| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Heng Zhang, Shengnan Wu, Da Xin. YAP accelerates Aβ(25-35)-induced apoptosis through upregulation of Bax expression by interaction with p73. Apoptosis : an international journal on programmed cell death. vol 16. issue 8. 2011-11-11. PMID:21562856. |
yap accelerates aβ(25-35)-induced apoptosis through upregulation of bax expression by interaction with p73. |
2011-11-11 |
2023-08-12 |
Not clear |
| Heng Zhang, Shengnan Wu, Da Xin. YAP accelerates Aβ(25-35)-induced apoptosis through upregulation of Bax expression by interaction with p73. Apoptosis : an international journal on programmed cell death. vol 16. issue 8. 2011-11-11. PMID:21562856. |
taken together, our findings first demonstrated that yap accelerated aβ-induced apoptosis through nucleus translocation, leading to the induction of bax expression and activation. |
2011-11-11 |
2023-08-12 |
Not clear |
| Sheau-Yun Yuan, Chi-Chen Lin, Shih-Lan Hsu, Ya-Wen Cheng, Jyh-Horng Wu, Chen-Li Cheng, Chi-Rei Yan. Leaf Extracts of Calocedrus formosana (Florin) Induce G2/M Cell Cycle Arrest and Apoptosis in Human Bladder Cancer Cells. Evidence-based complementary and alternative medicine : eCAM. vol 2011. 2011-11-10. PMID:21760824. |
the concurrent increase of bax and decrease of bcl-2 levels indicated that the extracts could induce apoptosis in these treated cells. |
2011-11-10 |
2023-08-12 |
human |
| Jeffrey M Harder, Richard T Libb. BBC3 (PUMA) regulates developmental apoptosis but not axonal injury induced death in the retina. Molecular neurodegeneration. vol 6. 2011-11-10. PMID:21762490. |
in the absence of the proapoptotic bcl-2 family member bax, developmental apoptosis in the retina is disrupted and extra neurons survive. |
2011-11-10 |
2023-08-12 |
mouse |
| Jeffrey M Harder, Richard T Libb. BBC3 (PUMA) regulates developmental apoptosis but not axonal injury induced death in the retina. Molecular neurodegeneration. vol 6. 2011-11-10. PMID:21762490. |
since the bcl-2 family members bim, bid, and bbc3 (puma) are powerful direct activators of bax, we used mice deficient for each of these genes to investigate their importance in developmental apoptosis. |
2011-11-10 |
2023-08-12 |
mouse |
| Abdiryim Yusup, Halmurat Upur, Anwar Umar, Benedicte Berke, Nicholas Moor. Ethanol Extract of Abnormal Savda Munziq, a Herbal Preparation of Traditional Uighur Medicine, Inhibits Caco-2 Cells Proliferation via Cell Cycle Arrest and Apoptosis. Evidence-based complementary and alternative medicine : eCAM. vol 2012. 2011-11-10. PMID:21785650. |
asmq ethanol extract possesses an inhibition effect on caco-2 cells proliferation, induction of cell apoptosis, cell cycle arrest in sub-g1 phase, and downregulation of bcl-2 and upregulation of bax gene expression. |
2011-11-10 |
2023-08-12 |
Not clear |
| Abdiryim Yusup, Halmurat Upur, Anwar Umar, Benedicte Berke, Nicholas Moor. Ethanol Extract of Abnormal Savda Munziq, a Herbal Preparation of Traditional Uighur Medicine, Inhibits Caco-2 Cells Proliferation via Cell Cycle Arrest and Apoptosis. Evidence-based complementary and alternative medicine : eCAM. vol 2012. 2011-11-10. PMID:21785650. |
the anticancer mechanism of asmq ethanol extract may be involved in antiproliferation, induction of apoptosis, cell cycle arrest, and regulation of apoptosis-related gene expression such as bcl-2 and bax activity pathway. |
2011-11-10 |
2023-08-12 |
Not clear |
| Wei Kai, Xu Xiaojun, Pu Ximing, Hou Zhenqing, Zhang Qiqin. Cytotoxic effects and the mechanism of three types of magnetic nanoparticles on human hepatoma BEL-7402 cells. Nanoscale research letters. vol 6. 2011-11-10. PMID:21801413. |
the increase in apoptosis was accompanied with the bax over-expression, mitochondrial membrane potential decrease, and the release of cytochrome c from mitochondria into cytosol. |
2011-11-10 |
2023-08-12 |
human |
| A Virmani, A Koverech, S F Ali, Z K Biniend. Acetyl-L-Carnitine Modulates TP53 and IL10 Gene Expression Induced by 3-NPA Evoked Toxicity in PC12 Cells. Current neuropharmacology. vol 9. issue 1. 2011-11-10. PMID:21886589. |
other genes associated with stress and apoptosis, parp-1, bcl-2, and bax were not affected by 3-npa or alc. |
2011-11-10 |
2023-08-12 |
rat |
| Yu-Huei Liu, Konan Peck, Jung-Yaw Li. Involvement of prohibitin upregulation in abrin-triggered apoptosis. Evidence-based complementary and alternative medicine : eCAM. vol 2012. 2011-11-10. PMID:21961024. |
in addition, abr significantly induced the expression of bax as well as the activation of caspase-3 and poly(adp-ribose) polymerase (parp) in jurkat t cells, whereas the reduction of phb by specific rna interference delayed abr-triggered apoptosis through the proapoptotic genes examined. |
2011-11-10 |
2023-08-12 |
Not clear |
| Wei Fu, Le Ma, Baoky Chu, Xue Wang, Marilyn M Bui, Jennifer Gemmer, Soner Altiok, W Jackson Pledge. The cyclin-dependent kinase inhibitor SCH 727965 (dinacliclib) induces the apoptosis of osteosarcoma cells. Molecular cancer therapeutics. vol 10. issue 6. 2011-11-09. PMID:21490307. |
sch activated the mitochondrial pathway of apoptosis as evidenced by caspase-9 cleavage and accumulation of cytoplasmic cytochrome c. amounts of the apoptotic proteins bax and bim increased in mitochondria, whereas amounts of the antiapoptotic proteins mcl-1 and bcl-x(l) declined. |
2011-11-09 |
2023-08-12 |
mouse |
| Hong-Quan Li, Jian-Dong Qiu, Li-Hua Yan. [Regulation of Astragalus heteropolysaccharides on synoviocytes apoptosis and proinflammatory cytokine secretion of rats with adjuvant arthritis]. Yao xue xue bao = Acta pharmaceutica Sinica. vol 44. issue 7. 2011-11-07. PMID:19806911. |
tnf-alpha and il-1beta contents in serum were determined with radioimmunoassay, pathomorphologic changes of synovium of knee joint were observed by histological section with he staining, synoviocyte apoptosis of knee joint of rats was analyzed by tunel detection, and bax and bcl-2 positive expression were detected by immunohistochemical method. |
2011-11-07 |
2023-08-12 |
rat |
| Hong-Quan Li, Jian-Dong Qiu, Li-Hua Yan. [Regulation of Astragalus heteropolysaccharides on synoviocytes apoptosis and proinflammatory cytokine secretion of rats with adjuvant arthritis]. Yao xue xue bao = Acta pharmaceutica Sinica. vol 44. issue 7. 2011-11-07. PMID:19806911. |
the results were as follows: (1) both ahps and twp could improve significantly primary and secondary clinical symptoms of rats with aa and inflammatory response in articular synovium; (2) the contents of tnf-alpha and il-1beta in serum of rats with aa increased significantly composed with those in groups treated with ahps (1 000 and 500 mg x kg(-1)), and the amount of synoviocyte apoptosis decreased significantly (p < 0.01 or p < 0.05); (3) the positive expression of bax in synovium of rats with aa was a little bit higher than that in normal control (p > 0.05), but the positive expression of bcl-2 significantly increased (p < 0.01). |
2011-11-07 |
2023-08-12 |
rat |
| Hong-Quan Li, Jian-Dong Qiu, Li-Hua Yan. [Regulation of Astragalus heteropolysaccharides on synoviocytes apoptosis and proinflammatory cytokine secretion of rats with adjuvant arthritis]. Yao xue xue bao = Acta pharmaceutica Sinica. vol 44. issue 7. 2011-11-07. PMID:19806911. |
ahps can induce synoviocyte apoptosis of rats with aa, which is achieved by the regulating effect of ahps on the positive expression of bax and bcl-2. |
2011-11-07 |
2023-08-12 |
rat |
| S P Vergara, C Lizama, J Brouwer-Visser, R D Moren. Expression of BCL-2 family genes in germ cells undergoing apoptosis during the first wave of spermatogenesis in the rat. Andrologia. vol 43. issue 4. 2011-11-07. PMID:21486404. |
we measured the mrna levels of several apoptosis-inducing proteins belonging to the bcl-2 family (bax, bad, puma, bok and bak) as well as those that prevent apoptosis (bcl-2, bcl-w and bcl-xl). |
2011-11-07 |
2023-08-12 |
rat |
| Pedro Eitz Ferrer, Stephanie Potthoff, Susanne Kirschnek, Georg Gasteiger, Wolfgang Kastenmüller, Holger Ludwig, Stefan A Paschen, Andreas Villunger, Gerd Sutter, Ingo Drexler, Georg Häcke. Induction of Noxa-mediated apoptosis by modified vaccinia virus Ankara depends on viral recognition by cytosolic helicases, leading to IRF-3/IFN-β-dependent induction of pro-apoptotic Noxa. PLoS pathogens. vol 7. issue 6. 2011-11-07. PMID:21698224. |
apoptosis largely proceeded through the pro-apoptotic bcl-2 family protein bak with some contribution from bax. |
2011-11-07 |
2023-08-12 |
mouse |
| Nigel Francis, See Heng Wong, Peter Hampson, Keqing Wang, Stephen P Young, Hans Peter Deigner, Michael Salmon, Dagmar Scheel-Toellner, Janet M Lor. Lactoferrin inhibits neutrophil apoptosis via blockade of proximal apoptotic signaling events. Biochimica et biophysica acta. vol 1813. issue 10. 2011-11-07. PMID:21781990. |
we also show that the effect of lactoferrin is mediated at an early stage in apoptosis as it inhibited activation of sphingomyelinase, generation of ceramide, activation of caspase 8 and bax and cleavage of bid. |
2011-11-07 |
2023-08-12 |
human |
| Honglin Hu, Frédéric Batteux, Christiane Chéreau, Niloufar Kavian, Wioleta Marut, Camille Gobeaux, Didier Borderie, Anh Tuan Dinh-Xuan, Bernard Weill, Carole Nicc. Clopidogrel protects from cell apoptosis and oxidative damage in a mouse model of renal ischaemia-reperfusion injury. The Journal of pathology. vol 225. issue 2. 2011-11-02. PMID:21630270. |
renal cell apoptosis induced by ir was decreased in kidneys of mice pretreated by clopidogrel, with an increase in bcl-2 and bcl-xl expression and a decrease in caspase-3, caspase-8, and bax expression. |
2011-11-02 |
2023-08-12 |
mouse |
| Hyunmi Lee, Jimmy A Rotolo, Judith Mesicek, Tuula Penate-Medina, Andreas Rimner, Wen-Chieh Liao, Xianglei Yin, Govind Ragupathi, Desiree Ehleiter, Erich Gulbins, Dayong Zhai, John C Reed, Adriana Haimovitz-Friedman, Zvi Fuks, Richard Kolesnic. Mitochondrial ceramide-rich macrodomains functionalize Bax upon irradiation. PloS one. vol 6. issue 6. 2011-11-02. PMID:21695182. |
evidence indicates that bax functions as a "lipidic" pore to regulate mitochondrial outer membrane permeabilization (momp), the apoptosis commitment step, through unknown membrane elements. |
2011-11-02 |
2023-08-12 |
Not clear |
| Wenna Liang, Xihai Li, Candong Li, Lianming Liao, Bizheng Gao, Huijuan Gan, Zhaoyang Yang, Linghong Liao, Xuzheng Che. Quercetin-mediated apoptosis via activation of the mitochondrial-dependent pathway in MG-63 osteosarcoma cells. Molecular medicine reports. vol 4. issue 5. 2011-11-01. PMID:21805050. |
the present study was undertaken to examine the effect of quercetin on cell viability, apoptosis and mitochondrial membrane potential, and to determine the molecular mechanism of quercetin-induced apoptosis by investigating the expression of bcl-2 family proteins (bcl-2, bax), cytochrome c, caspase-9 and caspase-3 in mg-63 cells. |
2011-11-01 |
2023-08-12 |
human |