| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Junhao Yan, Li Li, Nikan H Khatibi, Lei Yang, Ke Wang, Weiguang Zhang, Robert D Martin, Jingyan Han, John Zhang, Changman Zho. Blood-brain barrier disruption following subarchnoid hemorrhage may be faciliated through PUMA induction of endothelial cell apoptosis from the endoplasmic reticulum. Experimental neurology. vol 230. issue 2. 2011-08-15. PMID:21586287. |
immunohistochemical staining and western blot analysis demonstrated an increased expression of puma, bax, bak, grp78 and drp1 in the microvascular endothelial cells of the hippocampus, which was accompanied with endothelium apoptosis. |
2011-08-15 |
2023-08-12 |
rat |
| Isabelle Joyce de Lima Silva-Fernandes, Markênia Kélia Santos Alves, Valeska Portela Lima, Marcos Antônio Pereira de Lima, Marcos Aurélio Pessoa Barros, Márcia Valéria Pitombeira Ferreira, Silvia Helena Barem Rabenhors. Differential expression of MYC in H. pylori-related intestinal and diffuse gastric tumors. Virchows Archiv : an international journal of pathology. vol 458. issue 6. 2011-08-11. PMID:21538123. |
evidence suggests that the carcinogenic process guided by helicobacter pylori is related to the expression of cell cycle and apoptosis proteins as bcl-2, bax, and myc. |
2011-08-11 |
2023-08-12 |
Not clear |
| Yu Cheng, Erich Gulbins, Detlef Sieme. Activation of the permeability transition pore by Bax via inhibition of the mitochondrial BK channel. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology. vol 27. issue 3-4. 2011-08-10. PMID:21471707. |
upon induction of apoptosis, proapoptotic proteins of the bcl-2 family, in particular bax and bak, transfer the death signal to the organelle. |
2011-08-10 |
2023-08-12 |
rat |
| Qing-Yi Tong, Yong Qing, Dan Shu, Yang He, Ying-Lan Zhao, Yi Li, Zhen-Ling Wang, Shi-Yuan Zhang, Zhi-hua Xing, Cheng Xu, Yu-Quan Wei, Wen Huang, Xiao-Hua W. Deltonin, a steroidal saponin, inhibits colon cancer cell growth in vitro and tumor growth in vivo via induction of apoptosis and antiangiogenesis. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology. vol 27. issue 3-4. 2011-08-10. PMID:21471712. |
the deltonin treatment caused a noticeable apoptosis in tumor tissue, which associated with increased levels of bax, activated caspase-3, caspase-9, and cleaved poly (adpribose) polymerase, decreased pro-caspase-8, pro-caspase-9, bcl-2 expression levels and extracellular signal-regulated kinase-1/2 activity; and dose-dependently inhibit angiogenesis. |
2011-08-10 |
2023-08-12 |
mouse |
| Qin Zhang, Wei-Dong Huang, Xue-Ying Lv, Yun-Mei Yan. Ghrelin protects H9c2 cells from hydrogen peroxide-induced apoptosis through NF-κB and mitochondria-mediated signaling. European journal of pharmacology. vol 654. issue 2. 2011-08-09. PMID:21194528. |
in summary, ghrelin protects h9c2 cells from oxidative stress-induced apoptosis through downregulation of bax expression, caspase-9 activation and nf-κb phosphorylation, and upregulation of bcl-2 expression. |
2011-08-09 |
2023-08-12 |
Not clear |
| Xiangdong Lu, Chunyu Yang, Chaoying Yin, Terry Van Dyke, Karl Simi. Apoptosis is the essential target of selective pressure against p53, whereas loss of additional p53 functions facilitates carcinoma progression. Molecular cancer research : MCR. vol 9. issue 4. 2011-08-09. PMID:21385880. |
using a mouse brain carcinoma model that shows high selective pressure for p53 inactivation, we found that even partially abolishing p53-dependent apoptosis by bax inactivation was sufficient to significantly reduce the selective pressure for p53 loss. |
2011-08-09 |
2023-08-12 |
mouse |
| E Drakos, R R Singh, G Z Rassidakis, E Schlette, J Li, F X Claret, R J Ford, F Vega, L J Medeiro. Activation of the p53 pathway by the MDM2 inhibitor nutlin-3a overcomes BCL2 overexpression in a preclinical model of diffuse large B-cell lymphoma associated with t(14;18)(q32;q21). Leukemia. vol 25. issue 5. 2011-08-09. PMID:21394100. |
nutlin-3a-induced apoptosis was accompanied by bax and puma upregulation, bcl-xl downregulation, serine-70 dephosphorylation of bcl2, direct binding of bcl2 by p53, caspase-9 upregulation and caspase-3 cleavage. |
2011-08-09 |
2023-08-12 |
Not clear |
| Jieqiong Ma, Chanmin Liu, Yongqiang Chen, Jihong Jiang, Zhihong Qi. Cellular and molecular mechanisms of the Ganoderma applanatum extracts induces apoptosis on SGC-7901 gastric cancer cells. Cell biochemistry and function. vol 29. issue 3. 2011-08-09. PMID:21465494. |
to investigate the inhibition effect of ganoderma applanatum extract (gaeae) on human gastric cancer cell lines and apoptosis mechanism, alamar blue assay was used to assess the inhibition and apoptosis-inducing effect of the gaeae on proliferation of sgc-7901 cells, the dna ladders of the apoptosis cells was done, the mrna expression of p53, bax, bcl-2 and jnk were analysed by reverse transcription-polymerase chain reaction. |
2011-08-09 |
2023-08-12 |
human |
| Jieqiong Ma, Chanmin Liu, Yongqiang Chen, Jihong Jiang, Zhihong Qi. Cellular and molecular mechanisms of the Ganoderma applanatum extracts induces apoptosis on SGC-7901 gastric cancer cells. Cell biochemistry and function. vol 29. issue 3. 2011-08-09. PMID:21465494. |
in conclusion, our results indicated that the gaeae could enhance the sensitivity of sgc-7901 cells to the c-jun, p53, bax and bcl-2 induced apoptosis and provided a promising approach to anti-human gastric cancer therapy with ganoderma applanatum. |
2011-08-09 |
2023-08-12 |
human |
| Yuanxiang Jin, Shanshan Zheng, Zhengwei F. Embryonic exposure to cypermethrin induces apoptosis and immunotoxicity in zebrafish (Danio rerio). Fish & shellfish immunology. vol 30. issue 4-5. 2011-08-08. PMID:21316461. |
the mrna levels of some key genes including p53, puma, bax, apaf1, cas9 and cas3 on the mitochondrial pathway of cell apoptosis were significantly up-regulated at the concentration of 3 and 10 μg/l cyp. |
2011-08-08 |
2023-08-12 |
zebrafish |
| Yujie Shi, Shihe Yang, Sandi Troup, Xin Lu, Steve Callaghan, David S Park, Ying Xing, Xiaohe Yan. Resveratrol induces apoptosis in breast cancer cells by E2F1-mediated up-regulation of ASPP1. Oncology reports. vol 25. issue 6. 2011-08-08. PMID:21479363. |
moreover, resveratrol enhanced apoptosis of mcf-7/aspp1 cells, accompanied by higher expression of bax and p21. |
2011-08-08 |
2023-08-12 |
human |
| Mst Thangima Zannat, Rumpa B Bhattacharjee, Jnanankur Ba. In the absence of cellular poly (A) binding protein, the glycolytic enzyme GAPDH translocated to the cell nucleus and activated the GAPDH mediated apoptotic pathway by enhancing acetylation and serine 46 phosphorylation of p53. Biochemical and biophysical research communications. vol 409. issue 2. 2011-08-08. PMID:21539808. |
as a result, p53 translocated to the mitochondria to initiate bax mediated apoptosis. |
2011-08-08 |
2023-08-12 |
Not clear |
| Ya Tuo, Dengfeng Wang, Shengbin Li, Chen Che. Long-term exposure of INS-1 rat insulinoma cells to linoleic acid and glucose in vitro affects cell viability and function through mitochondrial-mediated pathways. Endocrine. vol 39. issue 2. 2011-08-04. PMID:21161439. |
cell viability, apoptosis, glucose-stimulated insulin secretion, bcl-2, and bax gene expression levels, mitochondrial membrane potential and cytochrome c release were examined. |
2011-08-04 |
2023-08-12 |
rat |
| Rida Fares, Samer Bazzi, Serine E Baydoun, Roula M Abdel-Massi. The antioxidant and anti-proliferative activity of the Lebanese Olea europaea extract. Plant foods for human nutrition (Dordrecht, Netherlands). vol 66. issue 1. 2011-08-04. PMID:21318304. |
to study whether cell death was due to apoptosis, cells were stained with annexin v-fitc and pi and the expression of important regulatory proteins (bcl-2, bax, and p53) involved in apoptosis were examined by western blot. |
2011-08-04 |
2023-08-12 |
human |
| Weiwei Zhang, Zhiping Wang, Tongsheng Che. Curcumol induces apoptosis via caspases-independent mitochondrial pathway in human lung adenocarcinoma ASTC-a-1 cells. Medical oncology (Northwood, London, England). vol 28. issue 1. 2011-08-02. PMID:20127426. |
dynamical imaging showed that curcumol induced a rapid translocation of bax from cytosol into mitochondria within 6 h, leading to a rapid dissipation of mitochondrial membrane potential (∆Ψm), implying that mitochondria play an important role in the curcumol-induced apoptosis. |
2011-08-02 |
2023-08-12 |
human |
| JoEllen Welsh, Lindsay N Zinser, Laurel Mianecki-Morton, Jamie Martin, Susan E Waltz, Howard James, Glendon M Zinse. Age-related changes in the epithelial and stromal compartments of the mammary gland in normocalcemic mice lacking the vitamin D3 receptor. PloS one. vol 6. issue 1. 2011-08-02. PMID:21298063. |
activation of caspase-3 and increased bax expression in mammary tissue of vdr ko mice suggests that enhanced apoptosis may contribute to loss of ductal branching. |
2011-08-02 |
2023-08-12 |
mouse |
| Nyree Crawford, Alex D Chacko, Kienan I Savage, Francis McCoy, Kelly Redmond, Daniel B Longley, Dean A Fennel. Platinum resistant cancer cells conserve sensitivity to BH3 domains and obatoclax induced mitochondrial apoptosis. Apoptosis : an international journal on programmed cell death. vol 16. issue 3. 2011-08-01. PMID:21107700. |
bax and bak are pivotal regulators of the mitochondrial apoptosis pathway, however little is known regarding their regulation in cisplatin resistant cells. |
2011-08-01 |
2023-08-12 |
Not clear |
| Guomin Niu, Songmei Yin, Shuangfeng Xie, Yiqing Li, Danian Nie, Liping Ma, Xiuju Wang, Yudan W. Quercetin induces apoptosis by activating caspase-3 and regulating Bcl-2 and cyclooxygenase-2 pathways in human HL-60 cells. Acta biochimica et biophysica Sinica. vol 43. issue 1. 2011-08-01. PMID:21173056. |
taken together, these findings suggested that quercetin induces apoptosis in a caspase-3-dependent pathway by inhibiting cox-2 expression and regulates the expression of downstream apoptotic components, including bcl-2 and bax. |
2011-08-01 |
2023-08-12 |
human |
| K S Robinson, A Clements, A C Williams, C N Berger, G Franke. Bax inhibitor 1 in apoptosis and disease. Oncogene. vol 30. issue 21. 2011-08-01. PMID:21297665. |
bax inhibitor 1 in apoptosis and disease. |
2011-08-01 |
2023-08-12 |
human |
| K S Robinson, A Clements, A C Williams, C N Berger, G Franke. Bax inhibitor 1 in apoptosis and disease. Oncogene. vol 30. issue 21. 2011-08-01. PMID:21297665. |
bax inhibitor 1 (bi-1) was originally discovered as an inhibitor of bax-induced apoptosis; this review highlights the fundamental importance of bi-1 in a wider context, including in tissue homeostasis and as a regulator of cellular stress. |
2011-08-01 |
2023-08-12 |
human |