| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Changbao Chen, Hua Zhou, Xiaoguang Liu, Zhongjun Liu, Qingjun M. Reduced expression of von Hippel-Lindau protein correlates with decreased apoptosis and high chondrosarcoma grade. The Journal of bone and joint surgery. American volume. vol 93. issue 19. 2011-12-29. PMID:22005870. |
the purpose of the present study was to investigate the expression profiles of pvhl in chondrosarcoma and its association with clinicopathologic parameters, bax expression, the apoptosis index, and overall survival of patients with chondrosarcoma. |
2011-12-29 |
2023-08-12 |
human |
| Yeong-Min Yoo, Eui-Man Jung, Ha-Young Kang, In-Gyu Choi, Kyung-Chul Choi, Eui-Bae Jeun. The sap of Acer okamotoanum decreases serum alcohol levels after acute ethanol ingestion in rats. International journal of molecular medicine. vol 28. issue 4. 2011-12-28. PMID:21687930. |
to investigate the involvement of mitochondrial regulation in the ethanol-induced hepatocyte apoptosis, we carried out an immunohistochemical analysis of bax and bcl-2. |
2011-12-28 |
2023-08-12 |
rat |
| Matem Tunçdemir, Melek Oztür. The effects of angiotensin-II receptor blockers on podocyte damage and glomerular apoptosis in a rat model of experimental streptozotocin-induced diabetic nephropathy. Acta histochemica. vol 113. issue 8. 2011-12-27. PMID:21269661. |
the aim of the study was to determine in a rat model of streptozotocin-induced diabetic nephropathy the expression of: wt-1 (for podocyte loss in the glomerulus), tgf-beta 1 (for tissue damage), caspase-3 and bax (for glomerular apoptosis) and the possible protective effects of an angiotensin ii type 1 receptor blocker. |
2011-12-27 |
2023-08-12 |
rat |
| Matem Tunçdemir, Melek Oztür. The effects of angiotensin-II receptor blockers on podocyte damage and glomerular apoptosis in a rat model of experimental streptozotocin-induced diabetic nephropathy. Acta histochemica. vol 113. issue 8. 2011-12-27. PMID:21269661. |
we conclude that the decrease in the number of podocytes is an early marker of diabetic nephropathy, at1 receptor blocker has renoprotective effects on the regulation of renal hemodynamics and on the control of tissue damage by preventing podocyte loss, which leads to decrease of bax and caspase-3 expressions of apoptosis related proteins, and may prevent glomerular cell apoptosis via angiotensin ii. |
2011-12-27 |
2023-08-12 |
rat |
| Xia Zhen, Juan Cen, Yun-Man Li, Fang Yan, Teng Guan, Xu-Zhen Tan. Cytotoxic effect and apoptotic mechanism of tanshinone A, a novel tanshinone derivative, on human erythroleukemic K562 cells. European journal of pharmacology. vol 667. issue 1-3. 2011-12-27. PMID:21699893. |
tanshinone a could arrest k562 cells in the g(0)/g(1) phase and induce apoptosis, decrease the mitochondrial transmembrane potential, decrease the expressions of bcl-2 and c-myc proteins, increase the expression of bax protein and the activity of caspase-3. |
2011-12-27 |
2023-08-12 |
human |
| Daniela Impellizzeri, Rosanna Di Paola, Emanuela Esposito, Emanuela Mazzon, Irene Paterniti, Alessia Melani, Placido Bramanti, Felicita Pedata, Salvatore Cuzzocre. CGS 21680, an agonist of the adenosine (A2A) receptor, decreases acute lung inflammation. European journal of pharmacology. vol 668. issue 1-2. 2011-12-27. PMID:21756897. |
furthermore, carrageenan induced the expression of nuclear factor-κb (nf-κb), inducible nitric oxide synthase (inos), nitrotyrosine, the activation of poly-adp-ribosyl polymerase (parp), as well as induced apoptosis (fas-ligand expression, bax and bcl-2 expression) in the lung tissues. |
2011-12-27 |
2023-08-12 |
mouse |
| Nazir M Khan, T B Poduva. Immunomodulatory and immunotoxic effects of bilirubin: molecular mechanisms. Journal of leukocyte biology. vol 90. issue 5. 2011-12-27. PMID:21807743. |
ucb activated the extrinsic and intrinsic pathways of apoptosis, as reflected by the markers, such as cd95, caspase-8, bax, mmp, cytoplasmic ca(+2), caspase-3, and dna fragmentation. |
2011-12-27 |
2023-08-12 |
mouse |
| Sophie C Cazanave, Justin L Mott, Steven F Bronk, Nathan W Werneburg, Christian D Fingas, X Wei Meng, Niklas Finnberg, Wafik S El-Deiry, Scott H Kaufmann, Gregory J Gore. Death receptor 5 signaling promotes hepatocyte lipoapoptosis. The Journal of biological chemistry. vol 286. issue 45. 2011-12-27. PMID:21941003. |
likewise, knockdown of dr5 or caspase-8 expression by shrna technology attenuated palmitate-induced bax activation and apoptosis in huh-7 cells, without altering induction of er stress markers. |
2011-12-27 |
2023-08-12 |
mouse |
| Pu Huang, Qun Zheng, Li-Hong X. The apoptotic effect of oral administration of microcystin-RR on mice liver. Environmental toxicology. vol 26. issue 5. 2011-12-23. PMID:20196164. |
apoptotic cell death in liver was detected by tunel assay, and the expression levels of bcl-2, bax and p53, grp 78 and chop which have been reported to be related to apoptosis and er stress were determined via western-blot. |
2011-12-23 |
2023-08-12 |
mouse |
| Lin Ye, Feng Wang, Rui-Hua Yan. Diabetes impairs learning performance and affects the mitochondrial function of hippocampal pyramidal neurons. Brain research. vol 1411. 2011-12-21. PMID:21798520. |
diabetes induced the apoptosis of neurons and translocation of bax from cytoplasm to mitochondria. |
2011-12-21 |
2023-08-12 |
rat |
| Lei Liu, Zhenzhen Zhang, Da Xin. Cell death via mitochondrial apoptotic pathway due to activation of Bax by lysosomal photodamage. Free radical biology & medicine. vol 51. issue 1. 2011-12-19. PMID:21530645. |
then the following spatiotemporal sequence of cellular events was observed during cell apoptosis: bcl-2-associated x protein (bax) activation, cytochrome c release, and caspase-9/-3 activation. |
2011-12-19 |
2023-08-12 |
human |
| Eun-Ryeong Hahm, Michelle B Moura, Eric E Kelley, Bennett Van Houten, Sruti Shiva, Shivendra V Sing. Withaferin A-induced apoptosis in human breast cancer cells is mediated by reactive oxygen species. PloS one. vol 6. issue 8. 2011-12-19. PMID:21853114. |
wa treatment resulted in activation of bax and bak in mda-mb-231 and mcf-7 cells, and sv40 immortalized embryonic fibroblasts derived from bax and bak double knockout mouse were significantly more resistant to wa-induced apoptosis compared with fibroblasts derived from wild-type mouse. |
2011-12-19 |
2023-08-12 |
mouse |
| Arindam P Ghosh, Jennifer D Cape, Barbara J Klocke, Kevin A Rot. Deficiency of pro-apoptotic Hrk attenuates programmed cell death in the developing murine nervous system but does not affect Bcl-x deficiency-induced neuron apoptosis. The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society. vol 59. issue 11. 2011-12-19. PMID:22043021. |
however, hrk deficiency does not significantly attenuate the widespread apoptosis seen in the bcl-x (-/-) embryonic nervous system, indicating that other bh3-only molecules, alone or in combination, may regulate bax activation in immature neurons. |
2011-12-19 |
2023-08-12 |
Not clear |
| Hong-Jie Xi, Tian-Hua Zhang, Tao Tao, Chun-Yu Song, Shu-Jun Lu, Xiao-Guang Cui, Zi-Yong Yu. Propofol improved neurobehavioral outcome of cerebral ischemia-reperfusion rats by regulating Bcl-2 and Bax expression. Brain research. vol 1410. 2011-12-16. PMID:21783180. |
because i/r may result in neuronal apoptosis, the apoptosis regulatory genes b-cell leukemia-2 (bcl-2) and bcl-2-associated x protein (bax) may be involved in the neuroprotective process. |
2011-12-16 |
2023-08-12 |
rat |
| Hong-Jie Xi, Tian-Hua Zhang, Tao Tao, Chun-Yu Song, Shu-Jun Lu, Xiao-Guang Cui, Zi-Yong Yu. Propofol improved neurobehavioral outcome of cerebral ischemia-reperfusion rats by regulating Bcl-2 and Bax expression. Brain research. vol 1410. 2011-12-16. PMID:21783180. |
hence, this study suggests that the neuroprotective effects of propofol against neuronal apoptosis may be a consequence of the regulation of bcl-2 and bax. |
2011-12-16 |
2023-08-12 |
rat |
| Rosanna Di Paola, Daniela Impellizzeri, Angela Trovato Salinaro, Emanuela Mazzon, Francesco Bellia, Monia Cavallaro, Carolin Cornelius, Graziella Vecchio, Vittorio Calabrese, Enrico Rizzarelli, Salvatore Cuzzocre. Administration of carnosine in the treatment of acute spinal cord injury. Biochemical pharmacology. vol 82. issue 10. 2011-12-16. PMID:21787762. |
the spinal cord was exposed via a four-level t5-t8 laminectomy and sci was produced by extradural compression of the spinal cord at level t6-t7 using an aneurysm clip with a closing force of 24 g. treatment with d-carnosine (150 mg/kg administered i.p., 1 h and 6h, after sci), but not l-carnosine significantly decreased (a) the degree of spinal cord inflammation and tissue injury (histological score), (b) neutrophil infiltration (myeloperoxidase activity), (c) nitrotyrosine formation, inducible no synthase (inos) and hsp70 expression, (d) proinflammatory cytokines, and (e) apoptosis (tunel staining, fas ligand, bax, and bcl-2 expression). |
2011-12-16 |
2023-08-12 |
Not clear |
| Zhiyun He, Dharmalingam Subramaniam, Satish Ramalingam, Animesh Dhar, Russell G Postier, Shahid Umar, Youcheng Zhang, Shrikant Anan. Honokiol radiosensitizes colorectal cancer cells: enhanced activity in cells with mismatch repair defects. American journal of physiology. Gastrointestinal and liver physiology. vol 301. issue 5. 2011-12-15. PMID:21836060. |
similarly, the combination induced higher levels of apoptosis (caspase 3 activation, bax to bcl2 ratio) in the hct116 cells compared with hct116-ch3 cells. |
2011-12-15 |
2023-08-12 |
Not clear |
| Alexander V Sirotkin, Monika Meszarošová, Roland Grossmann, Andrej Benčo, Francisco Valenzuel. Effect of inhibitor and activator of ghrelin receptor (GHS-R1a) on porcine ovarian granulosa cell functions. General and comparative endocrinology. vol 173. issue 1. 2011-12-14. PMID:21600209. |
effects of (d-lys3)-ghrp-6 added at doses of 0, 1, 10 or 100 ng/ml on the expression of markers of proliferation (pcna, cyclin b1, mapk/erk1,2), apoptosis (bax, p53, caspase 3) and release of steroid hormones (progesterone, testosterone, estradiol) were examined. |
2011-12-14 |
2023-08-12 |
Not clear |
| Changjiang Liu, Zhibin Shi, Lihong Fan, Chen Zhang, Kunzheng Wang, Bo Wan. Resveratrol improves neuron protection and functional recovery in rat model of spinal cord injury. Brain research. vol 1374. 2011-12-12. PMID:21111721. |
finally, resveratrol treatment inhibited injury-induced apoptosis as assessed by electrical microscopy and tunel staining and affected the expression level of apoptosis-related gene bax, bcl-2 and caspase-3, which indicated its anti-apoptosis role after sci. |
2011-12-12 |
2023-08-12 |
rat |
| Antony Gomes, Biplab Giri, Aftab Alam, Sanghamitra Mukherjee, Pushpak Bhattacharjee, Aparna Gome. Anticancer activity of a low immunogenic protein toxin (BMP1) from Indian toad (Bufo melanostictus, Schneider) skin extract. Toxicon : official journal of the International Society on Toxinology. vol 58. issue 1. 2011-12-09. PMID:21635912. |
the parallel induction of bax and p53 expression in hepg2 cells and the up-regulation of caspase 3 and caspase 9 due to bmp1 treatment indicated the involvement of p53-dependent intrinsic pathway of apoptosis. |
2011-12-09 |
2023-08-12 |
mouse |