo[b]fluoranthene disturbs reproductive performance in male offspring mice. Toxicology letters. vol 203. issue 1. 2011-06-17. PMID:21392559. |
to understand the molecular and cellular mechanisms by which the perinatal exposure to b[b]f decreased sperm quality, the testes of young adult f1 mice were examined for changes in expression of steroidogenesis-related and testicular apoptosis mediators and found that aryl hydrocarbon receptor, estrogen receptor α, and a set of proapoptotic proteins including bax, noxa, bad, and bim were significantly upregulated. |
2011-06-17 |
2023-08-12 |
mouse |
| Y Xie, W Sheng, J Miao, J Xiang, J Yan. Enhanced antitumor activity by combining an adenovirus harboring ING4 with cisplatin for hepatocarcinoma cells. Cancer gene therapy. vol 18. issue 3. 2011-06-15. PMID:21052098. |
we demonstrated that ad-ing4 plus cddp induced synergistic growth inhibition, enhanced apoptosis, and had an additive effect on upregulation of fas, bax, bak, cleaved bid, cleaved caspase-8, caspase-9, caspase-3 and cleaved parp, and on downregulation of bcl-2 and bcl-x(l) in smmc-7721 hepatocarcinoma cells. |
2011-06-15 |
2023-08-12 |
mouse |
| Fanghua Qi, Yoshinori Inagaki, Bo Gao, Xiaoyan Cui, Huanli Xu, Norihiro Kokudo, Anyuan Li, Wei Tan. Bufalin and cinobufagin induce apoptosis of human hepatocellular carcinoma cells via Fas- and mitochondria-mediated pathways. Cancer science. vol 102. issue 5. 2011-06-15. PMID:21288283. |
this apoptotic induction was associated with an increase in fas, bax and bid expression, a decrease in bcl-2 expression, disruption of the mitochondrial membrane potential, release of cytochrome c, activation of caspase-3, -8, -9 and -10, and the cleavage of poly(adp-ribose)polymerase (parp), which indicated that bufalin and cinobufagin induced apoptosis through both fas- and mitochondria-mediated pathways. |
2011-06-15 |
2023-08-12 |
human |
| Gemma Vilahur, Oriol Juan-Babot, Esther Peña, Blanca Oñate, Laura Casaní, Lina Badimo. Molecular and cellular mechanisms involved in cardiac remodeling after acute myocardial infarction. Journal of molecular and cellular cardiology. vol 50. issue 3. 2011-06-09. PMID:21219908. |
ischemic- (im) and non-ischemic myocardium (nim) was obtained for molecular analysis of: 1) apoptosis (p-bcl2, bax, p-p53, active-caspase-3); 2) the tlr-4-myd88-dependent and independent pathways; 3) akt/mtor/p70(s6k) axis activation; and, 4) fibrosis (tgf-β, collagen1-a1/a3). |
2011-06-09 |
2023-08-12 |
Not clear |
| Tongliang Bu, Yuling Mi, Weidong Zeng, Caiqiao Zhan. Protective effect of quercetin on cadmium-induced oxidative toxicity on germ cells in male mice. Anatomical record (Hoboken, N.J. : 2007). vol 294. issue 3. 2011-06-09. PMID:21337715. |
in addition, cadmium provoked germ cell apoptosis by upregulating expression of the proapoptotic proteins bax and caspase-3 and downregulating expression of the antiapoptotic protein bcl-xl. |
2011-06-09 |
2023-08-12 |
mouse |
| Tongliang Bu, Yuling Mi, Weidong Zeng, Caiqiao Zhan. Protective effect of quercetin on cadmium-induced oxidative toxicity on germ cells in male mice. Anatomical record (Hoboken, N.J. : 2007). vol 294. issue 3. 2011-06-09. PMID:21337715. |
additionally, quercetin protected germ cells from cadmium-induced apoptosis by downregulating the expression of bax and caspase-3 and upregulating bcl-xl expression. |
2011-06-09 |
2023-08-12 |
mouse |
| Cuiping Chi, Daisuke Hayashi, Masato Nemoto, Minako Nyui, Shiro Urano, Kazunori Anza. Vitamin E-deficiency did not exacerbate partial skin reactions in mice locally irradiated with X-rays. Journal of radiation research. vol 52. issue 1. 2011-06-07. PMID:21293070. |
although a deficiency in ve should lower resistance to free radicals in the mitochondrial membrane and thus enhance radiation-induced bax expression and apoptosis, it actually attenuated the increase in bax protein caused by irradiation. |
2011-06-07 |
2023-08-12 |
mouse |
| I Mendilcioglu, S Karaveli, G Erdogan, M Simsek, O Taskin, M Ozekinc. Apoptosis and expression of Bcl-2, Bax, p53, caspase-3, and Fas, Fas ligand in placentas complicated by preeclampsia. Clinical and experimental obstetrics & gynecology. vol 38. issue 1. 2011-06-07. PMID:21485723. |
apoptosis and expression of bcl-2, bax, p53, caspase-3, and fas, fas ligand in placentas complicated by preeclampsia. |
2011-06-07 |
2023-08-12 |
Not clear |
| I Mendilcioglu, S Karaveli, G Erdogan, M Simsek, O Taskin, M Ozekinc. Apoptosis and expression of Bcl-2, Bax, p53, caspase-3, and Fas, Fas ligand in placentas complicated by preeclampsia. Clinical and experimental obstetrics & gynecology. vol 38. issue 1. 2011-06-07. PMID:21485723. |
to determine whether preeclampsia is associated with an increase in placental apoptosis and altered expression of mediators of apoptosis such as fas, fas ligand, caspase-3, p53, bcl-2 and bax. |
2011-06-07 |
2023-08-12 |
Not clear |
| Yuzhen Liang, Muxun Zhang, Ning Xia, Yuelian Yang, Leping Fen. Effects of high concentration glucose on the expression of NF-kappaB, Bax and cytochrome C and apoptosis of islet cells in mice. Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban. vol 29. issue 4. 2011-06-06. PMID:19662359. |
effects of high concentration glucose on the expression of nf-kappab, bax and cytochrome c and apoptosis of islet cells in mice. |
2011-06-06 |
2023-08-12 |
mouse |
| Yuzhen Liang, Muxun Zhang, Ning Xia, Yuelian Yang, Leping Fen. Effects of high concentration glucose on the expression of NF-kappaB, Bax and cytochrome C and apoptosis of islet cells in mice. Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban. vol 29. issue 4. 2011-06-06. PMID:19662359. |
the roles of nf-kappab (nf-kappab) expression, bax activity and cytochrome c (cyt c) release, apoptosis of islet cells induced by high concentration glucose were explored in vitro. |
2011-06-06 |
2023-08-12 |
mouse |
| Yuzhen Liang, Muxun Zhang, Ning Xia, Yuelian Yang, Leping Fen. Effects of high concentration glucose on the expression of NF-kappaB, Bax and cytochrome C and apoptosis of islet cells in mice. Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban. vol 29. issue 4. 2011-06-06. PMID:19662359. |
bax activity and cyt c release were measured by immunofluorescence, and apoptosis was examined by hoechst33342 assay. |
2011-06-06 |
2023-08-12 |
mouse |