| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Juan Ignacio Barrasa, Nieves Olmo, Pablo Pérez-Ramos, Angélica Santiago-Gómez, Emilio Lecona, Javier Turnay, M Antonia Lizarb. Deoxycholic and chenodeoxycholic bile acids induce apoptosis via oxidative stress in human colon adenocarcinoma cells. Apoptosis : an international journal on programmed cell death. vol 16. issue 10. 2012-01-12. PMID:21789651. |
apoptosis is detected after 30 min-2 h of treatment, as observed by cell detachment, loss of membrane asymmetry, internucleosomal dna degradation, appearance of mitochondrial transition permeability (mpt), and caspase and bax activation. |
2012-01-12 |
2023-08-12 |
human |
| Ying Jiang, Xue Zhou, Xi Chen, Guangtao Yang, Qian Wang, Kaimin Rao, Wei Xiong, Jing Yua. Benzo(a)pyrene-induced mitochondrial dysfunction and cell death in p53-null Hep3B cells. Mutation research. vol 726. issue 1. 2012-01-12. PMID:21911080. |
in addition, after bap treatment, c-jun n-terminal kinase (jnk) and bax were activated during apoptosis and no change in p73 protein level was observed. |
2012-01-12 |
2023-08-12 |
human |
| Ying Jiang, Xue Zhou, Xi Chen, Guangtao Yang, Qian Wang, Kaimin Rao, Wei Xiong, Jing Yua. Benzo(a)pyrene-induced mitochondrial dysfunction and cell death in p53-null Hep3B cells. Mutation research. vol 726. issue 1. 2012-01-12. PMID:21911080. |
activation of jnk and bax possibly contributed to bap-induced apoptosis. |
2012-01-12 |
2023-08-12 |
human |
| Fatma Bensassi, Cindy Gallerne, Ossama Sharaf el Dein, Mohamed Rabeh Hajlaoui, Hassen Bacha, Christophe Lemair. Mechanism of Alternariol monomethyl ether-induced mitochondrial apoptosis in human colon carcinoma cells. Toxicology. vol 290. issue 2-3. 2012-01-12. PMID:22001388. |
moreover, no difference was observed in bax-ko cells in comparison to parental cells, suggesting that the pro-apoptotic protein bax is not involved in ame-induced mitochondrial apoptosis. |
2012-01-12 |
2023-08-12 |
human |
| Eun Jeong Choi, Gun-Hee Ki. Anticancer mechanism of equol in 7,12-dimethylbenz(a)anthracene-treated animals. International journal of oncology. vol 39. issue 3. 2012-01-11. PMID:21667019. |
this was associated with equol-induced apoptosis in mammary gland tumors, as evidenced by the decreased bcl-2 expression and increased bax expression, together with the activation of caspase-3 and poly(adp-ribose) polymerase (parp). |
2012-01-11 |
2023-08-12 |
mouse |
| Eun Jeong Choi, Gun-Hee Ki. Anticancer mechanism of equol in 7,12-dimethylbenz(a)anthracene-treated animals. International journal of oncology. vol 39. issue 3. 2012-01-11. PMID:21667019. |
dmba treatment induced apoptosis, as shown by a decrease in the bcl-2 levels and an increase in the levels of bax, cleaved caspase-3 and poly(adp-ribose) polymerase. |
2012-01-11 |
2023-08-12 |
mouse |
| Huang-Yao Tu, A-Mei Huang, Chi-Huang Teng, Tzyh-Chyuan Hour, Shyh-Chyun Yang, Yeong-Shiau Pu, Chun-Nan Li. Anthraquinone derivatives induce G2/M cell cycle arrest and apoptosis in NTUB1 cells. Bioorganic & medicinal chemistry. vol 19. issue 18. 2012-01-10. PMID:21852140. |
biological results suggested that the induction of g2/m arrest, apoptosis, and cell death by 9 may associate with increased expression of p21 and cyclin b1, elevation of bax and p53 levels, and generation of ros in the cell. |
2012-01-10 |
2023-08-12 |
human |
| Ulrika Nyman, Naveen Reddy Muppani, Boris Zhivotovsky, Bertrand Josep. Hsp72 mediates TAp73α anti-apoptotic effects in small cell lung carcinoma cells. Journal of cellular and molecular medicine. vol 15. issue 8. 2012-01-09. PMID:20807285. |
in addition, tap73α has been shown to inhibit bax activation and mitochondrial dysfunctions and thereby to confer small cell lung carcinoma (sclc) cells resistance to drug-induced apoptosis. |
2012-01-09 |
2023-08-12 |
Not clear |
| Shumin Zhang, Xuexi Tang, Jingwei Tian, Chunmei Li, Guanbo Zhang, Wanglin Jiang, Zunting Zhan. Cardioprotective effect of sulphonated formononetin on acute myocardial infarction in rats. Basic & clinical pharmacology & toxicology. vol 108. issue 6. 2012-01-09. PMID:21232020. |
the number of apoptosis cardiocytes is well accordance with the up-regulated expression of bcl-2 and the down-regulated expression of bax. |
2012-01-09 |
2023-08-12 |
rat |
| Xiaobo Yan, Jie Feng, Zhaoming Ye, Xudong Miao, Weixu Li, Disheng Yan. p53 siRNA inhibits apoptosis of U2OS cells treated with azurin. Molecular medicine reports. vol 4. issue 6. 2012-01-09. PMID:21822538. |
cells treated with p53 sirna and azurin showed more viable cells, a lower apoptosis rate, lower caspase-3 activity, and up-regulation of bcl-2, downregulation of bax compared to cells treated with negative sirna and azurin. |
2012-01-09 |
2023-08-12 |
human |
| Dennis B Huckabee, Mika B Jekabson. Identification of Bax-voltage-dependent anion channel 1 complexes in digitonin-solubilized cerebellar granule neurons. Journal of neurochemistry. vol 119. issue 5. 2012-01-09. PMID:21951169. |
a sixth 170 kda oligomer containing exclusively 6a7 bax and no vdac1 was identified after apoptosis induction. |
2012-01-09 |
2023-08-12 |
Not clear |
| Mustafa Sönmez, Gaffari Türk, Ali Osman Çeribaşı, Fatih Sakin, Ahmet Ateşşahi. Attenuating effect of lycopene and ellagic acid on 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced spermiotoxicity and testicular apoptosis. Drug and chemical toxicology. vol 34. issue 4. 2012-01-05. PMID:21714773. |
sperm motility, concentration, and abnormal sperm rate in epididymal tissue, testicular tissue lipid peroxidation (lpo), antioxidant enzyme activity, histopathological changes, and apoptosis (i.e., bax and bcl-2 proteins) were determined. |
2012-01-05 |
2023-08-12 |
rat |
| Nishant Mohan, Naren L Banik, Swapan K Ra. Combination of N-(4-hydroxyphenyl) retinamide and apigenin suppressed starvation-induced autophagy and promoted apoptosis in malignant neuroblastoma cells. Neuroscience letters. vol 502. issue 1. 2012-01-05. PMID:21801811. |
consistent with the hypothesis that inhibition of autophagy could induce apoptosis, we noticed inhibition of autophagy and induction of apoptosis in the serum-starved sh-sy5y cells with the suppression of the survival factor nf-κb, upregulation of pro-apoptotic bax, downregulation of anti-apoptotic bcl-2, activation of caspase-3, and degradation of poly(adp-ribose) polymerase (parp) after combination therapy. |
2012-01-05 |
2023-08-12 |
human |
| Karen Castillo, Diego Rojas-Rivera, Fernanda Lisbona, Benjamín Caballero, Melissa Nassif, Felipe A Court, Sebastian Schuck, Consuelo Ibar, Peter Walter, Jimena Sierralta, Alvaro Glavic, Claudio Het. BAX inhibitor-1 regulates autophagy by controlling the IRE1α branch of the unfolded protein response. The EMBO journal. vol 30. issue 21. 2012-01-05. PMID:21926971. |
bax inhibitor 1 (bi-1) is a highly conserved protein with a dual role in apoptosis and endoplasmic reticulum (er) stress signalling through the regulation of the er stress sensor inositol requiring kinase 1 α (ire1α). |
2012-01-05 |
2023-08-12 |
mouse |
| Vermont P Dia, Elvira Gonzalez de Meji. Lunasin potentiates the effect of oxaliplatin preventing outgrowth of colon cancer metastasis, binds to α5β1 integrin and suppresses FAK/ERK/NF-κB signaling. Cancer letters. vol 313. issue 2. 2012-01-05. PMID:21963225. |
moreover, lunasin potentiated the effect of oxaliplatin in modifying expression of proteins involved in apoptosis and metastasis including bax, bcl-2, ikk-α and p-p65. |
2012-01-05 |
2023-08-12 |
human |
| Ga Bin Park, Yeong Seok Kim, Hyun-Kyung Lee, Hyunkeun Song, Seonghan Kim, Dae-Ho Cho, Dae Young Hu. Reactive oxygen species and p38 MAPK regulate Bax translocation and calcium redistribution in salubrinal-induced apoptosis of EBV-transformed B cells. Cancer letters. vol 313. issue 2. 2012-01-05. PMID:22056078. |
reactive oxygen species and p38 mapk regulate bax translocation and calcium redistribution in salubrinal-induced apoptosis of ebv-transformed b cells. |
2012-01-05 |
2023-08-12 |
Not clear |
| Ga Bin Park, Yeong Seok Kim, Hyun-Kyung Lee, Hyunkeun Song, Seonghan Kim, Dae-Ho Cho, Dae Young Hu. Reactive oxygen species and p38 MAPK regulate Bax translocation and calcium redistribution in salubrinal-induced apoptosis of EBV-transformed B cells. Cancer letters. vol 313. issue 2. 2012-01-05. PMID:22056078. |
moreover, salubrinal subsequently led to activation of caspases, calcium redistribution, bax translocation, cytochrome c release, and apoptosis. |
2012-01-05 |
2023-08-12 |
Not clear |
| Saba Khan, Gorantla V Raghuram, Arpit Bhargava, Neelam Pathak, Dolly H Chandra, Subodh K Jain, Pradyumna K Mishr. Role and clinical significance of lymphocyte mitochondrial dysfunction in type 2 diabetes mellitus. Translational research : the journal of laboratory and clinical medicine. vol 158. issue 6. 2012-01-05. PMID:22061042. |
increased oxidative stress, mitochondrial membrane depolarization, activation of caspase-3, and parp observed in diabetic groups indicated bax triggered mitochondrial mediated cellular apoptosis. |
2012-01-05 |
2023-08-12 |
human |
| Jingbo Liu, Daiwen Chen, Xiangbing Mao, Bing Y. Effects of maternal folic acid supplementation on morphology and apoptosis-related gene expression in jejunum of newborn intrauterine growth retarded piglets. Archives of animal nutrition. vol 65. issue 5. 2012-01-05. PMID:22164959. |
the expression of genes encoding dna methyltransferase-1 (dnmt-1), genes related to cell apoptosis (p53, bcl-2 and bax) and genes involved in dna repair (mpg, apex1 and tdg, firstly cloned in the present study) were investigated by reverse transcription (rt)-pcr in the jejunal section of the intestine. |
2012-01-05 |
2023-08-12 |
Not clear |
| Cyrus Khandanpour, Christian Kosan, Marie-Claude Gaudreau, Ulrich Dührsen, Josée Hébert, Hui Zeng, Tarik Mörö. Growth factor independence 1 protects hematopoietic stem cells against apoptosis but also prevents the development of a myeloproliferative-like disease. Stem cells (Dayton, Ohio). vol 29. issue 2. 2011-12-30. PMID:21732494. |
we now report that gfi1 protects hscs against stress-induced apoptosis, probably, by repressing the proapoptotic target gene bax, since irradiated gfi1(-/-) hscs display higher expression of bax and show a higher rate of apoptosis than wt hscs. |
2011-12-30 |
2023-08-12 |
mouse |