| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Constanze Buhrmann, Ali Mobasheri, Franziska Busch, Constance Aldinger, Ralf Stahlmann, Azadeh Montaseri, Mehdi Shakibae. Curcumin modulates nuclear factor kappaB (NF-kappaB)-mediated inflammation in human tenocytes in vitro: role of the phosphatidylinositol 3-kinase/Akt pathway. The Journal of biological chemistry. vol 286. issue 32. 2012-05-11. PMID:21669872. |
the anti-inflammatory effects of curcumin included down-regulation of gene products that mediate matrix degradation (matrix metalloproteinase-1, -9, and -13), prostanoid production (cyclooxygenase-2), apoptosis (bax and activated caspase-3), and stimulation of cell survival (bcl-2), all known to be regulated by nf-κb. |
2012-05-11 |
2023-08-12 |
human |
| Sylviane Métrailler, Daniel F Schorderet, Sandra Cotte. Early apoptosis of rod photoreceptors in Rpe65(-/-) mice is associated with the upregulated expression of lysosomal-mediated autophagic genes. Experimental eye research. vol 96. issue 1. 2012-05-11. PMID:22227450. |
this wave of early apoptosis triggered bcl-2-related pathway and bax apoptotic activity, while activation of the caspases was not induced. |
2012-05-11 |
2023-08-12 |
mouse |
| Sung Ho Park, Jeong Heon Lee, Gwang-Beom Lee, Hyun-Jung Byun, Boh-Ram Kim, Chan-Yong Park, Hong-Bae Kim, Seung Bae Rh. PDCD6 additively cooperates with anti-cancer drugs through activation of NF-κB pathways. Cellular signalling. vol 24. issue 3. 2012-05-10. PMID:22142513. |
pdcd6 promotes tnfα-dependent apoptosis through the activation of nf-κb signaling pathways, increasing bax, p53, and p21 expression, while also down-regulating bcl-2 and bcl-xl expression. |
2012-05-10 |
2023-08-12 |
Not clear |
| Wen Liu, Zhi-qiang Gao, Ping Shen, Guo-dong Feng, Yang Zha, Yan-dong Zhang, Pei-mao Li. [Facial paralysis induced by herpes simplex virus type 1 and the study of facial neurons apoptosis in mice]. Zhonghua er bi yan hou tou jing wai ke za zhi = Chinese journal of otorhinolaryngology head and neck surgery. vol 46. issue 9. 2012-05-10. PMID:22177043. |
to study the apoptosis of facial motor neurons and the expression of apoptosis-related genes, bcl-2 and bax, in the animal model of viral facial paralysis. |
2012-05-10 |
2023-08-12 |
mouse |
| Changjing Zhuge, Ying Chang, Yanjun Li, Yingyu Chen, Jinzhi Le. PDCD5-regulated cell fate decision after ultraviolet-irradiation-induced DNA damage. Biophysical journal. vol 101. issue 11. 2012-05-09. PMID:22261045. |
our simulations indicate that the ultimate cell response to dna damage is dependent on a signal threshold mechanism, and the pdcd5 promotion of bax translocation plays an essential role in pdcd5-regulated cell apoptosis. |
2012-05-09 |
2023-08-12 |
human |
| Wenbin Hu, Fang Wang, Jingsheng Tang, Xinyu Liu, Zhu Yuan, Chunlai Nie, Yuquan We. Proapoptotic protein Smac mediates apoptosis in cisplatin-resistant ovarian cancer cells when treated with the anti-tumor agent AT101. The Journal of biological chemistry. vol 287. issue 1. 2012-05-08. PMID:22052903. |
at101 induced cell apoptosis by activating bax through a conformational change, translocation, and oligomerization. |
2012-05-08 |
2023-08-12 |
Not clear |
| Arash Kheradmand, Omid Dezfoulian, Masoud Alirezaei, Bahram Rasoulia. Ghrelin modulates testicular germ cells apoptosis and proliferation in adult normal rats. Biochemical and biophysical research communications. vol 419. issue 2. 2012-05-07. PMID:22360851. |
in fact, ghrelin balanced bax/bcl-2 ratio toward at increase of bax level in the spermatocytes and therefore may stimulate apoptosis in these germ cells. |
2012-05-07 |
2023-08-12 |
rat |
| Jung-Hee Kim, Jeong Woo Kang, Man Sub Kim, Yesol Bak, Yun Sun Park, Kang-Yeoun Jung, Yoong Ho Lim, Do-Young Yoo. The apoptotic effects of the flavonoid N101-2 in human cervical cancer cells. Toxicology in vitro : an international journal published in association with BIBRA. vol 26. issue 1. 2012-05-03. PMID:22056764. |
meanwhile, we detected processing of caspases-8, -9, and -3, cleavage of parp, as well as bax up-regulation, which indicates activation of mitochondria-emanated intrinsic apoptosis signaling. |
2012-05-03 |
2023-08-12 |
human |
| Shi-Ying Zheng, Yin Li, Dong Jiang, Jun Zhao, Jin-Feng G. Anticancer effect and apoptosis induction by quercetin in the human lung cancer cell line A-549. Molecular medicine reports. vol 5. issue 3. 2012-05-03. PMID:22200874. |
to further determine the molecular mechanism of apoptosis induced by qc, changes in the expression of bcl-2 and bax genes were detected by rt-pcr. |
2012-05-03 |
2023-08-12 |
mouse |
| Shi-Ying Zheng, Yin Li, Dong Jiang, Jun Zhao, Jin-Feng G. Anticancer effect and apoptosis induction by quercetin in the human lung cancer cell line A-549. Molecular medicine reports. vol 5. issue 3. 2012-05-03. PMID:22200874. |
this effect is associated with the induction of apoptosis in a-549 cells and the molecular mechanism may be related to the reduction in expression of the apoptosis-regulating gene bcl-2, and increase in expression of the apoptosis-regulating gene bax. |
2012-05-03 |
2023-08-12 |
mouse |
| Ryan E Henry, Zdenek Andrysik, Ramiro París, Matthew D Galbraith, Joaquín M Espinos. A DR4:tBID axis drives the p53 apoptotic response by promoting oligomerization of poised BAX. The EMBO journal. vol 31. issue 5. 2012-05-03. PMID:22246181. |
strikingly, we observe that key mediators of cell-cycle arrest (p21, 14-3-3σ) and apoptosis (puma, bax) are equally activated regardless of outcome. |
2012-05-03 |
2023-08-12 |
Not clear |
| San-Qiang Li, Rui-Fang Li, Shou-Min Xi, Shu Hu, Zhi-Qiang Jia, Shao-Ping Li, Xin-Li Wen, Ya-Kun Song, Shuai Li, Shi-Peng Li, Fei-Biao Wei, Xue-Liang Che. Systematical analysis of impacts of heat stress on the proliferation, apoptosis and metabolism of mouse hepatocyte. The journal of physiological sciences : JPS. vol 62. issue 1. 2012-05-01. PMID:22125186. |
the expression levels of hsp70, pcna, bax, bcl2, cytochrome p450 1a2 (cyp1a2), cyp2e1 and analog of cyp3a4 (not reported in mouse before), the parameters reflecting stress strength, cell proliferation, apoptosis and metabolism, were detected by western blotting, immunohistochemistry and semi-quantitative rt-pcr in test and control mice. |
2012-05-01 |
2023-08-12 |
mouse |
| Grace A Colletti, Mark T Miedel, James Quinn, Neel Andharia, Ora A Weisz, Kirill Kiselyo. Loss of lysosomal ion channel transient receptor potential channel mucolipin-1 (TRPML1) leads to cathepsin B-dependent apoptosis. The Journal of biological chemistry. vol 287. issue 11. 2012-05-01. PMID:22262857. |
inhibition of the proapoptotic protein bax prevents trpml1 kd-mediated apoptosis but does not prevent cytosolic release of catb. |
2012-05-01 |
2023-08-12 |
Not clear |
| Lili Liu, Ning Zhang, Jiayu Liu, Jie Min, Ningqiang Ma, Na Liu, Yi Liu, Helong Zhan. Lentivirus-mediated siRNA interference targeting SGO-1 inhibits human NSCLC cell growth. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. vol 33. issue 2. 2012-04-30. PMID:22161216. |
moreover, suppression of sgo-1 by lv-sgo-1 sirna increased the apoptosis of h1299 cells with down-regulated bcl-2 and up-regulated bax. |
2012-04-30 |
2023-08-12 |
human |
| Emil Rudolf, Miroslav Cervink. Sulforaphane induces cytotoxicity and lysosome- and mitochondria-dependent cell death in colon cancer cells with deleted p53. Toxicology in vitro : an international journal published in association with BIBRA. vol 25. issue 7. 2012-04-26. PMID:21557998. |
concomitantly, the expression of bax increased in the presence of jnk-mediated bcl-2 inhibition which was followed by mitochondrial release of cytochrome c and activation of apoptosis. |
2012-04-26 |
2023-08-12 |
Not clear |
| Nayoung Kim, Jae Cheal Yoo, Jae Yoon Han, Eun Mi Hwang, Yoon Sook Kim, Eun Young Jeong, Choong-Hyun Sun, Gwan-Su Yi, Gu Seob Roh, Hyun Joon Kim, Sang Soo Kang, Gyeong Jae Cho, Jae-Yong Park, Wan Sung Cho. Human nuclear clusterin mediates apoptosis by interacting with Bcl-XL through C-terminal coiled coil domain. Journal of cellular physiology. vol 227. issue 3. 2012-04-25. PMID:21567405. |
biochemical studies revealed that nclu sequestered bcl-xl via a putative bh3 motif in the c-terminal coiled coil (cc2) domain, releasing bax, and promoted apoptosis accompanied by activation of caspase-3 and cytochrome c release. |
2012-04-25 |
2023-08-12 |
human |
| Krishna K Singh, Praphulla C Shukla, Adrian Quan, Jean-François Desjardins, Fina Lovren, Yi Pan, Vinay Garg, Sumandeep Gosal, Ankit Garg, Paul E Szmitko, Michael D Schneider, Thomas G Parker, William L Stanford, Howard Leong-Poi, Hwee Teoh, Mohammed Al-Omran, Subodh Verm. BRCA2 protein deficiency exaggerates doxorubicin-induced cardiomyocyte apoptosis and cardiac failure. The Journal of biological chemistry. vol 287. issue 9. 2012-04-25. PMID:22157755. |
the levels of p53 and the p53-related proapoptotic proteins p53-up-regulated modulator of apoptosis (puma) and bax were significantly increased in samples from cm-brca2(-/-) mice. |
2012-04-25 |
2023-08-12 |
mouse |
| Yulin Zhang, Ying Shi, Luxin Qiao, Yu Sun, Wei Ding, Honghai Zhang, Ning Li, Dexi Che. Sigma-1 receptor agonists provide neuroprotection against gp120 via a change in bcl-2 expression in mouse neuronal cultures. Brain research. vol 1431. 2012-04-23. PMID:22133307. |
the mrna and protein levels of apoptosis associated bax and bcl-2 were determined with real-time qpcr and western blot. |
2012-04-23 |
2023-08-12 |
mouse |
| Ellen Gerhardt, Simone Gräber, Eva M Szego, Nicoleta Moisoi, L Miguel Martins, Tiago F Outeiro, Pawel Kerme. Idebenone and resveratrol extend lifespan and improve motor function of HtrA2 knockout mice. PloS one. vol 6. issue 12. 2012-04-23. PMID:22205977. |
while idebenone acts by downregulating the integrated stress response, resveratrol acts by attenuating apoptosis at the level of bax. |
2012-04-23 |
2023-08-12 |
mouse |
| Jerry E Chipuk, Gavin P McStay, Archana Bharti, Tomomi Kuwana, Christopher J Clarke, Leah J Siskind, Lina M Obeid, Douglas R Gree. Sphingolipid metabolism cooperates with BAK and BAX to promote the mitochondrial pathway of apoptosis. Cell. vol 148. issue 5. 2012-04-20. PMID:22385963. |
sphingolipid metabolism cooperates with bak and bax to promote the mitochondrial pathway of apoptosis. |
2012-04-20 |
2023-08-12 |
Not clear |