| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ling Yang, Weiwei Guo, Qunling Zhang, Hongyan Li, Xiaoyu Liu, Yunlong Yang, Ji Zuo, Wen Li. Crosstalk between Raf/MEK/ERK and PI3K/AKT in suppression of Bax conformational change by Grp75 under glucose deprivation conditions. Journal of molecular biology. vol 414. issue 5. 2012-02-03. PMID:21964438. |
during glucose deprivation (gd)-induced cellular stress, the molecular chaperone glucose-regulated protein 75 (grp75)/mortalin/pbp74/mthsp70 (hereafter termed "grp75") plays an important role in the suppression of apoptosis by inhibiting the bax conformational change that delays the release of cytochrome c. the molecular pathways by which it carries out these functions are still unclear. |
2012-02-03 |
2023-08-12 |
Not clear |
| Ling Yang, Weiwei Guo, Qunling Zhang, Hongyan Li, Xiaoyu Liu, Yunlong Yang, Ji Zuo, Wen Li. Crosstalk between Raf/MEK/ERK and PI3K/AKT in suppression of Bax conformational change by Grp75 under glucose deprivation conditions. Journal of molecular biology. vol 414. issue 5. 2012-02-03. PMID:21964438. |
the activated akt and extracellular signal-regulated protein kinases 1 and 2 by grp75 inhibited the bax conformational change and subsequent apoptosis. |
2012-02-03 |
2023-08-12 |
Not clear |
| Joshua A Smith, Arabinda Das, Jonathan T Butler, Swapan K Ray, Naren L Bani. Estrogen or estrogen receptor agonist inhibits lipopolysaccharide induced microglial activation and death. Neurochemical research. vol 36. issue 9. 2012-02-02. PMID:21127968. |
reverse transcriptase polymerase chain reaction (rt-pcr) analyses showed alterations in mrna expression of bax, bcl-2, calpain, and calpastatin during apoptosis. |
2012-02-02 |
2023-08-12 |
rat |
| Nadine Henke, Dmitrij A Lisak, Lars Schneider, Jörn Habicht, Matthias Pergande, Axel Methne. The ancient cell death suppressor BAX inhibitor-1. Cell calcium. vol 50. issue 3. 2012-02-02. PMID:21663964. |
bax inhibitor-1 (bi-1) was initially identified for its ability to inhibit bax-induced apoptosis in yeast cells and is the founding member of a family of highly hydrophobic proteins localized in diverse cellular membranes. |
2012-02-02 |
2023-08-12 |
Not clear |
| Yuan-Ta Lin, Yijuang Chern, Che-Kun James Shen, Hsin-Lan Wen, Ya-Chin Chang, Hung Li, Tzu-Hao Cheng, Hsiu Mei Hsieh-L. Human mesenchymal stem cells prolong survival and ameliorate motor deficit through trophic support in Huntington's disease mouse models. PloS one. vol 6. issue 8. 2012-02-02. PMID:21850243. |
the p-erk1/2 expression was increased while bax and caspase-3 levels were decreased after hbm-msc transplantation suggesting that the reduced level of apoptosis after hbm-msc transplantation was of benefit to the qa-lesioned mice. |
2012-02-02 |
2023-08-12 |
mouse |
| Ying-Bei Chen, Miguel A Aon, Yi-Te Hsu, Lucian Soane, Xinchen Teng, J Michael McCaffery, Wen-Chih Cheng, Bing Qi, Hongmei Li, Kambiz N Alavian, Margaret Dayhoff-Brannigan, Shifa Zou, Fernando J Pineda, Brian O'Rourke, Young H Ko, Peter L Pedersen, Leonard K Kaczmarek, Elizabeth A Jonas, J Marie Hardwic. Bcl-xL regulates mitochondrial energetics by stabilizing the inner membrane potential. The Journal of cell biology. vol 195. issue 2. 2012-02-02. PMID:21987637. |
mammalian bcl-x(l) protein localizes to the outer mitochondrial membrane, where it inhibits apoptosis by binding bax and inhibiting bax-induced outer membrane permeabilization. |
2012-02-02 |
2023-08-12 |
Not clear |
| Alex Yuri Simões Sato, Eliane Antonioli, Rodrigo Tambellini, Alexandre Holthausen Campo. ID1 inhibits USF2 and blocks TGF-β-induced apoptosis in mesangial cells. American journal of physiology. Renal physiology. vol 301. issue 6. 2012-02-01. PMID:21921026. |
on the other hand, tgf-β upregulates usf2, increasing bax (proapoptotic gene) levels and apoptosis rates. |
2012-02-01 |
2023-08-12 |
human |
| Yanmin Zhang, Jie Zhang, Bingling Dai, Nan Wang, Langchong H. Anti-proliferative and apoptotic effects of the novel taspine derivative tas41 in the Caco-2 cell line. Environmental toxicology and pharmacology. vol 31. issue 3. 2012-01-31. PMID:21787711. |
at the same time, expressions of apoptosis protein bcl-2 and bax were determined. |
2012-01-31 |
2023-08-12 |
Not clear |
| Nives Pustisek, Mirna Situ. UV-radiation, apoptosis and skin. Collegium antropologicum. vol 35 Suppl 2. 2012-01-31. PMID:22220467. |
the intrinsic or mitochondrial pathway of apoptosis is regulated by the bcl-2 family of proteins, anti-apoptotic (bcl-2, bcl-xl, bcl-w) and the pro-apoptotic (bax, bak, bid). |
2012-01-31 |
2023-08-12 |
Not clear |
| Guangfen Xiao, Xueyuan Tang, Chenjiao Yao, Chenghong Wan. Potentiation of arsenic trioxide-induced apoptosis by 8-bromo-7-methoxychrysin in human leukemia cells involves depletion of intracellular reduced glutathione. Acta biochimica et biophysica Sinica. vol 43. issue 9. 2012-01-30. PMID:21785114. |
this co-treatment caused mitochondrial transmembrane potential dissipation and stimulated the mitochondrial apoptotic pathway, as evidenced by cytochrome c release, down-regulation of x-linked inhibitor of apoptosis (xiap) and bcl-xl, and up-regulation of bax. |
2012-01-30 |
2023-08-12 |
human |
| Chunhua Lu, Shan Lu, Wei Liang, Jing Li, Xiaowei Dou, Chunjing Bian, Dan Shi, Lianming Liao, Robert Chunhua Zha. TAp63α mediates chemotherapeutic agent-induced apoptosis in human bone marrow mesenchymal stem cells. Stem cells and development. vol 20. issue 8. 2012-01-27. PMID:21142794. |
interference of tap63α led to drug resistance and decreased apoptosis, accompanied by reduced expression of bax, poly(adp-ribose) polymerase, and caspase-3. |
2012-01-27 |
2023-08-12 |
human |
| Ramaprasada Rao Kotipatruni, Venkata Ramesh Dasari, Krishna Kumar Veeravalli, Dzung H Dinh, Daniel Fassett, Jasti S Ra. p53- and Bax-mediated apoptosis in injured rat spinal cord. Neurochemical research. vol 36. issue 11. 2012-01-27. PMID:21748659. |
sub-cellular distribution of bax and cytochrome c indicated mitochondrial-mediated apoptosis taking place after spinal cord injury. |
2012-01-27 |
2023-08-12 |
rat |
| Xiangru Qu, Shaochun Qu, Xiaofeng Yu, Huali Xu, Yanping Chen, Xingyuan Ma, Dayuan Su. pseudo-G-Rh2 induces mitochondrial-mediated apoptosis in SGC-7901 human gastric cancer cells. Oncology reports. vol 26. issue 6. 2012-01-27. PMID:21887470. |
pseudo-g-rh2-induced apoptosis was associated with a drop in the mitochondrial transmembrane potential, down-regulation of bcl-2, up-regulation of bax and activation of caspase-9 and caspase-3. |
2012-01-27 |
2023-08-12 |
human |
| Pavel Babal, Rosica Milcheva, Svetlozara Petkova, Pavol Janega, Zuzana Hurnikov. Apoptosis as the adaptation mechanism in survival of Trichinella spiralis in the host. Parasitology research. vol 109. issue 4. 2012-01-26. PMID:21465261. |
in the context of low bax and caspase 3 expression and strong distribution of aif in the sarcoplasm and nucleus at the very early stage of infection, we suppose that aif-mediated signaling is involved in the apoptosis activation in the area of trichinella occupation. |
2012-01-26 |
2023-08-12 |
Not clear |
| B Cheng, S Pan, X Liu, S Zhang, X Su. Cell apoptosis of taste buds in circumvallate papillae in diabetic rats. Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association. vol 119. issue 8. 2012-01-25. PMID:21667436. |
immunohistochemical and western blot analyses revealed the downregulation of bcl-2, upregulation of bax, and increased activation of caspase-9 and -3, in diabetic rats, indicating that the apoptosis of taste bud cells may be mediated via the intrinsic mitochondrial pathway in diabetics. |
2012-01-25 |
2023-08-12 |
rat |
| B Žegura, G Gajski, A Štraser, V Garaj-Vrhova. Cylindrospermopsin induced DNA damage and alteration in the expression of genes involved in the response to DNA damage, apoptosis and oxidative stress. Toxicon : official journal of the International Society on Toxinology. vol 58. issue 6-7. 2012-01-24. PMID:21867723. |
cyn induced changes in the mrna expression of p53 and its downstream regulated dna damage responsive genes mdm2, gadd45α and apoptosis genes, bcl-2 and bax, as well as oxidative stress responsive genes (gpx1, sod1, gsr, gclc), while no changes in the expression of genes cdkn1a and cat were observed. |
2012-01-24 |
2023-08-12 |
human |
| Hong Lin, Wei Xiong, Xiang Zhang, Bolin Liu, Wei Zhang, Yongqiang Zhang, Jinxiang Cheng, Huiyong Huan. Notch-1 activation-dependent p53 restoration contributes to resveratrol-induced apoptosis in glioblastoma cells. Oncology reports. vol 26. issue 4. 2012-01-23. PMID:21743969. |
significant de-phosphorylation of akt, increased bax expression, decreased bcl-2 expression and cleavage of caspase-3 were also observed in resveratrol-induced apoptosis in glioblastoma cells. |
2012-01-23 |
2023-08-12 |
Not clear |
| Hong Lin, Wei Xiong, Xiang Zhang, Bolin Liu, Wei Zhang, Yongqiang Zhang, Jinxiang Cheng, Huiyong Huan. Notch-1 activation-dependent p53 restoration contributes to resveratrol-induced apoptosis in glioblastoma cells. Oncology reports. vol 26. issue 4. 2012-01-23. PMID:21743969. |
in addition, the de-phosphorylation of akt, increased expression of bax and cleavage of caspase-3 were not fully reversed by mrk-003 treatment, suggesting that p53 restoration is not the only mechanism underlying resveratrol-induced apoptosis. |
2012-01-23 |
2023-08-12 |
Not clear |
| Weicheng Hu, Woong Han, Chaoqing Huang, Myeong-Hyeon Wan. Protective effect of the methanolic extract from Duchesnea indica against oxidative stress in vitro and in vivo. Environmental toxicology and pharmacology. vol 31. issue 1. 2012-01-23. PMID:21787668. |
furthermore, dim inhibited cell apoptosis and bax expression induced by h(2)o(2). |
2012-01-23 |
2023-08-12 |
mouse |
| A Benco, A V Sirotkin, D Vasícek, S Pavlová, J Zemanová, J Kotwica, K Darlak, F Valenzuel. Involvement of the transcription factor STAT1 in the regulation of porcine ovarian granulosa cell functions treated and not treated with ghrelin. Reproduction (Cambridge, England). vol 138. issue 3. 2012-01-20. PMID:19528263. |
the effects of treatment with ghrelin (0, 1, 10, 100 ng/ml), transfection-induced overexpression of transcription factor stat1, and their combination on apoptosis (expression of apoptosis-related peptides caspase-3, bax and anti-apoptotic peptide bcl2), proliferation (expression of proliferating cell nuclear antigene pcna, proliferation-associated protein kinase mapk/erk1,2) and release of the hormones progesterone (p(4)), prostaglandin f (pgf) and oxytocin (oxt) in cultured porcine ovarian granulosa cells was evaluated using ria, immunocytochemistry and sds-page-western immunoblotting. |
2012-01-20 |
2023-08-12 |
Not clear |