| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hsu-Feng Lu, Yu-Jie Chie, Ming-Sung Yang, Kung-Wen Lu, Jene-John Fu, Jai-Sing Yang, Hung-Yi Chen, Te-Chun Hsia, Chia-Yu Ma, Siu-Wan Ip, Jing-Gung Chun. Apigenin induces apoptosis in human lung cancer H460 cells through caspase- and mitochondria-dependent pathways. Human & experimental toxicology. vol 30. issue 8. 2011-12-07. PMID:20937639. |
in the present studies, h460 cells were treated with apigenin for different time and then were analyzed for the morphological changes, induction of apoptosis, protein levels associated with apoptosis and results in dose-dependent induction of morphological changes, decrease in the percentage of viability, induced dna damage and apoptosis; down-modulation of the protein expression of bid, bcl-2, procaspase-8; up-regulation of protein levels of bax, caspase-3, aif, cytochrome c, grp78 and gadd153; decreased the levels of mitochondrial membrane potential and increased the productions of reactive oxygen species (ros) and ca(2+) in h460 cells. |
2011-12-07 |
2023-08-12 |
human |
| S S Agrawal, Sarita Saraswati, Rajani Mathur, Maneesha Pande. Antitumor properties of Boswellic acid against Ehrlich ascites cells bearing mouse. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. vol 49. issue 9. 2011-12-07. PMID:21513768. |
microscopic examination of tumors revealed that in ba-treated groups the expression of bax and caspase 3 increased, suggesting drug induced tumor cell apoptosis through activating the pro-apoptotic bcl-2 family and caspase-3. |
2011-12-07 |
2023-08-12 |
mouse |
| Soo-Jin Heo, Kil-Nam Kim, Weon-Jong Yoon, Chulhong Oh, Young-Ung Choi, Abu Affan, Yeon-Ju Lee, Hyi-Seung Lee, Do-Hyung Kan. Chromene induces apoptosis via caspase-3 activation in human leukemia HL-60 cells. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. vol 49. issue 9. 2011-12-07. PMID:21600262. |
se induced apoptosis was accompanied by downregulation of bcl-xl, upregulation of bax, activation of caspase-3, and cleavage of poly (adp-ribose) polymerase (parp). |
2011-12-07 |
2023-08-12 |
human |
| May Al-Maghrebi, Elijah O Kehinde, Jehoram T Ani. Survivin downregulation is associated with vasectomy-induced spermatogenic damage and apoptosis. Medical principles and practice : international journal of the Kuwait University, Health Science Centre. vol 20. issue 5. 2011-12-07. PMID:21757935. |
to evaluate the expression of the apoptotic genes survivin, bax and bcl-2 in vasectomized rabbits and to determine their relation with vasectomy-induced spermatogenic impairment and germ cell apoptosis. |
2011-12-07 |
2023-08-12 |
Not clear |
| Aurelie Nguyen Dinh Cat, Ana M Briones, Glaucia E Callera, Alvaro Yogi, Ying He, Augusto C Montezano, Rhian M Touy. Adipocyte-derived factors regulate vascular smooth muscle cells through mineralocorticoid and glucocorticoid receptors. Hypertension (Dallas, Tex. : 1979). vol 58. issue 3. 2011-12-07. PMID:21788604. |
eplerenone (mr antagonist), mifepristone (gr antagonist), and candesartan (at(1)r antagonist) inhibited acm-induced effects on extracellular signal-regulated kinase 1/2, p38mapk, and proliferating cell nuclear antigen, without influencing apoptosis (bax, bcl, and caspase 3). |
2011-12-07 |
2023-08-12 |
mouse |
| Cathleen Endtmann, Talin Ebrahimian, Thomas Czech, Omar Arfa, Ulrich Laufs, Mathias Fritz, Kerstin Wassmann, Nikos Werner, Vasileios Petoumenos, Georg Nickenig, Sven Wassman. Angiotensin II impairs endothelial progenitor cell number and function in vitro and in vivo: implications for vascular regeneration. Hypertension (Dallas, Tex. : 1979). vol 58. issue 3. 2011-12-07. PMID:21825227. |
ang ii redox-dependently induced epc apoptosis through increased apoptosis signal-regulating kinase 1, c-jun n-terminal kinase, and p38 mitogen-activated protein kinase phosphorylation; decreased bcl-2 and increased bax expression; and activation of caspase 3 but had no effect on the low cell proliferation. |
2011-12-07 |
2023-08-12 |
mouse |
| Jun Peng, Suzanne M Lapolla, Zhi Zhang, Jialing Li. The Bax BH3 peptide H2-H3 promotes apoptosis by inhibiting Bcl-2's pore-forming and anti-Bax activities in the membrane. Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi. vol 26. issue 4. 2011-12-06. PMID:19813621. |
the bax bh3 peptide h2-h3 promotes apoptosis by inhibiting bcl-2's pore-forming and anti-bax activities in the membrane. |
2011-12-06 |
2023-08-12 |
Not clear |
| Jun Peng, Suzanne M Lapolla, Zhi Zhang, Jialing Li. The Bax BH3 peptide H2-H3 promotes apoptosis by inhibiting Bcl-2's pore-forming and anti-Bax activities in the membrane. Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi. vol 26. issue 4. 2011-12-06. PMID:19813621. |
during the initiation of apoptosis, the anti-apoptotic bcl-2 and the pro-apoptotic bax form different pores to regulate the permeability of mitochondrial outer membrane, playing their opposite functions. |
2011-12-06 |
2023-08-12 |
Not clear |
| Jun Peng, Suzanne M Lapolla, Zhi Zhang, Jialing Li. The Bax BH3 peptide H2-H3 promotes apoptosis by inhibiting Bcl-2's pore-forming and anti-Bax activities in the membrane. Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi. vol 26. issue 4. 2011-12-06. PMID:19813621. |
we found that h2-h3 inhibited bcl-2's pore formation and neutralized bcl-2's inhibitory effect on bax pore formation in the membrane, whereas the mutant h2-h3 peptide that does not induce apoptosis in cells was shown to have no effect on bcl-2's activities. |
2011-12-06 |
2023-08-12 |
Not clear |
| Young Il Kim, Seung-Won Park, In-Hwa Choi, Jang-Hoon Lee, Hong-Jung Woo, Youngchul Ki. Effect of Orostachys japonicus on cell growth and apoptosis in human hepatic stellate cell line LX2. The American journal of Chinese medicine. vol 39. issue 3. 2011-12-06. PMID:21598425. |
o. japonicus inhibited proliferation of lx2 cells in a dose- and time-dependent manner, increased the apoptosis fraction at cell cycle progression with an accompanying dna fragmentation, and resulted in a significant decrease in bcl-2 and an increase in bax mrna levels. |
2011-12-06 |
2023-08-12 |
human |
| Yanyan Cao, Susan C Evans, Eroica Soans, Ahmed Malki, Yi Liu, Yan Liu, Xiaozhuo Che. Insulin receptor signaling activated by penta-O-galloyl-α-D: -glucopyranose induces p53 and apoptosis in cancer cells. Apoptosis : an international journal on programmed cell death. vol 16. issue 9. 2011-12-06. PMID:21671008. |
α-pgg induced apoptosis in rko cells through p53, bax and caspase 3. |
2011-12-06 |
2023-08-12 |
Not clear |
| Yanyan Cao, Susan C Evans, Eroica Soans, Ahmed Malki, Yi Liu, Yan Liu, Xiaozhuo Che. Insulin receptor signaling activated by penta-O-galloyl-α-D: -glucopyranose induces p53 and apoptosis in cancer cells. Apoptosis : an international journal on programmed cell death. vol 16. issue 9. 2011-12-06. PMID:21671008. |
all these results suggested that α-pgg induced p53, bax, and apoptosis through the ir-mek signaling pathway. |
2011-12-06 |
2023-08-12 |
Not clear |
| Paula Takahashi, Amanda Polson, David Reisma. Elevated transcription of the p53 gene in early S-phase leads to a rapid DNA-damage response during S-phase of the cell cycle. Apoptosis : an international journal on programmed cell death. vol 16. issue 9. 2011-12-06. PMID:21710255. |
when comparing exponentially growing swiss3t3 cells to those synchronized to enter s-phase simultaneously and treated with the dna damaging agent camptothecin, we found that with cells in s-phase, p53 protein levels increased earlier, bax and p21 transcription was activated earlier and to a greater extent and apoptosis occurred earlier and to a greater extent. |
2011-12-06 |
2023-08-12 |
Not clear |
| Sunny O Abarikwu, Ebenezer O Farombi, Mahendra P Kashyap, Aditya B Pan. Kolaviron protects apoptotic cell death in PC12 cells exposed to atrazine. Free radical research. vol 45. issue 9. 2011-12-06. PMID:21726175. |
kv treatment also demonstrates significant restoration in atz-induced alterations in the expression of apoptosis markers viz., p53, bax, bcl2, caspase-3, caspase-9, cyclooxygenase-2 (cox-2), c-jun and c-fos. |
2011-12-06 |
2023-08-12 |
rat |
| Chitra Subramanian, Jason A Jarzembowski, Anthony W Opipari, Valerie P Castle, Roland P S Kwo. HDAC6 deacetylates Ku70 and regulates Ku70-Bax binding in neuroblastoma. Neoplasia (New York, N.Y.). vol 13. issue 8. 2011-12-06. PMID:21847364. |
we have shown that overexpression of creb-binding protein (cbp), a known acetyltransferase that acetylates ku70, releases bax from ku70, triggering apoptosis. |
2011-12-06 |
2023-08-12 |
Not clear |
| Wataru Nakajima, Nobuyuki Tanak. Noxa induces apoptosis in oncogene-expressing cells through catch-and-release mechanism operating between Puma and Mcl-1. Biochemical and biophysical research communications. vol 413. issue 4. 2011-12-06. PMID:21945433. |
furthermore, noxa displaced puma's association with mcl-1, accompanied by mcl-1 degradation and apoptosis induction by activating mitochondrial apoptotic executers bax and bak. |
2011-12-06 |
2023-08-12 |
Not clear |
| Zhao Zhang, Yang Yang, Weijun Pang, Chao Sun, Gongshe Yan. [Effect and underlying mechanism of resveratol on porcine primary preadipocyte apoptosis]. Sheng wu gong cheng xue bao = Chinese journal of biotechnology. vol 26. issue 8. 2011-12-05. PMID:21090107. |
we used optical microscope and fluorescence microscope to observe morphological changes during apoptosis after hoechst 33258 fluorescent dyes staining; and rt-pcr and western blotting to measure the expression of apoptosis-associated gene sirt1, caspase-3, bcl-2, bax, p53, nf-kappab. |
2011-12-05 |
2023-08-12 |
Not clear |
| Ying Xue, Chao-Rong Tie, Jin Li, Ting Tian, Qi-Xiong L. Ligustrazine inhibits lipopolysaccharide-induced proliferation by affecting P27, Bcl-2 expression in rat mesangial cells. European journal of pharmacology. vol 665. issue 1-3. 2011-12-05. PMID:21586279. |
moreover, rat mesangial cells treated with lipopolysaccharide showed scanty apoptosis with up-regulation of bcl-2expression, while bax protein expression was not changed. |
2011-12-05 |
2023-08-12 |
rat |
| Qing Li, Yang Li, Xiaoyu Wang, Xuexun Fang, Kan He, Xiaoxi Guo, Zhuo Zhan, Chao Sun, Ying-Hua Ji. Co-treatment with ginsenoside Rh2 and betulinic acid synergistically induces apoptosis in human cancer cells in association with enhanced capsase-8 activation, bax translocation, and cytochrome c release. Molecular carcinogenesis. vol 50. issue 10. 2011-12-05. PMID:21751259. |
co-treatment with ginsenoside rh2 and betulinic acid synergistically induces apoptosis in human cancer cells in association with enhanced capsase-8 activation, bax translocation, and cytochrome c release. |
2011-12-05 |
2023-08-12 |
human |
| Xiaodong Du, Yu Cao, Ping Xue, Ziqi Lin, Zhi Zeng, Qing Xi. Protective effect of intermedin on myocardial cell in a rat model of severe acute pancreatitis. Cellular & molecular biology letters. vol 16. issue 3. 2011-12-05. PMID:21786034. |
terminal deoxynucleotidyl transferase-mediated dutp nick end labeling (tunel) revealed that myocardial apoptosis was extensively present in sap rats, and imd infusion led to increased expression of the prosurvival factor bcl-2, but decreased pro-apoptotic factors bax and caspase-3. |
2011-12-05 |
2023-08-12 |
human |