| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| A V Sirotkin, A Benčo, A Tandlmajerová, D Vašíče. Involvement of transcription factor p53 and leptin in control of porcine ovarian granulosa cell functions. Cell proliferation. vol 45. issue 1. 2012-02-16. PMID:22151798. |
it also stimulated expression of bax (which can be thought of as a marker of apoptosis), and reduced accumulation of proliferation-related substances pcna and cyclin b1. |
2012-02-16 |
2023-08-12 |
Not clear |
| A V Sirotkin, A Benčo, A Tandlmajerová, D Vašíče. Involvement of transcription factor p53 and leptin in control of porcine ovarian granulosa cell functions. Cell proliferation. vol 45. issue 1. 2012-02-16. PMID:22151798. |
(iii) the similarity of p53 and leptin's actions on bax and cyclin b1, and inability of p53 to further promote leptin action on this parameter suggest that p53 can be a mediator of leptin's action on ovarian cell apoptosis. |
2012-02-16 |
2023-08-12 |
Not clear |
| Linda Ebermann, Sylwia Wika, Inga Klumpe, Elke Hammer, Karin Klingel, Dirk Lassner, Uwe Völker, Ulrike Erben, Heinz Zeichhardt, Heinz-Peter Schultheiss, Andrea Dörne. The mitochondrial respiratory chain has a critical role in the antiviral process in Coxsackievirus B3-induced myocarditis. Laboratory investigation; a journal of technical methods and pathology. vol 92. issue 1. 2012-02-15. PMID:21968812. |
intrinsic apoptosis was activated demonstrated by elevated levels of bax, bcl-2, caspase 3 and dna degradation. |
2012-02-15 |
2023-08-12 |
mouse |
| Carina de Lima, Luciana Alves, Fabíola Iagher, Andressa Franzoi Machado, Marcelo Kryczyk, Ricardo Key Yamazaki, Gleisson Alisson Pereira Brito, Everson Araújo Nunes, Katya Naliwaiko, Luiz Cláudio Fernande. Tumor growth reduction in Walker 256 tumor-bearing rats performing anaerobic exercise: participation of Bcl-2, Bax, apoptosis, and peroxidation. Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme. vol 36. issue 4. 2012-02-14. PMID:21851206. |
tumor growth reduction in walker 256 tumor-bearing rats performing anaerobic exercise: participation of bcl-2, bax, apoptosis, and peroxidation. |
2012-02-14 |
2023-08-12 |
rat |
| Carina de Lima, Luciana Alves, Fabíola Iagher, Andressa Franzoi Machado, Marcelo Kryczyk, Ricardo Key Yamazaki, Gleisson Alisson Pereira Brito, Everson Araújo Nunes, Katya Naliwaiko, Luiz Cláudio Fernande. Tumor growth reduction in Walker 256 tumor-bearing rats performing anaerobic exercise: participation of Bcl-2, Bax, apoptosis, and peroxidation. Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme. vol 36. issue 4. 2012-02-14. PMID:21851206. |
apoptosis in the tumor cells of ex rats was 2-fold higher than in the tumor cells of sedentary rats; in addition, bax expression increased by 10% and bcl-2 decreased by 13% in ex rats. |
2012-02-14 |
2023-08-12 |
rat |
| Deyu Yang, Xia Liu, Rufang Zhang, Ke Cheng, Jun Mu, Liang Fang, Peng Xi. Increased apoptosis and different regulation of pro-apoptosis protein bax and anti-apoptosis protein bcl-2 in the olfactory bulb of a rat model of depression. Neuroscience letters. vol 504. issue 1. 2012-02-14. PMID:21903151. |
increased apoptosis and different regulation of pro-apoptosis protein bax and anti-apoptosis protein bcl-2 in the olfactory bulb of a rat model of depression. |
2012-02-14 |
2023-08-12 |
rat |
| Lesley Cheng, Danielle J Smith, Robin L Anderson, Phillip Nagle. Modulation of cellular Hsp72 levels in undifferentiated and neuron-like SH-SY5Y cells determines resistance to staurosporine-induced apoptosis. PloS one. vol 6. issue 9. 2012-02-14. PMID:21915333. |
the data are consistent with hsp72 blocking apoptosis upstream of bax recruitment to mitochondria. |
2012-02-14 |
2023-08-12 |
human |
| Louiza Belkacemi, Mina Desai, D Michael Nelson, Michael G Ros. Altered mitochondrial apoptotic pathway in placentas from undernourished rat gestations. American journal of physiology. Regulatory, integrative and comparative physiology. vol 301. issue 6. 2012-02-14. PMID:21918224. |
our results show that the mun placentas had significantly increased apoptosis, with lower expression of cytosolic and mitochondrial anti-apoptotic bcl2 and bcl-x(l), and significantly higher expression of pro-apoptotic bax and bak especially in the labyrinth zone. |
2012-02-14 |
2023-08-12 |
rat |
| Antonio Postigo, Michael Wa. The vaccinia virus-encoded Bcl-2 homologues do not act as direct Bax inhibitors. Journal of virology. vol 86. issue 1. 2012-02-14. PMID:22013032. |
many viruses, including members of several poxvirus genera, encode inhibitors that block apoptosis by simultaneously binding the proapoptotic bcl-2 proteins bak and bax. |
2012-02-14 |
2023-08-12 |
Not clear |
| Antonio Postigo, Michael Wa. The vaccinia virus-encoded Bcl-2 homologues do not act as direct Bax inhibitors. Journal of virology. vol 86. issue 1. 2012-02-14. PMID:22013032. |
meanwhile, infections with Δf1l or Δn1l/f1l virus resulted in similar levels of bax activation and apoptosis. |
2012-02-14 |
2023-08-12 |
Not clear |
| b' B Zegura, G Gajski, A Straser, V Garaj-Vrhovac, M Filipi\\xc4\\x8. Microcystin-LR induced DNA damage in human peripheral blood lymphocytes. Mutation research. vol 726. issue 2. 2012-02-13. PMID:22001196.' |
after 24h, dna damage-responsive genes (p53, mdm2, gadd45a, cdkn1a), a gene involved in apoptosis (bax) and oxidative stress-responsive genes (cat, gpx1, sod1, gsr, gclc) were up-regulated. |
2012-02-13 |
2023-08-12 |
human |
| James L Frankli. Redox regulation of the intrinsic pathway in neuronal apoptosis. Antioxidants & redox signaling. vol 14. issue 8. 2012-02-08. PMID:20812874. |
here i review possible mechanisms by which bax causes increased ros during neuronal apoptosis. |
2012-02-08 |
2023-08-12 |
Not clear |
| Vinicius F Carvalho, Luisa T Florim, Emiliano de O Barreto, Rafael C Torres, Marcelo M Batista, Fabio C Amendoeira, Renato S B Cordeiro, Marco A Martins, Patrícia M R E Silv. Inhibition of advanced glycation end products by aminoguanidine restores mast cell numbers and reactivity in alloxan-diabetic rats. European journal of pharmacology. vol 669. issue 1-3. 2012-02-08. PMID:21864526. |
mast cell apoptosis and levels of bax, a pro-apoptotic member of bcl-2 family, were evaluated by tunel and western blot, respectively. |
2012-02-08 |
2023-08-12 |
rat |
| Vinicius F Carvalho, Luisa T Florim, Emiliano de O Barreto, Rafael C Torres, Marcelo M Batista, Fabio C Amendoeira, Renato S B Cordeiro, Marco A Martins, Patrícia M R E Silv. Inhibition of advanced glycation end products by aminoguanidine restores mast cell numbers and reactivity in alloxan-diabetic rats. European journal of pharmacology. vol 669. issue 1-3. 2012-02-08. PMID:21864526. |
increased apoptosis and levels of bax in mast cells from diabetic rats were inhibited by aminoguanidine. |
2012-02-08 |
2023-08-12 |
rat |
| b' Barbara Zapa\\xc5\\x82a, Teresa Staszel, Beata Kie\\xc4\\x87-Wilk, Anna Polus, Anna Knapp, Iwona Wybra\\xc5\\x84ska, \\xc5\\x81ukasz Kaczy\\xc5\\x84ski, Aldona Dembi\\xc5\\x84ska-Kie\\xc4\\x8. [Humanin and its derivatives as peptides with potential antiapoptotic and confirmed neuroprotective activities]. Przeglad lekarski. vol 68. issue 7. 2012-02-07. PMID:22010475.' |
it was demonstrated that hn plays a protective role by an antiapoptotic activity interfering with bax activation, and suppressing bax-dependent apoptosis. |
2012-02-07 |
2023-08-12 |
human |
| Lei Cui, Yuezhen Deng, Yefei Rong, Wenhui Lou, Zhengfa Mao, Yuanyuan Feng, Dong Xie, Dayong Ji. IRF-2 is over-expressed in pancreatic cancer and promotes the growth of pancreatic cancer cells. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. vol 33. issue 1. 2012-02-06. PMID:22119988. |
mechanistically, irf-2 modulated the growth of pancreatic cancer cells through regulating proliferation and apoptosis effectors, such as cyclin d1 and bax. |
2012-02-06 |
2023-08-12 |
Not clear |
| Hui-Zhen Zhang, Feng-Quan Zhang, Chao-Feng Li, Dan Yi, Xiao-Li Fu, Liu-Xin Cu. A cyanobacterial toxin, microcystin-LR, induces apoptosis of sertoli cells by changing the expression levels of apoptosis-related proteins. The Tohoku journal of experimental medicine. vol 224. issue 3. 2012-02-03. PMID:21701130. |
both p53 and bax function as promoters of apoptosis, while bcl-2 is an apoptotic suppressor. |
2012-02-03 |
2023-08-12 |
human |
| Ke Xu, Xin Liang, Fang Wang, Lijuan Xie, Yufang Xu, Jianwen Liu, Xuhong Qia. Induction of G2/M phase arrest and apoptosis by potent antitumor APCA in human cervix carcinoma cells. Anti-cancer drugs. vol 22. issue 9. 2012-02-03. PMID:21808189. |
furthermore, translocation inhibition of nuclear factor-κb, upregulation of bax, and downregulation of bcl-2, caspase-3 and caspase-9 activation, and poly-(adp-ribose) polymerase cleavage were observed in hela cells treated with apca, which indicated that the mitochondrial pathway was involved in the apoptosis signal pathway. |
2012-02-03 |
2023-08-12 |
human |
| Melisa A Martínez-Paniagua, Stavroula Baritaki, Sara Huerta-Yepez, Vianney F Ortiz-Navarrete, Cesar González-Bonilla, Benjamin Bonavida, Mario I Veg. Mcl-1 and YY1 inhibition and induction of DR5 by the BH3-mimetic Obatoclax (GX15-070) contribute in the sensitization of B-NHL cells to TRAIL apoptosis. Cell cycle (Georgetown, Tex.). vol 10. issue 16. 2012-02-03. PMID:21822052. |
the pan bcl-2 family antagonist obatoclax (gx15-070), currently in clinical trials, was shown to sensitize trail-resistant tumors to trail-mediated apoptosis via the release of bak and bim from mcl-1 or bcl-2/bcl-xl complexes or by the activation of bax, though other mechanisms were not examined. |
2012-02-03 |
2023-08-12 |
Not clear |
| Kaori Shima, Teppei Morikawa, Mai Yamauchi, Aya Kuchiba, Yu Imamura, Xiaoyun Liao, Jeffrey A Meyerhardt, Charles S Fuchs, Shuji Ogin. TGFBR2 and BAX mononucleotide tract mutations, microsatellite instability, and prognosis in 1072 colorectal cancers. PloS one. vol 6. issue 9. 2012-02-03. PMID:21949851. |
the receptor tgfbr2 plays an important role in the tgfb1 (transforming growth factor-β, tgf-β) signaling pathway, and bax plays a key role in apoptosis. |
2012-02-03 |
2023-08-12 |
Not clear |