| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yong-Jun Li, Hong-Jun X. [Relationship between apoptotic effect of Resveratrol on KG-1 cells and expression of bcl-2/bax]. Zhongguo shi yan xue ye xue za zhi. vol 16. issue 5. 2011-07-12. PMID:18928588. |
compared with the control group, the cell number in s phase of kg-1 cells treated with res increased (p < 0.05), the apoptosis rate enhanced significantly (p < 0.01) and the expression level was down-regulated, while expression level of bax was obviously up-regulated (p < 0.01). |
2011-07-12 |
2023-08-12 |
Not clear |
| Yong-Jun Li, Hong-Jun X. [Relationship between apoptotic effect of Resveratrol on KG-1 cells and expression of bcl-2/bax]. Zhongguo shi yan xue ye xue za zhi. vol 16. issue 5. 2011-07-12. PMID:18928588. |
it is concluded that res significantly induces apoptosis of kg-1 cells in vitro, which is probably related to the down-regulation of bcl-2 expression and up-regulation of bax expression. |
2011-07-12 |
2023-08-12 |
Not clear |
| S Häcker, S Karl, I Mader, S Cristofanon, T Schweitzer, J Krauss, S Rutkowski, K-M Debatin, S Fuld. Histone deacetylase inhibitors prime medulloblastoma cells for chemotherapy-induced apoptosis by enhancing p53-dependent Bax activation. Oncogene. vol 30. issue 19. 2011-07-12. PMID:21562496. |
histone deacetylase inhibitors prime medulloblastoma cells for chemotherapy-induced apoptosis by enhancing p53-dependent bax activation. |
2011-07-12 |
2023-08-12 |
Not clear |
| S Häcker, S Karl, I Mader, S Cristofanon, T Schweitzer, J Krauss, S Rutkowski, K-M Debatin, S Fuld. Histone deacetylase inhibitors prime medulloblastoma cells for chemotherapy-induced apoptosis by enhancing p53-dependent Bax activation. Oncogene. vol 30. issue 19. 2011-07-12. PMID:21562496. |
combined treatment with ms-275 and doxorubicin or vp16 cooperates to promote binding of p53 to bax and p53-dependent bax activation, resulting in enhanced loss of mitochondrial membrane potential, cytochrome c release and caspase-dependent apoptosis. |
2011-07-12 |
2023-08-12 |
Not clear |
| Zhi-bin Liu, Wen-min Niu, Xiao-bang Yang, Xiao-mei Niu, Wang Yua. [Effect of "Xiusanzhen"on expression of hippocampal Bcl-2 and Bax proteins in Alzheimer disease rats]. Zhen ci yan jiu = Acupuncture research. vol 36. issue 1. 2011-07-12. PMID:21585051. |
to observe the effect of electroacupuncture (ea) of "xiusanzhen" [3 acupoints, i.e., bilateral "yingxiang" (li 20) and "yintang" (ex-hn 3)] on expression of b-cell lymphoma/leukemia-2 (bcl-2, an antiapoptosis protein) and bax (a protein for promoting apoptosis) in the hippocampus in alzheimer disease (ad) rats, so as to explore its clinical mechanisms underlying relieving ad. |
2011-07-12 |
2023-08-12 |
rat |
| Mun Yhung Jung, Nak Jin Choi, Chan Ho Oh, Hyun Kyung Shin, Suk Hoo Yoo. Selectively hydrogenated soybean oil exerts strong anti-prostate cancer activities. Lipids. vol 46. issue 3. 2011-07-11. PMID:21076944. |
the tunel method and immunohistochemical staining assays of bax, bcl-2, and survivin clearly showed that shso induced prostate cancer cell apoptosis in the tested rats. |
2011-07-11 |
2023-08-12 |
human |
| Marielle Doyon, Taben Mary Hale, Julie-Emilie Huot-Marchand, Rong Wu, Jacques de Champlain, Denis DeBloi. Does atorvastatin induce aortic smooth muscle cell apoptosis in vivo? Vascular pharmacology. vol 54. issue 1-2. 2011-07-07. PMID:20951229. |
primary endpoints included aortic medial hypertrophy and aortic smc hyperplasia, internucleosomal dna fragmentation and expression of the apoptosis regulatory proteins bax and bcl-2. |
2011-07-07 |
2023-08-12 |
rat |
| Shefali Krishna, Ivan Cherh Chiet Low, Shazib Pervai. Regulation of mitochondrial metabolism: yet another facet in the biology of the oncoprotein Bcl-2. The Biochemical journal. vol 435. issue 3. 2011-07-07. PMID:21486225. |
the canonical functional of bcl-2 in terms of apoptosis inhibition is its ability to prevent mitochondrial permeabilization via inhibiting the translocation and oligomerization of pro-apoptotic proteins such as bax; however, more recent evidence points to a novel mechanism of the anti-apoptotic activity of bcl-2. |
2011-07-07 |
2023-08-12 |
human |
| Ramesh M Ray, Sujoy Bhattacharya, Leonard R Johnso. Mdm2 inhibition induces apoptosis in p53 deficient human colon cancer cells by activating p73- and E2F1-mediated expression of PUMA and Siva-1. Apoptosis : an international journal on programmed cell death. vol 16. issue 1. 2011-07-05. PMID:20812030. |
the absence of p53 expression, higher basal bcl-xl and lower bax proteins prevented cpt-induced apoptosis. |
2011-07-05 |
2023-08-12 |
human |
| Jin-Jun Liu, Dong-Ling Li, Juan Zhou, Lei Sun, Ming Zhao, Shan-Shan Kong, You-Hua Wang, Xiao-Jiang Yu, Jun Zhou, Wei-Jin Zan. Acetylcholine prevents angiotensin II-induced oxidative stress and apoptosis in H9c2 cells. Apoptosis : an international journal on programmed cell death. vol 16. issue 1. 2011-07-05. PMID:20963497. |
in conclusion, ach prevents ang ii-induced h9c2 cells apoptosis through down-regulation of the at1 receptor and inhibition of ros-mediated p38 mapk activation as well as regulation of bcl-2, bax and caspase-3. |
2011-07-05 |
2023-08-12 |
mouse |
| Eunkuk Park, Gi-Ja Lee, Samjin Choi, Seok-Keun Choi, Su-Jin Chae, Sung-Wook Kang, Youngmi Kim Pak, Hun-Kuk Par. The role of glutamate release on voltage-dependent anion channels (VDAC)-mediated apoptosis in an eleven vessel occlusion model in rats. PloS one. vol 5. issue 12. 2011-07-05. PMID:21203570. |
to confirm neuronal apoptosis, the brains were removed 72 h after ischemia to detect the neuron-specific nuclear protein and pro-apoptotic proteins (cleaved caspase-3, vdac, p53 and bax). |
2011-07-05 |
2023-08-12 |
rat |
| Jingtao Tong, Ganfeng Xie, Jinxia He, Jianjun Li, Feng Pan, Houjie Lian. Synergistic antitumor effect of dichloroacetate in combination with 5-fluorouracil in colorectal cancer. Journal of biomedicine & biotechnology. vol 2011. 2011-07-05. PMID:21403907. |
moreover, compared with 5-fu alone, the apoptosis of crc cells treated with dca and 5-fu was enhanced and demonstrated with the changes of bcl-2, bax, and caspase-3 proteins. |
2011-07-05 |
2023-08-12 |
human |
| Antonella Muscella, Nadia Calabriso, Carla Vetrugno, Francesco Paolo Fanizzi, Sandra Angelica De Pascali, Santo Marsigliant. The signalling axis mediating neuronal apoptosis in response to [Pt(O,O'-acac)(γ-acac)(DMS)]. Biochemical pharmacology. vol 81. issue 11. 2011-07-05. PMID:21420390. |
here we have demonstrated that [pt(o,o'-acac)(γ-acac)(dms)] was more effective than cisplatin in provoking apoptosis characterized by: (a) mitochondria depolarization, (b) decrease of bcl-2 expression and increase of bax expressions with cytosol-to-mitochondria translocation, (c) activation of caspase-7 and -9 and (d) generation of reactive oxygen species (ros). |
2011-07-05 |
2023-08-12 |
human |
| Zhimin Zhou, Lihua Sun, Yingyi Wang, Zhifeng Wu, Jiong Geng, Weifeng Miu, Yi Pu, Yongping You, Zhengxiang Yang, Ning Li. Bone morphogenetic protein 4 inhibits cell proliferation and induces apoptosis in glioma stem cells. Cancer biotherapy & radiopharmaceuticals. vol 26. issue 1. 2011-06-30. PMID:21355779. |
this study shows that bmp4 inhibited u87 gsc proliferation (p < 0.01) via downregulation of cyclin d1 level and promoted gsc apoptosis through induction of bax expression and inhibition of bcl-2 and bcl-xl levels. |
2011-06-30 |
2023-08-12 |
human |
| F McCoy, J Hurwitz, N McTavish, I Paul, C Barnes, B O'Hagan, K Odrzywol, J Murray, D Longley, G McKerr, D A Fennel. Obatoclax induces Atg7-dependent autophagy independent of beclin-1 and BAX/BAK. Cell death & disease. vol 1. 2011-06-29. PMID:21368880. |
here we show that, although obatoclax can induce mitochondrial apoptosis dependent on bcl-2 associated x protein/bcl-2 antagonist killer (bax/bak) consistent with its on-target pharmacodynamics, simultaneous silencing of both bax and bak did not abolish acute toxicity or loss of clonogenicity. |
2011-06-29 |
2023-08-12 |
mouse |
| Takahiro Kodama, Tetsuo Takehara, Hayato Hikita, Satoshi Shimizu, Minoru Shigekawa, Wei Li, Takuya Miyagi, Atsushi Hosui, Tomohide Tatsumi, Hisashi Ishida, Tatsuya Kanto, Naoki Hiramatsu, Xiao-Ming Yin, Norio Hayash. BH3-only activator proteins Bid and Bim are dispensable for Bak/Bax-dependent thrombocyte apoptosis induced by Bcl-xL deficiency: molecular requisites for the mitochondrial pathway to apoptosis in platelets. The Journal of biological chemistry. vol 286. issue 16. 2011-06-28. PMID:21367852. |
a pivotal step in the mitochondrial pathway of apoptosis is activation of bak and bax, although the molecular mechanism remains controversial. |
2011-06-28 |
2023-08-12 |
mouse |
| Takahiro Kodama, Tetsuo Takehara, Hayato Hikita, Satoshi Shimizu, Minoru Shigekawa, Wei Li, Takuya Miyagi, Atsushi Hosui, Tomohide Tatsumi, Hisashi Ishida, Tatsuya Kanto, Naoki Hiramatsu, Xiao-Ming Yin, Norio Hayash. BH3-only activator proteins Bid and Bim are dispensable for Bak/Bax-dependent thrombocyte apoptosis induced by Bcl-xL deficiency: molecular requisites for the mitochondrial pathway to apoptosis in platelets. The Journal of biological chemistry. vol 286. issue 16. 2011-06-28. PMID:21367852. |
an in vitro study revealed that abt-737, a bad mimetic, induced platelet apoptosis in association with a conformational change of the amino terminus, translocation from the cytosol to mitochondria, and homo-oligomerization of bax. |
2011-06-28 |
2023-08-12 |
mouse |
| Takahiro Kodama, Tetsuo Takehara, Hayato Hikita, Satoshi Shimizu, Minoru Shigekawa, Wei Li, Takuya Miyagi, Atsushi Hosui, Tomohide Tatsumi, Hisashi Ishida, Tatsuya Kanto, Naoki Hiramatsu, Xiao-Ming Yin, Norio Hayash. BH3-only activator proteins Bid and Bim are dispensable for Bak/Bax-dependent thrombocyte apoptosis induced by Bcl-xL deficiency: molecular requisites for the mitochondrial pathway to apoptosis in platelets. The Journal of biological chemistry. vol 286. issue 16. 2011-06-28. PMID:21367852. |
abt-737-induced bax activation and apoptosis were also observed in bid/bim-deficient platelets. |
2011-06-28 |
2023-08-12 |
mouse |
| Takahiro Kodama, Tetsuo Takehara, Hayato Hikita, Satoshi Shimizu, Minoru Shigekawa, Wei Li, Takuya Miyagi, Atsushi Hosui, Tomohide Tatsumi, Hisashi Ishida, Tatsuya Kanto, Naoki Hiramatsu, Xiao-Ming Yin, Norio Hayash. BH3-only activator proteins Bid and Bim are dispensable for Bak/Bax-dependent thrombocyte apoptosis induced by Bcl-xL deficiency: molecular requisites for the mitochondrial pathway to apoptosis in platelets. The Journal of biological chemistry. vol 286. issue 16. 2011-06-28. PMID:21367852. |
despite residing in platelets, bh3-only activator proteins bid and bim are dispensable for bax activation and mitochondrial apoptosis. |
2011-06-28 |
2023-08-12 |
mouse |
| E Hervouet, F M Vallette, P-F Cartro. Impact of the DNA methyltransferases expression on the methylation status of apoptosis-associated genes in glioblastoma multiforme. Cell death & disease. vol 1. 2011-06-23. PMID:21364627. |
by analyzing human glioma biopsies, we first show that low level of apoptosis in tumor is correlated with aberrant methylation of the bcl-2, bax and xaf-1 genes, but not with the aberrant methylation of the bcl-w, survivin, tms1, caspase-8 and hrk genes. |
2011-06-23 |
2023-08-12 |
human |