| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ian Paul, Kienan I Savage, Jaine K Blayney, Elisabeth Lamers, Kathy Gately, Keith Kerr, Michael Sheaff, Kenneth Arthur, Derek J Richard, Peter W Hamilton, Jacqueline A James, Kenneth J O'Byrne, D Paul Harkin, Jennifer E Quinn, Dean A Fennel. PARP inhibition induces BAX/BAK-independent synthetic lethality of BRCA1-deficient non-small cell lung cancer. The Journal of pathology. vol 224. issue 4. 2011-09-09. PMID:21706479. |
importantly, this sensitivity was not attenuated in cells harbouring mitochondrial apoptosis block induced by co-depletion of bax and bak. |
2011-09-09 |
2023-08-12 |
Not clear |
| Guo-Hua Xia, Bao-An Chen, Hui-Xia Lu, Ze-Ye Shao, Jia-Hua Ding, Chong Gao, Ling-Li H. [Regulation of 2-methoxyestradiol-induced cell apoptosis by mcl-1 and bax genes in myelodysplastic syndrome]. Zhongguo shi yan xue ye xue za zhi. vol 17. issue 5. 2011-09-08. PMID:19840460. |
[regulation of 2-methoxyestradiol-induced cell apoptosis by mcl-1 and bax genes in myelodysplastic syndrome]. |
2011-09-08 |
2023-08-12 |
Not clear |
| Guo-Hua Xia, Bao-An Chen, Hui-Xia Lu, Ze-Ye Shao, Jia-Hua Ding, Chong Gao, Ling-Li H. [Regulation of 2-methoxyestradiol-induced cell apoptosis by mcl-1 and bax genes in myelodysplastic syndrome]. Zhongguo shi yan xue ye xue za zhi. vol 17. issue 5. 2011-09-08. PMID:19840460. |
the purpose of this study was to explore the mechanism underlying the regulation of 2-methoxyestradiol (2-me)-induced cell apoptosis by mcl-1 and bax gene in myelodysplastic syndrome (mds). |
2011-09-08 |
2023-08-12 |
Not clear |
| Yoshikazu Mikami, Motoki Senoo, Mio Lee, Kiyoshi Yamada, Kuniyasu Ochiai, Masaki J Honda, Eri Watanabe, Nobukazu Watanabe, Masanori Somei, Minoru Takag. Inhibitory effects of a tryptamine derivative on ultraviolet radiation-induced apoptosis in MC3T3-E1 mouse osteoblasts. Journal of pharmacological sciences. vol 115. issue 2. 2011-09-08. PMID:21282935. |
we investigated the effect of ms-ipa1 on apoptosis by analyzing caspase3/7 activity, translocation of phosphatidylserine (ps), and mrna expression levels of bcl-2 and bax. |
2011-09-08 |
2023-08-12 |
mouse |
| Alessandro Arduini, Gaetano Serviddio, Javier Escobar, Ana M Tormos, Francesco Bellanti, José Viña, María Monsalve, Juan Sastr. Mitochondrial biogenesis fails in secondary biliary cirrhosis in rats leading to mitochondrial DNA depletion and deletions. American journal of physiology. Gastrointestinal and liver physiology. vol 301. issue 1. 2011-09-06. PMID:21415417. |
key sensors and regulators of the energetic state and mitochondrial biogenesis, mitochondrial dna (mtdna)-to-nuclear dna (ndna) ratio (mtdna/ndna) relative copy number, mtdna deletions, and indexes of apoptosis (bax, bcl-2, and cleaved caspase 3) and cell proliferation (pcna) were evaluated. |
2011-09-06 |
2023-08-12 |
rat |
| Bartosz Wojtas, Beata Fijalkowska, Adam Wlodarczyk, Ada Schollenberger, Marek Niemialtowski, Beston Hamasur, Andrzej Pawlowski, Malgorzata Krzyzowsk. Mannosylated lipoarabinomannan balances apoptosis and inflammatory state in mycobacteria-infected and uninfected bystander macrophages. Microbial pathogenesis. vol 51. issue 1-2. 2011-09-06. PMID:21440050. |
manlam contributed to the infection of macrophages by protection from apoptosis with stabilized bcl-2 expression and down-regulated bax expression for infected cells (bcg) or with stabilized bcl-2 expression for uninfected bystander target cells (h37ra). |
2011-09-06 |
2023-08-12 |
mouse |
| Bartosz Wojtas, Beata Fijalkowska, Adam Wlodarczyk, Ada Schollenberger, Marek Niemialtowski, Beston Hamasur, Andrzej Pawlowski, Malgorzata Krzyzowsk. Mannosylated lipoarabinomannan balances apoptosis and inflammatory state in mycobacteria-infected and uninfected bystander macrophages. Microbial pathogenesis. vol 51. issue 1-2. 2011-09-06. PMID:21440050. |
inhibitors specific for c-jun-nh2-terminal kinase or stress-activated kinase (jnk) and p38 kinase decreased apoptosis of infected cells (bcg, h37ra) and of uninfected bystanders (h37ra) by down-regulating bax. |
2011-09-06 |
2023-08-12 |
mouse |
| Jiayu Gao, Winston A Morgan, Alberto Sanchez-Medina, Olivia Corcora. The ethanol extract of Scutellaria baicalensis and the active compounds induce cell cycle arrest and apoptosis including upregulation of p53 and Bax in human lung cancer cells. Toxicology and applied pharmacology. vol 254. issue 3. 2011-09-06. PMID:21457722. |
the ethanol extract of scutellaria baicalensis and the active compounds induce cell cycle arrest and apoptosis including upregulation of p53 and bax in human lung cancer cells. |
2011-09-06 |
2023-08-12 |
human |
| Jiayu Gao, Winston A Morgan, Alberto Sanchez-Medina, Olivia Corcora. The ethanol extract of Scutellaria baicalensis and the active compounds induce cell cycle arrest and apoptosis including upregulation of p53 and Bax in human lung cancer cells. Toxicology and applied pharmacology. vol 254. issue 3. 2011-09-06. PMID:21457722. |
following treatment, increased expression in the cancer cells of key proteins related to the enhancement of apoptosis was observed for p53 and bax. |
2011-09-06 |
2023-08-12 |
human |
| Fang-ling Sun, Lan Zhang, Ru-yi Zhang, Lin L. Tetrahydroxystilbene glucoside protects human neuroblastoma SH-SY5Y cells against MPP+-induced cytotoxicity. European journal of pharmacology. vol 660. issue 2-3. 2011-09-06. PMID:21497157. |
in addition, tsg suppressed both the upregulation of the ratio of bax to bcl-2 and the activation of caspase-3 induced by mpp+, and tsg inhibited apoptosis as detected by flow cytometric analysis using annexin-v and propidium (pi) label. |
2011-09-06 |
2023-08-12 |
human |
| Muzafar A Macha, Ajay Matta, Shyam Singh Chauhan, K W Michael Siu, Ranju Ralha. Guggulsterone targets smokeless tobacco induced PI3K/Akt pathway in head and neck cancer cells. PloS one. vol 6. issue 2. 2011-09-01. PMID:21383988. |
we hypothesized gs can abrogate the effects of st and nicotine on apoptosis in hnscc cells, in part by activation of pi3k/akt pathway and its downstream targets, bax and bad. |
2011-09-01 |
2023-08-12 |
Not clear |
| João Agostinho Machado-Neto, Patricia Favaro, Mariana Lazarini, Fernando Ferreira Costa, Sara T Olalla Saad, Fabiola Train. Knockdown of insulin receptor substrate 1 reduces proliferation and downregulates Akt/mTOR and MAPK pathways in K562 cells. Biochimica et biophysica acta. vol 1813. issue 8. 2011-08-30. PMID:21569802. |
nevertheless, apoptosis was unaffected by irs1 knockdown and no alterations were found in the phosphorylation of bad and in the expression of bcl2 and bax. |
2011-08-30 |
2023-08-12 |
Not clear |
| Xueli Wang, Bo Chen, Wei Xu, Shifeng Liu, Weihong Zhao, Jianqing W. Combined effects of klotho and soluble CD40 ligand on A549 lung cancer cells. Oncology reports. vol 25. issue 5. 2011-08-26. PMID:21308354. |
in this study, we found that klotho, soluble cd40 ligand and their combination can increase cell proliferation inhibition and the apoptosis rate in a549 cells by inhibiting the cell cycle, up-regulating bax gene expression and (or) down-regulating bcl-2 gene expression; and their combination has a stronger effect on a549 cell apoptosis and proliferation inhibition compared to klotho or scd40l alone. |
2011-08-26 |
2023-08-12 |
Not clear |
| Yanping Zou, Sam K C Chan. Effect of black soybean extract on the suppression of the proliferation of human AGS gastric cancer cells via the induction of apoptosis. Journal of agricultural and food chemistry. vol 59. issue 9. 2011-08-26. PMID:21462927. |
moreover, the involvement of black soybean extract in inducing apoptosis was confirmed by the expression of bax, bcl-2, caspase-3, and parp. |
2011-08-26 |
2023-08-12 |
human |
| Hongxun Gong, Xianming Chen, Xian Zhang, Fengfang Li. [Research on apoptosis changes of tensor veli palatini in patients with obstructive sleep apnea-hypopnea syndrome]. Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology, head, and neck surgery. vol 24. issue 3. 2011-08-25. PMID:20429379. |
to explore apoptosis changes of dilator muscles in the upper airway by detecting the expression of bax, bcl-2 in tensor veli palatini in patients with osahs. |
2011-08-25 |
2023-08-12 |
Not clear |
| Wen Ji Li, Seung-June O. PARP inhibition prevents oxidative injury of bladder induced by acute urinary retention and subsequent emptying. Apoptosis : an international journal on programmed cell death. vol 16. issue 6. 2011-08-25. PMID:21416227. |
the degree of bladder apoptosis, levels of malondialdehyde (mda), atp and nicotinamide adenine dinucleotide (nad+); expression of poly(adp-ribose) (par), phosphorylation of protein kinase b (akt); and levels of bcl-2, bax, and caspase 3 activity in the bladder were determined. |
2011-08-25 |
2023-08-12 |
rat |
| Ming-Fang Shen, Bao-An Chen, Jian Cheng, Feng Gao, Wen-Lin Xu, Jia-Hua Ding, Chong Gao, Xin-Chen Sun, Guo-Hong Li, Wen-Ji Chen, Li-Jie Liu, Xiao-Mao Li, Xue-Mei Wan. Effects of magnetic nanoparticle of fe(3)o(4) and 5-bromotetrandrine on apoptosis of K562/A02 leukemic cells induced by daunorubicin. Zhongguo shi yan xue ye xue za zhi. vol 17. issue 1. 2011-08-23. PMID:19236747. |
the apoptosis was detected by flow cytometry (fcm), wright staining and light microscope; the expressions of bax and bcl-2 were measured by western blot. |
2011-08-23 |
2023-08-12 |
Not clear |
| Xin-Yi Chen, Zhi Zheng, Ju Chen, Dong Yun L. [Effect of compound Zhe-Bei granule (CZBG) combined with doxorubicin on cell apoptosis and expression of related proteins in K562/A02 multidrug resistance tumor xenografts in mice]. Zhongguo shi yan xue ye xue za zhi. vol 17. issue 6. 2011-08-23. PMID:20030922. |
this study was purposed to investigate the effects of compound zhe-bei granule (czbg) combined with doxorubicin (dox) on the expression of bcl-2, bax and cell apoptosis rate in k562/a02 multidrug resistant tumor xenografts. |
2011-08-23 |
2023-08-12 |
mouse |
| Xin-Yi Chen, Zhi Zheng, Ju Chen, Dong Yun L. [Effect of compound Zhe-Bei granule (CZBG) combined with doxorubicin on cell apoptosis and expression of related proteins in K562/A02 multidrug resistance tumor xenografts in mice]. Zhongguo shi yan xue ye xue za zhi. vol 17. issue 6. 2011-08-23. PMID:20030922. |
the results indicated that as compared with normal saline control group and dox group, the high, middle, low dose of czbg combined with dox could increase the cell apoptosis rate of tumor xenografts with statistical significance (p < 0.05); and could decrease the iod value of bcl-2 and increase the iod value of bax in xenografts with statistical significance (p < 0.05). |
2011-08-23 |
2023-08-12 |
mouse |
| Xin-Yi Chen, Zhi Zheng, Ju Chen, Dong Yun L. [Effect of compound Zhe-Bei granule (CZBG) combined with doxorubicin on cell apoptosis and expression of related proteins in K562/A02 multidrug resistance tumor xenografts in mice]. Zhongguo shi yan xue ye xue za zhi. vol 17. issue 6. 2011-08-23. PMID:20030922. |
it is concluded that czbg combined with dox can enhance the apoptosis rate in k562/a02 cells, down-regulate the expression of bcl-2 and up-regulate the expression of bax, thereby, can reverse the multidrug resistance of k562/a02 cells by decreasing the ratio of bcl-2/bax. |
2011-08-23 |
2023-08-12 |
mouse |