| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hong-Wang Cui, Da-Li Wang, Guang-Feng Sun, Zai-Rong We. [Spermatogenic cell apoptosis and expressions of Bcl-2 and Bax proteins after burying the testis in the inguinal pocket]. Zhonghua nan ke xue = National journal of andrology. vol 17. issue 9. 2012-04-19. PMID:21961237. |
[spermatogenic cell apoptosis and expressions of bcl-2 and bax proteins after burying the testis in the inguinal pocket]. |
2012-04-19 |
2023-08-12 |
Not clear |
| Hong-Wang Cui, Da-Li Wang, Guang-Feng Sun, Zai-Rong We. [Spermatogenic cell apoptosis and expressions of Bcl-2 and Bax proteins after burying the testis in the inguinal pocket]. Zhonghua nan ke xue = National journal of andrology. vol 17. issue 9. 2012-04-19. PMID:21961237. |
to observe the apoptosis of spermatogenic cells and the expressions of bcl-2 and bax proteins after burying the testis in the inguinal pocket, and to investigate their relationship. |
2012-04-19 |
2023-08-12 |
Not clear |
| Hsueh-Fang Wang, Chien-Yu Tseng, Mu-Hsin Chang, James A Lin, Fu-Jen Tsai, Chang-Hai Tsai, Ying-Chen Lu, Chao-Hung Lai, Chih-Yang Huang, Cheng-Chih Tsa. Anti-inflammatory effects of probiotic Lactobacillus paracasi on ventricles of BALB/C mice treated with ovalbumin. The Chinese journal of physiology. vol 55. issue 1. 2012-04-19. PMID:22242953. |
the inflammatory pathway, including toll-like receptor 4 (tlr4), phospholate-jun-n-terminal kinase (p-jnk), jnk1/2 and tumor necrosis factor- alpha (tnf-α) and the mitochondria-dependent apoptosis phospholate-p38 (p-p38), bcl-2 associated agonist of cell death (bad), bcl-2 associated x (bax) and activated caspase 3, were found to be significant- ly increased in the hearts of allergy mice. |
2012-04-19 |
2023-08-12 |
mouse |
| Dong Chen, Xuefeng Zheng, Dalu Kang, Bomin Yan, Xiaoyi Liu, Yuan Gao, Kejun Zhan. Apoptosis and expression of the Bcl-2 family of proteins and P53 in human pancreatic ductal adenocarcinoma. Medical principles and practice : international journal of the Kuwait University, Health Science Centre. vol 21. issue 1. 2012-04-17. PMID:22024503. |
the purpose of this study was to clarify the association between p53 and the bcl-2 family (bcl-2, bax, bcl-xl, bcl-xs) expression and apoptosis in pancreatic ductal adenocarcinoma (pdac). |
2012-04-17 |
2023-08-12 |
human |
| Fang-hua Qi, An-yuan Li, Lin Zhao, Li Zhang, Guan-hua Du, Wei Tan. [Apoptosis-inducing effect of cinobufacini on human hepatoma cell line HepG2 and its mechanism of action]. Yao xue xue bao = Acta pharmaceutica Sinica. vol 45. issue 3. 2012-04-16. PMID:21351507. |
quantitative real-time rt-pcr and western blotting analysis were used to detect the mrna and protein expressions of apoptosis related factors bcl-2, bax and p53. |
2012-04-16 |
2023-08-12 |
human |
| Ying-Cheng Chung, Feng-Yao Tang, Jiunn-Wang Liao, Chia-Hua Chung, Ting-Ting Jong, Shih-Shiung Chen, Ching-Hsiu Tsai, En-Pei Chian. Isatis indigotica induces hepatocellular cancer cell death via caspase-independent apoptosis-inducing factor translocation apoptotic pathway in vitro and in vivo. Integrative cancer therapies. vol 10. issue 2. 2012-04-16. PMID:21382959. |
furthermore, cedli activates p53 and bax, reduces bcl-2 expression, and causes mitochondrial stress and the release of apoptosis-inducing factor into the cytosol followed by its translocation into the nucleus, resulting in hepatoma cell apoptosis. |
2012-04-16 |
2023-08-12 |
mouse |
| Maria Galuppo, Emanuela Esposito, Emanuela Mazzon, Rosanna Di Paola, Irene Paterniti, Daniela Impellizzeri, Salvatore Cuzzocre. MEK inhibition suppresses the development of lung fibrosis in the bleomycin model. Naunyn-Schmiedeberg's archives of pharmacology. vol 384. issue 1. 2012-04-16. PMID:21533992. |
pd98059 treatment shows therapeutic effects on pulmonary damage, decreasing many inflammatory and apoptotic parameters, such as (1) cytokine production; (2) ikbα degradation and nf-kb nuclear translocation; (3) inos expression; (4) nitrotyrosine and par localization; and (5) the degree of apoptosis, as evaluated by bax and bcl-2 balance, fas ligand expression, and terminal deoxynucleotidyl transferase dutp nick-end labeling staining. |
2012-04-16 |
2023-08-12 |
mouse |
| Guoxiong Xu, Jinhee Ahn, Soyoung Chang, Megumi Eguchi, Arnaud Ogier, Sungjun Han, Youngsam Park, Chiyoung Shim, Yangsoo Jang, Bo Yang, Aimin Xu, Yu Wang, Gary Sweene. Lipocalin-2 induces cardiomyocyte apoptosis by increasing intracellular iron accumulation. The Journal of biological chemistry. vol 287. issue 7. 2012-04-16. PMID:22117066. |
in conclusion, lcn2-induced cardiomyocyte apoptosis is of physiological significance and occurs via a mechanism involving elevated intracellular iron levels and bax translocation. |
2012-04-16 |
2023-08-12 |
mouse |
| Cheol-Hee Choi, Byung-Hoon Lee, Sang-Gun Ahn, Seon-Hee O. Proteasome inhibition-induced p38 MAPK/ERK signaling regulates autophagy and apoptosis through the dual phosphorylation of glycogen synthase kinase 3β. Biochemical and biophysical research communications. vol 418. issue 4. 2012-04-16. PMID:22310719. |
the treatment of mda-mb-231 cells with mg132 induced endoplasmic reticulum stress through the induction of atf6a, perk phosphorylation, and chop, and apoptosis through the cleavage of bax and procaspase-3. |
2012-04-16 |
2023-08-12 |
Not clear |
| Sook-Ja Lee, Haerim Jang, Chaehwa Par. Maspin increases Ku70 acetylation and Bax-mediated cell death in cancer cells. International journal of molecular medicine. vol 29. issue 2. 2012-04-13. PMID:22076034. |
maspin inhibited histone deacetylase 1 (hdac1) and thus increased the acetylation of ku70 and the dissociation of bax from ku70, which led to the induction of apoptosis. |
2012-04-13 |
2023-08-12 |
Not clear |
| Eun Jeong Choi, Jae In Lee, Gun-Hee Ki. Evaluation of the anticancer activities of thioflavanone and thioflavone in human breast cancer cell lines. International journal of molecular medicine. vol 29. issue 2. 2012-04-13. PMID:22076075. |
moreover, thioflavanone, but not thioflavone, induces apoptosis via p53-dependent expression of bax. |
2012-04-13 |
2023-08-12 |
human |
| Se-Hwan Kim, Kyung-Min Lim, Ji-Yoon Noh, Keunyoung Kim, Seojin Kang, Youn Kyeong Chang, Sue Shin, Jin-Ho Chun. Doxorubicin-induced platelet procoagulant activities: an important clue for chemotherapy-associated thrombosis. Toxicological sciences : an official journal of the Society of Toxicology. vol 124. issue 1. 2012-04-12. PMID:21865289. |
along with this, apoptosis was induced by dox as determined by the dissipation of mitochondrial membrane potential (Δψ), cytochrome c release, bax translocation, and caspase-3 activation. |
2012-04-12 |
2023-08-12 |
human |
| Cheng-Liang Yang, Ye-Gang Ma, Yi-Xue Xue, Yong-Yu Liu, Hui Xie, Guang-Rong Qi. Curcumin induces small cell lung cancer NCI-H446 cell apoptosis via the reactive oxygen species-mediated mitochondrial pathway and not the cell death receptor pathway. DNA and cell biology. vol 31. issue 2. 2012-04-09. PMID:21711158. |
instead, curcumin caused apoptosis by increasing bax expression while decreasing the expression of bcl-2 and bcl-xl. |
2012-04-09 |
2023-08-12 |
human |
| Biyun Ni, Qi Ma, Baowei Li, Lixia Zhao, Yong Liu, Yushan Zhu, Quan Che. Phenylarsine oxide induces apoptosis in Bax- and Bak-deficient cells through upregulation of Bim. Clinical cancer research : an official journal of the American Association for Cancer Research. vol 18. issue 1. 2012-04-09. PMID:22048238. |
bax and bak are regarded as key mediators for cytochrome c (cyt c) release and apoptosis. |
2012-04-09 |
2023-08-12 |
human |
| Yue-min Nan, Fang Han, Ling-bo Kong, Ya Li, Rong-qi Wang, Su-xian Zha. [Peroxisome proliferator activated receptor gamma activation and overexpression prevent hepatocellular apoptosis of nutritional fibrotic steatohepatitis in mice]. Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology. vol 19. issue 7. 2012-04-09. PMID:22152244. |
the expression levels of mrna and protein of pparg and apoptosis related genes, fas, fas ligand (fasl), b cell lymphoma/leukemia-2 (bcl-2), bcl-2 associated x protein (bax) and cysteine-containing aspartate-specific proteases-3 (caspase-3) were detected by real-time rt-pcr and western blot assay, respectively. |
2012-04-09 |
2023-08-12 |
mouse |
| Nayden G Naydenov, Gianni Harris, Bryan Brown, Katherine L Schaefer, Swadesh K Das, Paul B Fisher, Andrei I Ivano. Loss of soluble N-ethylmaleimide-sensitive factor attachment protein α (αSNAP) induces epithelial cell apoptosis via down-regulation of Bcl-2 expression and disruption of the Golgi. The Journal of biological chemistry. vol 287. issue 8. 2012-04-09. PMID:22194596. |
apoptosis was not caused by activation of the major prodeath regulators bax and p53 and was independent of a key αsnap binding partner, nsf. |
2012-04-09 |
2023-08-12 |
Not clear |
| Na Li, Yangyan He, Ling Wang, Chunfen Mo, Jie Zhang, Wei Zhang, Junhong Li, Zhiyong Liao, Xiaoqiang Tang, Hengyi Xia. D-galactose induces necroptotic cell death in neuroblastoma cell lines. Journal of cellular biochemistry. vol 112. issue 12. 2012-04-06. PMID:21826710. |
d-gal treatment can transcriptionally up-regulate the genes relevant to necroptosis (bmf, bnip3) and autophagy (atg5, tigar) but not the genes related to apoptosis (caspase3, bax, and p53). |
2012-04-06 |
2023-08-12 |
Not clear |
| Qiliang Cai, Yi Guo, Bingyi Xiao, Shuvomoy Banerjee, Abhik Saha, Jie Lu, Tina Glisovic, Erle S Robertso. Epstein-Barr virus nuclear antigen 3C stabilizes Gemin3 to block p53-mediated apoptosis. PLoS pathogens. vol 7. issue 12. 2012-04-06. PMID:22174681. |
small hairpin rna based knockdown of gemin3 in b lymphoma or lcl cells remarkably attenuates the ability of ebna3c to inhibit the transcription activity of p53 on its downstream genes p21 and bax, as well as apoptosis. |
2012-04-06 |
2023-08-12 |
human |
| Hosung Sohn, Jong-Seok Kim, Sung Jae Shin, Kwangwook Kim, Choul-Jae Won, Woo Sik Kim, Ki-Nam Min, Han-Gyu Choi, Je Chul Lee, Jeong-Kyu Park, Hwa-Jung Ki. Targeting of Mycobacterium tuberculosis heparin-binding hemagglutinin to mitochondria in macrophages. PLoS pathogens. vol 7. issue 12. 2012-04-06. PMID:22174691. |
enhanced reactive oxygen species (ros) production and bax activation were essential for hbha-induced apoptosis, as evidenced by a restoration of the viability of macrophages pretreated with n-acetylcysteine, a potent ros scavenger, or transfected with bax sirna. |
2012-04-06 |
2023-08-12 |
Not clear |
| Karima Rjiba-Touati, Imen Ayed-Boussema, Chayma Bouaziz, Anis Belarbia, Awatef Azzabi, Abdelatif Achour, Wafa Hassen, Hassen Bach. Protective effect of erythropoietin against cisplatin-induced nephrotoxicity in rats: antigenotoxic and antiapoptotic effect. Drug and chemical toxicology. vol 35. issue 1. 2012-04-05. PMID:21834728. |
apoptosis was revealed by an enhancement of proapoptotic protein (e.g., p53 and bax) levels, decrease in antiapoptotic proteins (e.g., bcl2 and hsp27), and increase in caspase-3 activity. |
2012-04-05 |
2023-08-12 |
rat |