| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Eun-Sook Kim, Choon-Sik Jeong, Aree Moo. Genipin, a constituent of Gardenia jasminoides Ellis, induces apoptosis and inhibits invasion in MDA-MB-231 breast cancer cells. Oncology reports. vol 27. issue 2. 2012-04-05. PMID:22020372. |
herein, we showed that genipin efficiently induced apoptosis in mda-mb-231 cells by the down-regulation of bcl-2, up-regulation of bax and proteolytic activation of caspase-3. |
2012-04-05 |
2023-08-12 |
human |
| Riping Zhang, Pei Tian, Qiang Chi, Jizhou Wang, Yongwei Wang, Lingyu Sun, Yang Liu, Suli Tian, Qifan Zhan. Human ether-à-go-go-related gene expression is essential for cisplatin to induce apoptosis in human gastric cancer. Oncology reports. vol 27. issue 2. 2012-04-05. PMID:22020779. |
silencing herg inhibited the apoptosis induced by cisplatin both in vitro and in vivo, by attenuating the cisplatin effects on bcl-2, bax and active caspase-3. |
2012-04-05 |
2023-08-12 |
mouse |
| Zhipeng Xu, Yuanlin Dong, Xu Wu, Jun Zhang, Sayre McAuliffe, Chuxiong Pan, Yiying Zhang, Fumito Ichinose, Yun Yue, Zhongcong Xi. The potential dual effects of anesthetic isoflurane on Aβ-induced apoptosis. Current Alzheimer research. vol 8. issue 7. 2012-04-04. PMID:21244349. |
h4 human neuroglioma cells, primary neurons from naive mice, and naive mice were treated with aβ and/or isoflurane, and levels of caspase-3 cleavage (activation), apoptosis, bcl-2, bax, and cytosolic calcium were determined. |
2012-04-04 |
2023-08-12 |
mouse |
| Rajeev Kumar Pandey, Kunal H Bhatt, Yogesh Dahiya, Ajit Sodh. Mycobacterium indicus pranii supernatant induces apoptotic cell death in mouse peritoneal macrophages in vitro. PloS one. vol 6. issue 2. 2012-04-02. PMID:21347304. |
it is demonstrated that the mip cell-free supernatant induced apoptosis is mitochondria-mediated and caspase independent and involves mitochondrial translocation of bax and subsequent release of aif and cytochrome c from the mitochondria. |
2012-04-02 |
2023-08-12 |
mouse |
| Tingting Zhang, Yanping Gao, Yu Mao, Quanbo Zhang, Caiyu Lin, Ping Lin, Jie Zhang, Xiujie Wan. Growth inhibition and apoptotic effect of alpha-eleostearic acid on human breast cancer cells. Journal of natural medicines. vol 66. issue 1. 2012-04-02. PMID:21691836. |
the mechanism for such effects might be associated with the inhibition of dna synthesis, induction of apoptosis, and cell cycle arrest of cancer cells through up-regulation of pparγ, p21, bax, p53, and caspase-3 expressions. |
2012-04-02 |
2023-08-12 |
human |
| Kwang-Beom Lee, Hyun-Jung Byun, Sung Ho Park, Chan-Yong Park, Seung-Hoon Lee, Seung Bae Rh. CYR61 controls p53 and NF-κB expression through PI3K/Akt/mTOR pathways in carboplatin-induced ovarian cancer cells. Cancer letters. vol 315. issue 1. 2012-04-02. PMID:22078465. |
cyr61 over-expression promotes cell proliferation by inhibiting carboplatin-induced apoptosis, decreasing bax expression, and increasing bcl-xl, mcl-1, and bcl-2. |
2012-04-02 |
2023-08-12 |
Not clear |
| Emma C Josefsson, Michael J White, Mark R Dowling, Benjamin T Kil. Platelet life span and apoptosis. Methods in molecular biology (Clifton, N.J.). vol 788. 2012-04-02. PMID:22130700. |
platelet apoptosis can be blocked by caspase inhibitors, or by genetic deletion of bak and its close relative bax. |
2012-04-02 |
2023-08-12 |
Not clear |
| Xiaocheng Yin, Lizhi Cao, Yanhui Peng, Yanfang Tan, Min Xie, Rui Kang, Kristen M Livesey, Daolin Tan. A critical role for UVRAG in apoptosis. Autophagy. vol 7. issue 10. 2012-03-30. PMID:21606679. |
uvrag inhibits bax translocation from the cytosol to mitochondria during chemotherapy- or uv irradiation-induced apoptosis of human tumor cells. |
2012-03-30 |
2023-08-12 |
human |
| Rong Zeng, Jing He, Jin Peng, Yan Chen, Sha Yi, Fei Zhao, Guohui Cu. The time-dependent autophagy protects against apoptosis with possible involvement of Sirt1 protein in multiple myeloma under nutrient depletion. Annals of hematology. vol 91. issue 3. 2012-03-30. PMID:21915620. |
bax translocation from cytoplasm to mitochondria and active caspase3 protein level were promoted time dependently along with the increase of apoptosis. |
2012-03-30 |
2023-08-12 |
Not clear |
| Zhuo Liu, Mingchao Li, Ke Chen, Jun Yang, Ruibao Chen, Tao Wang, Jihong Liu, Weimin Yang, Zhangqun Y. S-allylcysteine induces cell cycle arrest and apoptosis in androgen-independent human prostate cancer cells. Molecular medicine reports. vol 5. issue 2. 2012-03-30. PMID:22052207. |
we found that sac suppressed the proliferation of pc-3 cells and led to cell cycle arrest at the g0/g1 phases, as well as inducing cell apoptosis which was accompanied by the decreased expression of bcl-2 and increased expression of bax and caspase 8. |
2012-03-30 |
2023-08-12 |
human |
| Nathalie Zucchini-Pascal, Georges de Sousa, Jérôme Pizzol, Roger Rahman. Molecular investigation of the effects of lindane in rat hepatocytes: microarray and mechanistic studies. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. vol 49. issue 12. 2012-03-28. PMID:22001173. |
tempo (a well known free radical scavenger) and ro 31-8220 (an inhibitor of classical pkcs) prevented the inhibition of spontaneous and intrinsic apoptosis pathway (characterised by bcl-xl induction, bax down-regulation, caspases inhibition) and the induction of necrosis by lindane in rat hepatocytes. |
2012-03-28 |
2023-08-12 |
rat |
| Liuyi Dong, Yifei Fan, Xu Shao, Zhiwu Che. Vitexin protects against myocardial ischemia/reperfusion injury in Langendorff-perfused rat hearts by attenuating inflammatory response and apoptosis. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. vol 49. issue 12. 2012-03-28. PMID:22001368. |
therefore, these results demonstrate that vitexin exhibits significant protective effect against myocardial i/r injury in isolated rat heart, which is related to inhibition of the release of inflammatory cytokines and the apoptosis of cardiac muscle cell via up-regulating protein expression of bcl-2 as well as down-regulating bax and nf-κbp65. |
2012-03-28 |
2023-08-12 |
rat |
| Lili Zhang, Shulan Zhan. Modulating Bcl-2 family proteins and caspase-3 in induction of apoptosis by paeoniflorin in human cervical cancer cells. Phytotherapy research : PTR. vol 25. issue 10. 2012-03-27. PMID:21698669. |
in conclusion, pf can induce significantly the apoptosis of hela cells, which may be demonstrated by the down-regulation of anti-apoptosis gene bcl-2 and the up-regulation of pro-apoptosis genes bax and caspase-3. |
2012-03-27 |
2023-08-12 |
human |
| Jakub Jablonski, Ewa Jablonska, Agnieszka Leoni. The effect of N-nitrosodimethylamine (NDMA) on Bax and Mcl-1 expression in human neutrophils. Bulletin of environmental contamination and toxicology. vol 87. issue 6. 2012-03-22. PMID:21947543. |
in the present study we examined a role of pro-apoptotic bax and anti-apoptotic mcl-1 proteins, participating in the regulation of intrinsic apoptosis pathway in human neutrophils (pmns) exposed to n-nitrosodimethylamine (ndma), the environmental xenobiotic. |
2012-03-22 |
2023-08-12 |
human |
| Jakub Jablonski, Ewa Jablonska, Agnieszka Leoni. The effect of N-nitrosodimethylamine (NDMA) on Bax and Mcl-1 expression in human neutrophils. Bulletin of environmental contamination and toxicology. vol 87. issue 6. 2012-03-22. PMID:21947543. |
a deficit of anti-apoptotic mcl-1 and overexpression of the pro-apoptotic protein bax suggest that the apoptosis process in human neutrophils exposed to ndma is dependent on changes in the expression of these proteins. |
2012-03-22 |
2023-08-12 |
human |
| Beatrice D'Orsi, Helena Bonner, Liam P Tuffy, Heiko Düssmann, Ina Woods, Michael J Courtney, Manus W Ward, Jochen H M Preh. Calpains are downstream effectors of bax-dependent excitotoxic apoptosis. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 32. issue 5. 2012-03-22. PMID:22302823. |
here we investigated the role of calpain activation during nmda-induced excitotoxic injury in embryonic (e16-e18) murine cortical neurons that (1) underwent excitotoxic necrosis, characterized by immediate deregulation of ca(2+) homeostasis, a persistent depolarization of mitochondrial membrane potential (Δψ(m)), and insensitivity to bax-gene deletion, (2) underwent excitotoxic apoptosis, characterized by recovery of nmda-induced cytosolic ca(2+) increases, sensitivity to bax gene deletion, and delayed Δψ(m) depolarization and ca(2+) deregulation, or (3) that were tolerant to excitotoxic injury. |
2012-03-22 |
2023-08-12 |
Not clear |
| Shasha Li, Qinglu Luo, Liqun Huang, Yujun Hu, Qingjie Xia, Chengqi H. Effects of pulsed electromagnetic fields on cartilage apoptosis signalling pathways in ovariectomised rats. International orthopaedics. vol 35. issue 12. 2012-03-20. PMID:21404022. |
the purpose of this study was to determine the effect of exposure to pulsed electromagnetic fields (pemf) on modulation of the cartilage apoptosis signalling pathway in ovariectomised rats by monitoring the expression of mrna of x-linked inhibitor of apoptosis protein (xiap) and bax. |
2012-03-20 |
2023-08-12 |
rat |
| Cheng Zhen Liang, Jia Kai Zhang, Zhongli Shi, Bing Liu, Chengchun Q Shen, Hui Min Ta. Matrine induces caspase-dependent apoptosis in human osteosarcoma cells in vitro and in vivo through the upregulation of Bax and Fas/FasL and downregulation of Bcl-2. Cancer chemotherapy and pharmacology. vol 69. issue 2. 2012-03-20. PMID:21717192. |
matrine induces caspase-dependent apoptosis in human osteosarcoma cells in vitro and in vivo through the upregulation of bax and fas/fasl and downregulation of bcl-2. |
2012-03-20 |
2023-08-12 |
human |
| Jane Levesley, Meryl E Lusher, Janet C Lindsey, Steven C Clifford, Richard Grundy, Beth Coyl. RASSF1A and the BH3-only mimetic ABT-737 promote apoptosis in pediatric medulloblastoma cell lines. Neuro-oncology. vol 13. issue 12. 2012-03-20. PMID:21880625. |
we show that abt-737 increased susceptibility to apoptosis induced by dna damage regardless of rassf1a expression status through increased activation of bax. |
2012-03-20 |
2023-08-12 |
Not clear |
| Yanru Zhao, Guiying Hou, Yuquan Zhang, Jinyu Chi, Lingling Zhang, Xiaoyun Zou, Jiebing Tang, Yue Liu, Yu Fu, Xinhua Yi. Involvement of the calcium-sensing receptor in cyclosporin A-induced cardiomyocyte apoptosis in rats. Die Pharmazie. vol 66. issue 12. 2012-03-20. PMID:22312704. |
gdcl3, a specific activator of casr, further enhanced casr expression and cardiomyocyte apoptosis and led to the upregulation of cytochrome c, cleaved caspase-9, cleaved caspase-3, and bax, as well as the downregulation of bcl-2. |
2012-03-20 |
2023-08-12 |
rat |