| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xiaocheng Yin, Lizhi Cao, Rui Kang, Minghua Yang, Zhuo Wang, Yanhui Peng, Yanfang Tan, Liying Liu, Min Xie, Yiming Zhao, Kristen M Livesey, Daolin Tan. UV irradiation resistance-associated gene suppresses apoptosis by interfering with BAX activation. EMBO reports. vol 12. issue 7. 2011-10-11. PMID:21597469. |
uv irradiation resistance-associated gene suppresses apoptosis by interfering with bax activation. |
2011-10-11 |
2023-08-12 |
Not clear |
| Xiaocheng Yin, Lizhi Cao, Rui Kang, Minghua Yang, Zhuo Wang, Yanhui Peng, Yanfang Tan, Liying Liu, Min Xie, Yiming Zhao, Kristen M Livesey, Daolin Tan. UV irradiation resistance-associated gene suppresses apoptosis by interfering with BAX activation. EMBO reports. vol 12. issue 7. 2011-10-11. PMID:21597469. |
here, we present evidence that uvrag functions as an unusual bcl2-associated x protein (bax) suppressor to regulate apoptosis. |
2011-10-11 |
2023-08-12 |
Not clear |
| Xiaocheng Yin, Lizhi Cao, Rui Kang, Minghua Yang, Zhuo Wang, Yanhui Peng, Yanfang Tan, Liying Liu, Min Xie, Yiming Zhao, Kristen M Livesey, Daolin Tan. UV irradiation resistance-associated gene suppresses apoptosis by interfering with BAX activation. EMBO reports. vol 12. issue 7. 2011-10-11. PMID:21597469. |
our findings show that uvrag has an essential role in the intrinsic mitochondrial pathway of apoptosis by regulating the localization of bax. |
2011-10-11 |
2023-08-12 |
Not clear |
| Sridhar Radhakrishnan, Lavanya Reddivari, Robert Sclafani, Undurti N Das, Jairam Vanamal. Resveratrol potentiates grape seed extract induced human colon cancer cell apoptosis. Frontiers in bioscience (Elite edition). vol 3. 2011-10-10. PMID:21622155. |
apoptosis was strongly correlated with pp53 levels and bax:bcl-2 ratio, key players in the mitochondrial apoptotic pathway. |
2011-10-10 |
2023-08-12 |
human |
| Diana Londoño, Jenny Carvajal, Klemen Strle, Kwang S Kim, Diego Cadavi. IL-10 Prevents apoptosis of brain endothelium during bacteremia. Journal of immunology (Baltimore, Md. : 1950). vol 186. issue 12. 2011-10-07. PMID:21602495. |
hbmec apoptosis during exposure to a low number of bacteria was associated with downregulation of tnf and tnfaip3 and upregulation of bax. |
2011-10-07 |
2023-08-12 |
mouse |
| Chao-Lin Kuo, Shan-Ying Wu, Siu-Wan Ip, Ping-Ping Wu, Chun-Shu Yu, Jai-Sing Yang, Po-Yuan Chen, Shin-Hwar Wu, Jing-Gung Chun. Apoptotic death in curcumin-treated NPC-TW 076 human nasopharyngeal carcinoma cells is mediated through the ROS, mitochondrial depolarization and caspase-3-dependent signaling responses. International journal of oncology. vol 39. issue 2. 2011-10-07. PMID:21617861. |
curcumin-induced apoptosis was accompanied with upregulation of the protein expression of bax and downregulation of the protein levels of bcl-2, resulting in dysfunction of mitochondria and subsequently led to cytochrome c release and sequential activation of caspase-9 and caspase-3 in npc-tw 076 cells in a time-dependent manner. |
2011-10-07 |
2023-08-12 |
human |
| Bin Chu, Ying Zhang, Hong-Xing Liu, Yan-Xia Bai, Xing-Guo Zuo, Min-Qiu Lu, Meng-Qing Wu, Lei Shi, Lei Liu, Ping Zh. [Induction of apoptosis of leukemic tumor cells in mouse model with G-quadruplex ligand Tel03]. Zhongguo shi yan xue ye xue za zhi. vol 18. issue 1. 2011-10-06. PMID:20137119. |
cell apoptosis was detected with tunel assay and the expression levels of bcl-2 and bax were detected by western blot. |
2011-10-06 |
2023-08-12 |
mouse |
| Fei Wang, Bao-An Chen, Jian Cheng, Wen-Lin Xu, Xue-Mei Wang, Jia-Hua Ding, Chong Gao, Yun-Yu Sun, Jun Wang, Gang Zhao, Wen Bao, Hui-Hui Song, Feng Gao, Wei Zhang, Guo-Hua Xia, Xiao-Ping Pei, Wei-Wei Wu, Li Yin, Xue-Yun Sha. [Effects of hypoxia-inducible factor inhibitor on expression of HIF-1alpha and VEGF and induction of apoptosis in leukemic cell lines]. Zhongguo shi yan xue ye xue za zhi. vol 18. issue 1. 2011-10-06. PMID:20137122. |
after treatment of u937 cell with 4 micromol/l yc-1, cell apoptosis was assayed by dapi staining under fluorescent microscope and flow cytometry with annexin v-fitc/pi staining; the expression levels of hif-1alpha mrna and vegf mrna were measured with rt-pcr; the expression levels of hif-1alpha, vegf, bax, bcl-2 and caspase-3 proteins were measured by western blot. |
2011-10-06 |
2023-08-12 |
Not clear |
| Fu-Xu Wang, Fang Zhao, Ling Pan, Xue-Jun Zhang, Jian-Min Luo, Jing-Ci Yang, Li Yao, Xing-Yan DU, Zuo-Ren Don. [Preliminary study on the effect of TRAIL on adhesion and apoptosis of multiple myeloma cell line RPMI8226 and its mechanism]. Zhongguo shi yan xue ye xue za zhi. vol 18. issue 1. 2011-10-06. PMID:20137126. |
the inhibition effects of trail on cells growth and adhesion were assayed by mtt; cell apoptosis was detected by annexin v and pi; expression of genes bax, bcl-2, mcl-1, carp1, carp2, xiap and cflip were determined by semi-quantitative rt-pcr; apoptosis-related protein expression was detected by western blot. |
2011-10-06 |
2023-08-12 |
Not clear |
| Fu-Xu Wang, Fang Zhao, Ling Pan, Xue-Jun Zhang, Jian-Min Luo, Jing-Ci Yang, Li Yao, Xing-Yan DU, Zuo-Ren Don. [Preliminary study on the effect of TRAIL on adhesion and apoptosis of multiple myeloma cell line RPMI8226 and its mechanism]. Zhongguo shi yan xue ye xue za zhi. vol 18. issue 1. 2011-10-06. PMID:20137126. |
trail induced apoptosis in rpmi8226 cells, the expression level of genes bcl-2, mcl-1, carp1, carp2, xiap and cflip decreased, while the expression level of bax increased, but the expression level of caspase-3 and nf-kappab p65(rela) proteins decreased. |
2011-10-06 |
2023-08-12 |
Not clear |
| Ya-Juan Li, Jian-Ming Zeng, Shi-Feng Huang, Xiao-Zhong Wang, Shi-Qiao Zhao, Wei-Jun Bai, Wei-Xi Cao, Zong-Gan Huang, Wen-Li Fen. Selective leukemia cell death by activation of the double-stranded RNA-dependent protein kinase PKR. International journal of molecular medicine. vol 28. issue 2. 2011-10-04. PMID:21468538. |
moreover, we observed expression of bcr-abl as rna in k562 cells which resulted in selective apoptosis induction through specific activation of pkr, leading to phosphorylation of eif2α, global inhibition of protein synthesis, caspase-8 activation and bax up-regulation. |
2011-10-04 |
2023-08-12 |
Not clear |
| Ya-Juan Li, Jian-Ming Zeng, Shi-Feng Huang, Xiao-Zhong Wang, Shi-Qiao Zhao, Wei-Jun Bai, Wei-Xi Cao, Zong-Gan Huang, Wen-Li Fen. Selective leukemia cell death by activation of the double-stranded RNA-dependent protein kinase PKR. International journal of molecular medicine. vol 28. issue 2. 2011-10-04. PMID:21468538. |
taken together, our results indicate that targeted pkr activation led to selective apoptosis induction in k562 cells, which correlated with caspase-8 activity and enhanced expression of bax. |
2011-10-04 |
2023-08-12 |
Not clear |
| Michelina Festa, Luis Del Valle, Kamel Khalili, Renato Franco, Giosuè Scognamiglio, Vincenzo Graziano, Vincenzo De Laurenzi, Maria Caterina Turco, Alessandra Rosat. BAG3 protein is overexpressed in human glioblastoma and is a potential target for therapy. The American journal of pathology. vol 178. issue 6. 2011-10-03. PMID:21561597. |
finally, we determined that the underlying molecular mechanism requires the formation of a complex of bag3, hsp70, and bax that prevents bax translocation to mitochondria, thus protecting tumor cells from apoptosis. |
2011-10-03 |
2023-08-12 |
human |
| Thayele Purayil Hamsa, Punathil Thejass, Girija Kutta. Induction of apoptosis by sulforaphane in highly metastatic B16F-10 melanoma cells. Drug and chemical toxicology. vol 34. issue 3. 2011-10-03. PMID:21649489. |
sfn-induced apoptosis was associated with the activation of caspases 3 and 9, bax, and p53 and the downregulation of bcl-2, caspase-8, bid, and nf-kb. |
2011-10-03 |
2023-08-12 |
Not clear |
| Yinyuan Wu, Dianjun Wang, Xiaodong Wang, Yinyin Wang, Fangli Ren, Donald Chang, Zhijie Chang, Baoqing Ji. Caspase 3 is activated through caspase 8 instead of caspase 9 during H2O2-induced apoptosis in HeLa cells. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology. vol 27. issue 5. 2011-10-03. PMID:21691071. |
finally, we found that bax did not translocate from the cytosol to the mitochondrial membrane during h(2)o(2)-induced apoptosis. |
2011-10-03 |
2023-08-12 |
Not clear |
| Elena Beltran, Vicente Fresquet, Javier Martinez-Useros, Jose A Richter-Larrea, Ainara Sagardoy, Izaskun Sesma, Luciana L Almada, Santiago Montes-Moreno, Reiner Siebert, Stefan Gesk, Maria J Calasanz, Raquel Malumbres, Melissa Rieger, Felipe Prosper, Izidore S Lossos, Miguel Angel Piris, Martin E Fernandez-Zapico, Jose A Martinez-Climen. A cyclin-D1 interaction with BAX underlies its oncogenic role and potential as a therapeutic target in mantle cell lymphoma. Proceedings of the National Academy of Sciences of the United States of America. vol 108. issue 30. 2011-10-03. PMID:21746927. |
accordingly, cyclin-d1 inhibition sensitized the lymphoma cells to apoptosis through bax release. |
2011-10-03 |
2023-08-12 |
mouse |
| Hui-Juan Xu, Ren Zhong, Yan-Xia Zhao, Xue-Rong Li, Yuan Lu, Ai-Qin Song, Xiu-Ying Pang, Ru-Yong Yao, Li-Rong Su. [Proliferative inhibition and apoptotic induction effects of crocin on human leukemia HL-60 cells and their mechanisms]. Zhongguo shi yan xue ye xue za zhi. vol 18. issue 4. 2011-09-30. PMID:20723294. |
the mechanisms by which crocin induced apoptosis in hl-60 cells may be related to the inhibition of bcl-2 and activation of bax. |
2011-09-30 |
2023-08-12 |
human |
| Nadine Darwiche, Ansam Sinjab, Ghada Abou-Lteif, Mirella Bou Chedid, Olivier Hermine, Ghassan Dbaibo, Ali Bazarbach. Inhibition of mammalian target of rapamycin signaling by everolimus induces senescence in adult T-cell leukemia/lymphoma and apoptosis in peripheral T-cell lymphomas. International journal of cancer. vol 129. issue 4. 2011-09-30. PMID:21064094. |
everolimus-mediated apoptosis was also associated with an upregulation of p53 upregulated modulator of apoptosis (puma-α) proteins, an increase in bax proteins and downregulation of bcl-x(l) proteins in all tested htlv-i-positive and -negative malignant cell lines. |
2011-09-30 |
2023-08-12 |
human |
| V Graupner, E Alexander, T Overkamp, O Rothfuss, V De Laurenzi, B F Gillissen, P T Daniel, K Schulze-Osthoff, F Essman. Differential regulation of the proapoptotic multidomain protein Bak by p53 and p73 at the promoter level. Cell death and differentiation. vol 18. issue 7. 2011-09-30. PMID:21233848. |
during apoptosis bcl-2 proteins control permeabilization of the mitochondrial outer membrane leading to the release of cytochrome c. essential gatekeepers for cytochrome c release are the proapoptotic multidomain proteins, bax, and bak. |
2011-09-30 |
2023-08-12 |
Not clear |
| Hayato Hikita, Tetsuo Takehara, Takahiro Kodama, Satoshi Shimizu, Minoru Shigekawa, Atsushi Hosui, Takuya Miyagi, Tomohide Tatsumi, Hisashi Ishida, Wei Li, Tatsuya Kanto, Naoki Hiramatsu, Shigeomi Shimizu, Yoshihide Tsujimoto, Norio Hayash. Delayed-onset caspase-dependent massive hepatocyte apoptosis upon Fas activation in Bak/Bax-deficient mice. Hepatology (Baltimore, Md.). vol 54. issue 1. 2011-09-30. PMID:21425311. |
the proapoptotic bcl-2 family proteins bak and bax serve as an essential gateway to the mitochondrial pathway of apoptosis. |
2011-09-30 |
2023-08-12 |
mouse |