| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Chih-Hua Tseng, Cherng-Chyi Tzeng, Kuin-Yu Chung, Chai-Lin Kao, Chih-Yao Hsu, Chih-Mei Cheng, Keng-Shiang Huang, Yeh-Long Che. Synthesis and antiproliferative evaluation of 6-aryl-11-iminoindeno[1,2-c]quinoline derivatives. Bioorganic & medicinal chemistry. vol 19. issue 24. 2012-03-19. PMID:22079254. |
further investigations have shown that 23a induced cell cycle arrest at g2/m phase and induce apoptosis via activation of p53, bax, and caspase-8 which consequently cause cell death. |
2012-03-19 |
2023-08-12 |
Not clear |
| Huanjun Pan, Dongye Li, Fang Fang, Dan Chen, Lingling Qi, Ruiqu Zhang, Tongda Xu, Hong Su. Salvianolic acid A demonstrates cardioprotective effects in rat hearts and cardiomyocytes after ischemia/reperfusion injury. Journal of cardiovascular pharmacology. vol 58. issue 5. 2012-03-15. PMID:21795988. |
in the present study, we tested cell viability, shortening amplitude, necrosis, apoptosis, and the expression levels of akt, phosphorylated akt, bcl-2, bax, and caspase-3 after 3-hour simulated ischemia and 2- or 6-hour simulated reperfusion in cardiomyocytes. |
2012-03-15 |
2023-08-12 |
rat |
| Ki-Eun Bae, Young-Woong Choi, Sang-Tae Kim, Young-Kyoon Ki. Components of rhizome extract of Cnidium officinale Makino and their in vitro biological effects. Molecules (Basel, Switzerland). vol 16. issue 10. 2012-03-15. PMID:22019572. |
in addition, falcarindiol induced apoptosis through strongly increased mrna expression of bax and p53, and slightly reduced bcl-2 mrna levels in a dose dependent manner. |
2012-03-15 |
2023-08-12 |
human |
| Geert Bultynck, Santeri Kiviluoto, Nadine Henke, Hristina Ivanova, Lars Schneider, Volodymyr Rybalchenko, Tomas Luyten, Koen Nuyts, Wim De Borggraeve, Ilya Bezprozvanny, Jan B Parys, Humbert De Smedt, Ludwig Missiaen, Axel Methne. The C terminus of Bax inhibitor-1 forms a Ca2+-permeable channel pore. The Journal of biological chemistry. vol 287. issue 4. 2012-03-15. PMID:22128171. |
bax inhibitor-1 (bi-1) is a multitransmembrane domain-spanning endoplasmic reticulum (er)-located protein that is evolutionarily conserved and protects against apoptosis and er stress. |
2012-03-15 |
2023-08-12 |
Not clear |
| Kevin B Clayton, Petar Podlesniy, Joana Figueiro-Silva, Guillermo López-Doménech, Lluis Benitez, Marta Enguita, Maria A Abad, Eduardo Soriano, Ramon Trulla. NP1 regulates neuronal activity-dependent accumulation of BAX in mitochondria and mitochondrial dynamics. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 32. issue 4. 2012-03-12. PMID:22279230. |
in cultured cerebellar granule neurons, low neuronal activity triggers the intrinsic program of apoptosis, which requires protein synthesis-dependent bax translocation to mitochondria, a process that may underlie neuronal damage in neurodegeneration. |
2012-03-12 |
2023-08-12 |
mouse |
| Kevin B Clayton, Petar Podlesniy, Joana Figueiro-Silva, Guillermo López-Doménech, Lluis Benitez, Marta Enguita, Maria A Abad, Eduardo Soriano, Ramon Trulla. NP1 regulates neuronal activity-dependent accumulation of BAX in mitochondria and mitochondrial dynamics. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 32. issue 4. 2012-03-12. PMID:22279230. |
here we report that np1 facilitates the accumulation of bax in mitochondria and regulates mitochondrial dynamics during apoptosis in rat and mouse cerebellar granule neurons in culture. |
2012-03-12 |
2023-08-12 |
mouse |
| Ianors Iandiev, Mike Francke, Felix Makarov, Margrit Hollborn, Susann Uhlmann, Antje Wurm, Alexey Savvinov, Leon Kohen, Andreas Reichenbach, Peter Wiedemann, Thomas Pannicke, Andreas Bringman. Effects of intravitreal bevacizumab (Avastin) on the porcine retina. Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie. vol 249. issue 12. 2012-03-09. PMID:21845390. |
to evaluate the effects of intravitreal bevacizumab (avastin) on the porcine retina, with respect to structural alterations, expression of proteins involved in apoptosis (bax, caspase-3, caspase-9) and gliosis (vimentin, gfap), expression of factors which influence the development of vascular edema (vegf, pedf), and of membrane channels implicated in retinal osmohomeostasis (kir4.1, aquaporin-1, aquaporin-4). |
2012-03-09 |
2023-08-12 |
Not clear |
| Cheng-Yi Chang, Chiung-Chyi Shen, Hong-Lin Su, Chun-Jung Che. Gefitinib induces apoptosis in human glioma cells by targeting Bad phosphorylation. Journal of neuro-oncology. vol 105. issue 3. 2012-03-08. PMID:21744078. |
the importance of bax in mediating gefitinib-induced apoptosis was confirmed by the attenuation of apoptosis by bax sirna and bax channel blocker. |
2012-03-08 |
2023-08-12 |
human |
| Du Cheng, Nuo Cao, Jifeng Chen, Xingsu Yu, Xintao Shua. Multifunctional nanocarrier mediated co-delivery of doxorubicin and siRNA for synergistic enhancement of glioma apoptosis in rat. Biomaterials. vol 33. issue 4. 2012-03-07. PMID:22061491. |
in particular, animal studies using the in situ rat c6 glioma model showed that the folate-targeted co-delivery of bcl-2 sirna and dox caused not only an obvious down-regulation of the anti-apoptotic bcl-2 gene but also a remarkable up-regulation of the pro-apoptotic bax gene, resulting in the significantly elevated level of caspase-3 activation and remarkable cell apoptosis in tumor tissues. |
2012-03-07 |
2023-08-12 |
rat |
| N Khandelwal, J Simpson, G Taylor, S Rafique, A Whitehouse, J Hiscox, L A Star. Nucleolar NF-κB/RelA mediates apoptosis by causing cytoplasmic relocalization of nucleophosmin. Cell death and differentiation. vol 18. issue 12. 2012-03-06. PMID:21660047. |
we show by multiple approaches that nucleolar translocation of rela is causally involved in the relocalization of npm from the nucleolus to the cytoplasm and that rela-induced cytoplasmic npm mediates apoptosis by facilitating the mitochondrial accumulation of bax. |
2012-03-06 |
2023-08-12 |
Not clear |
| Patricia Galán-Malo, Laura Vela, Oscar Gonzalo, Rubén Calvo-Sanjuán, Lucía Gracia-Fleta, Javier Naval, Isabel Marz. Cell fate after mitotic arrest in different tumor cells is determined by the balance between slippage and apoptotic threshold. Toxicology and applied pharmacology. vol 258. issue 3. 2012-03-06. PMID:22178383. |
overexpression of bcl-x(l) or silencing bax and bak expression delayed the onset of apoptosis in jurkat and rpmi 8226 cells, enabling mitotic slippage and endoreduplication. |
2012-03-06 |
2023-08-12 |
human |
| Archana Aggarwal, M M Misro, Ankur Maheshwari, Neeta Sehga. Differential modulation of apoptotic gene expression by N-acetyl-L-cysteine in Leydig cells stimulated persistently with hCG in vivo. Molecular and cellular endocrinology. vol 348. issue 1. 2012-03-05. PMID:21856376. |
leydig cell apoptosis declined significantly (p<0.001) with down-regulation of upstream, fas, fasl, caspase-8, bax and caspase-9, jnk/pjnk and downstream caspase-3 and parp. |
2012-03-05 |
2023-08-12 |
rat |
| Yun-Chih Hsieh, Yerra Koteswara Rao, Jacqueline Whang-Peng, Chi-Ying F Huang, Song-Kun Shyue, Shih-Lan Hsu, Yew-Min Tzen. Antcin B and its ester derivative from Antrodia camphorata induce apoptosis in hepatocellular carcinoma cells involves enhancing oxidative stress coincident with activation of intrinsic and extrinsic apoptotic pathway. Journal of agricultural and food chemistry. vol 59. issue 20. 2012-03-05. PMID:21916504. |
this study investigated the roles of caspase cascades, reactive oxygen species (ros), dna damage, mitochondrial disruption, and bax and bcl-2 proteins in mab- and ab-induced apoptosis of hepatocellular carcinoma (hcc) hepg2 cells. |
2012-03-05 |
2023-08-12 |
Not clear |
| Yun-Chih Hsieh, Yerra Koteswara Rao, Jacqueline Whang-Peng, Chi-Ying F Huang, Song-Kun Shyue, Shih-Lan Hsu, Yew-Min Tzen. Antcin B and its ester derivative from Antrodia camphorata induce apoptosis in hepatocellular carcinoma cells involves enhancing oxidative stress coincident with activation of intrinsic and extrinsic apoptotic pathway. Journal of agricultural and food chemistry. vol 59. issue 20. 2012-03-05. PMID:21916504. |
additionally, the enhanced apoptotic effect correlates with high expression of fas, fas ligand, as well as bax and decreased protein levels of bcl-(xl) and bcl-2, suggesting that both the extrinsic and intrinsic apoptosis pathways were involved in the apoptotic processes. |
2012-03-05 |
2023-08-12 |
Not clear |
| Yan-Yan Lu, Zhi-Qiang Xuan, Xue-Zhi L. [DMF-induced adult hepatocyte apoptosis and its effects on expression of Bcl-2, Bax and Caspase-3]. Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases. vol 26. issue 5. 2012-03-01. PMID:18727869. |
[dmf-induced adult hepatocyte apoptosis and its effects on expression of bcl-2, bax and caspase-3]. |
2012-03-01 |
2023-08-12 |
human |
| N Yivgi-Ohana, M Eifer, Y Addadi, M Neeman, A Gros. Utilizing mitochondrial events as biomarkers for imaging apoptosis. Cell death & disease. vol 2. 2012-03-01. PMID:21633389. |
we report here a novel method for the detection of mitochondrial events during apoptosis, namely translocation of bax to mitochondria and release of cytochrome c (cyt c) using bimolecular fluorescence complementation. |
2012-03-01 |
2023-08-12 |
Not clear |
| Conghui Han, Zhen Gong, Lin Hao, Jianjun Yang, Jianpeng Hu, Bingzheng Dong, Tao Fan, Wenhao Tang, Gaojun Ten. Mechanism of monoclonal antibody-coupled Staphylococcus superantigen-A induced apoptosis in human bladder cancer cells. Cell biochemistry and biophysics. vol 61. issue 3. 2012-03-01. PMID:21769564. |
sea targeting by mab significantly increases apoptosis in biu-87 cells, possibly through the up-regulation of proapoptotic protein bax and down regulation of antiapoptotic protein, bcl-2. |
2012-03-01 |
2023-08-12 |
human |
| Juke Ma, Sumei Lu, Liang Yu, Jiajun Tian, Jianfeng Li, Haibo Wang, Wei X. FaDu cell characteristics induced by multidrug resistance. Oncology reports. vol 26. issue 5. 2012-03-01. PMID:21833476. |
furthermore, caspase-3, bcl-2 and bax expression was altered accordingly to resist apoptosis in the fadu/t cells. |
2012-03-01 |
2023-08-12 |
Not clear |
| Yongzhi Wang, Lingchao Chen, Zhaoshi Bao, Shouwei Li, Gan You, Wei Yan, Zhendong Shi, Yanwei Liu, Pei Yang, Wei Zhang, Lei Han, Chunsheng Kang, Tao Jian. Inhibition of STAT3 reverses alkylator resistance through modulation of the AKT and β-catenin signaling pathways. Oncology reports. vol 26. issue 5. 2012-03-01. PMID:21887474. |
inhibition of stat3 dramatically decreased the ic50 of tmz, increasing tmz-induced apoptosis while up-regulating expression of bcl-2 and down-regulating expression of bax. |
2012-03-01 |
2023-08-12 |
human |
| Liang Zhang, Hong-Juan Yao, Yang Yu, Yan Zhang, Ruo-Jing Li, Rui-Jun Ju, Xiao-Xing Wang, Meng-Ge Sun, Ji-Feng Shi, Wan-Liang L. Mitochondrial targeting liposomes incorporating daunorubicin and quinacrine for treatment of relapsed breast cancer arising from cancer stem cells. Biomaterials. vol 33. issue 2. 2012-03-01. PMID:21983136. |
the mitochondrial targeting liposomes evidently increased the mitochondrial uptake of drugs, were selectively accumulated into mitochondria, activated the pro-apoptotic bax protein, dissipated the mitochondrial membrane potential, opened the mitochondrial permeability transition pores, released cytochrome c by translocation, and initiated a cascade of caspase 9 and 3 reactions, thereby inducing apoptosis of mcf-7 cancer stem cells. |
2012-03-01 |
2023-08-12 |
mouse |