| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| A Benco, A V Sirotkin, D Vasícek, S Pavlová, J Zemanová, J Kotwica, K Darlak, F Valenzuel. Involvement of the transcription factor STAT1 in the regulation of porcine ovarian granulosa cell functions treated and not treated with ghrelin. Reproduction (Cambridge, England). vol 138. issue 3. 2012-01-20. PMID:19528263. |
furthermore, they demonstrated the involvement of the transcription factor stat1 in controlling these functions, the promotion of some markers of apoptosis (bax), inhibition of some markers of proliferation (mapk/erk1,2) and stimulation of pgf release. |
2012-01-20 |
2023-08-12 |
Not clear |
| Y Zhu, H Lv, Y Xie, W Sheng, J Xiang, J Yan. Enhanced tumor suppression by an ING4/IL-24 bicistronic adenovirus-mediated gene cotransfer in human non-small cell lung cancer cells. Cancer gene therapy. vol 18. issue 9. 2012-01-20. PMID:21660060. |
we demonstrated that ing4 and il-24 combination treatment by adenovirus-mediated ing4 and il-24 coexpression induced additive growth suppression and apoptosis as well as an overlapping effect on upregulation of p21, p27, fas, bax and cleaved caspases-8, 9, 3 and downregulation of bcl-2 in in vitro a549 lung carcinoma cells. |
2012-01-20 |
2023-08-12 |
mouse |
| Xin Zhang, Jing Zhao, Saeromi Kang, Myeongjin Yi, Song You, Dong-Soo Shin, Dong-Kyoo Ki. A novel cromakalim analogue induces cell cycle arrest and apoptosis in human cervical carcinoma HeLa cells through the caspase- and mitochondria-dependent pathway. International journal of oncology. vol 39. issue 6. 2012-01-20. PMID:21833470. |
this apoptotic induction was associated with an increase in bax expression, a decrease in bcl-2 expression, release of cytochrome c and subsequent activation of caspase-9 and -3, which indicated that compound 6 induced apoptosis via caspase- and mitochondria-dependent pathway. |
2012-01-20 |
2023-08-12 |
human |
| Prasanthi Karna, Sushma R Gundala, Meenakshi V Gupta, Shahab A Shamsi, Ralphenia D Pace, Clayton Yates, Satya Narayan, Ritu Anej. Polyphenol-rich sweet potato greens extract inhibits proliferation and induces apoptosis in prostate cancer cells in vitro and in vivo. Carcinogenesis. vol 32. issue 12. 2012-01-20. PMID:21948980. |
we also observed alterations of apoptosis regulatory molecules such as inactivation of bcl2, upregulation of bax, cytochrome c release and activation of downstream apoptotic signaling. |
2012-01-20 |
2023-08-12 |
mouse |
| Wei Zhang, Bao-An Chen, Wen Bao, Jian Cheng, Yan Sun, Jie Cheng, Min Zhang, Xiao-Min Zhang, Yan Che. [Effects of hyperbaric oxygen combined with adriamycin in inducing apoptosis of K562/A02 cells]. Zhongguo shi yan xue ye xue za zhi. vol 19. issue 3. 2012-01-19. PMID:21729536. |
the cell apoptosis and expression of caspase-3 activity were analyzed by flow cytometry and transmission electron microscopy; the expression levels of hif-1α, bcl-2 and bax mrna were detected by quantitative real time pcr; the caspase 8 activity was determined by using caspase 8 kit; the expression level of p-gp was detected by western blot. |
2012-01-19 |
2023-08-12 |
Not clear |
| Wei Zhang, Bao-An Chen, Wen Bao, Jian Cheng, Yan Sun, Jie Cheng, Min Zhang, Xiao-Min Zhang, Yan Che. [Effects of hyperbaric oxygen combined with adriamycin in inducing apoptosis of K562/A02 cells]. Zhongguo shi yan xue ye xue za zhi. vol 19. issue 3. 2012-01-19. PMID:21729536. |
the results showed that the apoptosis rate of k562/a02 cells in combination group (0.2 mpa hbo + adm) was higher than that in adm group [(47.36 ± 3.87) % vs (28.51 ± 1.09) %], the difference was statistical significant (p < 0.05); the expression levels of hif-1α mrna, p-gp and bcl-2 in combination group were lower than those in adm group, there were significant differences (p < 0.05); the activities of bax, caspase 3 and caspase 8 proteins in combination group were higher than those in adm group, the difference was statistical significant (p < 0.05). |
2012-01-19 |
2023-08-12 |
Not clear |
| Pei Li, Che Chen, Ya-Ming Xi, Hao Zhang, Ming Li, Wei Den. [Apoptosis-inducing effect of clostridium difficile toxin A on K562 cells and its mechanism]. Zhongguo shi yan xue ye xue za zhi. vol 19. issue 3. 2012-01-19. PMID:21729540. |
it is concluded that tcd a inhibits cell growth of k562 by inducing apoptosis, and the up-regulation of bax protein and activation of caspase-3 may play important roles in these processes. |
2012-01-19 |
2023-08-12 |
Not clear |
| Marvin Rubenstein, Courtney M P Hollowell, Patrick Guina. Bax expression remains unchanged following antisense treatment directed against BCL-2. Medical oncology (Northwood, London, England). vol 28. issue 3. 2012-01-18. PMID:20422317. |
employing rt-pcr, the expression of two apoptosis regulating proteins, bcl-2 and non-targeted bax, was then evaluated. |
2012-01-18 |
2023-08-12 |
Not clear |
| Marvin Rubenstein, Courtney M P Hollowell, Patrick Guina. Bax expression remains unchanged following antisense treatment directed against BCL-2. Medical oncology (Northwood, London, England). vol 28. issue 3. 2012-01-18. PMID:20422317. |
in an effort to determine a compensatory response by cells evading apoptosis in the presence of bcl-2 suppression, the levels of mrna encoding the non-targeted apoptosis activating protein bax were evaluated. |
2012-01-18 |
2023-08-12 |
Not clear |
| Marvin Rubenstein, Courtney M P Hollowell, Patrick Guina. Bax expression remains unchanged following antisense treatment directed against BCL-2. Medical oncology (Northwood, London, England). vol 28. issue 3. 2012-01-18. PMID:20422317. |
in lncap cells, bcl-2 suppression does not influence bax expression and, at least for this protein, there is no compensatory change in bax expression regulating apoptosis at this level. |
2012-01-18 |
2023-08-12 |
Not clear |
| Qin Huang, Qiu-Xia Qu, Fang Xie, Jian-Ming Hu, You-Guo Chen, Xue-Guang Zhan. Sensitization of SiHa cell to gemcitabine by CD40 activation and its overexpression in cervical carcinoma. Medical oncology (Northwood, London, England). vol 28. issue 3. 2012-01-18. PMID:20467921. |
apoptosis in siha was associated with an increasing ratio of bax to bcl-xl in mrna levels. |
2012-01-18 |
2023-08-12 |
human |
| A Chimento, R Sirianni, F Zolea, C Bois, C Delalande, S Andò, M Maggiolini, S Aquila, S Carreau, V Pezz. Gper and ESRs are expressed in rat round spermatids and mediate oestrogen-dependent rapid pathways modulating expression of cyclin B1 and Bax. International journal of andrology. vol 34. issue 5 Pt 1. 2012-01-18. PMID:20969598. |
collectively, these data demonstrate that e2 activates, through esrs and gper, pathways involved in the regulation of genes controlling rat rs apoptosis and differentiation such as cyclin b1 and bax. |
2012-01-18 |
2023-08-12 |
rat |
| S Samantaray, V H Knaryan, C Le Gal, S K Ray, N L Bani. Calpain inhibition protected spinal cord motoneurons against 1-methyl-4-phenylpyridinium ion and rotenone. Neuroscience. vol 192. 2012-01-18. PMID:21723922. |
cytoprotection by calpeptin was observed with marked decreases in bax: bcl-2 ratio and activities of calpain and caspase-3, which affirmed the role of mitochondrial dysfunction and involvement of intrinsic pathway in mediation of apoptosis. |
2012-01-18 |
2023-08-12 |
Not clear |
| Rhiannon E Lloyd, Raquel Romar, Carmen Matás, Alfonso Gutiérrez-Adán, William V Holt, Pilar Co. Effects of oviductal fluid on the development, quality, and gene expression of porcine blastocysts produced in vitro. Reproduction (Cambridge, England). vol 137. issue 4. 2012-01-17. PMID:19153191. |
using real-time pcr, grade 1 (very good morphological quality) and grade 2 (good morphological quality) blastocysts were analyzed for gene transcripts related to apoptosis (bax, bcl2l1), mitochondrial dna (mtdna) transcription/replication (polg, polg2, and tfam), blastomere connection and morula compaction (gja1), and blastocyst formation and pluripotency (pou5f1). |
2012-01-17 |
2023-08-12 |
cattle |
| Hannah Rachel Vasanthi, Subhendu Mukherjee, Diptarka Ray, Karuppiah Shanmugasundara Pandian Jayachandran, Istvan Lekli, Dipak Kumar Da. Protective role of air potato (Dioscorea bulbifera) of yam family in myocardial ischemic reperfusion injury. Food & function. vol 1. issue 3. 2012-01-16. PMID:21776477. |
role of db on apoptosis was also evaluated by determining caspase 3 as well as by examining pro-apoptotic and anti-apoptotic proteins bax and bcl2 by western blot analysis followed by tunel assay. |
2012-01-16 |
2023-08-12 |
rat |
| Jie Ping, Ai-mei Gao, Hai-quan Qin, Xiao-ning Wei, Jing Bai, Lian Liu, Xiao-hai Li, Rui-wen Li, Ying Ao, Hui Wan. Indole-3-carbinol enhances the resolution of rat liver fibrosis and stimulates hepatic stellate cell apoptosis by blocking the inhibitor of κB kinase α/inhibitor of κB-α/nuclear factor-κB pathway. The Journal of pharmacology and experimental therapeutics. vol 339. issue 2. 2012-01-16. PMID:21862660. |
moreover, i3c significantly increased the hsc-t6 apoptosis rate and the expression ratio of bax to bcl-2. |
2012-01-16 |
2023-08-12 |
rat |
| Eva Calviño, María Cristina Estañ, Gloria P Simón, Pilar Sancho, María del Carmen Boyano-Adánez, Elena de Blas, Jacqueline Bréard, Patricio Alle. Increased apoptotic efficacy of lonidamine plus arsenic trioxide combination in human leukemia cells. Reactive oxygen species generation and defensive protein kinase (MEK/ERK, Akt/mTOR) modulation. Biochemical pharmacology. vol 82. issue 11. 2012-01-16. PMID:21889928. |
apoptosis induction by lonidamine/ato involves mitochondrial dysfunction, as indicated by early mitochondrial permeability transition pore opening and late mitochondrial transmembrane potential dissipation, as well as activation of the intrinsic apoptotic pathway, as indicated by bcl-x(l) and mcl-1 down-regulation, bax translocation to mitochondria, cytochrome c and omi/htra2 release to the cytosol, xiap down-regulation, and caspase-9 and -3 cleavage/activation, with secondary (bcl-2-inhibitable) activation of the caspase-8/bid axis. |
2012-01-16 |
2023-08-12 |
human |
| Tiziana Genovese, Emanuela Mazzon, Irene Paterniti, Emanuela Esposito, Salvatore Cuzzocre. Neuroprotective effects of olprinone after cerebral ischemia/reperfusion injury in rats. Neuroscience letters. vol 503. issue 2. 2012-01-13. PMID:21872644. |
we also demonstrated that olprinone reduces levels of apoptosis (tunel, bax and bcl-2 expression) resulting in a reduction in the infarct volume in ischemia-reperfusion brain injury. |
2012-01-13 |
2023-08-12 |
rat |
| Joana Paixão, Teresa C P Dinis, Leonor M Almeid. Dietary anthocyanins protect endothelial cells against peroxynitrite-induced mitochondrial apoptosis pathway and Bax nuclear translocation: an in vitro approach. Apoptosis : an international journal on programmed cell death. vol 16. issue 10. 2012-01-12. PMID:21785847. |
dietary anthocyanins protect endothelial cells against peroxynitrite-induced mitochondrial apoptosis pathway and bax nuclear translocation: an in vitro approach. |
2012-01-12 |
2023-08-12 |
Not clear |
| Joana Paixão, Teresa C P Dinis, Leonor M Almeid. Dietary anthocyanins protect endothelial cells against peroxynitrite-induced mitochondrial apoptosis pathway and Bax nuclear translocation: an in vitro approach. Apoptosis : an international journal on programmed cell death. vol 16. issue 10. 2012-01-12. PMID:21785847. |
actually, pre-incubation of cells with 25 μm anthocyanins prevented them from peroxynitrite-mediated apoptosis, which was evaluated by the loss of mitochondrial membrane potential, caspases-9 and-3 activation, the increase in cytoplasmatic bax levels and the inactivation of the pi3 k/akt pathway. |
2012-01-12 |
2023-08-12 |
Not clear |